Motif ID: HES1.p2

Z-value: 1.593


Transcription factors associated with HES1.p2:

Gene SymbolEntrez IDGene Name
HES1 3280 hairy and enhancer of split 1, (Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HES1chr3_+_195336625-0.146.1e-01Click!


Activity profile for motif HES1.p2.

activity profile for motif HES1.p2


Sorted Z-values histogram for motif HES1.p2

Sorted Z-values for motif HES1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HES1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr21_+_34367747 1.821 MRPS6
mitochondrial ribosomal protein S6
chr1_+_226937732 1.367 RHOU
ras homolog gene family, member U
chr15_+_39573363 1.260 NM_002220
ITPKA
inositol 1,4,5-trisphosphate 3-kinase A
chr1_-_218168548 1.222 NM_018713
SLC30A10
solute carrier family 30, member 10
chr18_+_586997 1.154 NM_014410
CLUL1
clusterin-like 1 (retinal)
chr2_+_85619802 1.078 MAT2A
methionine adenosyltransferase II, alpha
chr9_-_125070613 1.011 NM_018387
STRBP
spermatid perinuclear RNA binding protein
chr19_-_411995 0.996 NM_012435
SHC2
SHC (Src homology 2 domain containing) transforming protein 2
chr1_-_94147537 0.981 GCLM
glutamate-cysteine ligase, modifier subunit
chr2_-_203444468 0.973 NM_138468
ICA1L
islet cell autoantigen 1,69kDa-like
chr2_+_149118791 0.959 EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr6_-_13819931 0.942 RANBP9
RAN binding protein 9
chr1_-_94147574 0.941 NM_002061
GCLM
glutamate-cysteine ligase, modifier subunit
chr10_+_92912676 0.891 PCGF5
polycomb group ring finger 5
chr2_+_170298700 0.884 KLHL23
kelch-like 23 (Drosophila)
chr16_-_79687367 0.857 NM_004483
GCSH
glycine cleavage system protein H (aminomethyl carrier)
chr5_+_665454 0.857 CEP72
centrosomal protein 72kDa
chr6_+_31976754 0.841 NM_001178063
C2
complement component 2
chr7_-_100068612 0.830 TFR2
transferrin receptor 2
chr2_+_10009242 0.804 NM_198182
GRHL1
grainyhead-like 1 (Drosophila)
chr5_+_665404 0.792 NM_018140
CEP72
centrosomal protein 72kDa
chr21_+_34367678 0.789 NM_032476
NM_006933
MRPS6
SLC5A3
mitochondrial ribosomal protein S6
solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
chr20_+_34667624 0.779 C20orf24
chromosome 20 open reading frame 24
chr1_+_29113589 0.775 NM_001166006
EPB41
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
chr9_+_100907292 0.774


chr22_-_20551937 0.758 MAPK1
mitogen-activated protein kinase 1
chr2_+_85619797 0.753 NM_005911
MAT2A
methionine adenosyltransferase II, alpha
chr1_-_17637398 0.749 RCC2
regulator of chromosome condensation 2
chrX_-_18282698 0.746 NM_006089
SCML2
sex comb on midleg-like 2 (Drosophila)
chrX_-_109447970 0.736 NM_001025580
NM_015365
AMMECR1

Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1

chrX_-_9693916 0.730 NM_000273
GPR143
G protein-coupled receptor 143
chr15_+_48261649 0.730 NM_001159629
NM_003645
SLC27A2

solute carrier family 27 (fatty acid transporter), member 2

chr19_-_8279157 0.728 NM_001165895
NM_016579
CD320

CD320 molecule

chr22_-_20551953 0.721 NM_002745
NM_138957
MAPK1

mitogen-activated protein kinase 1

chr22_+_18091065 0.718 NM_000407
GP1BB
glycoprotein Ib (platelet), beta polypeptide
chr9_+_130491340 0.712 SET
SET nuclear oncogene
chr7_-_148212310 0.708 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr6_+_157722467 0.708 NM_024630
NM_153746
ZDHHC14

zinc finger, DHHC-type containing 14

chr7_-_130004119 0.692 NM_012133
COPG2
coatomer protein complex, subunit gamma 2
chr2_+_182464713 0.690 NM_001130445
NM_006751
SSFA2

sperm specific antigen 2

chr5_+_131657964 0.689 NM_003059
SLC22A4
solute carrier family 22 (organic cation/ergothioneine transporter), member 4
chr16_-_87535106 0.688 NM_175931
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr2_+_11804190 0.684 NM_145693
LPIN1
lipin 1
chr22_-_20551722 0.681 MAPK1
mitogen-activated protein kinase 1
chr15_+_65600520 0.680 NM_001143936
C15orf61
chromosome 15 open reading frame 61
chr4_+_39734902 0.679 NM_018177
N4BP2
NEDD4 binding protein 2
chr16_+_15397120 0.675 MPV17L
MPV17 mitochondrial membrane protein-like
chr6_-_13819622 0.670 NM_005493
RANBP9
RAN binding protein 9
chr3_-_47798337 0.664 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr9_-_125070675 0.659 NM_001171137
STRBP
spermatid perinuclear RNA binding protein
chr6_+_37245860 0.652 NM_002648
PIM1
pim-1 oncogene
chr19_-_1352474 0.651 NM_000156
NM_138924
GAMT

guanidinoacetate N-methyltransferase

chr19_+_54309443 0.650 LIN7B
lin-7 homolog B (C. elegans)
chr1_-_218168404 0.648


chr15_+_24799174 0.645 NM_033223
GABRG3
gamma-aminobutyric acid (GABA) A receptor, gamma 3
chr2_-_101291483 0.644 NM_173647
RNF149
ring finger protein 149
chr6_-_13819463 0.632 RANBP9
RAN binding protein 9
chr2_+_10101822 0.623 NM_001177718
KLF11
Kruppel-like factor 11
chr17_+_50698169 0.620 HLF
hepatic leukemia factor
chr2_-_10505902 0.619 NM_002539
ODC1
ornithine decarboxylase 1
chr2_-_10506033 0.619 ODC1
ornithine decarboxylase 1
chr2_+_182464910 0.613 SSFA2
sperm specific antigen 2
chr16_+_15397087 0.613 NM_001128423
NM_173803
MPV17L

MPV17 mitochondrial membrane protein-like

chr6_+_57145292 0.610 BAG2
BCL2-associated athanogene 2
chr1_-_165789640 0.610 NM_003851
CREG1
cellular repressor of E1A-stimulated genes 1
chr19_+_54309423 0.609 NM_022165
LIN7B
lin-7 homolog B (C. elegans)
chr6_+_111911226 0.608 LOC643749
hypothetical LOC643749
chr3_-_13436802 0.607 NM_024923
NUP210
nucleoporin 210kDa
chr1_-_52791309 0.607 NM_001009881
NM_015269
ZCCHC11

zinc finger, CCHC domain containing 11

chr22_-_17798998 0.604 HIRA
HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
chr2_+_10101081 0.603 NM_003597
NM_001177716
KLF11

Kruppel-like factor 11

chr1_-_17637576 0.602 RCC2
regulator of chromosome condensation 2
chr17_-_73636362 0.601 TMC6
transmembrane channel-like 6
chr20_+_254205 0.589 NM_006943
SOX12
SRY (sex determining region Y)-box 12
chr5_-_6686347 0.585 NM_001193455
NM_017755
NSUN2

NOP2/Sun domain family, member 2

chr3_-_13436725 0.582 NUP210
nucleoporin 210kDa
chr7_+_73226538 0.582 EIF4H
eukaryotic translation initiation factor 4H
chr6_-_125664913 0.578 NM_016063
HDDC2
HD domain containing 2
chr5_-_32480586 0.571 NM_016107
ZFR
zinc finger RNA binding protein
chr22_+_18081968 0.571 NM_002688
SEPT5
septin 5
chr2_-_152393209 0.570 NM_001037174
NM_012097
NM_177985
ARL5A


ADP-ribosylation factor-like 5A


chr22_+_18447732 0.569 NM_001190326
NM_022720
DGCR8

DiGeorge syndrome critical region gene 8

chr1_+_25629968 0.567 NM_018202
TMEM57
transmembrane protein 57
chr2_+_122229590 0.565 NM_004622
TSN
translin
chr7_-_130004101 0.562 COPG2
coatomer protein complex, subunit gamma 2
chr9_+_100907189 0.560 TGFBR1
transforming growth factor, beta receptor 1
chr4_+_57468847 0.558 REST
RE1-silencing transcription factor
chr7_+_24579239 0.558 NM_016447
MPP6
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr22_-_19686351 0.556 NM_001008695
NM_030573
THAP7

THAP domain containing 7

chr4_-_24195113 0.556 DHX15
DEAH (Asp-Glu-Ala-His) box polypeptide 15
chr22_-_19543099 0.553 PI4KA
phosphatidylinositol 4-kinase, catalytic, alpha
chr17_-_73636386 0.553 NM_001127198
TMC6
transmembrane channel-like 6
chr6_-_125664770 0.548 HDDC2
HD domain containing 2
chr16_-_45565068 0.546 NM_005880
DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr1_-_45444812 0.541 NM_020883
ZSWIM5
zinc finger, SWIM-type containing 5
chr1_+_23218515 0.538 NM_001009999
NM_015013
KDM1A

lysine (K)-specific demethylase 1A

chr4_+_25930405 0.537 NM_005349
NM_203283
RBPJ

recombination signal binding protein for immunoglobulin kappa J region

chr9_+_132700462 0.537 ABL1
c-abl oncogene 1, non-receptor tyrosine kinase
chr3_-_47798279 0.536 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr1_-_165789630 0.536 CREG1
cellular repressor of E1A-stimulated genes 1
chr6_+_43846735 0.535 VEGFA
vascular endothelial growth factor A
chr2_+_203207912 0.533 FAM117B
family with sequence similarity 117, member B
chr17_-_39757660 0.532 SLC25A39
solute carrier family 25, member 39
chr1_-_165789586 0.532 CREG1
cellular repressor of E1A-stimulated genes 1
chr5_-_32480486 0.531 ZFR
zinc finger RNA binding protein
chr4_+_57469122 0.531 REST
RE1-silencing transcription factor
chr2_+_170363573 0.524 NM_003142
SSB
Sjogren syndrome antigen B (autoantigen La)
chr9_+_130491370 0.522 SET
SET nuclear oncogene
chr8_-_141714785 0.521 NM_001164623
NM_012154
EIF2C2

eukaryotic translation initiation factor 2C, 2

chr3_-_47798341 0.516 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr8_-_30789846 0.514 PPP2CB
protein phosphatase 2, catalytic subunit, beta isozyme
chr5_-_6686149 0.514 NSUN2
NOP2/Sun domain family, member 2
chr1_-_32574185 0.513 NM_023009
MARCKSL1
MARCKS-like 1
chr21_-_39642935 0.512 HMGN1
high-mobility group nucleosome binding domain 1
chr6_-_3401512 0.511 SLC22A23
solute carrier family 22, member 23
chr4_+_57468792 0.510 NM_005612
REST
RE1-silencing transcription factor
chr17_+_52517529 0.509 NM_003488
AKAP1
A kinase (PRKA) anchor protein 1
chr1_-_94147616 0.505 GCLM
glutamate-cysteine ligase, modifier subunit
chr9_-_139437404 0.503 EXD3
exonuclease 3'-5' domain containing 3
chr7_+_149651202 0.500 NM_001142928
NM_023942
LRRC61

leucine rich repeat containing 61

chr7_-_65084668 0.500 NM_000181
GUSB
glucuronidase, beta
chr16_+_83291055 0.499 NM_005153
USP10
ubiquitin specific peptidase 10
chr3_-_47798347 0.498 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr16_+_387176 0.496 NM_005009
NME4
non-metastatic cells 4, protein expressed in
chr1_-_92124064 0.495 TGFBR3
transforming growth factor, beta receptor III
chr1_+_23218572 0.492 KDM1A
lysine (K)-specific demethylase 1A
chr11_-_129689524 0.492 ZBTB44
zinc finger and BTB domain containing 44
chr16_+_83291107 0.492 USP10
ubiquitin specific peptidase 10
chr1_-_29380969 0.489 SRSF4
serine/arginine-rich splicing factor 4
chr5_+_75734759 0.488 NM_006633
IQGAP2
IQ motif containing GTPase activating protein 2
chr9_+_132961723 0.486 AIF1L
allograft inflammatory factor 1-like
chr9_+_132961683 0.486 NM_001185095
NM_001185096
NM_031426
AIF1L


allograft inflammatory factor 1-like


chr2_+_75039273 0.486 NM_019896
POLE4
polymerase (DNA-directed), epsilon 4 (p12 subunit)
chr21_+_29593098 0.483 BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr6_-_74286876 0.478 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr20_-_48980858 0.478 NM_015339
NM_181442
ADNP

activity-dependent neuroprotector homeobox

chr16_+_83291112 0.475 USP10
ubiquitin specific peptidase 10
chr7_-_103417198 0.474 NM_005045
NM_173054
RELN

reelin

chr21_-_39642880 0.473 NM_004965
HMGN1
high-mobility group nucleosome binding domain 1
chr7_-_148212312 0.472 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr3_-_24511456 0.470 THRB
thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
chr15_-_73531082 0.469 NM_001145358
SIN3A
SIN3 homolog A, transcription regulator (yeast)
chr3_-_47798381 0.467 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr11_+_67836575 0.465 NM_002335
LRP5
low density lipoprotein receptor-related protein 5
chr8_-_30789865 0.465 NM_001009552
PPP2CB
protein phosphatase 2, catalytic subunit, beta isozyme
chr10_+_22650145 0.464 BMI1
BMI1 polycomb ring finger oncogene
chr16_+_83291097 0.462 USP10
ubiquitin specific peptidase 10
chr3_+_134775404 0.460 CDV3
CDV3 homolog (mouse)
chr2_+_206732859 0.458 EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr22_-_17799215 0.457 NM_003325
HIRA
HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
chr11_+_8660913 0.456 RPL27A
ribosomal protein L27a
chr2_-_99472910 0.456 NM_001037872
NM_016316
REV1

REV1 homolog (S. cerevisiae)

chr8_-_102287083 0.456 NM_001042510
NM_016096
ZNF706

zinc finger protein 706

chr6_+_143423656 0.455 NM_016108
AIG1
androgen-induced 1
chr6_+_150112549 0.454 PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr1_+_9522133 0.451 SLC25A33
solute carrier family 25, member 33
chr22_+_18485057 0.451 RANBP1
RAN binding protein 1
chr11_-_46824364 0.448 CKAP5
cytoskeleton associated protein 5
chr2_-_70167949 0.448


chr22_-_17799177 0.447 HIRA
HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
chr11_+_14621884 0.446 PDE3B
phosphodiesterase 3B, cGMP-inhibited
chr1_+_93317374 0.446 NM_001164391
NM_001164392
NM_001164393
NM_007358
MTF2



metal response element binding transcription factor 2



chr1_+_117253882 0.445 NM_020440
PTGFRN
prostaglandin F2 receptor negative regulator
chrX_-_7076146 0.445 NM_001135565
NM_001178135
NM_001178136
NM_012080
HDHD1



haloacid dehalogenase-like hydrolase domain containing 1



chr17_+_26060617 0.444


chr1_-_11674264 0.442 NM_001127325
MAD2L2
MAD2 mitotic arrest deficient-like 2 (yeast)
chr17_+_69939806 0.441 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr12_-_115199293 0.439 NM_015335
MED13L
mediator complex subunit 13-like
chr21_+_29593088 0.439 NM_001186
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr2_-_38457934 0.439 NM_001135673
NM_022374
ATL2

atlastin GTPase 2

chr1_+_26310854 0.439 NM_152835
PDIK1L
PDLIM1 interacting kinase 1 like
chr8_+_97343313 0.438 PTDSS1
phosphatidylserine synthase 1
chr6_+_157140733 0.437 NM_017519
NM_020732
ARID1B

AT rich interactive domain 1B (SWI1-like)

chr8_-_124289107 0.437


chr17_+_42023353 0.436 NM_006178
NSF
N-ethylmaleimide-sensitive factor
chr1_+_160797973 0.434 UAP1
UDP-N-acteylglucosamine pyrophosphorylase 1
chr21_-_39642712 0.431 HMGN1
high-mobility group nucleosome binding domain 1
chr18_+_2645885 0.430 NM_015295
SMCHD1
structural maintenance of chromosomes flexible hinge domain containing 1
chr17_+_71024178 0.429 NM_207346
TSEN54
tRNA splicing endonuclease 54 homolog (S. cerevisiae)
chr8_-_101391421 0.429 NM_183419
RNF19A
ring finger protein 19A
chr7_+_149651481 0.428 LRRC61
leucine rich repeat containing 61
chr6_-_119712596 0.428 NM_005907
MAN1A1
mannosidase, alpha, class 1A, member 1
chr19_+_2851895 0.427 NM_173480
ZNF57
zinc finger protein 57
chr6_+_150112537 0.427 PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr1_+_9522107 0.426 NM_032315
SLC25A33
solute carrier family 25, member 33
chr7_-_148212230 0.424 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr10_+_92970487 0.424 PCGF5
polycomb group ring finger 5
chr3_-_47798390 0.424 NM_003074
SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr21_-_39642808 0.421 HMGN1
high-mobility group nucleosome binding domain 1
chr1_-_29380850 0.421 SRSF4
serine/arginine-rich splicing factor 4
chr8_+_142471290 0.420


chrX_-_62487693 0.419 NM_001012968
SPIN4
spindlin family, member 4
chr1_-_51757490 0.416 EPS15
epidermal growth factor receptor pathway substrate 15
chr22_-_19543012 0.415 PI4KA
phosphatidylinositol 4-kinase, catalytic, alpha
chr1_+_165456572 0.414 NM_001198786
NM_002697
POU2F1

POU class 2 homeobox 1

chr1_-_53566331 0.413 NM_033300
LRP8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr17_-_23996268 0.413 KIAA0100
KIAA0100
chr22_-_20314274 0.412 NM_001017964
YDJC
YdjC homolog (bacterial)
chr19_+_37763927 0.409 NM_004708
PDCD5
programmed cell death 5
chr22_+_38183262 0.408 NM_002409
MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.37 5.04e-46 GO:0044237 cellular metabolic process
1.44 2.55e-38 GO:0044260 cellular macromolecule metabolic process
1.29 1.03e-35 GO:0008152 metabolic process
1.32 3.88e-35 GO:0044238 primary metabolic process
1.35 2.48e-28 GO:0043170 macromolecule metabolic process
1.46 1.75e-27 GO:0034641 cellular nitrogen compound metabolic process
1.50 3.54e-26 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.44 3.65e-26 GO:0006807 nitrogen compound metabolic process
1.14 4.98e-22 GO:0009987 cellular process
1.47 1.30e-20 GO:0044267 cellular protein metabolic process
1.48 1.83e-20 GO:0044249 cellular biosynthetic process
1.50 6.67e-20 GO:0090304 nucleic acid metabolic process
1.45 1.86e-19 GO:0009058 biosynthetic process
1.51 1.33e-16 GO:0010467 gene expression
1.51 2.46e-15 GO:0016070 RNA metabolic process
1.34 3.13e-13 GO:0019538 protein metabolic process
2.10 4.20e-13 GO:0016568 chromatin modification
1.48 7.53e-13 GO:0034645 cellular macromolecule biosynthetic process
1.45 7.73e-13 GO:0006464 protein modification process
1.47 1.79e-12 GO:0009059 macromolecule biosynthetic process
1.43 2.87e-12 GO:0043412 macromolecule modification
1.45 3.61e-11 GO:0006996 organelle organization
1.77 4.56e-11 GO:0051276 chromosome organization
1.87 1.46e-10 GO:0006325 chromatin organization
1.54 2.75e-09 GO:0007049 cell cycle
1.29 6.69e-08 GO:0071841 cellular component organization or biogenesis at cellular level
1.25 8.84e-08 GO:0071840 cellular component organization or biogenesis
1.62 5.34e-07 GO:0006396 RNA processing
1.28 1.20e-06 GO:0071842 cellular component organization at cellular level
1.24 1.21e-06 GO:0016043 cellular component organization
1.84 3.00e-06 GO:0070647 protein modification by small protein conjugation or removal
2.13 5.01e-06 GO:0016569 covalent chromatin modification
2.13 6.48e-06 GO:0016570 histone modification
1.89 8.19e-06 GO:0010608 posttranscriptional regulation of gene expression
1.60 1.27e-05 GO:0000278 mitotic cell cycle
1.80 3.09e-05 GO:0006511 ubiquitin-dependent protein catabolic process
1.48 4.95e-05 GO:0022402 cell cycle process
1.75 5.08e-05 GO:0018193 peptidyl-amino acid modification
1.84 5.38e-05 GO:0032446 protein modification by small protein conjugation
1.43 5.72e-05 GO:0032774 RNA biosynthetic process
1.39 6.07e-05 GO:0044248 cellular catabolic process
1.76 7.59e-05 GO:0051603 proteolysis involved in cellular protein catabolic process
1.30 7.76e-05 GO:0044281 small molecule metabolic process
1.77 8.88e-05 GO:0019941 modification-dependent protein catabolic process
1.72 9.01e-05 GO:0030163 protein catabolic process
1.51 1.17e-04 GO:0022403 cell cycle phase
1.59 1.23e-04 GO:0044265 cellular macromolecule catabolic process
1.76 1.25e-04 GO:0043632 modification-dependent macromolecule catabolic process
1.72 1.25e-04 GO:0051301 cell division
1.53 1.36e-04 GO:0051726 regulation of cell cycle
1.34 1.39e-04 GO:0009056 catabolic process
1.73 2.06e-04 GO:0044257 cellular protein catabolic process
1.20 2.82e-04 GO:0060255 regulation of macromolecule metabolic process
1.56 3.00e-04 GO:0016071 mRNA metabolic process
1.43 3.78e-04 GO:0006351 transcription, DNA-dependent
1.23 4.20e-04 GO:0010468 regulation of gene expression
1.73 6.01e-04 GO:0051325 interphase
1.51 7.06e-04 GO:0009057 macromolecule catabolic process
1.57 8.18e-04 GO:0034621 cellular macromolecular complex subunit organization
1.72 1.15e-03 GO:0051329 interphase of mitotic cell cycle
1.78 1.22e-03 GO:0016567 protein ubiquitination
1.83 1.31e-03 GO:0051186 cofactor metabolic process
2.18 1.42e-03 GO:0051188 cofactor biosynthetic process
1.61 2.71e-03 GO:0006397 mRNA processing
1.68 2.95e-03 GO:0006412 translation
1.73 3.66e-03 GO:0034660 ncRNA metabolic process
1.94 3.87e-03 GO:0006417 regulation of translation
1.16 4.16e-03 GO:0019222 regulation of metabolic process
1.36 5.27e-03 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.51 6.17e-03 GO:0006974 response to DNA damage stimulus
2.39 8.51e-03 GO:0006338 chromatin remodeling
1.44 8.89e-03 GO:0007167 enzyme linked receptor protein signaling pathway
1.59 1.22e-02 GO:0034622 cellular macromolecular complex assembly
1.23 1.24e-02 GO:0048523 negative regulation of cellular process
1.45 1.44e-02 GO:0006259 DNA metabolic process
2.15 1.48e-02 GO:0040029 regulation of gene expression, epigenetic
1.16 1.63e-02 GO:0031323 regulation of cellular metabolic process
1.21 1.73e-02 GO:0048519 negative regulation of biological process
1.74 2.24e-02 GO:0071375 cellular response to peptide hormone stimulus
1.82 2.84e-02 GO:0006732 coenzyme metabolic process
1.10 3.43e-02 GO:0050789 regulation of biological process
2.00 3.82e-02 GO:0006399 tRNA metabolic process
1.80 4.10e-02 GO:0032869 cellular response to insulin stimulus
1.20 4.23e-02 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.40 4.38e-02 GO:0046483 heterocycle metabolic process
1.34 4.44e-02 GO:0010605 negative regulation of macromolecule metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.22 7.12e-63 GO:0044424 intracellular part
1.20 2.23e-60 GO:0005622 intracellular
1.27 9.85e-49 GO:0043227 membrane-bounded organelle
1.27 1.37e-48 GO:0043231 intracellular membrane-bounded organelle
1.23 1.60e-46 GO:0043229 intracellular organelle
1.23 4.27e-46 GO:0043226 organelle
1.23 8.93e-33 GO:0005737 cytoplasm
1.31 5.20e-29 GO:0005634 nucleus
1.30 3.65e-26 GO:0044446 intracellular organelle part
1.53 1.53e-25 GO:0070013 intracellular organelle lumen
1.52 7.23e-25 GO:0031974 membrane-enclosed lumen
1.29 7.72e-25 GO:0044422 organelle part
1.51 4.54e-24 GO:0043233 organelle lumen
1.51 1.17e-22 GO:0044428 nuclear part
1.26 3.53e-22 GO:0044444 cytoplasmic part
1.54 4.07e-20 GO:0031981 nuclear lumen
1.56 2.20e-15 GO:0005739 mitochondrion
1.54 2.92e-14 GO:0005654 nucleoplasm
1.42 3.08e-14 GO:0005829 cytosol
1.05 3.16e-11 GO:0044464 cell part
1.05 3.39e-11 GO:0005623 cell
1.27 3.85e-11 GO:0032991 macromolecular complex
1.64 2.65e-09 GO:0044429 mitochondrial part
1.58 3.56e-08 GO:0031967 organelle envelope
1.56 8.92e-08 GO:0031975 envelope
1.67 2.01e-07 GO:0030529 ribonucleoprotein complex
1.71 2.18e-07 GO:0031966 mitochondrial membrane
1.70 2.46e-07 GO:0005740 mitochondrial envelope
1.25 8.89e-07 GO:0043228 non-membrane-bounded organelle
1.25 8.89e-07 GO:0043232 intracellular non-membrane-bounded organelle
1.63 2.30e-06 GO:0005730 nucleolus
1.74 9.12e-06 GO:0019866 organelle inner membrane
1.22 1.30e-05 GO:0043234 protein complex
1.73 4.01e-05 GO:0005743 mitochondrial inner membrane
1.46 8.39e-05 GO:0044451 nucleoplasm part
1.25 1.07e-04 GO:0031090 organelle membrane
1.49 5.50e-04 GO:0005694 chromosome
1.95 2.46e-03 GO:0000151 ubiquitin ligase complex
1.49 3.89e-03 GO:0044427 chromosomal part
1.68 6.76e-03 GO:0000785 chromatin
1.66 1.76e-02 GO:0005813 centrosome
1.60 2.34e-02 GO:0005759 mitochondrial matrix
3.48 3.37e-02 GO:0031519 PcG protein complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.22 6.02e-23 GO:0005515 protein binding
1.11 7.01e-18 GO:0005488 binding
1.25 7.29e-17 GO:0003824 catalytic activity
1.39 8.42e-14 GO:0000166 nucleotide binding
1.30 9.40e-13 GO:0003676 nucleic acid binding
1.43 9.07e-12 GO:0016740 transferase activity
1.43 3.29e-10 GO:0032559 adenyl ribonucleotide binding
1.42 4.38e-10 GO:0030554 adenyl nucleotide binding
1.38 6.60e-10 GO:0032553 ribonucleotide binding
1.38 6.60e-10 GO:0032555 purine ribonucleotide binding
1.37 1.00e-09 GO:0017076 purine nucleotide binding
1.42 2.00e-09 GO:0005524 ATP binding
1.37 3.05e-09 GO:0035639 purine ribonucleoside triphosphate binding
1.57 7.06e-09 GO:0003723 RNA binding
1.52 2.29e-06 GO:0019899 enzyme binding
1.45 4.86e-06 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.64 1.31e-05 GO:0016874 ligase activity
1.24 1.93e-04 GO:0003677 DNA binding
2.43 4.30e-04 GO:0031625 ubiquitin protein ligase binding
1.67 1.11e-03 GO:0016879 ligase activity, forming carbon-nitrogen bonds
2.39 2.37e-03 GO:0042393 histone binding
1.67 3.56e-03 GO:0016881 acid-amino acid ligase activity
1.37 7.32e-03 GO:0016301 kinase activity
1.58 1.44e-02 GO:0016564 transcription repressor activity
1.57 1.53e-02 GO:0016563 transcription activator activity
1.48 1.82e-02 GO:0019904 protein domain specific binding
1.65 2.86e-02 GO:0019787 small conjugating protein ligase activity
1.35 3.16e-02 GO:0017111 nucleoside-triphosphatase activity
1.66 3.25e-02 GO:0004842 ubiquitin-protein ligase activity
1.56 3.98e-02 GO:0008134 transcription factor binding
1.29 4.26e-02 GO:0030528 transcription regulator activity
1.70 4.45e-02 GO:0003682 chromatin binding