Motif ID: HLF.p2

Z-value: 1.551


Transcription factors associated with HLF.p2:

Gene SymbolEntrez IDGene Name
HLF 3131 hepatic leukemia factor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HLFchr17_+_506999650.792.4e-04Click!


Activity profile for motif HLF.p2.

activity profile for motif HLF.p2


Sorted Z-values histogram for motif HLF.p2

Sorted Z-values for motif HLF.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HLF.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_113601608 2.863 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr2_+_113601616 1.820 IL1RN
interleukin 1 receptor antagonist
chr10_-_52315436 1.509 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr1_-_62557655 1.450 NM_181712
KANK4
KN motif and ankyrin repeat domains 4
chr16_+_70646008 1.364 NM_001126102
NM_005143
HP

haptoglobin

chr6_-_50045296 1.352 NM_001037729
DEFB113
defensin, beta 113
chr1_-_228916486 1.344 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr8_+_124263932 1.234 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chr20_+_16676997 1.233 NM_020157
OTOR
otoraplin
chr4_+_187424336 1.223 F11
coagulation factor XI
chr3_+_187917791 1.138 NM_000893
NM_001102416
NM_001166451
KNG1


kininogen 1


chr8_+_124264054 1.086 FAM83A
family with sequence similarity 83, member A
chr1_-_228916470 1.074 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr9_+_116125123 1.052 NM_000607
ORM1
orosomucoid 1
chr9_-_70780574 1.044


chr11_-_4675524 1.033 NM_030774
OR51E2
olfactory receptor, family 51, subfamily E, member 2
chr10_-_82039158 0.942 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr1_-_62557559 0.937 KANK4
KN motif and ankyrin repeat domains 4
chr3_-_12561962 0.937 NM_001195279
LOC100129480
hypothetical protein LOC100129480
chr1_-_228916559 0.920 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr19_+_40541327 0.900 NM_005304
FFAR3
free fatty acid receptor 3
chr2_+_64540843 0.899 HSPC159
galectin-related protein
chr19_-_6410735 0.876 NM_024103
SLC25A23
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
chr16_+_55963899 0.848 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr3_+_46591048 0.847 NM_001174136
TDGF1
teratocarcinoma-derived growth factor 1
chr20_+_58064360 0.834 NM_173644
C20orf197
chromosome 20 open reading frame 197
chr6_-_30188845 0.817 NM_007028
TRIM31
tripartite motif containing 31
chr19_-_46048033 0.808 NM_000762
CYP2A6
cytochrome P450, family 2, subfamily A, polypeptide 6
chr2_-_98646367 0.805 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr3_-_121883647 0.804 HGD
homogentisate 1,2-dioxygenase
chr2_+_108360798 0.794 NM_006588
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr14_-_20694023 0.780 NM_001004731
OR5AU1
olfactory receptor, family 5, subfamily AU, member 1
chr11_-_14950366 0.777 NM_001033952
NM_001033953
NM_001741
CALCA


calcitonin-related polypeptide alpha


chr9_+_110664366 0.776 NM_006687
ACTL7A
actin-like 7A
chr19_-_56147971 0.776 NM_001077491
NM_001077492
NM_012427
KLK5


kallikrein-related peptidase 5


chr3_+_187813538 0.761 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr11_-_102081654 0.744 NM_022122
MMP27
matrix metallopeptidase 27
chr3_+_120984246 0.736 NM_022002
NR1I2
nuclear receptor subfamily 1, group I, member 2
chr1_+_115373937 0.728 NM_000549
TSHB
thyroid stimulating hormone, beta
chr10_-_95350949 0.722 NM_006744
RBP4
retinol binding protein 4, plasma
chr17_+_39280041 0.716 NM_001168322
NM_001168323
NM_001168324
NM_145273
CD300LG



CD300 molecule-like family member g



chr4_+_100704262 0.713 NM_000253
MTTP
microsomal triglyceride transfer protein
chr1_+_151081953 0.680 NM_001128600
LCE6A
late cornified envelope 6A
chr22_+_49272078 0.676 NM_017584
MIOX
myo-inositol oxygenase
chr8_-_27524744 0.675 NM_203339
CLU
clusterin
chr8_-_145187553 0.669 NM_017570
OPLAH
5-oxoprolinase (ATP-hydrolysing)
chr1_+_149221122 0.643 NM_003568
ANXA9
annexin A9
chr16_+_70654625 0.636 NM_020995
HPR
haptoglobin-related protein
chr19_-_40684638 0.626 NM_001035516
DMKN
dermokine
chr7_+_143511480 0.621 NM_198495
CTAGE4
CTAGE8
CTAGE family, member 4
CTAGE family, member 8
chr7_+_129634935 0.618 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr20_+_4614796 0.610 NM_000311
NM_001080121
NM_001080122
NM_183079
NM_001080123
PRNP




prion protein




chr11_-_116168316 0.601 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr11_+_76516957 0.598 NM_000260
NM_001127179
NM_001127180
MYO7A


myosin VIIA


chr17_-_31548167 0.592 NM_001001437
NM_021006
CCL3L3
CCL3
CCL3L1
chemokine (C-C motif) ligand 3-like 3
chemokine (C-C motif) ligand 3
chemokine (C-C motif) ligand 3-like 1
chr3_+_187813553 0.588 AHSG
alpha-2-HS-glycoprotein
chr6_-_24491498 0.583 NM_001195610
DCDC2
doublecortin domain containing 2
chr3_+_187866464 0.582 NM_000412
HRG
histidine-rich glycoprotein
chr17_+_31562577 0.581 NM_207007
NM_001001435
CCL4L2
CCL4L1
chemokine (C-C motif) ligand 4-like 2
chemokine (C-C motif) ligand 4-like 1
chr1_+_205328834 0.580 NM_001017365
NM_001017366
C4BPB

complement component 4 binding protein, beta

chr6_-_132073849 0.579 NM_001145659
CTAGE9
CTAGE family, member 9
chr17_-_38978772 0.576 NM_001986
ETV4
ets variant 4
chr10_-_116434364 0.564 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr17_-_31352643 0.556 CCL14-CCL15
CCL15
CCL14-CCL15 read-through transcript
chemokine (C-C motif) ligand 15
chr19_-_411995 0.551 NM_012435
SHC2
SHC (Src homology 2 domain containing) transforming protein 2
chr2_+_65517316 0.542 FLJ16124
FLJ16124 protein
chr17_+_72047709 0.538 NM_001077620
PRCD
progressive rod-cone degeneration
chr10_+_70650064 0.537 NM_025130
HKDC1
hexokinase domain containing 1
chr19_-_46080496 0.535 NM_000764
NM_030589
CYP2A7

cytochrome P450, family 2, subfamily A, polypeptide 7

chr17_-_15311649 0.534 NM_173622
CDRT4
CMT1A duplicated region transcript 4
chr17_-_31352720 0.530 CCL14-CCL15
CCL14-CCL15 read-through transcript
chr2_+_113542017 0.530 NM_173161
IL1F10
interleukin 1 family, member 10 (theta)
chr14_+_23633101 0.512 NM_001018073
NM_004563
PCK2

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

chr3_-_172227152 0.510 SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr11_+_113280727 0.510 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr21_-_30836051 0.501 NM_181612
KRTAP19-6
keratin associated protein 19-6
chr21_-_31041390 0.496 NM_181617
KRTAP21-2
keratin associated protein 21-2
chr6_+_32003180 0.494 NM_000063
NM_001145903
C2

complement component 2

chr20_+_29492071 0.494 NM_153324
DEFB123
defensin, beta 123
chr13_-_45577144 0.493 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr2_+_69995740 0.492 MXD1
MAX dimerization protein 1
chr20_+_61967078 0.492 TPD52L2
tumor protein D52-like 2
chr4_+_71096830 0.486 NM_017855
ODAM
odontogenic, ameloblast asssociated
chrX_+_65152004 0.484


chr7_-_143597313 0.475 NM_198495
CTAGE4
CTAGE8
CTAGE family, member 4
CTAGE family, member 8
chr16_+_66614645 0.474 NM_017803
DUS2L
dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae)
chr16_-_54424517 0.470 NM_001025194
NM_001025195
NM_001266
CES1


carboxylesterase 1


chr7_-_111216180 0.469 DOCK4
dedicator of cytokinesis 4
chr20_+_61967094 0.465 TPD52L2
tumor protein D52-like 2
chrX_-_134883500 0.464 MMGT1
membrane magnesium transporter 1
chr9_+_102987137 0.457 NM_017753
LPPR1
lipid phosphate phosphatase-related protein type 1
chr6_+_32003380 0.449 C2
complement component 2
chr17_+_49255237 0.436 NM_032559
KIF2B
kinesin family member 2B
chr7_+_34664342 0.436 NM_207172
NM_207173
NPSR1

neuropeptide S receptor 1

chr12_-_1791146 0.432 CACNA2D4
calcium channel, voltage-dependent, alpha 2/delta subunit 4
chr10_+_18669619 0.430 NM_201590
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr6_-_32047637 0.428 DOM3Z
dom-3 homolog Z (C. elegans)
chr20_+_61967122 0.424 TPD52L2
tumor protein D52-like 2
chr16_-_54424473 0.422 CES1
carboxylesterase 1
chr17_-_36346240 0.418 KRT23
keratin 23 (histone deacetylase inducible)
chr3_-_47932479 0.418


chr11_+_93394025 0.414 NM_001098672
HEPHL1
hephaestin-like 1
chr3_+_134976965 0.411 TF
transferrin
chrX_+_100111352 0.408 NM_001012990
NM_001162490
NM_001162491
ARL13A


ADP-ribosylation factor-like 13A


chr17_-_70131389 0.404 NM_181449
CD300E
CD300e molecule
chr21_-_43671355 0.398 NM_173354
SIK1
salt-inducible kinase 1
chrX_+_41191630 0.397 NM_022567
NYX
nyctalopin
chr5_+_126140213 0.393 NM_005573
LMNB1
lamin B1
chr12_-_10497195 0.391 NM_002259
NM_007328
KLRC1

killer cell lectin-like receptor subfamily C, member 1

chr16_+_29942155 0.390 NM_001109659
NM_001109660
C16orf92

chromosome 16 open reading frame 92

chr1_+_152644471 0.386 IL6R
interleukin 6 receptor
chr4_+_71418886 0.386 NM_212557
AMTN
amelotin
chr20_+_61967033 0.383 NM_003288
NM_199359
NM_199360
NM_199361
NM_199362
NM_199363
TPD52L2





tumor protein D52-like 2





chr17_+_65612589 0.380 NM_170742
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr7_-_143085704 0.380 NM_178561
CTAGE6P
CTAGE family, member 6, pseudogene
chr17_-_71352017 0.376 UNC13D
unc-13 homolog D (C. elegans)
chr9_+_116131889 0.375 NM_000608
ORM2
orosomucoid 2
chr11_-_28086263 0.372 KIF18A
kinesin family member 18A
chr2_+_201464884 0.368 NM_001142356
NIF3L1
NIF3 NGG1 interacting factor 3-like 1 (S. pombe)
chr3_+_143824955 0.363 NM_002670
PLS1
plastin 1
chr9_-_106705867 0.362 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr14_+_20493467 0.361 NM_002934
RNASE2
ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
chr12_-_28016182 0.359 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr22_+_33792125 0.354 NM_001008494
ISX
intestine-specific homeobox
chr3_-_49701085 0.352 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr9_-_103237851 0.350 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr6_+_20642665 0.348 NM_017774
CDKAL1
CDK5 regulatory subunit associated protein 1-like 1
chr17_-_53849929 0.346 NM_017763
RNF43
ring finger protein 43
chr1_+_227506751 0.345 NM_006542
SPHAR
S-phase response (cyclin related)
chr19_-_50779914 0.344 OPA3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr1_+_11171967 0.343 NM_021146
ANGPTL7
angiopoietin-like 7
chr10_-_116434102 0.340 ABLIM1
actin binding LIM protein 1
chr6_+_131936057 0.340 NM_000045
ARG1
arginase, liver
chr9_+_71009746 0.339 NM_001170415
NM_001170416
TJP2

tight junction protein 2 (zona occludens 2)

chr3_-_172227223 0.338 SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr2_+_69995807 0.338 MXD1
MAX dimerization protein 1
chr5_+_150612805 0.335 NM_000405
NM_001167607
GM2A

GM2 ganglioside activator

chr1_-_205210567 0.335 NM_001122979
NM_001170631
NM_032029
FCAMR


Fc receptor, IgA, IgM, high affinity


chr20_+_2030527 0.334 NM_080836
STK35
serine/threonine kinase 35
chr17_-_53849888 0.333 RNF43
ring finger protein 43
chr21_-_42060266 0.332 NM_020639
RIPK4
receptor-interacting serine-threonine kinase 4
chr1_-_228916958 0.331 NM_000029
AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr9_-_69729926 0.329 CBWD5
CBWD3
CBWD6
COBW domain containing 5
COBW domain containing 3
COBW domain containing 6
chr20_+_41621119 0.329 SGK2
serum/glucocorticoid regulated kinase 2
chr2_+_219453487 0.327 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr17_-_75427644 0.326 NM_003655
CBX4
chromobox homolog 4
chr4_+_77214886 0.323 NM_001130016
NM_001179
ART3

ADP-ribosyltransferase 3

chr14_+_20568184 0.322 NM_173846
TPPP2
tubulin polymerization-promoting protein family member 2
chr14_+_20429382 0.318 NM_002935
RNASE2
RNASE3
ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
ribonuclease, RNase A family, 3
chr22_-_27787793 0.318 NM_015370
C22orf31
chromosome 22 open reading frame 31
chr6_-_24597717 0.313 NM_177483
NM_001503
GPLD1

glycosylphosphatidylinositol specific phospholipase D1

chr20_+_31613800 0.309 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr16_+_9093035 0.309 NM_014117
C16orf72
chromosome 16 open reading frame 72
chr7_-_129379947 0.307 NM_003344
NM_182697
UBE2H

ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)

chr8_-_6722848 0.307 NM_005218
DEFB1
defensin, beta 1
chr17_-_61655915 0.305 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr19_-_4491078 0.303 LRG1
leucine-rich alpha-2-glycoprotein 1
chr14_-_19871267 0.301 NM_021178
NM_182849
CCNB1IP1

cyclin B1 interacting protein 1, E3 ubiquitin protein ligase

chr7_+_55987046 0.301 NM_015969
MRPS17
mitochondrial ribosomal protein S17
chr4_-_110942783 0.299 NM_000204
CFI
complement factor I
chr1_+_150005754 0.293 NM_016178
OAZ3
ornithine decarboxylase antizyme 3
chr10_+_89257569 0.288 NM_001178118
MINPP1
multiple inositol-polyphosphate phosphatase 1
chr3_-_58175437 0.285 NM_004944
DNASE1L3
deoxyribonuclease I-like 3
chr20_+_41621079 0.285 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr3_+_187813405 0.282 AHSG
alpha-2-HS-glycoprotein
chr2_+_232165818 0.280 NM_152614
C2orf57
chromosome 2 open reading frame 57
chr18_+_54039779 0.278 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr4_+_119174947 0.278 NM_004784
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr17_-_38530935 0.276 NM_007297
NM_007299
NM_007294
NM_007300
BRCA1



breast cancer 1, early onset



chr5_+_147695314 0.275 NM_001040433
SPINK9
serine peptidase inhibitor, Kazal type 9
chr14_-_21172837 0.274 NM_001005466
OR10G2
olfactory receptor, family 10, subfamily G, member 2
chr4_+_155703581 0.271 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chrX_-_13744933 0.268 GPM6B
glycoprotein M6B
chr9_-_68552337 0.267 NM_001085457
CBWD5
CBWD3
CBWD1
CBWD6
COBW domain containing 5
COBW domain containing 3
COBW domain containing 1
COBW domain containing 6
chr2_-_31491057 0.266 XDH
xanthine dehydrogenase
chr8_+_21972804 0.263 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr14_+_95740916 0.263 BDKRB2
bradykinin receptor B2
chr8_-_86441115 0.262 NM_001164830
CA1
carbonic anhydrase I
chr6_+_26312758 0.259 NM_003545
HIST1H4E
histone cluster 1, H4e
chr2_+_190710730 0.259 NM_001042521
C2orf88
chromosome 2 open reading frame 88
chr6_-_132987106 0.258 NM_001033080
TAAR2
trace amine associated receptor 2
chr19_-_55833113 0.258 NM_032298
SYT3
synaptotagmin III
chr17_+_38575939 0.256 NM_031862
NM_031858
NBR1

neighbor of BRCA1 gene 1

chr6_-_119512035 0.256 NM_001100411
FAM184A
family with sequence similarity 184, member A
chr2_+_169634330 0.255 DHRS9
dehydrogenase/reductase (SDR family) member 9
chr1_-_100416358 0.255 NM_144620
LRRC39
leucine rich repeat containing 39
chr5_+_175241449 0.255 CPLX2
complexin 2
chr7_+_89870707 0.254 CLDN12
claudin 12
chr2_+_101974737 0.254 NM_004633
IL1R2
interleukin 1 receptor, type II
chr2_+_183697327 0.253 NM_138285
NUP35
nucleoporin 35kDa
chr7_+_142978994 0.252 NM_001008747
CTAGE6P
CTAGE15P
CTAGE family, member 6, pseudogene
CTAGE family, member 15, pseudogene
chr18_-_41932255 0.252 ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr17_-_46479127 0.250 SPAG9
sperm associated antigen 9
chr17_-_31353196 0.250 NM_032965
CCL15
chemokine (C-C motif) ligand 15
chr20_-_48980858 0.250 NM_015339
NM_181442
ADNP

activity-dependent neuroprotector homeobox

chr9_-_129752687 0.249 NM_203305
FAM102A
family with sequence similarity 102, member A
chr10_-_101180191 0.248 NM_002079
GOT1
glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)
chr2_-_43676603 0.247 NM_001083953
NM_022065
THADA

thyroid adenoma associated

chr19_+_50663089 0.246 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr10_+_114123765 0.246 ACSL5
acyl-CoA synthetase long-chain family member 5

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.90 3.91e-04 GO:0005615 extracellular space
1.65 8.48e-03 GO:0044421 extracellular region part
1.39 4.39e-02 GO:0005576 extracellular region

Nothing significant found in function category.