Motif ID: HNF4A_NR2F1,2.p2

Z-value: 3.201


Transcription factors associated with HNF4A_NR2F1,2.p2:

Gene SymbolEntrez IDGene Name
HNF4A 3172 hepatocyte nuclear factor 4, alpha
NR2F1 7025 nuclear receptor subfamily 2, group F, member 1
NR2F2 7026 nuclear receptor subfamily 2, group F, member 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HNF4Achr20_+_424632790.861.8e-05Click!
NR2F1chr5_+_929463480.391.4e-01Click!
NR2F2chr15_+_946748490.107.1e-01Click!


Activity profile for motif HNF4A_NR2F1,2.p2.

activity profile for motif HNF4A_NR2F1,2.p2


Sorted Z-values histogram for motif HNF4A_NR2F1,2.p2

Sorted Z-values for motif HNF4A_NR2F1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF4A_NR2F1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_241193492 4.746 NM_001195381
NM_001195382
GPR35

G protein-coupled receptor 35

chr12_+_51783540 4.679 NM_003578
SOAT2
sterol O-acyltransferase 2
chr12_+_51783554 4.618 SOAT2
sterol O-acyltransferase 2
chr16_+_21152516 3.749 NM_145865
ANKS4B
ankyrin repeat and sterile alpha motif domain containing 4B
chr17_+_24394281 3.495 PIPOX
pipecolic acid oxidase
chr2_-_238164042 3.472 RAB17
RAB17, member RAS oncogene family
chr17_+_69950782 3.257 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr10_-_101831579 3.223 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr1_-_167822248 3.133 F5
coagulation factor V (proaccelerin, labile factor)
chr19_+_5774817 3.117 NM_004558
NRTN
neurturin
chr17_+_75766875 3.057 NM_024110
CARD14
caspase recruitment domain family, member 14
chr9_-_14858974 3.027 FREM1
FRAS1 related extracellular matrix 1
chr13_+_112825113 3.006 NM_000504
F10
coagulation factor X
chr6_+_33280396 2.957 NM_014234
HSD17B8
hydroxysteroid (17-beta) dehydrogenase 8
chr16_-_86527608 2.947 NM_001739
CA5A
carbonic anhydrase VA, mitochondrial
chr1_-_110108048 2.826 NM_024526
NM_133181
NM_139053
EPS8L3


EPS8-like 3


chr14_-_93924873 2.692 NM_000295
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr9_-_126309510 2.687 NM_004959
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr2_-_238164452 2.582 NM_022449
RAB17
RAB17, member RAS oncogene family
chr3_-_52454082 2.540 NM_020163
SEMA3G
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
chr1_-_228916559 2.520 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr2_+_219354692 2.512 NM_000784
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr1_-_172153087 2.510 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr4_-_9632192 2.481 NM_020041
SLC2A9
solute carrier family 2 (facilitated glucose transporter), member 9
chr16_-_51138306 2.425 NM_001080430
TOX3
TOX high mobility group box family member 3
chr1_-_172153024 2.401 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr2_-_74606819 2.343 NM_133637
DQX1
DEAQ box RNA-dependent ATPase 1
chr4_+_4594619 2.330 LOC100507266
hypothetical LOC100507266
chr6_-_32034607 2.324 NM_002904
RDBP
RD RNA binding protein
chr17_+_24394043 2.310 NM_016518
PIPOX
pipecolic acid oxidase
chr6_+_30238961 2.274 NM_033229
TRIM15
tripartite motif containing 15
chr6_+_131190237 2.264 NM_001195597
LOC285733
hypothetical LOC285733
chr7_-_50600536 2.246 NM_001082971
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr20_-_3592045 2.245 NM_022139
NM_145762
GFRA4

GDNF family receptor alpha 4

chr10_+_102722275 2.223 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr6_+_32034767 2.203 SKIV2L
superkiller viralicidic activity 2-like (S. cerevisiae)
chr1_+_15941503 2.195 NM_001013641
TMEM82
transmembrane protein 82
chr2_+_27573206 2.169 NM_001486
GCKR
glucokinase (hexokinase 4) regulator
chr1_-_149611768 2.141 NM_003944
SELENBP1
selenium binding protein 1
chr1_-_228916958 2.133 NM_000029
AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr17_-_7023378 2.129 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chr2_-_233586145 2.019 NGEF
neuronal guanine nucleotide exchange factor
chr1_-_153537810 2.012 NM_000298
PKLR
pyruvate kinase, liver and RBC
chr17_+_4621924 1.991 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr20_+_55569542 1.961 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr19_+_50086357 1.936 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr17_-_33982580 1.919 SRCIN1
SRC kinase signaling inhibitor 1
chr20_-_3097070 1.916 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr6_+_32021793 1.904 CFB
complement factor B
chr1_-_176205672 1.903 NM_033127
SEC16B
SEC16 homolog B (S. cerevisiae)
chr4_-_120462705 1.897 NM_000134
FABP2
fatty acid binding protein 2, intestinal
chr17_-_39822366 1.885 NM_000419
ITGA2B
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
chr10_+_101532450 1.878 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr1_-_167822334 1.856 NM_000130
F5
coagulation factor V (proaccelerin, labile factor)
chr2_+_11597530 1.830 NM_148903
GREB1
growth regulation by estrogen in breast cancer 1
chr6_+_32090516 1.797 NM_007293
NM_001002029
C4A
C4B
complement component 4A (Rodgers blood group)
complement component 4B (Chido blood group)
chr3_-_195553297 1.766 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr16_-_16224791 1.765 NM_001079528
NM_001171
ABCC6

ATP-binding cassette, sub-family C (CFTR/MRP), member 6

chr19_-_60412624 1.760 NM_001161440
NM_002842
PTPRH

protein tyrosine phosphatase, receptor type, H

chr17_+_35147697 1.753 NM_005310
GRB7
growth factor receptor-bound protein 7
chr11_+_696607 1.746 EPS8L2
EPS8-like 2
chr3_-_58497913 1.742 NM_003500
ACOX2
acyl-CoA oxidase 2, branched chain
chr19_+_4104593 1.740 NM_032607
CREB3L3
cAMP responsive element binding protein 3-like 3
chr11_+_73036241 1.738 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr2_-_233586164 1.717 NM_019850
NGEF
neuronal guanine nucleotide exchange factor
chr17_+_38259620 1.715 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr11_-_116168316 1.708 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr19_+_6323443 1.694 NM_032306
ALKBH7
alkB, alkylation repair homolog 7 (E. coli)
chr18_+_45594326 1.687


chr19_+_50086482 1.685 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr1_+_203740391 1.683 CDK18
cyclin-dependent kinase 18
chr16_+_31312097 1.679 NM_005353
ITGAD
integrin, alpha D
chr11_-_1549719 1.672 NM_004420
DUSP8
dual specificity phosphatase 8
chr19_+_50086362 1.665 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr10_+_101532544 1.665 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr19_+_40321584 1.661 FXYD1
FXYD domain containing ion transport regulator 1
chr16_+_55963883 1.652 CX3CL1
chemokine (C-X3-C motif) ligand 1
chr22_-_49413326 1.647 NM_000487
NM_001085425
NM_001085426
NM_001085427
NM_001085428
ARSA




arylsulfatase A




chr2_+_242398954 1.641 NEU4
sialidase 4
chr4_+_658250 1.640 MYL5
myosin, light chain 5, regulatory
chr20_+_31059038 1.636 NM_025227
BPIL1
bactericidal/permeability-increasing protein-like 1
chr1_+_219026661 1.624 NM_022746
MOSC1
MOCO sulphurase C-terminal domain containing 1
chr5_-_42847716 1.620 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr16_+_31619427 1.619 KIAA0664L3
KIAA0664-like 3
chr10_-_135229035 1.617 NM_001143763
NM_001143764
SYCE1

synaptonemal complex central element protein 1

chr16_+_31619415 1.599 KIAA0664L3
KIAA0664-like 3
chr14_+_38805622 1.588 CTAGE5
CTAGE family, member 5
chr12_-_7935010 1.565 SLC2A14
solute carrier family 2 (facilitated glucose transporter), member 14
chr6_+_32034559 1.551 NM_006929
SKIV2L
superkiller viralicidic activity 2-like (S. cerevisiae)
chr5_+_133870175 1.549


chr2_+_218992053 1.546 NM_007127
VIL1
villin 1
chr20_-_49852353 1.546 NM_020436
SALL4
sal-like 4 (Drosophila)
chr19_-_7874426 1.536


chr1_+_26220852 1.531 NM_004455
EXTL1
exostoses (multiple)-like 1
chr11_-_116213511 1.531 NM_000039
APOA1
apolipoprotein A-I
chr6_+_32057779 1.528 NM_007293
NM_001002029
C4A
C4B
complement component 4A (Rodgers blood group)
complement component 4B (Chido blood group)
chr1_-_24307514 1.515 MYOM3
myomesin family, member 3
chr14_-_20642629 1.504 NM_001102454
ZNF219
zinc finger protein 219
chr12_+_119900677 1.496 HNF1A
HNF1 homeobox A
chr3_-_42892195 1.494 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr17_+_53625084 1.486 NM_000502
EPX
eosinophil peroxidase
chr20_+_62266270 1.484 NM_004535
MYT1
myelin transcription factor 1
chr1_-_159459999 1.481 NM_001643
APOA2
apolipoprotein A-II
chr8_+_21972631 1.468 NM_001114138
NM_001978
EPB49

erythrocyte membrane protein band 4.9 (dematin)

chr11_-_60819110 1.463 VWCE
von Willebrand factor C and EGF domains
chr20_+_30831298 1.458 NM_175850
DNMT3B
DNA (cytosine-5-)-methyltransferase 3 beta
chr1_-_176205970 1.457 SEC16B
SEC16 homolog B (S. cerevisiae)
chr19_-_53558961 1.453 NM_018273
TMEM143
transmembrane protein 143
chr19_+_18357966 1.444 NM_004864
GDF15
growth differentiation factor 15
chr17_-_6958773 1.436 NM_001181
NM_080912
NM_080913
ASGR2


asialoglycoprotein receptor 2


chr2_-_27457088 1.433 NM_144631
ZNF513
zinc finger protein 513
chr11_+_74548472 1.423 NM_001145211
SLCO2B1
solute carrier organic anion transporter family, member 2B1
chr11_-_64520964 1.419 NM_138456
BATF2
basic leucine zipper transcription factor, ATF-like 2
chr6_+_32021687 1.405 NM_001710
CFB
complement factor B
chr7_+_149201962 1.400 ATP6V0E2
ATPase, H+ transporting V0 subunit e2
chr11_+_60391590 1.387 NM_207341
ZP1
zona pellucida glycoprotein 1 (sperm receptor)
chr6_+_32021742 1.381 CFB
complement factor B
chr19_-_18196302 1.380 NM_001098819
PDE4C
phosphodiesterase 4C, cAMP-specific
chr11_+_46697345 1.374 F2
coagulation factor II (thrombin)
chr14_-_93924663 1.374 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr7_-_75461897 1.366 NM_031925
TMEM120A
transmembrane protein 120A
chr16_+_82540172 1.364 NM_013370
NM_182980
OSGIN1

oxidative stress induced growth inhibitor 1

chr11_+_46697312 1.362 NM_000506
F2
coagulation factor II (thrombin)
chr1_+_155052094 1.359 NM_001007792
NTRK1
neurotrophic tyrosine kinase, receptor, type 1
chr1_-_159459814 1.356 APOA2
apolipoprotein A-II
chr2_-_88208650 1.349 NM_001443
FABP1
fatty acid binding protein 1, liver
chr22_+_44277354 1.348 NM_001996
NM_006485
NM_006486
NM_006487
FBLN1



fibulin 1



chr19_+_50086350 1.342 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr19_+_40213431 1.337 NM_001037
NM_199037
SCN1B

sodium channel, voltage-gated, type I, beta

chr19_+_50086405 1.320 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr14_+_73073570 1.313 NM_001037161
ACOT1
acyl-CoA thioesterase 1
chr3_+_52787478 1.313 NM_001166434
ITIH1
inter-alpha (globulin) inhibitor H1
chr17_-_71535076 1.307 NM_001988
EVPL
envoplakin
chr19_+_59333232 1.303 NM_014516
CNOT3
CCR4-NOT transcription complex, subunit 3
chr3_-_121883647 1.294 HGD
homogentisate 1,2-dioxygenase
chr1_+_9222489 1.292 H6PD
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
chr9_-_34366831 1.291 NM_020702
KIAA1161
KIAA1161
chr22_+_20899155 1.291


chr14_-_104957120 1.273 LOC100507437
hypothetical LOC100507437
chr2_-_26635069 1.266 NM_194248
OTOF
otoferlin
chr3_+_185580554 1.265 NM_003741
CHRD
chordin
chr11_-_60819273 1.262 NM_152718
VWCE
von Willebrand factor C and EGF domains
chr12_+_119900931 1.258 NM_000545
HNF1A
HNF1 homeobox A
chr19_-_38052481 1.253 NM_001126335
NM_014270
SLC7A9

solute carrier family 7 (cationic amino acid transporter, y+ system), member 9

chr2_-_74521061 1.252 NM_001015056
NM_033046
RTKN

rhotekin

chr12_+_110688728 1.242 NM_000690
ALDH2
aldehyde dehydrogenase 2 family (mitochondrial)
chr8_+_21972804 1.242 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr6_+_32021831 1.232 CFB
complement factor B
chr14_+_73105515 1.232 NM_006821
ACOT2
acyl-CoA thioesterase 2
chr17_+_35147738 1.231 GRB7
growth factor receptor-bound protein 7
chr6_+_32003380 1.230 C2
complement component 2
chr13_+_112808102 1.226 NM_000131
NM_019616
F7

coagulation factor VII (serum prothrombin conversion accelerator)

chr17_-_33179118 1.222 NM_000458
NM_001165923
HNF1B

HNF1 homeobox B

chr19_-_51109875 1.219 NM_001029861
NANOS2
nanos homolog 2 (Drosophila)
chrX_-_70045285 1.212 NM_001003811
NM_031276
TEX11

testis expressed 11

chr11_+_64114857 1.211 NM_144585
NM_153378
SLC22A12

solute carrier family 22 (organic anion/urate transporter), member 12

chr5_+_80292313 1.209 NM_006909
RASGRF2
Ras protein-specific guanine nucleotide-releasing factor 2
chr1_+_166812466 1.208 NM_002995
XCL1
chemokine (C motif) ligand 1
chr17_+_1593040 1.195 NM_001165920
SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr16_+_66258205 1.194 NM_001012984
C16orf86
chromosome 16 open reading frame 86
chr15_+_71953020 1.192 NM_153356
TBC1D21
TBC1 domain family, member 21
chr1_+_26220895 1.187 EXTL1
exostoses (multiple)-like 1
chr2_+_74595073 1.184 NM_016170
TLX2
T-cell leukemia homeobox 2
chr19_-_45132372 1.181 NM_003890
FCGBP
Fc fragment of IgG binding protein
chr16_+_8675904 1.179 NM_020686
ABAT
4-aminobutyrate aminotransferase
chr7_-_93027057 1.178 NM_001164738
CALCR
calcitonin receptor
chr14_+_38805251 1.176 NM_203356
CTAGE5
CTAGE family, member 5
chr2_+_10009242 1.171 NM_198182
GRHL1
grainyhead-like 1 (Drosophila)
chr17_+_1592879 1.166 NM_000934
NM_001165921
SERPINF2

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

chr19_+_17281352 1.164 DDA1
DET1 and DDB1 associated 1
chr17_-_71534906 1.160 EVPL
envoplakin
chr21_+_42946719 1.154 NM_001001567
NM_001001568
NM_001001569
NM_001001570
NM_001001571
NM_001001572
NM_001001573
NM_001001574
NM_001001575
NM_001001576
NM_001001577
NM_001001578
NM_001001579
NM_001001580
NM_001001581
NM_001001582
NM_001001583
NM_001001584
NM_001001585
NM_002606
PDE9A



















phosphodiesterase 9A



















chr11_-_6148131 1.153 NM_001004052
OR52B2
olfactory receptor, family 52, subfamily B, member 2
chr2_-_21079145 1.151 APOB
apolipoprotein B (including Ag(x) antigen)
chr19_+_17281374 1.135 DDA1
DET1 and DDB1 associated 1
chr2_+_218929822 1.134 NM_198559
C2orf62
chromosome 2 open reading frame 62
chr19_-_584474 1.132 POLRMT
polymerase (RNA) mitochondrial (DNA directed)
chr19_-_63556632 1.126 NM_130786
A1BG
alpha-1-B glycoprotein
chr7_-_155297576 1.125 NM_000193
SHH
sonic hedgehog
chr6_+_32003180 1.123 NM_000063
NM_001145903
C2

complement component 2

chr16_-_54424517 1.122 NM_001025194
NM_001025195
NM_001266
CES1


carboxylesterase 1


chrX_-_105169370 1.120 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chrX_+_106030049 1.118 NM_001171092
CLDN2
claudin 2
chr22_+_31526801 1.116 NM_000362
TIMP3
TIMP metallopeptidase inhibitor 3
chr2_-_70634129 1.114 NM_001099691
NM_003236
TGFA

transforming growth factor, alpha

chr2_+_11591692 1.108 NM_014668
GREB1
growth regulation by estrogen in breast cancer 1
chr19_-_1125263 1.100 NM_014963
SBNO2
strawberry notch homolog 2 (Drosophila)
chr20_+_42417752 1.096 NM_001030003
NM_001030004
NM_175914
HNF4A


hepatocyte nuclear factor 4, alpha


chr17_+_4638966 1.089 NM_001014985
GLTPD2
glycolipid transfer protein domain containing 2
chr14_+_20226762 1.089 NM_001097577
NM_194431
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr1_-_26553168 1.071 NM_001039775
AIM1L
absent in melanoma 1-like
chr9_-_98368913 1.069 NM_001077181
CDC14B
CDC14 cell division cycle 14 homolog B (S. cerevisiae)
chr5_-_156322784 1.068 NM_001146726
NM_138379
TIMD4

T-cell immunoglobulin and mucin domain containing 4

chr8_-_22145795 1.060 NM_001099335
NM_014759
PHYHIP

phytanoyl-CoA 2-hydroxylase interacting protein

chr8_+_22492586 1.057 PDLIM2
PDZ and LIM domain 2 (mystique)
chr10_-_50640327 1.053 NM_001143996
NM_001143997
NM_018245
OGDHL


oxoglutarate dehydrogenase-like


chr19_+_6323805 1.053 ALKBH7
alkB, alkylation repair homolog 7 (E. coli)
chr3_-_127760447 1.048 NM_152533
C3orf22
chromosome 3 open reading frame 22
chr17_-_7471832 1.047 NM_133491
SAT2
spermidine/spermine N1-acetyltransferase family member 2
chr19_-_4293718 1.044 STAP2
signal transducing adaptor family member 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.23 8.60e-03 GO:0042221 response to chemical stimulus
1.23 1.72e-02 GO:0065008 regulation of biological quality
1.36 4.30e-02 GO:0055114 oxidation-reduction process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.46 5.33e-05 GO:0005624 membrane fraction
1.44 1.19e-04 GO:0005626 insoluble fraction
1.33 2.33e-03 GO:0000267 cell fraction
1.44 4.86e-02 GO:0005740 mitochondrial envelope

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.82 2.71e-02 GO:0005504 fatty acid binding