Motif ID: HMGA1,2.p2

Z-value: 1.081


Transcription factors associated with HMGA1,2.p2:

Gene SymbolEntrez IDGene Name
HMGA1 3159 high mobility group AT-hook 1
HMGA2 8091 high mobility group AT-hook 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HMGA2chr12_+_64504408-0.401.3e-01Click!
HMGA1chr6_+_343130070.322.3e-01Click!


Activity profile for motif HMGA1,2.p2.

activity profile for motif HMGA1,2.p2


Sorted Z-values histogram for motif HMGA1,2.p2

Sorted Z-values for motif HMGA1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HMGA1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_169465995 3.326 NM_001081686
NM_021176
G6PC2

glucose-6-phosphatase, catalytic, 2

chr7_+_123036312 2.605 NM_080928
ASB15
ankyrin repeat and SOCS box containing 15
chr4_+_74566325 2.586 NM_001133
AFM
afamin
chr9_-_94226380 2.427 NM_005014
OMD
osteomodulin
chr12_+_8557402 2.224 NM_080387
CLEC4D
C-type lectin domain family 4, member D
chr17_-_64568641 2.220 NM_080283
ABCA9
ATP-binding cassette, sub-family A (ABC1), member 9
chr4_+_75393053 2.123 NM_001013442
EPGN
epithelial mitogen homolog (mouse)
chr6_-_27988152 1.925 NM_033057
OR2B2
olfactory receptor, family 2, subfamily B, member 2
chr9_+_126460511 1.912


chr2_+_102401580 1.818 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr1_+_196874839 1.798 PTPRC
protein tyrosine phosphatase, receptor type, C
chr1_-_158815895 1.769 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr1_+_196874759 1.624 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr19_-_62348381 1.508 NM_052882
ZIM3
zinc finger, imprinted 3
chr18_+_50139168 1.500 NM_173529
C18orf54
chromosome 18 open reading frame 54
chr14_-_57133361 1.498 NM_001080455
SLC35F4
solute carrier family 35, member F4
chr7_+_102340579 1.456 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr7_-_91632525 1.403 NM_001161528
LOC401387
leucine-rich repeat and death domain-containing protein
chr11_-_101906640 1.366 NM_002423
MMP7
matrix metallopeptidase 7 (matrilysin, uterine)
chr1_+_194887630 1.365 NM_000186
NM_001014975
CFH

complement factor H

chr7_-_16471817 1.363 NM_015464
SOSTDC1
sclerostin domain containing 1
chr2_-_87102453 1.340 NM_002665
NM_001032392
PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr7_+_150013716 1.329 NM_015660
GIMAP2
GTPase, IMAP family member 2
chr17_+_65582981 1.327 NM_018658
NM_170741
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chrX_-_70243362 1.317 NM_001025265
CXorf65
chromosome X open reading frame 65
chr2_-_169596078 1.304 NM_003742
ABCB11
ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr9_-_99740243 1.286 NM_197978
HEMGN
hemogen
chr7_-_7724762 1.249 NM_002947
RPA3
replication protein A3, 14kDa
chr7_-_112545840 1.244 LOC401397
hypothetical LOC401397
chrX_+_138440560 1.243 NM_000133
F9
coagulation factor IX
chr3_+_122769467 1.238 NM_001012659
ARGFX
arginine-fifty homeobox
chr12_+_10054492 1.227 NM_001129998
NM_205852
CLEC12B

C-type lectin domain family 12, member B

chr7_-_112545847 1.217 LOC401397
hypothetical LOC401397
chr2_-_95846109 1.208 LOC150759
hypothetical LOC150759
chr11_-_5130174 1.201 NM_012375
OR52A1
olfactory receptor, family 52, subfamily A, member 1
chr11_+_4799126 1.191 NM_001004753
OR51F2
olfactory receptor, family 51, subfamily F, member 2
chr11_+_55799604 1.153 NM_001004745
OR5T1
olfactory receptor, family 5, subfamily T, member 1
chr3_+_39346200 1.127 NM_005201
CCR8
chemokine (C-C motif) receptor 8
chrX_-_114158388 1.114 NM_000640
IL13RA2
interleukin 13 receptor, alpha 2
chr11_-_123695302 1.113 NM_001002918
OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr1_+_245779018 1.102 NM_145278
C1orf150
chromosome 1 open reading frame 150
chr2_-_188021117 1.085 NM_005795
CALCRL
calcitonin receptor-like
chr12_+_53927248 1.078 NM_001005490
OR6C74
olfactory receptor, family 6, subfamily C, member 74
chr7_-_115458010 1.075 NM_001018058
NM_012252
TFEC

transcription factor EC

chrX_-_55074125 1.066 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chr7_+_143043871 1.064 NM_001130026
FAM115C
family with sequence similarity 115, member C
chr1_+_196874867 1.061 PTPRC
protein tyrosine phosphatase, receptor type, C
chr6_+_31690957 1.060 NM_004847
NM_001623
AIF1

allograft inflammatory factor 1

chr11_-_117305277 1.053 NM_001077263
TMPRSS13
transmembrane protease, serine 13
chr10_+_70517863 1.045 SRGN
serglycin
chr1_-_158815850 1.043 CD84
CD84 molecule
chr1_-_158948176 1.024 NM_001778
CD48
CD48 molecule
chr11_-_5819702 1.015 NM_001005167
OR52E6
olfactory receptor, family 52, subfamily E, member 6
chr4_+_157044296 1.015 NM_005651
TDO2
tryptophan 2,3-dioxygenase
chr10_+_70517823 1.013 NM_002727
SRGN
serglycin
chr6_+_47857733 1.012 NM_181744
OPN5
opsin 5
chr10_-_62002672 1.008 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr19_-_14750347 1.007 NM_013447
NM_152916
NM_152917
NM_152918
NM_152919
NM_152920
NM_152921
EMR2






egf-like module containing, mucin-like, hormone receptor-like 2






chr5_+_161427225 1.005 NM_000816
NM_198903
NM_198904
GABRG2


gamma-aminobutyric acid (GABA) A receptor, gamma 2


chr5_+_57823017 0.998 NM_152687
GAPT
GRB2-binding adaptor protein, transmembrane
chr11_+_113280727 0.990 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr3_+_171112053 0.979 NM_182610
SAMD7
sterile alpha motif domain containing 7
chr18_-_22699650 0.959 NM_001650
AQP4
aquaporin 4
chr21_-_14840506 0.954 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr2_-_170138558 0.951 NM_024622
FASTKD1
FAST kinase domains 1
chr3_-_152529999 0.950 NM_176894
P2RY13
purinergic receptor P2Y, G-protein coupled, 13
chr5_-_147996769 0.946 NM_001040169
NM_001040172
NM_001040173
NM_199453
HTR4



5-hydroxytryptamine (serotonin) receptor 4



chr22_-_15682555 0.931 NM_175878
XKR3
XK, Kell blood group complex subunit-related family, member 3
chr6_+_132915522 0.930 NM_053278
TAAR8
trace amine associated receptor 8
chr4_+_119174947 0.924 NM_004784
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr5_-_39238818 0.915 FYB
FYN binding protein
chr14_+_76362467 0.913 NM_194287
C14orf166B
chromosome 14 open reading frame 166B
chr11_-_5110383 0.909 NM_001005160
OR52A5
olfactory receptor, family 52, subfamily A, member 5
chr1_-_205272619 0.905 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr11_-_5279750 0.893 NM_033179
OR51B4
olfactory receptor, family 51, subfamily B, member 4
chr5_+_140227951 0.889 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chr1_-_156937065 0.882 NM_001005279
OR6K2
olfactory receptor, family 6, subfamily K, member 2
chr9_-_73865318 0.876 NM_001128618
C9orf57
chromosome 9 open reading frame 57
chr17_+_65612589 0.872 NM_170742
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr12_-_101396459 0.871 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr1_-_155936904 0.869 NM_052939
FCRL3
Fc receptor-like 3
chr1_-_171286634 0.864 NM_005092
TNFSF18
tumor necrosis factor (ligand) superfamily, member 18
chr15_-_53440069 0.856 CCPG1
cell cycle progression 1
chr11_+_71605466 0.856 NM_000803
NM_001113534
NM_001113535
NM_001113536
FOLR2



folate receptor 2 (fetal)



chr7_-_115458064 0.855 TFEC
transcription factor EC
chr3_-_152517204 0.853 NM_023915
GPR87
G protein-coupled receptor 87
chr1_+_61315378 0.852


chr18_+_606671 0.851 NM_199167
CLUL1
clusterin-like 1 (retinal)
chr1_+_86707113 0.848 NM_001285
CLCA1
chloride channel accessory 1
chr5_+_154373452 0.846 NM_001099293
KIF4B
kinesin family member 4B
chr6_-_123999640 0.839 NM_006073
TRDN
triadin
chr17_-_30909219 0.834 NM_001129820
SLFN14
schlafen family member 14
chr11_-_55994548 0.831 NM_001004742
OR5M3
olfactory receptor, family 5, subfamily M, member 3
chr16_+_33111656 0.830 NM_001099687
TP53TG3B
TP53 target 3B
chr13_+_42253685 0.829 NM_182508
C13orf30
chromosome 13 open reading frame 30
chr4_+_75449720 0.822 NM_001432
EREG
epiregulin
chr3_-_191650291 0.820 NM_207316
TMEM207
transmembrane protein 207
chr7_+_80105718 0.816 NM_000072
NM_001001548
CD36

CD36 molecule (thrombospondin receptor)

chr1_-_47468029 0.815 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chr1_-_160648429 0.811 NM_053282
SH2D1B
SH2 domain containing 1B
chr12_-_9976173 0.805 NM_001130711
CLEC2A
C-type lectin domain family 2, member A
chr6_+_28032997 0.805 NM_012367
OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr5_-_20024050 0.803 NM_001167667
NM_004934
CDH18

cadherin 18, type 2

chr5_-_90645974 0.800 LOC100505994
hypothetical LOC100505994
chr5_-_88155360 0.795 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr8_-_87311624 0.794 NM_138817
SLC7A13
solute carrier family 7, (cationic amino acid transporter, y+ system) member 13
chr17_+_25292748 0.793 NM_198529
EFCAB5
EF-hand calcium binding domain 5
chr1_+_185064654 0.788 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr7_+_141054621 0.785 NM_001105558
WEE2
WEE1 homolog 2 (S. pombe)
chr11_+_59804634 0.785 NM_148975
MS4A4A
membrane-spanning 4-domains, subfamily A, member 4
chrX_+_115215985 0.783 NM_000686
AGTR2
angiotensin II receptor, type 2
chr12_-_83954185 0.778 NM_001100917
TSPAN19
tetraspanin 19
chr1_-_167969802 0.777 NM_000450
SELE
selectin E
chr13_-_45577144 0.777 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr17_-_64752550 0.775 NM_080282
ABCA10
ATP-binding cassette, sub-family A (ABC1), member 10
chr5_+_40945315 0.773 NM_000587
C7
complement component 7
chr7_-_126670804 0.772 NM_000845
GRM8
glutamate receptor, metabotropic 8
chr7_-_113346284 0.771 NM_002711
PPP1R3A
protein phosphatase 1, regulatory (inhibitor) subunit 3A
chr10_-_17211795 0.771 NM_001081
CUBN
cubilin (intrinsic factor-cobalamin receptor)
chr1_-_184696839 0.770 NM_002597
PDC
phosducin
chr4_-_74704964 0.769 NM_177532
NM_201431
RASSF6

Ras association (RalGDS/AF-6) domain family member 6

chr12_+_18305740 0.769 NM_004570
PIK3C2G
phosphoinositide-3-kinase, class 2, gamma polypeptide
chr10_+_74323344 0.769 NM_152635
OIT3
oncoprotein induced transcript 3
chr4_-_38710376 0.766 NM_024943
TMEM156
transmembrane protein 156
chr6_+_14032655 0.760 NM_001165034
RNF182
ring finger protein 182
chr10_+_115514567 0.757 NM_182601
C10orf81
chromosome 10 open reading frame 81
chr17_-_6924227 0.753 NM_006344
NM_182906
CLEC10A

C-type lectin domain family 10, member A

chr6_-_53638464 0.748 NM_001003760
KLHL31
kelch-like 31 (Drosophila)
chr6_-_68655708 0.746


chr4_-_70396167 0.742 NM_021139
UGT2B4
UDP glucuronosyltransferase 2 family, polypeptide B4
chr1_-_245902965 0.741 NM_001005487
OR13G1
olfactory receptor, family 13, subfamily G, member 1
chr19_-_9098625 0.736 NM_001001958
OR7G3
olfactory receptor, family 7, subfamily G, member 3
chr5_-_121842680 0.733


chr3_+_157321030 0.732 NM_172160
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr3_-_36756355 0.732 NM_033403
DCLK3
doublecortin-like kinase 3
chrX_-_62487693 0.731 NM_001012968
SPIN4
spindlin family, member 4
chr3_+_115099007 0.730 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr5_+_94752803 0.725 NM_152548
FAM81B
family with sequence similarity 81, member B
chr14_+_20319049 0.723 NM_005615
RNASE6
ribonuclease, RNase A family, k6
chr1_-_143786993 0.722 NM_022359
PDE4DIP
phosphodiesterase 4D interacting protein
chr12_-_68379331 0.722 NM_032735
BEST3
bestrophin 3
chr5_+_40945374 0.720 C7
complement component 7
chr11_+_26310253 0.719 NM_031418
ANO3
anoctamin 3
chr5_+_170143289 0.718 NM_014211
GABRP
gamma-aminobutyric acid (GABA) A receptor, pi
chr2_+_157822355 0.706 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr5_-_131907071 0.704 NM_000879
IL5
interleukin 5 (colony-stimulating factor, eosinophil)
chr7_+_123353144 0.704 NM_001174045
NM_001174046
SPAM1

sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)

chr18_-_22696532 0.704 NM_004028
AQP4
aquaporin 4
chrX_+_134693879 0.699 NM_001017436
NM_152582
CT45A3
CT45A4
CT45A2
cancer/testis antigen family 45, member A3
cancer/testis antigen family 45, member A4
cancer/testis antigen family 45, member A2
chr15_+_56217686 0.697 NM_020980
AQP9
aquaporin 9
chr1_+_78858675 0.697 NM_006820
IFI44L
interferon-induced protein 44-like
chr10_+_97749837 0.696 NM_001001732
NM_001159747
CC2D2B

coiled-coil and C2 domain containing 2B

chr1_-_76170563 0.693 NM_080868
ASB17
ankyrin repeat and SOCS box containing 17
chrX_-_12972641 0.688 NM_174901
FAM9C
family with sequence similarity 9, member C
chr7_-_135263737 0.687 MTPN
LUZP6
myotrophin
leucine zipper protein 6
chr12_-_9804682 0.683 NM_001781
CD69
CD69 molecule
chr1_+_171871283 0.681 NM_001195190
LOC730159
hypothetical protein LOC730159
chr3_-_167037946 0.680 NM_000055
BCHE
butyrylcholinesterase
chr11_+_63032034 0.680 NM_001142537
NM_001142538
LGALS12

lectin, galactoside-binding, soluble, 12

chr5_-_39400319 0.680 NM_001737
C9
complement component 9
chr1_+_111571803 0.676 NM_001025197
NM_004000
CHI3L2

chitinase 3-like 2

chr16_+_33168191 0.676 NM_001099687
TP53TG3B
TP53 target 3B
chr7_+_50106227 0.670 NM_001161834
C7orf72
chromosome 7 open reading frame 72
chr12_-_94469357 0.669 NM_032147
USP44
ubiquitin specific peptidase 44
chr6_+_34590624 0.669 PACSIN1
protein kinase C and casein kinase substrate in neurons 1
chr11_-_102001259 0.667 NM_004771
MMP20
matrix metallopeptidase 20
chr12_+_21570457 0.666 NM_030572
C12orf39
chromosome 12 open reading frame 39
chr6_-_87861492 0.665 NM_000735
CGA
glycoprotein hormones, alpha polypeptide
chr14_+_59934178 0.662


chr12_+_10015274 0.660 NM_138337
NM_201623
CLEC12A

C-type lectin domain family 12, member A

chr12_-_49076658 0.660 NM_001145475
FAM186A
family with sequence similarity 186, member A
chr11_-_32772731 0.656 NM_001008391
CCDC73
coiled-coil domain containing 73
chr6_+_154449334 0.655 NM_001145287
OPRM1
opioid receptor, mu 1
chr10_+_118177371 0.654 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chr2_-_178495768 0.654 NM_001077358
PDE11A
phosphodiesterase 11A
chr20_-_30703219 0.653 NM_182584
C20orf203
chromosome 20 open reading frame 203
chr5_-_83052606 0.653 NM_001884
HAPLN1
hyaluronan and proteoglycan link protein 1
chr12_-_53975282 0.652 NM_001005493
OR6C6
olfactory receptor, family 6, subfamily C, member 6
chr17_-_72151314 0.651 NM_018414
ST6GALNAC1
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
chr11_-_107969554 0.650 NM_015065
EXPH5
exophilin 5
chr4_-_88669625 0.650 NM_001128310
NM_004684
SPARCL1

SPARC-like 1 (hevin)

chr19_-_7009644 0.646 NM_001164425
MBD3L3
methyl-CpG-binding domain protein 3-like 3-like
chr6_-_32447626 0.645 NM_006781
C6orf10
chromosome 6 open reading frame 10
chr5_+_140481763 0.644 NM_018938
PCDHB4
protocadherin beta 4
chr1_-_191422346 0.642 NM_003783
B3GALT2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr21_-_18697829 0.642 NM_002772
TMPRSS15
transmembrane protease, serine 15
chr2_-_136590210 0.639 NM_001008540
CXCR4
chemokine (C-X-C motif) receptor 4
chr7_+_121300394 0.638 NM_002851
PTPRZ1
protein tyrosine phosphatase, receptor-type, Z polypeptide 1
chr1_+_195503956 0.636 NM_001193640
NM_201253
CRB1

crumbs homolog 1 (Drosophila)

chr18_-_59480082 0.634 NM_006919
SERPINB3
SERPINB4
serpin peptidase inhibitor, clade B (ovalbumin), member 3
serpin peptidase inhibitor, clade B (ovalbumin), member 4
chr19_+_14554895 0.633 NM_207390
CLEC17A
C-type lectin domain family 17, member A
chrX_+_105298953 0.632 NM_001171020
NM_152423
MUM1L1

melanoma associated antigen (mutated) 1-like 1

chr1_+_65492679 0.631 LOC645195
DNAJC6
hypothetical LOC645195
DnaJ (Hsp40) homolog, subfamily C, member 6
chr8_-_82769761 0.627 NM_001010893
SLC10A5
solute carrier family 10 (sodium/bile acid cotransporter family), member 5
chr19_+_60168463 0.623 NM_001174081
NLRP2
NLR family, pyrin domain containing 2
chrX_+_79562601 0.622 NM_152630
FAM46D
family with sequence similarity 46, member D
chr4_-_139382672 0.621 NM_014331
SLC7A11
solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
chrX_-_80344096 0.618 NM_030763
HMGN5
high-mobility group nucleosome binding domain 5
chr7_+_21434818 0.616


chrX_+_21868635 0.613 NM_004595
SMS
spermine synthase

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.30 1.34e-19 GO:0007606 sensory perception of chemical stimulus
2.37 3.49e-19 GO:0007608 sensory perception of smell
1.76 1.35e-12 GO:0007600 sensory perception
1.44 1.11e-06 GO:0050877 neurological system process
1.33 1.02e-04 GO:0003008 system process
1.32 2.81e-02 GO:0002376 immune system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.23 2.52e-08 GO:0071944 cell periphery
1.23 3.06e-08 GO:0005886 plasma membrane
1.17 1.64e-06 GO:0031224 intrinsic to membrane
1.17 3.46e-06 GO:0016021 integral to membrane
1.13 9.84e-05 GO:0044425 membrane part
1.09 4.22e-03 GO:0016020 membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.40 8.41e-20 GO:0004984 olfactory receptor activity
1.85 3.19e-17 GO:0004930 G-protein coupled receptor activity
1.54 9.26e-16 GO:0004872 receptor activity
1.64 2.02e-15 GO:0004888 transmembrane receptor activity
1.42 6.73e-12 GO:0004871 signal transducer activity
1.42 6.73e-12 GO:0060089 molecular transducer activity
3.42 3.79e-02 GO:0005544 calcium-dependent phospholipid binding