Motif ID: HOX{A5,B5}.p2

Z-value: 0.832


Transcription factors associated with HOX{A5,B5}.p2:

Gene SymbolEntrez IDGene Name
HOXA5 3202 homeobox A5
HOXB5 3215 homeobox B5

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HOXA5chr7_-_271497500.243.6e-01Click!
HOXB5chr17_-_440263210.068.2e-01Click!


Activity profile for motif HOX{A5,B5}.p2.

activity profile for motif HOX{A5,B5}.p2


Sorted Z-values histogram for motif HOX{A5,B5}.p2

Sorted Z-values for motif HOX{A5,B5}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A5,B5}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_5289079 2.325 NM_001040661
NM_153247
SLC29A4

solute carrier family 29 (nucleoside transporters), member 4

chr12_+_53241365 1.296 NM_001165975
PDE1B
phosphodiesterase 1B, calmodulin-dependent
chr4_-_189263395 1.119 NM_173553
TRIML2
tripartite motif family-like 2
chr1_+_246682699 1.074 NM_001004136
OR2T2
olfactory receptor, family 2, subfamily T, member 2
chr19_-_47040347 0.970 NM_173506
LYPD4
LY6/PLAUR domain containing 4
chr3_-_166397142 0.958 NM_014926
SLITRK3
SLIT and NTRK-like family, member 3
chr17_+_6620275 0.951 NM_153230
FBXO39
F-box protein 39
chr2_+_234266250 0.945 NM_001072
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr1_+_154855709 0.930 NM_021817
HAPLN2
hyaluronan and proteoglycan link protein 2
chr17_-_44249379 0.877 NM_001130918
TTLL6
tubulin tyrosine ligase-like family, member 6
chr12_-_6668680 0.868 ZNF384
zinc finger protein 384
chr3_-_197023096 0.831 MUC4
mucin 4, cell surface associated
chr16_-_56562512 0.814 NM_001135639
NM_001297
CNGB1

cyclic nucleotide gated channel beta 1

chrX_+_48265107 0.806 NM_006579
EBP
emopamil binding protein (sterol isomerase)
chr19_+_51190178 0.802 NM_001080402
CCDC61
coiled-coil domain containing 61
chr20_-_49852353 0.788 NM_020436
SALL4
sal-like 4 (Drosophila)
chrX_+_100220491 0.775 NM_021637
TMEM35
transmembrane protein 35
chr19_-_54958326 0.772 NM_021733
TSKS
testis-specific serine kinase substrate
chr11_+_4859624 0.709 NM_001004759
OR51T1
olfactory receptor, family 51, subfamily T, member 1
chr6_+_31651319 0.706 NM_000594
TNF
tumor necrosis factor
chr3_-_188903038 0.697 NM_001004312
RTP2
receptor (chemosensory) transporter protein 2
chrX_+_128700605 0.697 NM_003399
XPNPEP2
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
chr19_+_8180179 0.686 NM_024552
LASS4
LAG1 homolog, ceramide synthase 4
chr1_+_4614528 0.684 AJAP1
adherens junctions associated protein 1
chr5_+_133870175 0.683


chr1_+_196874867 0.682 PTPRC
protein tyrosine phosphatase, receptor type, C
chr17_+_7279485 0.680 NM_178518
TMEM102
transmembrane protein 102
chr19_-_47328399 0.680 NM_002698
POU2F2
POU class 2 homeobox 2
chr17_-_36276987 0.658 NM_000223
KRT12
keratin 12
chr11_+_108798084 0.647 C11orf87
chromosome 11 open reading frame 87
chr2_-_74498351 0.646 NM_001145054
C2orf81
chromosome 2 open reading frame 81
chr19_+_51190535 0.635 CCDC61
coiled-coil domain containing 61
chr3_-_129023850 0.624 NM_007283
MGLL
monoglyceride lipase
chr8_-_143996257 0.618 NM_000498
CYP11B2
cytochrome P450, family 11, subfamily B, polypeptide 2
chr16_+_2873196 0.611 NM_001142499
NM_001142500
NM_138439
FLYWCH2


FLYWCH family member 2


chr12_-_6668787 0.605 NM_001039918
NM_133476
ZNF384

zinc finger protein 384

chr22_-_35938298 0.598 NM_001051
SSTR3
somatostatin receptor 3
chr9_+_139619969 0.585 ARRDC1
arrestin domain containing 1
chrX_-_107112244 0.582 NM_031273
TEX13B
testis expressed 13B
chr16_-_48418418 0.580 NM_015069
ZNF423
zinc finger protein 423
chr9_-_28709302 0.575 NM_152570
LINGO2
leucine rich repeat and Ig domain containing 2
chr11_+_5574440 0.573 NM_001003818
NM_001198644
NM_001198645
NM_001003819
TRIM6


TRIM6-TRIM34
tripartite motif containing 6


TRIM6-TRIM34 readthrough
chr11_+_5573906 0.569 NM_058166
TRIM6
tripartite motif containing 6
chr20_+_32598352 0.565 NM_181509
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr17_-_70039187 0.559 NM_174892
CD300LB
CD300 molecule-like family member b
chr3_-_46481346 0.558 NM_002343
LTF
lactotransferrin
chr12_+_54231249 0.556 NM_001005494
OR6C4
olfactory receptor, family 6, subfamily C, member 4
chr2_-_74580173 0.551 LBX2
ladybird homeobox 2
chr11_+_17714070 0.531 NM_001112741
NM_004976
KCNC1

potassium voltage-gated channel, Shaw-related subfamily, member 1

chr7_-_139948780 0.522 NM_015689
DENND2A
DENN/MADD domain containing 2A
chr3_+_185300660 0.519 NM_182589
HTR3E
5-hydroxytryptamine (serotonin) receptor 3, family member E
chr22_+_34126104 0.516 NM_006739
MCM5
minichromosome maintenance complex component 5
chr16_-_30993004 0.508 NM_024706
ZNF668
zinc finger protein 668
chr1_-_245763763 0.503 NM_198074
OR2C3
olfactory receptor, family 2, subfamily C, member 3
chr11_-_6633427 0.495 NM_003737
DCHS1
dachsous 1 (Drosophila)
chr1_-_150805852 0.490 NM_178435
LCE3E
late cornified envelope 3E
chr13_-_38462857 0.490 NM_001144033
NM_145286
STOML3

stomatin (EPB72)-like 3

chr8_-_70909754 0.482 NM_030958
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr12_+_6884157 0.481 NM_001135217
NM_006992
NM_201650
LRRC23


leucine rich repeat containing 23


chr3_+_116824840 0.477 NM_001130064
NM_002045
GAP43

growth associated protein 43

chr1_-_120737466 0.477 NM_001004340
NM_001017986
FCGR1A
FCGR1B

Fc fragment of IgG, high affinity Ia, receptor (CD64)
Fc fragment of IgG, high affinity Ib, receptor (CD64)

chr17_-_35911340 0.465 NM_032865
TNS4
tensin 4
chr2_+_11190629 0.460 NM_182500
C2orf50
chromosome 2 open reading frame 50
chr17_-_39340414 0.455 MPP2
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
chr7_+_2248966 0.455 NM_198953
NM_198954
NUDT1

nudix (nucleoside diphosphate linked moiety X)-type motif 1

chr17_-_39340638 0.448 NM_005374
MPP2
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
chr12_+_48784057 0.444 NM_005276
GPD1
glycerol-3-phosphate dehydrogenase 1 (soluble)
chr1_-_246869181 0.441 NM_001001827
OR2T35
olfactory receptor, family 2, subfamily T, member 35
chr19_-_17819814 0.439 NM_000215
JAK3
Janus kinase 3
chr17_+_7563763 0.427 NM_020877
DNAH2
dynein, axonemal, heavy chain 2
chr14_-_22974707 0.427 NM_000257
MYH7
myosin, heavy chain 7, cardiac muscle, beta
chr1_+_24518501 0.427 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chr22_-_35914200 0.424 NM_031910
NM_182486
C1QTNF6

C1q and tumor necrosis factor related protein 6

chr22_-_37858871 0.423 CBX7
chromobox homolog 7
chr12_-_90096275 0.423 NM_133504
NM_133505
NM_133506
NM_133507
DCN



decorin



chrX_-_111212659 0.416 NM_012471
TRPC5
transient receptor potential cation channel, subfamily C, member 5
chr19_-_54258935 0.412 NM_006179
NTF4
neurotrophin 4
chr16_+_85101605 0.410 NM_001451
FOXF1
forkhead box F1
chr14_+_95222506 0.407 NM_004918
NM_199206
TCL1B

T-cell leukemia/lymphoma 1B

chr8_+_144428083 0.406 GLI4
GLI family zinc finger 4
chr22_+_40800213 0.405 FAM109B
family with sequence similarity 109, member B
chr19_-_17819773 0.404 JAK3
Janus kinase 3
chr19_+_46207335 0.398 CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr13_+_113574925 0.397 NM_001143945
GAS6
growth arrest-specific 6
chr1_+_24518398 0.391 NM_198173
NM_198174
GRHL3

grainyhead-like 3 (Drosophila)

chr17_+_71109734 0.389 MYO15B
myosin XVB pseudogene
chr13_+_28496746 0.385 NM_001033602
MTUS2
microtubule associated tumor suppressor candidate 2
chrX_+_114430547 0.380 NM_016383
LUZP4
leucine zipper protein 4
chr5_-_35974493 0.380 NM_001042625
NM_144647
CAPSL

calcyphosine-like

chr5_+_17270474 0.380 NM_006317
BASP1
brain abundant, membrane attached signal protein 1
chr11_+_89341319 0.378 NM_001136486
TRIM64
tripartite motif containing 64
chr19_-_13925192 0.378 NM_001146254
NM_001146255
PODNL1

podocan-like 1

chr9_+_139619957 0.375 ARRDC1
arrestin domain containing 1
chr1_+_201711578 0.374 PRELP
proline/arginine-rich end leucine-rich repeat protein
chr8_+_11388918 0.373 NM_001715
BLK
B lymphoid tyrosine kinase
chr1_+_180685878 0.371 NM_001137669
RGSL1
regulator of G-protein signaling like 1
chr1_-_155336223 0.371 NM_001004341
ETV3L
ets variant 3-like
chr22_-_34930705 0.366 NM_030643
NM_145660
APOL4

apolipoprotein L, 4

chr11_-_47330797 0.360 NM_000256
MYBPC3
myosin binding protein C, cardiac
chr3_+_100840129 0.357 NM_001850
NM_020351
COL8A1

collagen, type VIII, alpha 1

chr6_-_137857213 0.357 NM_175747
OLIG3
oligodendrocyte transcription factor 3
chr14_-_22904257 0.354 EFS
embryonal Fyn-associated substrate
chr1_-_155053124 0.354 NM_001161441
NM_001161442
NM_001161444
NM_003975
SH2D2A



SH2 domain containing 2A



chr15_-_72804763 0.353 NM_000499
CYP1A1
cytochrome P450, family 1, subfamily A, polypeptide 1
chr19_-_51097694 0.353 NM_001012643
MYPOP
Myb-related transcription factor, partner of profilin
chr18_+_73090913 0.351 NM_001480
GALR1
galanin receptor 1
chr10_+_115300579 0.351 NM_001177660
HABP2
hyaluronan binding protein 2
chr15_+_80741876 0.349 LOC80154
hypothetical LOC80154
chr11_-_118055564 0.349 NM_007180
TREH
trehalase (brush-border membrane glycoprotein)
chr12_+_6800950 0.349 NM_014449
NM_019858
GPR162

G protein-coupled receptor 162

chr19_+_55046229 0.348 PTOV1
prostate tumor overexpressed 1
chrX_+_46962370 0.346 NM_033018
CDK16
cyclin-dependent kinase 16
chr16_+_70117523 0.340 NM_005769
NM_001166395
CHST4

carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4

chr14_-_22904239 0.336 EFS
embryonal Fyn-associated substrate
chr18_+_21967813 0.336 NM_001025096
NM_001025097
NM_144662
PSMA8


proteasome (prosome, macropain) subunit, alpha type, 8


chr10_-_99521701 0.335 NM_003015
SFRP5
secreted frizzled-related protein 5
chr19_+_52451570 0.334 NM_015603
CCDC9
coiled-coil domain containing 9
chr10_+_50487146 0.332 NM_020984
CHAT
choline O-acetyltransferase
chr2_+_97696462 0.331 NM_001079
ZAP70
zeta-chain (TCR) associated protein kinase 70kDa
chr18_-_46600295 0.331 NM_001127175
NM_001127176
NM_031939
MRO


maestro


chr9_+_27099138 0.330 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr1_-_157014048 0.327 NM_001005278
OR6N2
olfactory receptor, family 6, subfamily N, member 2
chrX_-_6463158 0.326 NM_016379
VCX2
VCX3A
variable charge, X-linked 2
variable charge, X-linked 3A
chr15_-_83002797 0.324 NM_021077
NM_205858
NMB

neuromedin B

chr1_+_202000906 0.320 NM_001136190
NM_017773
LAX1

lymphocyte transmembrane adaptor 1

chr14_+_60045621 0.319 NM_007374
SIX6
SIX homeobox 6
chr11_-_117600918 0.317 NM_001098526
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr8_-_95298706 0.315 NM_001144663
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr1_-_90955365 0.314 NM_020063
BARHL2
BarH-like homeobox 2
chr19_-_54860833 0.313 NM_001197122
NM_001197123
NM_001197124
NM_001197125
NM_001197126
NM_001197127
NM_001197128
NM_001571
IRF3







interferon regulatory factor 3







chr11_+_10428799 0.312 NM_000480
AMPD3
adenosine monophosphate deaminase 3
chr19_+_52451642 0.311 CCDC9
coiled-coil domain containing 9
chr17_+_24944605 0.311 NM_152345
ANKRD13B
ankyrin repeat domain 13B
chr5_+_148766632 0.308 LOC728264
hypothetical LOC728264
chr20_-_42249631 0.308 NM_020433
NM_175913
JPH2

junctophilin 2

chr3_-_42892636 0.304 NM_004391
CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr2_-_63669022 0.304 WDPCP
WD repeat containing planar cell polarity effector
chr11_+_118259684 0.304 NM_001716
CXCR5
chemokine (C-X-C motif) receptor 5
chr11_+_70954256 0.303 NM_001012710
KRTAP5-10
keratin associated protein 5-10
chr9_+_139619977 0.301 ARRDC1
arrestin domain containing 1
chr19_-_1966628 0.300 NM_017797
BTBD2
BTB (POZ) domain containing 2
chr20_-_23755297 0.295 NM_001322
CST2
cystatin SA
chr14_-_22596522 0.295 NM_022478
NM_144985
CDH24

cadherin 24, type 2

chr5_+_357290 0.295 NM_020731
AHRR
aryl-hydrocarbon receptor repressor
chr17_-_7107229 0.294 NM_001185022
CLDN7
claudin 7
chr22_+_36286350 0.293 NM_152243
CDC42EP1
CDC42 effector protein (Rho GTPase binding) 1
chr1_+_148020869 0.290 NM_000566
FCGR1A
Fc fragment of IgG, high affinity Ia, receptor (CD64)
chr1_-_109853808 0.289 NM_020703
AMIGO1
adhesion molecule with Ig-like domain 1
chr19_-_51168396 0.288 NM_002516
NOVA2
neuro-oncological ventral antigen 2
chr9_+_116943917 0.284 NM_017418
DEC1
deleted in esophageal cancer 1
chr19_+_52908412 0.284 NM_014601
EHD2
EH-domain containing 2
chr17_+_71141108 0.283 NM_001162995
LOC643008
hypothetical protein LOC643008
chr4_-_115120251 0.283 NM_024590
ARSJ
arylsulfatase family, member J
chrX_-_8729377 0.280 NM_001171186
NM_174951
FAM9A

family with sequence similarity 9, member A

chr8_-_93176819 0.280 RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chrX_-_1291526 0.279 NM_001012288
NM_022148
CRLF2

cytokine receptor-like factor 2

chr11_-_59237893 0.278 NM_001005324
OR10V1
olfactory receptor, family 10, subfamily V, member 1
chr9_-_5620070 0.277 C9orf46
chromosome 9 open reading frame 46
chr15_+_72005864 0.276 LOXL1
lysyl oxidase-like 1
chr1_+_87368044 0.275 LOC339524
hypothetical LOC339524
chr4_+_30331543 0.275 PCDH7
protocadherin 7
chr19_-_54636425 0.273 NM_020309
SLC17A7
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
chr1_+_156229934 0.273 KIRREL
kin of IRRE like (Drosophila)
chr7_-_32077504 0.272 NM_001191059
NM_005020
PDE1C

phosphodiesterase 1C, calmodulin-dependent 70kDa

chr12_-_8110196 0.271 NM_004054
C3AR1
complement component 3a receptor 1
chr9_-_21375258 0.270 NM_000605
IFNA2
interferon, alpha 2
chr9_+_139619917 0.268 ARRDC1
arrestin domain containing 1
chr1_-_148051859 0.267 NM_001123375
HIST2H3D
histone cluster 2, H3d
chr7_+_100310658 0.267 SRRT
serrate RNA effector molecule homolog (Arabidopsis)
chr1_+_34993234 0.267 NM_005268
GJB5
gap junction protein, beta 5, 31.1kDa
chr2_-_63669265 0.265 NM_015910
WDPCP
WD repeat containing planar cell polarity effector
chr6_-_29503468 0.264 NM_013937
OR11A1
olfactory receptor, family 11, subfamily A, member 1
chr14_+_20568184 0.263 NM_173846
TPPP2
tubulin polymerization-promoting protein family member 2
chr16_-_70168449 0.261 NM_000353
TAT
tyrosine aminotransferase
chr9_+_139619875 0.258 NM_152285
ARRDC1
arrestin domain containing 1
chr13_+_57103944 0.258 PCDH17
protocadherin 17
chr7_+_78920846 0.258 LOC100505881
hypothetical LOC100505881
chr12_-_8110268 0.257 C3AR1
complement component 3a receptor 1
chr16_-_1971180 0.257 NM_172167
NM_172168
NOXO1

NADPH oxidase organizer 1

chrX_-_139414890 0.256 NM_005634
SOX3
SRY (sex determining region Y)-box 3
chr12_+_7038240 0.254 NM_001734
NM_201442
C1S

complement component 1, s subcomponent

chr19_+_55046088 0.254 NM_017432
PTOV1
prostate tumor overexpressed 1
chr17_-_8711701 0.253 NM_001010855
PIK3R6
phosphoinositide-3-kinase, regulatory subunit 6
chr15_+_72005839 0.250 NM_005576
LOXL1
lysyl oxidase-like 1
chr6_+_90660906 0.250 NM_032602
GJA10
gap junction protein, alpha 10, 62kDa
chrX_+_51562894 0.249 NM_001005332
MAGED1
melanoma antigen family D, 1
chr3_+_89239363 0.247 NM_005233
NM_182644
EPHA3

EPH receptor A3

chr5_-_141041982 0.245 NM_022481
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr1_+_26516967 0.243 NM_001803
CD52
CD52 molecule
chr22_+_29361672 0.242 NM_001001479
SLC35E4
solute carrier family 35, member E4
chr19_+_61798434 0.241 NM_021216
ZNF71
zinc finger protein 71
chr11_+_47386621 0.241 NM_001128225
NM_152264
SLC39A13

solute carrier family 39 (zinc transporter), member 13

chr19_-_55091942 0.241 NM_152899
IL4I1
interleukin 4 induced 1
chr2_-_31491057 0.241 XDH
xanthine dehydrogenase
chr9_+_139153409 0.240 NM_000832
NM_001185090
NM_001185091
NM_007327
NM_021569
GRIN1




glutamate receptor, ionotropic, N-methyl D-aspartate 1




chr3_+_51397756 0.239 MANF
mesencephalic astrocyte-derived neurotrophic factor
chr3_+_11009436 0.239 SLC6A1
solute carrier family 6 (neurotransmitter transporter, GABA), member 1
chr3_-_188339882 0.238 NM_052969
RPL39L
ribosomal protein L39-like
chr11_-_56905178 0.238 NM_006093
PRG3
proteoglycan 3
chr6_+_29902734 0.237 NM_002127
HLA-G
major histocompatibility complex, class I, G

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.24 1.18e-05 GO:0050896 response to stimulus
1.77 4.20e-04 GO:0006952 defense response
1.24 5.04e-04 GO:0032501 multicellular organismal process
1.60 5.12e-04 GO:0002376 immune system process
1.75 1.97e-03 GO:0006955 immune response
1.29 2.91e-03 GO:0023052 signaling
1.55 3.52e-02 GO:0007154 cell communication
1.39 4.11e-02 GO:0007166 cell surface receptor linked signaling pathway
1.14 4.84e-02 GO:0065007 biological regulation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.38 2.63e-09 GO:0005886 plasma membrane
1.37 7.09e-09 GO:0071944 cell periphery
1.46 9.51e-06 GO:0044459 plasma membrane part
1.39 1.08e-03 GO:0005576 extracellular region
1.18 1.65e-03 GO:0044425 membrane part
1.20 2.48e-03 GO:0031224 intrinsic to membrane
1.19 6.40e-03 GO:0016021 integral to membrane
1.14 1.39e-02 GO:0016020 membrane
1.42 4.22e-02 GO:0031226 intrinsic to plasma membrane
1.42 4.80e-02 GO:0005887 integral to plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.57 3.52e-03 GO:0003823 antigen binding
1.41 5.21e-03 GO:0004872 receptor activity
2.47 2.01e-02 GO:0005539 glycosaminoglycan binding
1.34 2.35e-02 GO:0004871 signal transducer activity
1.34 2.35e-02 GO:0060089 molecular transducer activity
1.43 3.82e-02 GO:0004888 transmembrane receptor activity