Motif ID: HMX1.p2

Z-value: 0.837


Transcription factors associated with HMX1.p2:

Gene SymbolEntrez IDGene Name
HMX1 3166 H6 family homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot


Activity profile for motif HMX1.p2.

activity profile for motif HMX1.p2


Sorted Z-values histogram for motif HMX1.p2

Sorted Z-values for motif HMX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HMX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_+_62740878 1.496 NM_020663
RHOJ
ras homolog gene family, member J
chr20_-_41251878 1.255 NM_007050
NM_133170
PTPRT

protein tyrosine phosphatase, receptor type, T

chr16_-_85099941 1.093 LOC400550
hypothetical LOC400550
chr8_-_26780665 1.088 ADRA1A
adrenergic, alpha-1A-, receptor
chr11_+_69602055 1.078 NM_018043
ANO1
anoctamin 1, calcium activated chloride channel
chr18_-_44189625 1.056 ZBTB7C
zinc finger and BTB domain containing 7C
chr17_+_19255083 0.917 NM_007148
RNF112
ring finger protein 112
chr5_-_168660293 0.879 NM_003062
SLIT3
slit homolog 3 (Drosophila)
chr7_+_128257698 0.867 NM_001127487
NM_001458
FLNC

filamin C, gamma

chr21_-_38954433 0.809 ERG
v-ets erythroblastosis virus E26 oncogene homolog (avian)
chr2_+_100087812 0.799


chr1_+_155130146 0.750 NM_001080471
PEAR1
platelet endothelial aggregation receptor 1
chr20_-_21442663 0.741 NM_002509
NKX2-2
NK2 homeobox 2
chr7_+_5609416 0.739 FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr2_-_241408296 0.718 NM_004321
KIF1A
kinesin family member 1A
chr1_-_175400441 0.715 ASTN1
astrotactin 1
chr18_-_55091596 0.711 NM_013435
RAX
retina and anterior neural fold homeobox
chr1_-_27159462 0.702 NM_152365
C1orf172
chromosome 1 open reading frame 172
chrX_-_142550535 0.663 NM_173078
SLITRK4
SLIT and NTRK-like family, member 4
chr5_-_10406690 0.656


chr1_-_32002222 0.651 NM_001703
BAI2
brain-specific angiogenesis inhibitor 2
chr8_+_120497732 0.649 NM_002514
NOV
nephroblastoma overexpressed gene
chr1_+_12149637 0.648 NM_001066
TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B
chr4_+_2390469 0.647 NM_001193282
LOC402160
hypothetical protein LOC402160
chr13_-_113651815 0.643 NM_182614
FAM70B
family with sequence similarity 70, member B
chr9_+_134843918 0.624 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chrX_+_37429927 0.614 NM_021083
XK
X-linked Kx blood group (McLeod syndrome)
chr14_+_100370559 0.608 MEG3
maternally expressed 3 (non-protein coding)
chr19_-_14467890 0.601 GIPC1
GIPC PDZ domain containing family, member 1
chr16_-_716367 0.590 NM_001031737
CCDC78
coiled-coil domain containing 78
chr2_-_219633481 0.584 NM_002181
IHH
Indian hedgehog
chr19_-_61874934 0.582 ZNF835
zinc finger protein 835
chr1_-_109853808 0.580 NM_020703
AMIGO1
adhesion molecule with Ig-like domain 1
chr6_-_10990048 0.578 NM_004752
GCM2
glial cells missing homolog 2 (Drosophila)
chr5_+_146594718 0.574 NM_001112724
NM_145001
STK32A

serine/threonine kinase 32A

chr1_+_180836050 0.568


chr18_-_490583 0.567 NM_130386
COLEC12
collectin sub-family member 12
chr4_-_11039600 0.564 NM_005114
HS3ST1
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
chr19_-_14467939 0.551 NM_005716
NM_202467
NM_202468
NM_202469
NM_202470
NM_202494
GIPC1





GIPC PDZ domain containing family, member 1





chr3_+_46996150 0.547 NM_015175
NBEAL2
neurobeachin-like 2
chr8_-_143996257 0.543 NM_000498
CYP11B2
cytochrome P450, family 11, subfamily B, polypeptide 2
chr3_+_214668 0.541


chr6_+_41714171 0.541 NM_005586
MDFI
MyoD family inhibitor
chr14_+_28306633 0.531 FOXG1
forkhead box G1
chr1_+_12149662 0.531 TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B
chr3_-_18441763 0.521 NM_001195470
NM_002971
SATB1

SATB homeobox 1

chr19_-_41034734 0.520 NM_004646
NPHS1
nephrosis 1, congenital, Finnish type (nephrin)
chr19_-_10558906 0.516 NM_005498
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr19_+_60006877 0.516 NM_001080770
NM_001080772
NM_002255
KIR2DL4


killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4


chr15_+_39032927 0.513 NM_001142776
NM_024111
CHAC1

ChaC, cation transport regulator homolog 1 (E. coli)

chr1_-_32054164 0.507 NM_144569
SPOCD1
SPOC domain containing 1
chr1_+_151917674 0.506 NM_000906
NPR1
natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
chr7_+_50314801 0.504 NM_006060
IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr11_+_66381451 0.504 NM_024036
LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chrX_-_139414890 0.503 NM_005634
SOX3
SRY (sex determining region Y)-box 3
chr8_-_29263714 0.500 NM_001394
DUSP4
dual specificity phosphatase 4
chr8_-_26780645 0.500


chr19_+_40474867 0.497 NM_002361
NM_080600
MAG

myelin associated glycoprotein

chr1_+_11461764 0.496 NM_020780
PTCHD2
patched domain containing 2
chr6_-_166641860 0.495 NM_175922
PRR18
proline rich 18
chr17_+_1906262 0.494 NM_001098202
HIC1
hypermethylated in cancer 1
chr7_-_131911808 0.494 NM_001105543
NM_020911
PLXNA4

plexin A4

chr14_+_101097440 0.492 NM_001362
DIO3
deiodinase, iodothyronine, type III
chr19_-_50797258 0.486 GPR4
G protein-coupled receptor 4
chr2_+_130655970 0.486 NM_025029
MZT2B
mitotic spindle organizing protein 2B
chr7_-_143523582 0.485 NM_001003702
ARHGEF35
Rho guanine nucleotide exchange factor (GEF) 35
chr1_-_231498081 0.479 NM_014801
PCNXL2
pecanex-like 2 (Drosophila)
chr1_+_25816545 0.473 NM_020379
MAN1C1
mannosidase, alpha, class 1C, member 1
chr17_+_1566566 0.473 NM_001163673
NM_152348
WDR81

WD repeat domain 81

chr19_-_10202947 0.471 NM_004230
S1PR2
sphingosine-1-phosphate receptor 2
chr4_-_647974 0.469 PDE6B
phosphodiesterase 6B, cGMP-specific, rod, beta
chr8_+_23442307 0.464 NM_016612
SLC25A37
solute carrier family 25, member 37
chr12_-_6668680 0.463 ZNF384
zinc finger protein 384
chr16_+_65754788 0.463 NM_001040667
NM_001538
HSF4

heat shock transcription factor 4

chr5_+_31229609 0.462 CDH6
cadherin 6, type 2, K-cadherin (fetal kidney)
chr17_+_37967946 0.461


chr7_+_72486044 0.461 NM_003508
FZD9
frizzled homolog 9 (Drosophila)
chr11_+_1367665 0.460 NM_003957
BRSK2
BR serine/threonine kinase 2
chr15_-_56093477 0.458 NM_170697
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr22_-_35970230 0.458 NM_002872
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr10_+_99248605 0.456 NM_024954
UBTD1
ubiquitin domain containing 1
chr16_+_665680 0.451 RHBDL1
rhomboid, veinlet-like 1 (Drosophila)
chr11_-_407324 0.450 NM_001135053
NM_021805
SIGIRR

single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

chr18_+_12244317 0.449 NM_001279
CIDEA
cell death-inducing DFFA-like effector a
chr19_-_55071645 0.437 AKT1S1
AKT1 substrate 1 (proline-rich)
chr19_-_43570503 0.437 NM_152657
GGN
gametogenetin
chr1_+_15941503 0.436 NM_001013641
TMEM82
transmembrane protein 82
chr16_-_1763036 0.431 NM_023936
MRPS34
mitochondrial ribosomal protein S34
chr21_-_41801950 0.428 NM_005656
TMPRSS2
transmembrane protease, serine 2
chr19_-_18246166 0.426 NM_001145304
NM_001145305
NM_025249
KIAA1683


KIAA1683


chr3_-_173648896 0.425 NM_004122
NM_198407
GHSR

growth hormone secretagogue receptor

chr19_+_14108974 0.422


chr4_+_88939725 0.420 NM_004967
IBSP
integrin-binding sialoprotein
chr4_-_1232742 0.420 CTBP1
C-terminal binding protein 1
chr17_-_76064842 0.415 NM_002522
NPTX1
neuronal pentraxin I
chr19_-_1125263 0.414 NM_014963
SBNO2
strawberry notch homolog 2 (Drosophila)
chrX_-_100801472 0.412 NM_014782
NM_177949
ARMCX2

armadillo repeat containing, X-linked 2

chr1_-_200182338 0.412 NM_012134
LMOD1
leiomodin 1 (smooth muscle)
chrX_-_128616594 0.408 NM_017413
APLN
apelin
chr4_-_1232882 0.406 NM_001012614
NM_001328
CTBP1

C-terminal binding protein 1

chr11_+_66381077 0.406 LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr4_-_123073642 0.403 NM_003305
TRPC3
transient receptor potential cation channel, subfamily C, member 3
chr16_-_17472238 0.401 NM_022166
XYLT1
xylosyltransferase I
chr17_-_70480385 0.400 NM_030630
C17orf28
chromosome 17 open reading frame 28
chr10_-_48010879 0.398 NM_002900
RBP3
retinol binding protein 3, interstitial
chr19_+_43446937 0.396 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr11_-_117305277 0.396 NM_001077263
TMPRSS13
transmembrane protease, serine 13
chr7_-_131911768 0.393 PLXNA4
plexin A4
chr1_-_31942206 0.393 NM_001856
COL16A1
collagen, type XVI, alpha 1
chr4_-_2390050 0.388 NM_001172656
NM_001172657
NM_001172658
NM_020972
ZFYVE28



zinc finger, FYVE domain containing 28



chr10_+_83625049 0.387 NM_001010848
NM_001165972
NRG3

neuregulin 3

chr8_+_143542378 0.387 NM_001702
BAI1
brain-specific angiogenesis inhibitor 1
chr11_+_128751044 0.386 NM_003658
BARX2
BARX homeobox 2
chr22_-_37598160 0.385 CBX6
chromobox homolog 6
chr22_-_37598115 0.385 CBX6
chromobox homolog 6
chr7_+_143683365 0.385 NM_005435
ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chr19_-_5631502 0.385 C19orf70
chromosome 19 open reading frame 70
chr16_+_87232501 0.381 NM_013278
IL17C
interleukin 17C
chr12_+_111980044 0.381 NM_004416
DTX1
deltex homolog 1 (Drosophila)
chr9_-_130980359 0.376 NM_203434
IER5L
immediate early response 5-like
chr13_-_37341859 0.374 NM_001135955
NM_001135956
NM_001135957
NM_001135958
NM_003306
NM_016179
TRPC4





transient receptor potential cation channel, subfamily C, member 4





chr17_-_71747867 0.371 NM_052916
RNF157
ring finger protein 157
chr16_+_23101538 0.371 NM_001039
SCNN1G
sodium channel, nonvoltage-gated 1, gamma
chr19_-_295778 0.368 NM_017550
MIER2
mesoderm induction early response 1, family member 2
chr8_-_57521702 0.368 NM_001135690
PENK
proenkephalin
chr1_-_31942142 0.368 COL16A1
collagen, type XVI, alpha 1
chr4_+_94969064 0.367 NM_005172
ATOH1
atonal homolog 1 (Drosophila)
chr11_-_67032125 0.367 CDK2AP2
cyclin-dependent kinase 2 associated protein 2
chr1_+_154297588 0.366 NM_020387
RAB25
RAB25, member RAS oncogene family
chr3_-_193928038 0.366 NM_004113
FGF12
fibroblast growth factor 12
chr2_-_197165495 0.365 NM_020760
HECW2
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
chr19_-_1125257 0.364 SBNO2
strawberry notch homolog 2 (Drosophila)
chr8_-_105548323 0.364 NM_001385
DPYS
dihydropyrimidinase
chr9_-_109290107 0.364 KLF4
Kruppel-like factor 4 (gut)
chr19_+_38314837 0.363 NM_173479
WDR88
WD repeat domain 88
chr5_-_134942867 0.363 NM_004887
CXCL14
chemokine (C-X-C motif) ligand 14
chr12_-_47679459 0.361 DDN
dendrin
chr11_+_63337421 0.360 C11orf84
chromosome 11 open reading frame 84
chr11_+_65162114 0.358 NM_006747
SIPA1
signal-induced proliferation-associated 1
chr7_-_143622188 0.357 ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chr6_-_40663089 0.357 NM_020737
LRFN2
leucine rich repeat and fibronectin type III domain containing 2
chr10_+_72826656 0.356 NM_001171930
NM_001171931
NM_001171932
NM_022124
NM_052836
CDH23




cadherin-related 23




chr5_-_139992621 0.356 NM_000591
CD14
CD14 molecule
chr17_-_70220605 0.356 NM_139018
CD300LF
CD300 molecule-like family member f
chr22_-_18687511 0.354 NM_033257
DGCR6L
DiGeorge syndrome critical region gene 6-like
chr5_+_76150637 0.354 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr18_+_41448763 0.353 NM_007163
SLC14A2
solute carrier family 14 (urea transporter), member 2
chr13_+_42046182 0.352 NM_003701
TNFSF11
tumor necrosis factor (ligand) superfamily, member 11
chr19_-_2259155 0.350 NM_001101391
LINGO3
leucine rich repeat and Ig domain containing 3
chr19_+_1358531 0.349 NM_018959
NM_170711
DAZAP1

DAZ associated protein 1

chr12_+_40117751 0.349 NM_013377
PDZRN4
PDZ domain containing ring finger 4
chr19_-_54093749 0.348 NM_003323
TULP2
tubby like protein 2
chr12_-_53064723 0.348 NM_015481
ZNF385A
zinc finger protein 385A
chr22_+_35777561 0.348 NM_024681
KCTD17
potassium channel tetramerisation domain containing 17
chr16_+_666075 0.346 NM_003961
RHBDL1
rhomboid, veinlet-like 1 (Drosophila)
chr16_-_1999796 0.345 ZNF598
zinc finger protein 598
chr11_+_66580861 0.345 NM_014578
RHOD
ras homolog gene family, member D
chr9_-_130980302 0.344 IER5L
immediate early response 5-like
chr8_-_72918697 0.344 MSC
musculin
chr11_+_67567022 0.343 NM_006053
TCIRG1
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
chr17_-_72045218 0.342 NM_134268
CYGB
cytoglobin
chr21_-_41140457 0.342 DSCAM
Down syndrome cell adhesion molecule
chr5_+_76150588 0.341 NM_005242
F2RL1
coagulation factor II (thrombin) receptor-like 1
chr9_-_139202855 0.341 NM_013366
ANAPC2
anaphase promoting complex subunit 2
chr17_-_70480345 0.341


chr3_+_128874458 0.340 NM_172027
ABTB1
ankyrin repeat and BTB (POZ) domain containing 1
chr1_-_158883666 0.339 NM_003037
SLAMF1
signaling lymphocytic activation molecule family member 1
chr2_-_6924092 0.339 CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr9_+_263025 0.339 NM_001190458
NM_001193536
DOCK8

dedicator of cytokinesis 8

chr1_-_200182090 0.339 LMOD1
leiomodin 1 (smooth muscle)
chr6_+_16346759 0.338 NM_006877
GMPR
guanosine monophosphate reductase
chr22_+_39096576 0.338 SGSM3
small G protein signaling modulator 3
chr11_+_63337498 0.337 NM_138471
C11orf84
chromosome 11 open reading frame 84
chr16_-_1999760 0.337 NM_178167
ZNF598
zinc finger protein 598
chr7_+_156496360 0.337 LOC645249
hypothetical LOC645249
chr15_-_38332401 0.336 NM_001039905
C15orf56
chromosome 15 open reading frame 56
chr8_-_72918938 0.333 MSC
musculin
chr18_-_20231709 0.333 OSBPL1A
oxysterol binding protein-like 1A
chr5_+_170779664 0.331 FGF18
fibroblast growth factor 18
chr17_+_40192072 0.331 NM_002390
ADAM11
ADAM metallopeptidase domain 11
chr1_-_55039458 0.331 NM_001114108
NM_017904
TTC22

tetratricopeptide repeat domain 22

chrX_+_48915127 0.330 NM_002668
PLP2
proteolipid protein 2 (colonic epithelium-enriched)
chr20_+_2224612 0.329 NM_003245
TGM3
transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
chr12_+_121000938 0.329 MLXIP
MLX interacting protein
chr8_+_102573837 0.328 NM_024915
GRHL2
grainyhead-like 2 (Drosophila)
chr1_-_45081190 0.328 NM_001166292
NM_003738
PTCH2

patched 2

chr5_-_9599157 0.327 NM_003966
SEMA5A
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr19_+_1358664 0.327 DAZAP1
DAZ associated protein 1
chr11_+_63337607 0.326 C11orf84
chromosome 11 open reading frame 84
chr19_+_2240996 0.324


chr4_-_78038025 0.324 NM_001029870
ANKRD56
ankyrin repeat domain 56
chr11_+_64448628 0.324 NM_006244
PPP2R5B
protein phosphatase 2, regulatory subunit B', beta
chr9_+_129951552 0.323 NM_005564
LCN2
lipocalin 2
chr6_+_30002084 0.323


chrX_-_78509662 0.323 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chr2_-_219566364 0.322 NM_005209
NM_057093
NM_057094
CRYBA2


crystallin, beta A2


chr8_+_32525269 0.322 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr2_-_133144094 0.321 LYPD1
LY6/PLAUR domain containing 1
chr22_+_39096563 0.320 SGSM3
small G protein signaling modulator 3
chr3_-_153470022 0.320 LOC401093
hypothetical LOC401093

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.43 1.83e-06 GO:0030154 cell differentiation
1.40 1.18e-05 GO:0048869 cellular developmental process
1.70 3.17e-05 GO:2000026 regulation of multicellular organismal development
1.47 4.66e-05 GO:0007399 nervous system development
1.39 2.44e-04 GO:0048583 regulation of response to stimulus
1.58 2.54e-04 GO:0050793 regulation of developmental process
1.42 3.29e-04 GO:0023051 regulation of signaling
1.45 4.12e-04 GO:0009966 regulation of signal transduction
1.26 5.20e-04 GO:0007275 multicellular organismal development
1.25 6.62e-04 GO:0023052 signaling
1.29 7.56e-04 GO:0048731 system development
1.45 1.19e-03 GO:0051239 regulation of multicellular organismal process
1.33 1.85e-03 GO:0048523 negative regulation of cellular process
1.96 2.09e-03 GO:0022603 regulation of anatomical structure morphogenesis
1.78 2.34e-03 GO:0051094 positive regulation of developmental process
1.30 4.23e-03 GO:0048519 negative regulation of biological process
3.04 7.06e-03 GO:0050770 regulation of axonogenesis
1.22 9.60e-03 GO:0032502 developmental process
1.50 1.01e-02 GO:0022008 neurogenesis
1.24 1.52e-02 GO:0048856 anatomical structure development
1.17 1.69e-02 GO:0032501 multicellular organismal process
1.23 1.73e-02 GO:0007165 signal transduction
1.56 2.14e-02 GO:0045595 regulation of cell differentiation
1.26 2.29e-02 GO:0048518 positive regulation of biological process
1.89 3.04e-02 GO:0051960 regulation of nervous system development
2.86 3.54e-02 GO:0048762 mesenchymal cell differentiation
2.92 4.07e-02 GO:0014031 mesenchymal cell development
1.48 4.21e-02 GO:0040011 locomotion
1.46 4.55e-02 GO:0048468 cell development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.29 1.44e-08 GO:0005886 plasma membrane
1.28 4.74e-08 GO:0071944 cell periphery
1.36 1.44e-05 GO:0044459 plasma membrane part
1.11 1.45e-02 GO:0016020 membrane
1.63 4.83e-02 GO:0031012 extracellular matrix

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.45 3.49e-03 GO:0005102 receptor binding