Motif ID: HNF1A.p2

Z-value: 4.198


Transcription factors associated with HNF1A.p2:

Gene SymbolEntrez IDGene Name
HNF1A 6927 HNF1 homeobox A

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HNF1Achr12_+_1199006770.885.8e-06Click!


Activity profile for motif HNF1A.p2.

activity profile for motif HNF1A.p2


Sorted Z-values histogram for motif HNF1A.p2

Sorted Z-values for motif HNF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF1A.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_24491498 11.672 NM_001195610
 DCDC2
doublecortin domain containing 2
chrX_-_105169370 10.675 NM_000354
 SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr17_-_61655915 8.959 NM_000042
 APOH
apolipoprotein H (beta-2-glycoprotein I)
chr20_+_42463279 8.913 NM_000457
NM_178849
NM_178850
 HNF4A


hepatocyte nuclear factor 4, alpha


chr20_+_42463350 8.030 HNF4A
hepatocyte nuclear factor 4, alpha
chr14_-_93859394 7.901 NM_001756
 SERPINA6
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
chr1_+_48460943 7.488 NM_001011547
NM_001135181
 SLC5A9

solute carrier family 5 (sodium/glucose cotransporter), member 9

chr20_+_42417752 7.465 NM_001030003
NM_001030004
NM_175914
 HNF4A


hepatocyte nuclear factor 4, alpha


chr4_+_74520796 7.248 NM_001134
 AFP
alpha-fetoprotein
chr20_+_42463387 7.215 HNF4A
hepatocyte nuclear factor 4, alpha
chr8_-_17797127 7.159 NM_147203
NM_201553
NM_004467
NM_201552
 FGL1



fibrinogen-like 1



chr16_+_21152516 7.109 NM_145865
 ANKS4B
ankyrin repeat and sterile alpha motif domain containing 4B
chr7_-_50600536 6.958 NM_001082971
 DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr19_-_40995564 6.843 PRODH2
proline dehydrogenase (oxidase) 2
chr14_-_93924663 6.677 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr7_-_44547382 6.524 NM_001101648
NM_013389
 NPC1L1

NPC1 (Niemann-Pick disease, type C1, gene)-like 1

chr14_+_20226762 6.340 NM_001097577
NM_194431
 ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr20_+_42463419 6.177 HNF4A
hepatocyte nuclear factor 4, alpha
chr16_-_86527608 5.914 NM_001739
 CA5A
carbonic anhydrase VA, mitochondrial
chr4_-_110942576 5.902 CFI
complement factor I

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 29 entries
enrichment   p-value GO term description
55.28 7.62e-03 GO:0034392 negative regulation of smooth muscle cell apoptosis
25.13 1.03e-03 GO:0046415 urate metabolic process
24.57 1.60e-02 GO:0009812 flavonoid metabolic process
24.57 1.60e-02 GO:0051918 negative regulation of fibrinolysis
23.03 1.74e-03 GO:0051917 regulation of fibrinolysis
20.10 4.08e-02 GO:0009698 phenylpropanoid metabolic process
13.82 6.59e-04 GO:0030195 negative regulation of blood coagulation
13.35 8.55e-04 GO:0050819 negative regulation of coagulation
10.05 3.19e-02 GO:0001523 retinoid metabolic process
10.05 3.19e-02 GO:0016101 diterpenoid metabolic process
9.92 7.21e-03 GO:0030193 regulation of blood coagulation
9.44 1.02e-02 GO:0006721 terpenoid metabolic process
9.22 1.21e-02 GO:0050818 regulation of coagulation
8.16 1.83e-03 GO:0010951 negative regulation of endopeptidase activity
8.06 3.00e-02 GO:0033993 response to lipid
8.06 3.00e-02 GO:0061041 regulation of wound healing
7.25 1.75e-02 GO:0072376 protein activation cascade
6.81 2.81e-02 GO:0019748 secondary metabolic process
5.82 1.73e-04 GO:0006805 xenobiotic metabolic process
5.82 1.73e-04 GO:0071466 cellular response to xenobiotic stimulus

Gene overrepresentation in compartment category:

Showing 1 to 14 of 14 entries
enrichment   p-value GO term description
23.69 3.91e-02 GO:0005577 fibrinogen complex
23.69 3.91e-02 GO:0046581 intercellular canaliculus
9.57 6.92e-05 GO:0031983 vesicle lumen
9.41 3.60e-04 GO:0031093 platelet alpha granule lumen
9.22 4.25e-04 GO:0034774 secretory granule lumen
8.85 5.86e-04 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
7.63 1.84e-03 GO:0031091 platelet alpha granule
5.27 1.40e-05 GO:0016324 apical plasma membrane
4.46 6.19e-05 GO:0045177 apical part of cell
2.43 5.10e-04 GO:0005615 extracellular space
2.17 1.27e-02 GO:0005624 membrane fraction
2.10 2.25e-02 GO:0005626 insoluble fraction
1.99 1.78e-02 GO:0044421 extracellular region part
1.92 2.84e-02 GO:0000267 cell fraction

Gene overrepresentation in function category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
14.74 3.58e-02 GO:0008514 organic anion transmembrane transporter activity
13.82 1.48e-04 GO:0015020 glucuronosyltransferase activity
8.51 1.93e-02 GO:0005504 fatty acid binding
7.63 2.68e-03 GO:0033293 monocarboxylic acid binding
7.54 3.87e-02 GO:0043498 cell surface binding
5.66 8.83e-03 GO:0004867 serine-type endopeptidase inhibitor activity
4.40 5.79e-03 GO:0031406 carboxylic acid binding
4.14 2.22e-02 GO:0004866 endopeptidase inhibitor activity
3.98 3.18e-02 GO:0061135 endopeptidase regulator activity
3.93 3.57e-02 GO:0030414 peptidase inhibitor activity
3.43 3.20e-03 GO:0004857 enzyme inhibitor activity
2.04 2.41e-02 GO:0030234 enzyme regulator activity