Motif ID: HES1.p2

Z-value: 1.593


Transcription factors associated with HES1.p2:

Gene SymbolEntrez IDGene Name
HES1 3280 hairy and enhancer of split 1, (Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HES1chr3_+_195336625-0.146.1e-01Click!


Activity profile for motif HES1.p2.

activity profile for motif HES1.p2


Sorted Z-values histogram for motif HES1.p2

Sorted Z-values for motif HES1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HES1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr21_+_34367747 1.821 MRPS6
mitochondrial ribosomal protein S6
chr1_+_226937732 1.367 RHOU
ras homolog gene family, member U
chr15_+_39573363 1.260 NM_002220
 ITPKA
inositol 1,4,5-trisphosphate 3-kinase A
chr1_-_218168548 1.222 NM_018713
 SLC30A10
solute carrier family 30, member 10
chr18_+_586997 1.154 NM_014410
 CLUL1
clusterin-like 1 (retinal)
chr2_+_85619802 1.078 MAT2A
methionine adenosyltransferase II, alpha
chr9_-_125070613 1.011 NM_018387
 STRBP
spermatid perinuclear RNA binding protein
chr19_-_411995 0.996 NM_012435
 SHC2
SHC (Src homology 2 domain containing) transforming protein 2
chr1_-_94147537 0.981 GCLM
glutamate-cysteine ligase, modifier subunit
chr2_-_203444468 0.973 NM_138468
 ICA1L
islet cell autoantigen 1,69kDa-like
chr2_+_149118791 0.959 EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr6_-_13819931 0.942 RANBP9
RAN binding protein 9
chr1_-_94147574 0.941 NM_002061
 GCLM
glutamate-cysteine ligase, modifier subunit
chr10_+_92912676 0.891 PCGF5
polycomb group ring finger 5
chr2_+_170298700 0.884 KLHL23
kelch-like 23 (Drosophila)
chr16_-_79687367 0.857 NM_004483
 GCSH
glycine cleavage system protein H (aminomethyl carrier)
chr5_+_665454 0.857 CEP72
centrosomal protein 72kDa
chr6_+_31976754 0.841 NM_001178063
 C2
complement component 2
chr7_-_100068612 0.830 TFR2
transferrin receptor 2
chr2_+_10009242 0.804 NM_198182
 GRHL1
grainyhead-like 1 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 86 entries
enrichment   p-value GO term description
2.39 8.51e-03 GO:0006338 chromatin remodeling
2.18 1.42e-03 GO:0051188 cofactor biosynthetic process
2.15 1.48e-02 GO:0040029 regulation of gene expression, epigenetic
2.13 5.01e-06 GO:0016569 covalent chromatin modification
2.13 6.48e-06 GO:0016570 histone modification
2.10 4.20e-13 GO:0016568 chromatin modification
2.00 3.82e-02 GO:0006399 tRNA metabolic process
1.94 3.87e-03 GO:0006417 regulation of translation
1.89 8.19e-06 GO:0010608 posttranscriptional regulation of gene expression
1.87 1.46e-10 GO:0006325 chromatin organization
1.84 3.00e-06 GO:0070647 protein modification by small protein conjugation or removal
1.84 5.38e-05 GO:0032446 protein modification by small protein conjugation
1.83 1.31e-03 GO:0051186 cofactor metabolic process
1.82 2.84e-02 GO:0006732 coenzyme metabolic process
1.80 3.09e-05 GO:0006511 ubiquitin-dependent protein catabolic process
1.80 4.10e-02 GO:0032869 cellular response to insulin stimulus
1.78 1.22e-03 GO:0016567 protein ubiquitination
1.77 4.56e-11 GO:0051276 chromosome organization
1.77 8.88e-05 GO:0019941 modification-dependent protein catabolic process
1.76 7.59e-05 GO:0051603 proteolysis involved in cellular protein catabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 43 entries
enrichment   p-value GO term description
3.48 3.37e-02 GO:0031519 PcG protein complex
1.95 2.46e-03 GO:0000151 ubiquitin ligase complex
1.74 9.12e-06 GO:0019866 organelle inner membrane
1.73 4.01e-05 GO:0005743 mitochondrial inner membrane
1.71 2.18e-07 GO:0031966 mitochondrial membrane
1.70 2.46e-07 GO:0005740 mitochondrial envelope
1.68 6.76e-03 GO:0000785 chromatin
1.67 2.01e-07 GO:0030529 ribonucleoprotein complex
1.66 1.76e-02 GO:0005813 centrosome
1.64 2.65e-09 GO:0044429 mitochondrial part
1.63 2.30e-06 GO:0005730 nucleolus
1.60 2.34e-02 GO:0005759 mitochondrial matrix
1.58 3.56e-08 GO:0031967 organelle envelope
1.56 2.20e-15 GO:0005739 mitochondrion
1.56 8.92e-08 GO:0031975 envelope
1.54 4.07e-20 GO:0031981 nuclear lumen
1.54 2.92e-14 GO:0005654 nucleoplasm
1.53 1.53e-25 GO:0070013 intracellular organelle lumen
1.52 7.23e-25 GO:0031974 membrane-enclosed lumen
1.51 4.54e-24 GO:0043233 organelle lumen

Gene overrepresentation in function category:

Showing 1 to 20 of 32 entries
enrichment   p-value GO term description
2.43 4.30e-04 GO:0031625 ubiquitin protein ligase binding
2.39 2.37e-03 GO:0042393 histone binding
1.70 4.45e-02 GO:0003682 chromatin binding
1.67 1.11e-03 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.67 3.56e-03 GO:0016881 acid-amino acid ligase activity
1.66 3.25e-02 GO:0004842 ubiquitin-protein ligase activity
1.65 2.86e-02 GO:0019787 small conjugating protein ligase activity
1.64 1.31e-05 GO:0016874 ligase activity
1.58 1.44e-02 GO:0016564 transcription repressor activity
1.57 7.06e-09 GO:0003723 RNA binding
1.57 1.53e-02 GO:0016563 transcription activator activity
1.56 3.98e-02 GO:0008134 transcription factor binding
1.52 2.29e-06 GO:0019899 enzyme binding
1.48 1.82e-02 GO:0019904 protein domain specific binding
1.45 4.86e-06 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.43 9.07e-12 GO:0016740 transferase activity
1.43 3.29e-10 GO:0032559 adenyl ribonucleotide binding
1.42 4.38e-10 GO:0030554 adenyl nucleotide binding
1.42 2.00e-09 GO:0005524 ATP binding
1.39 8.42e-14 GO:0000166 nucleotide binding