Motif ID: HIC1.p2

Z-value: 3.695


Transcription factors associated with HIC1.p2:

Gene SymbolEntrez IDGene Name
HIC1 3090 hypermethylated in cancer 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HIC1chr17_+_19062620.731.3e-03Click!


Activity profile for motif HIC1.p2.

activity profile for motif HIC1.p2


Sorted Z-values histogram for motif HIC1.p2

Sorted Z-values for motif HIC1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIC1.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_109757442 5.977 NM_001845
COL4A1
collagen, type IV, alpha 1
chr14_+_105012106 5.626 NM_001312
CRIP2
cysteine-rich protein 2
chr9_+_115958051 5.473 NM_032888
COL27A1
collagen, type XXVII, alpha 1
chr13_+_109757593 5.327 NM_001846
COL4A2
collagen, type IV, alpha 2
chr1_+_22909916 5.072 NM_004442
NM_017449
EPHB2

EPH receptor B2

chr19_-_61324456 4.747 NM_001002836
ZNF787
zinc finger protein 787
chr14_+_104402626 4.700 NM_001112726
NM_015005
KIAA0284

KIAA0284

chr5_-_171813960 4.413 SH3PXD2B
SH3 and PX domains 2B
chr11_-_11987414 4.402 DKK3
dickkopf homolog 3 (Xenopus laevis)
chr9_+_123501186 4.393 DAB2IP
DAB2 interacting protein
chr16_-_4106186 4.107 NM_001116
ADCY9
adenylate cyclase 9
chr5_+_92946348 4.099 NR2F1
nuclear receptor subfamily 2, group F, member 1
chr2_+_235525355 4.080 NM_014521
SH3BP4
SH3-domain binding protein 4
chr9_-_139060285 3.921 NPDC1
neural proliferation, differentiation and control, 1
chr11_+_101485946 3.886 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chr5_-_171814026 3.864 NM_001017995
SH3PXD2B
SH3 and PX domains 2B
chr11_-_6633427 3.845 NM_003737
DCHS1
dachsous 1 (Drosophila)
chr2_-_235070431 3.623 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chr12_+_95112131 3.604 NM_005230
ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr7_-_44331544 3.553 NM_001220
NM_172078
NM_172079
NM_172080
NM_172081
NM_172082
NM_172083
NM_172084
CAMK2B







calcium/calmodulin-dependent protein kinase II beta







chr10_+_134060681 3.498 NM_001098637
NM_138499
PWWP2B

PWWP domain containing 2B

chr9_-_135847106 3.435 NM_001134398
NM_003371
VAV2

vav 2 guanine nucleotide exchange factor

chr8_+_142207866 3.381 NM_014957
DENND3
DENN/MADD domain containing 3
chr9_-_71476917 3.365 NM_001163
APBA1
amyloid beta (A4) precursor protein-binding, family A, member 1
chr14_+_103621768 3.365 NM_001080464
ASPG
asparaginase homolog (S. cerevisiae)
chr16_-_4106022 3.343 ADCY9
adenylate cyclase 9
chr16_-_79395379 3.195 NM_152342
CDYL2
chromodomain protein, Y-like 2
chr12_-_131415854 3.133 NM_001122636
GALNT9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9)
chr12_+_119562737 3.058 NM_001033677
CABP1
calcium binding protein 1
chr13_+_97593711 2.999 FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr13_+_26029879 2.937 WASF3
WAS protein family, member 3
chr8_+_32525269 2.929 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr12_-_41269679 2.908 NM_153026
PRICKLE1
prickle homolog 1 (Drosophila)
chr12_+_3056781 2.894 NM_001168320
NM_006675
TSPAN9

tetraspanin 9

chr9_+_136673534 2.888 COL5A1
collagen, type V, alpha 1
chr13_-_109236897 2.883 NM_003749
IRS2
insulin receptor substrate 2
chr13_+_97593469 2.831 FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr5_-_2804768 2.825 NM_001134222
NM_033267
IRX2

iroquois homeobox 2

chr9_-_139060377 2.798 NPDC1
neural proliferation, differentiation and control, 1
chr1_+_22762575 2.793 NM_001006943
NM_020526
EPHA8

EPH receptor A8

chr12_+_95112385 2.774 ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr9_-_21549696 2.773 LOC554202
hypothetical LOC554202
chr15_+_99237527 2.737 NM_000693
ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr4_+_77829743 2.733 SHROOM3
shroom family member 3
chr12_-_123023052 2.729 NM_025140
CCDC92
coiled-coil domain containing 92
chr2_+_241023908 2.718 GPC1
glypican 1
chr16_+_2016807 2.679 NM_001130012
NM_004785
SLC9A3R2

solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2

chr2_-_1727247 2.676 PXDN
peroxidasin homolog (Drosophila)
chr5_+_14196287 2.675 NM_007118
TRIO
triple functional domain (PTPRF interacting)
chr14_-_104515738 2.675 NM_138420
AHNAK2
AHNAK nucleoprotein 2
chr19_+_49943773 2.636 NM_005178
BCL3
B-cell CLL/lymphoma 3
chr16_-_4105703 2.628 ADCY9
adenylate cyclase 9
chr15_+_78774664 2.622 NM_021214
FAM108C1
family with sequence similarity 108, member C1
chr10_-_99521701 2.620 NM_003015
SFRP5
secreted frizzled-related protein 5
chr11_-_11987458 2.606 NM_013253
DKK3
dickkopf homolog 3 (Xenopus laevis)
chr19_-_6230927 2.574 NM_005934
MLLT1
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
chr6_-_170441493 2.524 NM_005618
DLL1
delta-like 1 (Drosophila)
chr9_+_136358145 2.522 RXRA
retinoid X receptor, alpha
chr4_-_177950658 2.514 NM_005429
VEGFC
vascular endothelial growth factor C
chr6_+_72055235 2.491 OGFRL1
opioid growth factor receptor-like 1
chr11_-_525532 2.470 NM_001130442
NM_005343
NM_176795
HRAS


v-Ha-ras Harvey rat sarcoma viral oncogene homolog


chr7_-_27136876 2.450 NM_002141
HOXA4
homeobox A4
chr18_+_74841262 2.432 NM_171999
SALL3
sal-like 3 (Drosophila)
chr3_-_129024665 2.420 NM_001003794
MGLL
monoglyceride lipase
chr14_+_92049396 2.417 NM_024832
RIN3
Ras and Rab interactor 3
chr2_-_127580975 2.413 NM_004305
NM_139343
NM_139344
NM_139345
NM_139346
NM_139347
NM_139348
NM_139349
NM_139350
NM_139351
BIN1









bridging integrator 1









chr8_+_27547379 2.407 NM_016240
NM_182826
SCARA3

scavenger receptor class A, member 3

chr14_+_104226769 2.396 NM_001031714
NM_022489
NM_032714
INF2


inverted formin, FH2 and WH2 domain containing


chr2_-_233501069 2.393 NM_001114090
NGEF
neuronal guanine nucleotide exchange factor
chr2_-_1727292 2.388 NM_012293
PXDN
peroxidasin homolog (Drosophila)
chr18_+_75540786 2.381 NM_004715
NM_048368
CTDP1

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1

chr11_+_75056343 2.376


chr14_-_103251497 2.361 NM_001100118
NM_001100119
NM_005432
XRCC3


X-ray repair complementing defective repair in Chinese hamster cells 3


chrX_+_9943793 2.329 NM_015691
WWC3
WWC family member 3
chr17_-_24940728 2.273 NM_001085454
NM_014030
GIT1

G protein-coupled receptor kinase interacting ArfGAP 1

chr13_-_39075304 2.270 LHFP
lipoma HMGIC fusion partner
chr10_-_128067001 2.249 ADAM12
ADAM metallopeptidase domain 12
chr9_+_115678365 2.235 NM_133374
ZNF618
zinc finger protein 618
chr3_-_50515857 2.234 NM_001005505
NM_001174051
NM_006030
CACNA2D2


calcium channel, voltage-dependent, alpha 2/delta subunit 2


chr10_+_126140330 2.218 NM_001167880
NM_022126
LHPP

phospholysine phosphohistidine inorganic pyrophosphate phosphatase

chr13_+_26029799 2.212 NM_006646
WASF3
WAS protein family, member 3
chr19_+_38377329 2.209 NM_002333
LRP3
low density lipoprotein receptor-related protein 3
chr2_-_175578156 2.181 NM_001025201
NM_001822
CHN1

chimerin (chimaerin) 1

chr9_-_139060416 2.178 NM_015392
NPDC1
neural proliferation, differentiation and control, 1
chr8_+_26491317 2.178 NM_001386
DPYSL2
dihydropyrimidinase-like 2
chr9_+_115957537 2.174 COL27A1
collagen, type XXVII, alpha 1
chr15_+_90198031 2.164 SLCO3A1
solute carrier organic anion transporter family, member 3A1
chr3_-_130807865 2.161 NM_015103
PLXND1
plexin D1
chr22_+_36286350 2.148 NM_152243
CDC42EP1
CDC42 effector protein (Rho GTPase binding) 1
chr11_-_11987198 2.130 NM_015881
DKK3
dickkopf homolog 3 (Xenopus laevis)
chr9_+_131974506 2.129 NM_014286
NCS1
neuronal calcium sensor 1
chr22_-_41446740 2.127 NM_017436
A4GALT
alpha 1,4-galactosyltransferase
chr8_+_27547303 2.111 SCARA3
scavenger receptor class A, member 3
chr1_+_33494745 2.100 NM_152493
ZNF362
zinc finger protein 362
chr9_+_136358134 2.090 NM_002957
RXRA
retinoid X receptor, alpha
chr3_+_50167424 2.087 SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr19_+_1892157 2.085 NM_001319
CSNK1G2
casein kinase 1, gamma 2
chr1_-_6480058 2.081 NM_001042663
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr6_+_1335067 2.070 NM_001452
FOXF2
forkhead box F2
chr16_+_85158357 2.066 NM_005251
FOXC2
forkhead box C2 (MFH-1, mesenchyme forkhead 1)
chr3_-_126257425 2.062 NM_020733
HEG1
HEG homolog 1 (zebrafish)
chr7_+_2525922 2.057 NM_001040167
NM_001040168
LFNG

LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

chr14_+_51188289 2.043 NM_152330
FRMD6
FERM domain containing 6
chr14_+_85069217 2.040


chr19_+_60803412 2.029 NM_153219
ZNF524
zinc finger protein 524
chr4_-_52599181 2.021 NM_000232
SGCB
sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
chr3_+_50167851 2.020 NM_004186
SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr19_+_50004134 2.009 NM_001013257
NM_005581
BCAM

basal cell adhesion molecule (Lutheran blood group)

chr11_-_11987115 2.004 DKK3
dickkopf homolog 3 (Xenopus laevis)
chr8_-_41286088 1.996 NM_003012
SFRP1
secreted frizzled-related protein 1
chr8_-_143855438 1.995 NM_177476
NM_177477
LYNX1

Ly6/neurotoxin 1

chr5_-_146869811 1.992 NM_001197294
DPYSL3
dihydropyrimidinase-like 3
chr9_+_136673464 1.979 NM_000093
COL5A1
collagen, type V, alpha 1
chr1_-_22136263 1.967 NM_005529
HSPG2
heparan sulfate proteoglycan 2
chr11_+_832821 1.962 NM_001025238
NM_001025239
NM_003271
NM_001025235
NM_001025236
TSPAN4




tetraspanin 4




chr3_+_128874458 1.950 NM_172027
ABTB1
ankyrin repeat and BTB (POZ) domain containing 1
chr1_+_19843261 1.948 NM_005380
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr2_+_10969513 1.944 NM_002236
KCNF1
potassium voltage-gated channel, subfamily F, member 1
chr10_+_124124196 1.939 PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr1_+_31659246 1.939 NM_001199039
NM_018565
SERINC2

serine incorporator 2

chr4_-_24523605 1.938 NM_001130726
CCDC149
coiled-coil domain containing 149
chr17_+_5914364 1.935 NM_015253
WSCD1
WSC domain containing 1
chr4_+_151218862 1.935 NM_001040260
NM_001040261
DCLK2

doublecortin-like kinase 2

chr22_-_32646325 1.930 NM_004737
NM_133642
LARGE

like-glycosyltransferase

chr7_+_55054416 1.922 EGFR
epidermal growth factor receptor
chr15_-_81744469 1.919 NM_001717
BNC1
basonuclin 1
chr3_+_30623376 1.906 TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr19_-_2259155 1.882 NM_001101391
LINGO3
leucine rich repeat and Ig domain containing 3
chr20_-_49073023 1.875 NM_002237
KCNG1
potassium voltage-gated channel, subfamily G, member 1
chr18_-_68361742 1.874 CBLN2
cerebellin 2 precursor
chr7_-_131911808 1.870 NM_001105543
NM_020911
PLXNA4

plexin A4

chr13_-_94162249 1.866 NM_007084
SOX21
SRY (sex determining region Y)-box 21
chr2_-_96174865 1.865 NM_004418
DUSP2
dual specificity phosphatase 2
chr12_+_26003218 1.844 NM_001164748
NM_007211
RASSF8

Ras association (RalGDS/AF-6) domain family (N-terminal) member 8

chr17_-_24940521 1.837 GIT1
G protein-coupled receptor kinase interacting ArfGAP 1
chr10_+_128583984 1.832 NM_001380
DOCK1
dedicator of cytokinesis 1
chr18_+_75540831 1.830 CTDP1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
chr13_-_100866839 1.829 NALCN
sodium leak channel, non-selective
chr12_-_108802561 1.823 NM_016433
GLTP
glycolipid transfer protein
chr14_+_64240996 1.823 PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr11_+_19691397 1.821 NM_145117
NM_182964
NAV2

neuron navigator 2

chr3_+_71885890 1.821 NM_018971
GPR27
G protein-coupled receptor 27
chr14_+_64240902 1.801 NM_015549
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr14_+_104852225 1.785 PACS2
phosphofurin acidic cluster sorting protein 2
chr19_+_40213431 1.783 NM_001037
NM_199037
SCN1B

sodium channel, voltage-gated, type I, beta

chr16_+_85101605 1.782 NM_001451
FOXF1
forkhead box F1
chr19_-_15204194 1.780 NM_024794
EPHX3
epoxide hydrolase 3
chr12_-_107775462 1.773 NM_001161330
NM_018984
SSH1

slingshot homolog 1 (Drosophila)

chr22_+_31527678 1.766 TIMP3
TIMP metallopeptidase inhibitor 3
chr9_-_13269562 1.757 MPDZ
multiple PDZ domain protein
chr20_+_8997660 1.753 NM_001172646
PLCB4
phospholipase C, beta 4
chr2_+_109112428 1.752 NM_001099289
SH3RF3
SH3 domain containing ring finger 3
chr17_+_24944605 1.749 NM_152345
ANKRD13B
ankyrin repeat domain 13B
chr7_-_27162688 1.748 NM_006896
HOXA7
homeobox A7
chr19_-_11234117 1.734 NM_020812
DOCK6
dedicator of cytokinesis 6
chr3_-_129023850 1.733 NM_007283
MGLL
monoglyceride lipase
chr9_-_138454071 1.732 NM_019892
INPP5E
inositol polyphosphate-5-phosphatase, 72 kDa
chr17_-_77602938 1.727 NM_002917
RFNG
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr7_+_3307445 1.722 NM_152744
SDK1
sidekick homolog 1, cell adhesion molecule (chicken)
chr20_-_55718351 1.722 NM_020182
PMEPA1
prostate transmembrane protein, androgen induced 1
chr12_+_107047594 1.718 NM_014653
WSCD2
WSC domain containing 2
chr17_+_75689955 1.715 GAA
glucosidase, alpha; acid
chr13_-_39075355 1.715 NM_005780
LHFP
lipoma HMGIC fusion partner
chr15_+_94674849 1.710 NM_021005
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr19_+_15079141 1.709 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr6_+_72055197 1.707 NM_024576
OGFRL1
opioid growth factor receptor-like 1
chr17_+_58058774 1.703 MRC2
mannose receptor, C type 2
chr17_-_74433048 1.703 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr3_-_162305319 1.701 NM_033169
NM_001038628
NM_003781
NM_033167
NM_033168
B3GALNT1




beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)




chr2_-_241408296 1.695 NM_004321
KIF1A
kinesin family member 1A
chr17_-_77422463 1.690 ARHGDIA
Rho GDP dissociation inhibitor (GDI) alpha
chr5_-_146869613 1.686 DPYSL3
dihydropyrimidinase-like 3
chr7_+_2565238 1.676 IQCE
IQ motif containing E
chr1_-_56817717 1.673 PPAP2B
phosphatidic acid phosphatase type 2B
chr19_-_1188840 1.671 NM_152769
C19orf26
chromosome 19 open reading frame 26
chr22_-_19122047 1.671 SCARF2
scavenger receptor class F, member 2
chr5_+_76150588 1.671 NM_005242
F2RL1
coagulation factor II (thrombin) receptor-like 1
chr19_+_748452 1.671 PTBP1
polypyrimidine tract binding protein 1
chr2_+_29191711 1.670 NM_024692
CLIP4
CAP-GLY domain containing linker protein family, member 4
chr14_+_101097440 1.661 NM_001362
DIO3
deiodinase, iodothyronine, type III
chr19_+_748390 1.657 NM_002819
NM_031990
NM_031991
NM_175847
PTBP1



polypyrimidine tract binding protein 1



chr7_-_81910956 1.657 NM_000722
CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr9_-_15297148 1.654 TTC39B
tetratricopeptide repeat domain 39B
chr8_+_37672427 1.650 NM_025069
ZNF703
zinc finger protein 703
chr11_-_112851051 1.648 NM_000795
NM_016574
DRD2

dopamine receptor D2

chr3_-_51976428 1.640 NM_020418
NM_001174100
NM_033008
PCBP4


poly(rC) binding protein 4


chr18_+_54489597 1.635 NM_006785
NM_173844
MALT1

mucosa associated lymphoid tissue lymphoma translocation gene 1

chr11_-_124137260 1.627 NM_138961
ESAM
endothelial cell adhesion molecule
chr8_-_119192985 1.624 NM_000127
EXT1
exostosin 1
chr2_-_242274862 1.622 DTYMK
deoxythymidylate kinase (thymidylate kinase)
chr20_+_4077466 1.621 SMOX
spermine oxidase
chr17_-_75624048 1.620 NM_019020
TBC1D16
TBC1 domain family, member 16
chr22_+_36632242 1.620 NM_033386
MICALL1
MICAL-like 1
chr19_+_748448 1.616 PTBP1
polypyrimidine tract binding protein 1
chr15_+_90197884 1.615 NM_001145044
NM_013272
SLCO3A1

solute carrier organic anion transporter family, member 3A1

chr5_+_76150637 1.612 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr11_+_1367665 1.605 NM_003957
BRSK2
BR serine/threonine kinase 2
chr11_-_44928803 1.604 NM_001076787
NM_006034
TP53I11

tumor protein p53 inducible protein 11

chr8_-_48813236 1.602 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr16_+_4361775 1.602 NM_138440
VASN
vasorin

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.50 1.68e-23 GO:0007399 nervous system development
1.48 2.51e-23 GO:0023051 regulation of signaling
1.49 1.89e-22 GO:0009653 anatomical structure morphogenesis
1.64 5.39e-22 GO:0022008 neurogenesis
1.49 3.05e-21 GO:0009966 regulation of signal transduction
1.64 7.51e-21 GO:0048699 generation of neurons
1.29 2.03e-20 GO:0007275 multicellular organismal development
1.39 2.96e-20 GO:0048869 cellular developmental process
1.32 5.15e-20 GO:0048731 system development
1.39 6.20e-20 GO:0030154 cell differentiation
1.83 1.74e-19 GO:0000904 cell morphogenesis involved in differentiation
1.17 2.01e-19 GO:0050794 regulation of cellular process
1.29 4.00e-19 GO:0048856 anatomical structure development
1.26 4.66e-19 GO:0032502 developmental process
1.59 1.04e-18 GO:0048468 cell development
1.71 2.54e-17 GO:0000902 cell morphogenesis
1.85 4.33e-17 GO:0007409 axonogenesis
1.84 4.47e-17 GO:0048667 cell morphogenesis involved in neuron differentiation
1.65 5.17e-17 GO:0030182 neuron differentiation
1.82 7.28e-17 GO:0048812 neuron projection morphogenesis
1.67 3.74e-16 GO:0032989 cellular component morphogenesis
1.15 7.50e-16 GO:0050789 regulation of biological process
1.74 1.58e-15 GO:0032990 cell part morphogenesis
1.75 2.42e-15 GO:0031175 neuron projection development
1.74 2.70e-15 GO:0048858 cell projection morphogenesis
1.14 6.43e-15 GO:0065007 biological regulation
1.64 7.08e-15 GO:0030030 cell projection organization
1.67 1.76e-14 GO:0048666 neuron development
1.09 1.84e-13 GO:0009987 cellular process
1.22 1.82e-12 GO:0023052 signaling
1.29 4.23e-12 GO:0048519 negative regulation of biological process
1.30 5.16e-12 GO:0048523 negative regulation of cellular process
1.82 5.44e-12 GO:0007411 axon guidance
1.32 1.05e-11 GO:0048583 regulation of response to stimulus
1.43 2.35e-11 GO:0010646 regulation of cell communication
1.66 2.98e-11 GO:0072358 cardiovascular system development
1.66 2.98e-11 GO:0072359 circulatory system development
1.22 1.44e-10 GO:0007165 signal transduction
1.82 2.68e-10 GO:0001944 vasculature development
1.43 2.92e-10 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.78 3.31e-10 GO:0060284 regulation of cell development
1.54 3.55e-10 GO:0007167 enzyme linked receptor protein signaling pathway
1.55 4.19e-10 GO:0045893 positive regulation of transcription, DNA-dependent
1.52 9.29e-10 GO:0051254 positive regulation of RNA metabolic process
1.51 1.68e-09 GO:0010628 positive regulation of gene expression
1.51 2.00e-09 GO:0045595 regulation of cell differentiation
1.25 5.27e-09 GO:0048522 positive regulation of cellular process
1.42 7.05e-09 GO:0050793 regulation of developmental process
1.23 1.17e-08 GO:0071842 cellular component organization at cellular level
1.46 1.43e-08 GO:2000026 regulation of multicellular organismal development
1.79 1.46e-08 GO:0001568 blood vessel development
1.28 2.19e-08 GO:0048513 organ development
1.56 2.24e-08 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.59 2.72e-08 GO:0048646 anatomical structure formation involved in morphogenesis
1.58 3.33e-08 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.19 8.42e-08 GO:0016043 cellular component organization
1.50 9.07e-08 GO:0009887 organ morphogenesis
1.17 1.15e-07 GO:0051716 cellular response to stimulus
1.70 1.34e-07 GO:0022603 regulation of anatomical structure morphogenesis
1.22 1.54e-07 GO:0048518 positive regulation of biological process
1.41 1.55e-07 GO:0040011 locomotion
1.63 2.17e-07 GO:0051056 regulation of small GTPase mediated signal transduction
1.53 2.18e-07 GO:0007417 central nervous system development
2.06 2.74e-07 GO:0030111 regulation of Wnt receptor signaling pathway
1.60 4.45e-07 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
2.06 4.72e-07 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.31 4.98e-07 GO:0035556 intracellular signal transduction
1.42 6.03e-07 GO:0051173 positive regulation of nitrogen compound metabolic process
1.26 6.80e-07 GO:0007166 cell surface receptor linked signaling pathway
1.58 6.95e-07 GO:0009968 negative regulation of signal transduction
1.21 7.01e-07 GO:0071841 cellular component organization or biogenesis at cellular level
2.05 7.49e-07 GO:0022604 regulation of cell morphogenesis
1.71 7.58e-07 GO:0051960 regulation of nervous system development
2.41 9.31e-07 GO:0050770 regulation of axonogenesis
1.78 9.87e-07 GO:0048011 nerve growth factor receptor signaling pathway
1.31 1.23e-06 GO:0051239 regulation of multicellular organismal process
1.50 1.25e-06 GO:0045892 negative regulation of transcription, DNA-dependent
1.74 1.35e-06 GO:0046578 regulation of Ras protein signal transduction
1.41 1.36e-06 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.73 1.76e-06 GO:0050767 regulation of neurogenesis
1.49 2.58e-06 GO:0051253 negative regulation of RNA metabolic process
1.41 2.72e-06 GO:0010557 positive regulation of macromolecule biosynthetic process
1.42 3.59e-06 GO:0009890 negative regulation of biosynthetic process
1.53 3.67e-06 GO:0023057 negative regulation of signaling
1.38 3.94e-06 GO:0009888 tissue development
2.11 4.38e-06 GO:0010720 positive regulation of cell development
1.53 4.54e-06 GO:0010648 negative regulation of cell communication
1.17 5.48e-06 GO:0071840 cellular component organization or biogenesis
1.64 5.48e-06 GO:0048729 tissue morphogenesis
2.21 5.85e-06 GO:0060828 regulation of canonical Wnt receptor signaling pathway
1.49 6.78e-06 GO:0048585 negative regulation of response to stimulus
1.17 1.03e-05 GO:0080090 regulation of primary metabolic process
1.42 1.04e-05 GO:0031327 negative regulation of cellular biosynthetic process
1.42 1.21e-05 GO:0010558 negative regulation of macromolecule biosynthetic process
1.16 1.37e-05 GO:0031323 regulation of cellular metabolic process
1.73 2.32e-05 GO:0048514 blood vessel morphogenesis
1.43 2.56e-05 GO:0010629 negative regulation of gene expression
1.47 2.98e-05 GO:0006935 chemotaxis
1.47 2.98e-05 GO:0042330 taxis
1.55 4.06e-05 GO:0048598 embryonic morphogenesis
1.92 5.09e-05 GO:0048705 skeletal system morphogenesis
1.41 5.92e-05 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.94 5.95e-05 GO:0010975 regulation of neuron projection development
1.35 6.66e-05 GO:0031328 positive regulation of cellular biosynthetic process
1.41 8.17e-05 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.52 8.69e-05 GO:0007264 small GTPase mediated signal transduction
1.41 8.86e-05 GO:0051172 negative regulation of nitrogen compound metabolic process
1.56 9.58e-05 GO:0045597 positive regulation of cell differentiation
1.34 1.00e-04 GO:0009891 positive regulation of biosynthetic process
1.83 1.28e-04 GO:0031344 regulation of cell projection organization
1.71 1.47e-04 GO:0045664 regulation of neuron differentiation
1.28 1.59e-04 GO:0031325 positive regulation of cellular metabolic process
1.56 1.61e-04 GO:0001501 skeletal system development
1.14 1.67e-04 GO:0019222 regulation of metabolic process
1.58 2.25e-04 GO:0051270 regulation of cellular component movement
1.52 2.44e-04 GO:0007420 brain development
1.37 2.48e-04 GO:0009790 embryo development
1.34 3.24e-04 GO:0051128 regulation of cellular component organization
1.46 3.97e-04 GO:0051094 positive regulation of developmental process
1.51 4.50e-04 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.92 4.65e-04 GO:0035023 regulation of Rho protein signal transduction
1.17 4.70e-04 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.19 5.06e-04 GO:0006355 regulation of transcription, DNA-dependent
2.16 5.24e-04 GO:0048638 regulation of developmental growth
1.31 5.35e-04 GO:0010605 negative regulation of macromolecule metabolic process
2.09 6.32e-04 GO:0030178 negative regulation of Wnt receptor signaling pathway
1.57 7.54e-04 GO:0035295 tube development
1.31 8.24e-04 GO:0031324 negative regulation of cellular metabolic process
1.17 8.27e-04 GO:0051171 regulation of nitrogen compound metabolic process
1.31 8.55e-04 GO:0006351 transcription, DNA-dependent
1.27 1.03e-03 GO:0010604 positive regulation of macromolecule metabolic process
1.29 1.07e-03 GO:0009892 negative regulation of metabolic process
1.26 1.10e-03 GO:0009893 positive regulation of metabolic process
1.18 1.24e-03 GO:0051252 regulation of RNA metabolic process
1.73 1.35e-03 GO:0001525 angiogenesis
1.41 1.87e-03 GO:0019226 transmission of nerve impulse
1.41 1.87e-03 GO:0035637 multicellular organismal signaling
2.04 2.11e-03 GO:0050769 positive regulation of neurogenesis
1.40 2.28e-03 GO:0009967 positive regulation of signal transduction
1.14 2.71e-03 GO:0060255 regulation of macromolecule metabolic process
1.28 3.23e-03 GO:0007154 cell communication
1.43 3.47e-03 GO:0032583 regulation of gene-specific transcription
2.38 3.49e-03 GO:0001704 formation of primary germ layer
1.28 4.49e-03 GO:0009605 response to external stimulus
1.73 4.75e-03 GO:0034330 cell junction organization
1.16 5.09e-03 GO:0009889 regulation of biosynthetic process
1.38 5.21e-03 GO:0023056 positive regulation of signaling
1.45 5.79e-03 GO:0043009 chordate embryonic development
1.63 6.02e-03 GO:0032582 negative regulation of gene-specific transcription
1.45 6.68e-03 GO:0009792 embryo development ending in birth or egg hatching
1.58 7.32e-03 GO:0002009 morphogenesis of an epithelium
2.02 7.55e-03 GO:0007173 epidermal growth factor receptor signaling pathway
2.73 7.70e-03 GO:0050771 negative regulation of axonogenesis
1.53 7.78e-03 GO:0045596 negative regulation of cell differentiation
1.54 7.94e-03 GO:0030334 regulation of cell migration
1.27 8.71e-03 GO:0032879 regulation of localization
1.37 8.83e-03 GO:0010647 positive regulation of cell communication
1.15 9.40e-03 GO:0031326 regulation of cellular biosynthetic process
1.16 9.88e-03 GO:0010468 regulation of gene expression
1.50 9.98e-03 GO:0040012 regulation of locomotion
1.54 1.04e-02 GO:0030036 actin cytoskeleton organization
1.10 1.12e-02 GO:0032501 multicellular organismal process
1.38 1.12e-02 GO:0007010 cytoskeleton organization
1.46 1.12e-02 GO:0007389 pattern specification process
1.68 1.19e-02 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
1.43 1.19e-02 GO:0010627 regulation of intracellular protein kinase cascade
2.54 1.27e-02 GO:0030516 regulation of axon extension
1.50 1.28e-02 GO:0007423 sensory organ development
1.21 1.40e-02 GO:0065009 regulation of molecular function
1.52 1.49e-02 GO:2000145 regulation of cell motility
1.16 1.71e-02 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.16 1.78e-02 GO:0042221 response to chemical stimulus
1.65 2.07e-02 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
2.44 2.12e-02 GO:0050772 positive regulation of axonogenesis
1.60 2.69e-02 GO:0035239 tube morphogenesis
1.53 2.76e-02 GO:0048568 embryonic organ development
1.96 3.10e-02 GO:0010721 negative regulation of cell development
2.07 3.33e-02 GO:0050768 negative regulation of neurogenesis
1.66 3.34e-02 GO:0045165 cell fate commitment
1.45 3.49e-02 GO:0051093 negative regulation of developmental process
1.38 3.92e-02 GO:0007268 synaptic transmission
1.15 4.30e-02 GO:0010556 regulation of macromolecule biosynthetic process
2.08 4.39e-02 GO:0042058 regulation of epidermal growth factor receptor signaling pathway
1.89 4.39e-02 GO:0060485 mesenchyme development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.07 5.62e-10 GO:0005622 intracellular
1.07 7.13e-09 GO:0044424 intracellular part
1.48 1.74e-08 GO:0030054 cell junction
1.09 4.87e-08 GO:0005737 cytoplasm
1.95 8.56e-08 GO:0005912 adherens junction
1.85 6.01e-07 GO:0070161 anchoring junction
1.03 9.45e-06 GO:0044464 cell part
1.03 1.02e-05 GO:0005623 cell
2.00 2.80e-05 GO:0005925 focal adhesion
1.69 1.27e-04 GO:0031252 cell leading edge
1.28 2.13e-04 GO:0005794 Golgi apparatus
1.90 2.13e-04 GO:0005924 cell-substrate adherens junction
1.06 2.52e-04 GO:0043226 organelle
1.06 2.95e-04 GO:0043229 intracellular organelle
1.87 3.40e-04 GO:0030055 cell-substrate junction
1.18 5.42e-04 GO:0044459 plasma membrane part
1.41 1.59e-03 GO:0045202 synapse
1.06 1.75e-03 GO:0043231 intracellular membrane-bounded organelle
1.06 1.84e-03 GO:0043227 membrane-bounded organelle
1.09 2.34e-03 GO:0044444 cytoplasmic part
1.26 3.88e-03 GO:0042995 cell projection
1.50 3.90e-03 GO:0005667 transcription factor complex
1.40 7.51e-03 GO:0031012 extracellular matrix
1.34 1.24e-02 GO:0000139 Golgi membrane
1.18 1.94e-02 GO:0012505 endomembrane system
1.42 2.03e-02 GO:0015629 actin cytoskeleton
1.35 3.17e-02 GO:0043005 neuron projection
1.29 3.65e-02 GO:0044431 Golgi apparatus part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.41 3.17e-10 GO:0001071 nucleic acid binding transcription factor activity
1.41 3.17e-10 GO:0003700 sequence-specific DNA binding transcription factor activity
1.39 3.23e-09 GO:0030528 transcription regulator activity
1.11 4.76e-09 GO:0005515 protein binding
1.64 1.18e-07 GO:0003779 actin binding
1.06 1.65e-07 GO:0005488 binding
1.53 2.41e-07 GO:0030695 GTPase regulator activity
1.43 2.85e-07 GO:0043565 sequence-specific DNA binding
1.48 5.27e-07 GO:0008092 cytoskeletal protein binding
1.50 1.46e-06 GO:0060589 nucleoside-triphosphatase regulator activity
1.58 3.49e-05 GO:0005083 small GTPase regulator activity
1.70 5.25e-05 GO:0010843 promoter binding
1.46 7.32e-05 GO:0019904 protein domain specific binding
1.67 9.50e-05 GO:0000975 regulatory region DNA binding
1.67 9.50e-05 GO:0001067 regulatory region nucleic acid binding
1.67 9.50e-05 GO:0044212 transcription regulatory region DNA binding
1.53 3.26e-04 GO:0008134 transcription factor binding
2.07 6.02e-04 GO:0005089 Rho guanyl-nucleotide exchange factor activity
1.71 6.35e-04 GO:0005085 guanyl-nucleotide exchange factor activity
1.82 1.09e-03 GO:0051020 GTPase binding
1.92 1.47e-03 GO:0005088 Ras guanyl-nucleotide exchange factor activity
1.76 8.68e-03 GO:0017124 SH3 domain binding
2.28 1.56e-02 GO:0017048 Rho GTPase binding
1.43 1.59e-02 GO:0016564 transcription repressor activity
1.76 1.87e-02 GO:0031267 small GTPase binding
1.36 2.06e-02 GO:0004674 protein serine/threonine kinase activity
1.79 2.91e-02 GO:0017016 Ras GTPase binding