Motif ID: HBP1_HMGB_SSRP1_UBTF.p2

Z-value: 1.842


Transcription factors associated with HBP1_HMGB_SSRP1_UBTF.p2:

Gene SymbolEntrez IDGene Name
HBP1 26959 HMG-box transcription factor 1
HMGB2 3148 high-mobility group box 2
HMGB3 3149 high-mobility group box 3
SSRP1 6749 structure specific recognition protein 1
UBTF 7343 upstream binding transcription factor, RNA polymerase I

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
UBTFchr17_-_396523910.224.0e-01Click!
HMGB2chr4_-_174492029-0.224.0e-01Click!
HBP1chr7_+_1065966410.077.8e-01Click!
HMGB3chrX_+_1499024150.039.2e-01Click!
SSRP1chr11_-_568599000.029.3e-01Click!


Activity profile for motif HBP1_HMGB_SSRP1_UBTF.p2.

activity profile for motif HBP1_HMGB_SSRP1_UBTF.p2


Sorted Z-values histogram for motif HBP1_HMGB_SSRP1_UBTF.p2

Sorted Z-values for motif HBP1_HMGB_SSRP1_UBTF.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HBP1_HMGB_SSRP1_UBTF.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_12398514 3.302 NM_001168319
NM_001955
 EDN1

endothelin 1

chr7_+_134114912 2.473 CALD1
caldesmon 1
chr7_+_134114957 2.470 CALD1
caldesmon 1
chr6_+_148705421 2.356 NM_015278
 SASH1
SAM and SH3 domain containing 1
chr16_+_85169615 2.303 NM_005250
 FOXL1
forkhead box L1
chr13_-_73606362 2.077 KLF12
Kruppel-like factor 12
chr2_+_101874809 2.025 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr6_+_114285209 2.021 NM_002356
 MARCKS
myristoylated alanine-rich protein kinase C substrate
chr4_+_86918882 1.962 ARHGAP24
Rho GTPase activating protein 24
chr9_+_18464090 1.957 NM_001040272
NM_052866
 ADAMTSL1

ADAMTS-like 1

chr3_-_116272911 1.904 NM_001164343
 ZBTB20
zinc finger and BTB domain containing 20
chr12_-_16649211 1.902 LMO3
LIM domain only 3 (rhombotin-like 2)
chr13_-_73605914 1.852 NM_007249
 KLF12
Kruppel-like factor 12
chr12_+_13240987 1.828 EMP1
epithelial membrane protein 1
chrX_-_99778340 1.802 NM_003270
 TSPAN6
tetraspanin 6
chr9_+_18464138 1.798 ADAMTSL1
ADAMTS-like 1
chr5_-_111119846 1.786 NM_001142483
 C5orf13
chromosome 5 open reading frame 13
chr11_-_85107569 1.774 NM_206929
 SYTL2
synaptotagmin-like 2
chr9_+_27099138 1.734 NM_000459
 TEK
TEK tyrosine kinase, endothelial
chr1_-_197173159 1.674 LOC100131234
familial acute myelogenous leukemia related factor

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 123 entries
enrichment   p-value GO term description
5.39 4.31e-02 GO:0001953 negative regulation of cell-matrix adhesion
2.86 3.84e-05 GO:0051271 negative regulation of cellular component movement
2.79 3.38e-04 GO:0030336 negative regulation of cell migration
2.79 3.38e-04 GO:2000146 negative regulation of cell motility
2.55 1.29e-03 GO:0040013 negative regulation of locomotion
2.44 2.85e-02 GO:0048706 embryonic skeletal system development
2.37 2.85e-04 GO:0048705 skeletal system morphogenesis
2.30 4.26e-03 GO:0006469 negative regulation of protein kinase activity
2.18 1.59e-02 GO:0033673 negative regulation of kinase activity
2.18 4.18e-02 GO:0035023 regulation of Rho protein signal transduction
2.13 2.93e-02 GO:0010769 regulation of cell morphogenesis involved in differentiation
2.11 3.57e-02 GO:0022604 regulation of cell morphogenesis
2.09 2.44e-02 GO:0007156 homophilic cell adhesion
2.08 3.15e-06 GO:0001568 blood vessel development
2.04 3.59e-04 GO:0048514 blood vessel morphogenesis
2.02 6.36e-06 GO:0001944 vasculature development
2.00 5.03e-04 GO:0048011 nerve growth factor receptor signaling pathway
1.97 2.60e-05 GO:0030029 actin filament-based process
1.97 3.13e-04 GO:0030036 actin cytoskeleton organization
1.96 2.11e-04 GO:0030334 regulation of cell migration

Gene overrepresentation in compartment category:

Showing 1 to 20 of 36 entries
enrichment   p-value GO term description
3.37 4.09e-03 GO:0042641 actomyosin
3.18 1.92e-08 GO:0030027 lamellipodium
2.77 1.10e-06 GO:0005925 focal adhesion
2.75 3.42e-07 GO:0030055 cell-substrate junction
2.64 5.25e-06 GO:0005924 cell-substrate adherens junction
2.39 1.67e-06 GO:0005912 adherens junction
2.32 2.94e-07 GO:0031252 cell leading edge
2.29 2.69e-06 GO:0070161 anchoring junction
2.17 4.94e-03 GO:0044420 extracellular matrix part
2.10 1.33e-02 GO:0044449 contractile fiber part
2.05 2.34e-02 GO:0030016 myofibril
1.99 3.28e-02 GO:0043292 contractile fiber
1.82 1.92e-04 GO:0015629 actin cytoskeleton
1.78 5.88e-03 GO:0016323 basolateral plasma membrane
1.72 3.24e-02 GO:0016604 nuclear body
1.63 1.63e-02 GO:0005578 proteinaceous extracellular matrix
1.54 4.74e-04 GO:0030054 cell junction
1.51 1.61e-04 GO:0044451 nucleoplasm part
1.40 2.21e-05 GO:0005654 nucleoplasm
1.38 1.64e-07 GO:0031981 nuclear lumen

Gene overrepresentation in function category:

Showing 1 to 20 of 21 entries
enrichment   p-value GO term description
3.30 3.42e-04 GO:0008013 beta-catenin binding
2.54 4.53e-03 GO:0005089 Rho guanyl-nucleotide exchange factor activity
2.44 1.36e-03 GO:0005088 Ras guanyl-nucleotide exchange factor activity
2.15 1.80e-02 GO:0019838 growth factor binding
2.14 5.12e-10 GO:0003779 actin binding
1.97 1.26e-12 GO:0008092 cytoskeletal protein binding
1.72 5.19e-03 GO:0005083 small GTPase regulator activity
1.55 7.25e-03 GO:0030695 GTPase regulator activity
1.55 7.34e-03 GO:0060589 nucleoside-triphosphatase regulator activity
1.53 6.41e-05 GO:0019899 enzyme binding
1.51 5.08e-04 GO:0043565 sequence-specific DNA binding
1.47 2.54e-05 GO:0001071 nucleic acid binding transcription factor activity
1.47 2.54e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
1.44 1.05e-04 GO:0030528 transcription regulator activity
1.42 3.43e-02 GO:0005509 calcium ion binding
1.36 1.70e-02 GO:0030234 enzyme regulator activity
1.25 1.20e-03 GO:0003677 DNA binding
1.24 2.11e-20 GO:0005515 protein binding
1.23 2.24e-02 GO:0008270 zinc ion binding
1.22 1.46e-04 GO:0003676 nucleic acid binding