Motif ID: HOXA9_MEIS1.p2

Z-value: 0.654


Transcription factors associated with HOXA9_MEIS1.p2:

Gene SymbolEntrez IDGene Name
HOXA9 3205 homeobox A9
MEIS1 4211 Meis homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MEIS1chr2_+_66516196-0.391.4e-01Click!
HOXA9chr7_-_27171673,
chr7_-_27171648
0.116.8e-01Click!


Activity profile for motif HOXA9_MEIS1.p2.

activity profile for motif HOXA9_MEIS1.p2


Sorted Z-values histogram for motif HOXA9_MEIS1.p2

Sorted Z-values for motif HOXA9_MEIS1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOXA9_MEIS1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_29382381 0.800 NM_030946
OR14J1
olfactory receptor, family 14, subfamily J, member 1
chr1_-_115039614 0.794 NM_000036
NM_001172626
AMPD1

adenosine monophosphate deaminase 1

chr13_+_77007809 0.784 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr2_+_68445821 0.726 NM_002664
PLEK
pleckstrin
chr3_-_191650291 0.653 NM_207316
TMEM207
transmembrane protein 207
chr1_+_196874839 0.649 PTPRC
protein tyrosine phosphatase, receptor type, C
chr4_-_40211324 0.635 RBM47
RNA binding motif protein 47
chr7_+_143457083 0.552 NM_001001659
OR2A14
olfactory receptor, family 2, subfamily A, member 14
chr1_-_611896 0.481 NM_001005224
NM_001005221
NM_001005277
OR4F3
OR4F29
OR4F16
olfactory receptor, family 4, subfamily F, member 3
olfactory receptor, family 4, subfamily F, member 29
olfactory receptor, family 4, subfamily F, member 16
chr3_-_173723754 0.476 NM_001190943
NM_001190942
NM_003810
TNFSF10


tumor necrosis factor (ligand) superfamily, member 10


chr6_-_29451042 0.438 NM_030959
OR12D3
olfactory receptor, family 12, subfamily D, member 3
chr6_+_28032997 0.374 NM_012367
OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr4_-_122357104 0.368 NM_001128843
TNIP3
TNFAIP3 interacting protein 3
chr3_+_99699137 0.348 NM_001004737
OR5K2
olfactory receptor, family 5, subfamily K, member 2
chr1_+_196874759 0.343 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr1_+_58899 0.339 NM_001005484
OR4F4
OR4F5
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 5
chr15_+_42815851 0.330 NM_080745
NM_182985
TRIM69

tripartite motif containing 69

chr16_+_29597965 0.328 QPRT
quinolinate phosphoribosyltransferase
chr1_+_196874867 0.325 PTPRC
protein tyrosine phosphatase, receptor type, C
chr15_+_36776090 0.322 NM_207444
C15orf53
chromosome 15 open reading frame 53
chr11_-_4675524 0.321 NM_030774
OR51E2
olfactory receptor, family 51, subfamily E, member 2
chr1_+_245818284 0.302 NM_001001915
OR2G2
olfactory receptor, family 2, subfamily G, member 2
chr1_-_167865973 0.299 NM_003005
SELP
selectin P (granule membrane protein 140kDa, antigen CD62)
chr7_+_143646150 0.291 NM_001005287
NM_001001802
OR2A1
OR2A42
olfactory receptor, family 2, subfamily A, member 1
olfactory receptor, family 2, subfamily A, member 42
chr2_+_68445936 0.283 PLEK
pleckstrin
chr5_+_128328685 0.282 SLC27A6
solute carrier family 27 (fatty acid transporter), member 6
chr6_-_27988152 0.278 NM_033057
OR2B2
olfactory receptor, family 2, subfamily B, member 2
chr19_-_15451203 0.275 NM_052890
PGLYRP2
peptidoglycan recognition protein 2
chr20_-_44575599 0.273 NM_018102
NM_199441
ZNF334

zinc finger protein 334

chr18_+_9875722 0.271 NM_001098529
NM_032243
TXNDC2

thioredoxin domain containing 2 (spermatozoa)

chr12_-_85756766 0.269 NM_013244
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr1_-_157313179 0.265 NM_004833
AIM2
absent in melanoma 2
chr19_-_14853166 0.263 NM_030901
OR7A17
olfactory receptor, family 7, subfamily A, member 17
chr5_-_137099602 0.255 NM_017415
KLHL3
kelch-like 3 (Drosophila)
chr14_+_19473606 0.253 NM_001004063
OR4K1
olfactory receptor, family 4, subfamily K, member 1
chr1_-_196776697 0.251 NM_133262
NM_133326
ATP6V1G3

ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3

chr2_+_204440753 0.248 NM_001037631
NM_005214
CTLA4

cytotoxic T-lymphocyte-associated protein 4

chr1_+_938709 0.239 NM_005101
ISG15
ISG15 ubiquitin-like modifier
chr6_-_32665409 0.231 NM_002124
HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr5_-_38881636 0.229


chr2_+_237143118 0.225 NM_020311
CXCR7
chemokine (C-X-C motif) receptor 7
chr15_-_56093477 0.223 NM_170697
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr4_+_71713324 0.223 NM_031889
ENAM
enamelin
chr20_-_60435983 0.215 NM_080833
C20orf151
chromosome 20 open reading frame 151
chr2_+_169631777 0.214 NM_199204
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr21_-_46849413 0.212 NM_006272
S100B
S100 calcium binding protein B
chr15_-_100280784 0.211 NM_001004195
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr8_-_6407882 0.211 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr18_-_29882555 0.210 NM_001198549
NOL4
nucleolar protein 4
chr9_-_135435165 0.208 NM_001080515
FAM163B
family with sequence similarity 163, member B
chr8_-_38577891 0.204


chr15_+_46285789 0.203 NM_000338
NM_001184832
SLC12A1

solute carrier family 12 (sodium/potassium/chloride transporters), member 1

chr3_-_139960874 0.201 NM_006219
PIK3CB
phosphoinositide-3-kinase, catalytic, beta polypeptide
chr11_-_5946299 0.200 NM_001146033
OR56A5
olfactory receptor, family 56, subfamily A, member 5
chr9_-_99740243 0.199 NM_197978
HEMGN
hemogen
chr17_-_26665194 0.195 EVI2B
ecotropic viral integration site 2B
chr1_-_246525502 0.193 NM_001004692
OR2T12
olfactory receptor, family 2, subfamily T, member 12
chr10_-_76488277 0.192 NM_001003892
DUPD1
dual specificity phosphatase and pro isomerase domain containing 1
chr19_+_10689763 0.190 DNM2
dynamin 2
chr16_+_29597829 0.189 NM_014298
QPRT
quinolinate phosphoribosyltransferase
chr5_-_9683462 0.188 NM_019599
TAS2R1
taste receptor, type 2, member 1
chr11_-_104515670 0.187 NM_021571
CARD18
caspase recruitment domain family, member 18
chr21_-_31175722 0.186 NM_175858
KRTAP11-1
keratin associated protein 11-1
chrX_-_130792297 0.185 LOC286467
hypothetical LOC286467
chr1_+_67404756 0.181 NM_144701
IL23R
interleukin 23 receptor
chr19_+_10689725 0.181 NM_001005360
NM_001005361
NM_001005362
NM_001190716
NM_004945
DNM2




dynamin 2




chr4_+_68995761 0.175 NM_014058
TMPRSS11E
transmembrane protease, serine 11E
chr9_+_129951552 0.173 NM_005564
LCN2
lipocalin 2
chr17_+_53587492 0.170 NM_012374
OR4D1
olfactory receptor, family 4, subfamily D, member 1
chr19_+_10689750 0.165 DNM2
dynamin 2
chr7_+_72883128 0.164 NM_001305
CLDN4
claudin 4
chr5_-_22889192 0.163 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr12_-_51332214 0.162 NM_000423
KRT2
keratin 2
chr11_+_56224436 0.159 NM_001005213
NM_001013358
OR9G1
OR9G9
olfactory receptor, family 9, subfamily G, member 1
olfactory receptor, family 9, subfamily G, member 9
chr3_+_49815690 0.156 NM_203370
C3orf54
chromosome 3 open reading frame 54
chr5_+_180726874 0.145 NM_001005224
NM_001005221
NM_001005277
OR4F3
OR4F29
OR4F16
olfactory receptor, family 4, subfamily F, member 3
olfactory receptor, family 4, subfamily F, member 29
olfactory receptor, family 4, subfamily F, member 16
chr11_-_62145952 0.145 NM_012200
B3GAT3
beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
chr1_-_200397300 0.143 PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr8_-_27997306 0.143 NM_001010906
C8orf80
chromosome 8 open reading frame 80
chr2_-_135498716 0.141 NM_001018046
NM_025052
YSK4

YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae)

chr1_+_357502 0.138 NM_001005224
NM_001005221
NM_001005277
OR4F3
OR4F29
OR4F16
olfactory receptor, family 4, subfamily F, member 3
olfactory receptor, family 4, subfamily F, member 29
olfactory receptor, family 4, subfamily F, member 16
chr15_-_41346346 0.134 NM_004245
NM_201631
TGM5

transglutaminase 5

chr1_-_93172119 0.134


chr1_-_84099261 0.134


chr19_+_10689813 0.133 DNM2
dynamin 2
chr14_+_77939845 0.129 NM_004796
NRXN3
neurexin 3
chrX_-_137777382 0.126 NM_001139502
FGF13
fibroblast growth factor 13
chr9_+_92629525 0.125 NM_001174167
SYK
spleen tyrosine kinase
chr11_-_16387001 0.125 NM_001145811
SOX6
SRY (sex determining region Y)-box 6
chr2_+_219432789 0.124 NM_006522
WNT6
wingless-type MMTV integration site family, member 6
chr19_+_61624 0.124 NM_001005240
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr2_+_88605283 0.121 NM_152670
C2orf51
chromosome 2 open reading frame 51
chr11_+_48284350 0.121 NM_001004725
OR4S1
olfactory receptor, family 4, subfamily S, member 1
chr9_+_124463665 0.119 NM_001005236
OR1L1
olfactory receptor, family 1, subfamily L, member 1
chr3_+_14691609 0.117 NM_001184957
NM_001184958
NM_032137
C3orf20


chromosome 3 open reading frame 20


chr7_-_84589182 0.114 NM_152754
SEMA3D
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr12_-_66905802 0.113 NM_018402
IL26
interleukin 26
chr5_-_134290789 0.113


chr19_+_10689772 0.112 DNM2
dynamin 2
chr6_-_25044156 0.111 FAM65B
family with sequence similarity 65, member B
chr17_-_39094787 0.111 NM_001040002
MEOX1
mesenchyme homeobox 1
chr11_-_7804094 0.110 NM_153445
OR5P3
olfactory receptor, family 5, subfamily P, member 3
chr1_-_13263334 0.109 NM_001012276
PRAMEF8
PRAMEF7
PRAME family member 8
PRAME family member 7
chr6_+_70633168 0.108 NM_001858
COL19A1
collagen, type XIX, alpha 1
chr2_-_2313894 0.107 NM_015025
MYT1L
myelin transcription factor 1-like
chr6_-_49712483 0.107 NM_000324
RHAG
Rh-associated glycoprotein
chr20_-_43641378 0.106 NM_130896
NM_181510
WFDC8

WAP four-disulfide core domain 8

chrX_-_110541029 0.106 NM_000555
DCX
doublecortin
chr12_-_119961143 0.103 NM_003733
NM_198213
OASL

2'-5'-oligoadenylate synthetase-like

chr2_-_43756964 0.103 NM_001101330
LOC728819
hCG1645220
chr2_-_207291364 0.101 NM_001093730
DYTN
dystrotelin
chr8_+_143778529 0.099 NM_001160354
NM_001160355
NM_017527
LY6K


lymphocyte antigen 6 complex, locus K


chr4_+_71298187 0.096 NM_021225
PROL1
proline rich, lacrimal 1
chr5_-_22889487 0.096 NM_004061
CDH12
cadherin 12, type 2 (N-cadherin 2)
chr5_-_169749215 0.095 NM_004137
KCNMB1
potassium large conductance calcium-activated channel, subfamily M, beta member 1
chr5_+_140583098 0.095 NM_018934
PCDHB14
protocadherin beta 14
chr17_-_36444626 0.094 NM_030966
KRTAP1-3
keratin associated protein 1-3
chr7_+_128365482 0.093 NM_032643
IRF5
interferon regulatory factor 5
chr6_-_25940247 0.091 NM_005074
SLC17A1
solute carrier family 17 (sodium phosphate), member 1
chr1_-_9052207 0.091 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr6_+_31782618 0.091 NM_001003693
LY6G6F
lymphocyte antigen 6 complex, locus G6F
chr14_+_19735334 0.091 NM_001005503
OR11G2
olfactory receptor, family 11, subfamily G, member 2
chr10_+_115988999 0.089 NM_198496
VWA2
von Willebrand factor A domain containing 2
chr12_-_52827275 0.088


chr1_+_151498802 0.086 NM_000427
LOR
loricrin
chr10_-_23673777 0.083 NM_153714
C10orf67
chromosome 10 open reading frame 67
chrX_+_79562601 0.082 NM_152630
FAM46D
family with sequence similarity 46, member D
chr21_-_33107813 0.082 NM_001162495
NM_001162496
NM_019596
C21orf62


chromosome 21 open reading frame 62


chr17_-_26665213 0.081 EVI2B
ecotropic viral integration site 2B
chr4_-_68511738 0.081 NM_001114387
NM_182606
TMPRSS11A

transmembrane protease, serine 11A

chr1_+_195213289 0.081 NM_030787
CFHR5
complement factor H-related 5
chr11_+_62813947 0.080 NM_001039752
SLC22A10
solute carrier family 22, member 10
chrX_+_37750778 0.079 NM_001163335
NM_138780
SYTL5

synaptotagmin-like 5

chr3_+_112743615 0.078 NM_005816
NM_198196
CD96

CD96 molecule

chr4_-_153820535 0.078 NM_152680
TMEM154
transmembrane protein 154
chrX_-_30505804 0.077 NM_025159
CXorf21
chromosome X open reading frame 21
chrX_-_106033202 0.077 NM_001171706
NM_138382
RIPPLY1

ripply1 homolog (zebrafish)

chr9_+_4782974 0.075 RCL1
RNA terminal phosphate cyclase-like 1
chr1_-_109651140 0.074 NM_001010985
MYBPHL
myosin binding protein H-like
chr3_+_123279439 0.073 NM_006889
CD86
CD86 molecule
chrX_-_77469635 0.073 NM_006639
CYSLTR1
cysteinyl leukotriene receptor 1
chr6_+_116956868 0.073 NM_153036
FAM26D
family with sequence similarity 26, member D
chr12_+_53809731 0.072 NM_001005243
OR9K2
olfactory receptor, family 9, subfamily K, member 2
chr12_-_107551783 0.071 NM_003006
SELPLG
selectin P ligand
chr19_-_3723208 0.070 NM_032753
RAX2
retina and anterior neural fold homeobox 2
chrX_-_43717864 0.070 NM_000266
NDP
Norrie disease (pseudoglioma)
chr12_+_92595281 0.070 NM_003805
CRADD
CASP2 and RIPK1 domain containing adaptor with death domain
chr10_+_80942362 0.068 NM_001099692
EIF5AL1
eukaryotic translation initiation factor 5A-like 1
chr6_-_159386007 0.067 NM_054114
NM_138810
NM_152133
TAGAP


T-cell activation RhoGTPase activating protein


chr17_-_26665220 0.065 NM_006495
EVI2B
ecotropic viral integration site 2B
chrX_+_70281405 0.065 NM_001166660
NM_018977
NM_181303
NLGN3


neuroligin 3


chr19_-_14813688 0.065 NM_001005190
OR7A10
olfactory receptor, family 7, subfamily A, member 10
chr1_+_24522116 0.064 NM_021180
GRHL3
grainyhead-like 3 (Drosophila)
chr12_-_44670475 0.063 SCAF11
SR-related CTD-associated factor 11
chr2_-_6924092 0.062 CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr7_-_38279757 0.061 NM_001003799
NM_001003806
TARP

TRGV9
TCR gamma alternate reading frame protein

T cell receptor gamma variable 9
chr2_-_113310796 0.058 NM_000576
IL1B
interleukin 1, beta
chr12_+_8866416 0.057 NM_144670
A2ML1
alpha-2-macroglobulin-like 1
chr10_-_75071498 0.056 NM_021245
MYOZ1
myozenin 1
chr3_-_115380539 0.056 NM_000796
NM_033663
DRD3

dopamine receptor D3

chr9_-_72926333 0.055 NM_001007471
TRPM3
transient receptor potential cation channel, subfamily M, member 3
chrX_+_27736027 0.055 NM_182506
MAGEB10
melanoma antigen family B, 10
chr19_+_9222605 0.055 NM_001079935
OR7E24
olfactory receptor, family 7, subfamily E, member 24
chr3_+_174598937 0.053 NM_014932
NLGN1
neuroligin 1
chr3_-_188903038 0.053 NM_001004312
RTP2
receptor (chemosensory) transporter protein 2
chr6_-_52217185 0.053 NM_052872
IL17F
interleukin 17F
chr7_+_63143255 0.052 NM_001159522
ZNF727
zinc finger protein 727
chr4_-_47831002 0.052 NM_003328
TXK
TXK tyrosine kinase
chr11_+_5862076 0.051 NM_001005165
OR52E4
olfactory receptor, family 52, subfamily E, member 4
chr19_-_54258935 0.051 NM_006179
NTF4
neurotrophin 4
chr13_+_78068246 0.051 LOC780529
hypothetical LOC780529
chr10_+_35524835 0.049 NM_182721
NM_182722
NM_182723
NM_182724
NM_182725
CREM




cAMP responsive element modulator




chrX_-_15243647 0.049 NM_080873
ASB11
ankyrin repeat and SOCS box containing 11
chr10_+_70517863 0.048 SRGN
serglycin
chr3_+_99484421 0.048 NM_001005482
OR5H2
olfactory receptor, family 5, subfamily H, member 2
chr12_+_10348311 0.048 NM_001114396
KLRD1
killer cell lectin-like receptor subfamily D, member 1
chr1_-_150463292 0.047 NM_001009931
HRNR
hornerin
chr21_-_44836811 0.047 NM_198688
KRTAP10-6
keratin associated protein 10-6
chr19_+_46904374 0.046 CEACAM5
carcinoembryonic antigen-related cell adhesion molecule 5
chr3_+_112743729 0.046 CD96
CD96 molecule
chr11_+_60223622 0.045 NM_031457
MS4A8B
membrane-spanning 4-domains, subfamily A, member 8B
chr12_-_44670613 0.045 SCAF11
SR-related CTD-associated factor 11
chr5_+_147695314 0.044 NM_001040433
SPINK9
serine peptidase inhibitor, Kazal type 9
chr1_-_148854503 0.044


chr2_+_33514896 0.044 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr12_+_20739555 0.044 NM_001145945
NM_001145946
NM_001145944
NM_017435
SLCO1C1



solute carrier organic anion transporter family, member 1C1



chr11_-_4933518 0.043 NM_001004748
OR51A2
olfactory receptor, family 51, subfamily A, member 2
chr11_-_8921155 0.043 NM_020646
ASCL3
achaete-scute complex homolog 3 (Drosophila)
chr10_+_129237602 0.042 NM_001030013
NPS
neuropeptide S
chr6_+_37030186 0.042 NM_153370
PI16
peptidase inhibitor 16
chr1_-_57204208 0.041 NM_000066
C8B
complement component 8, beta polypeptide
chr6_-_111995213 0.041 NM_001164283
TRAF3IP2
TRAF3 interacting protein 2
chr2_-_37269193 0.040 NM_001032377
SULT6B1
sulfotransferase family, cytosolic, 6B, member 1
chr1_-_23393808 0.040 NM_000864
HTR1D
5-hydroxytryptamine (serotonin) receptor 1D
chr19_-_51856129 0.039 NM_145056
DACT3
dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)
chr7_-_143560850 0.038 NM_001005287
NM_001001802
OR2A1
OR2A42
olfactory receptor, family 2, subfamily A, member 1
olfactory receptor, family 2, subfamily A, member 42
chr18_-_27594696 0.038 NM_001034172
MCART2
mitochondrial carrier triple repeat 2
chr11_+_6854431 0.037 NM_207186
OR10A4
olfactory receptor, family 10, subfamily A, member 4
chr14_+_19458580 0.037 NM_001005483
OR4K5
olfactory receptor, family 4, subfamily K, member 5
chr18_-_59137948 0.037 BCL2
B-cell CLL/lymphoma 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
5.48 1.89e-14 GO:0007606 sensory perception of chemical stimulus
5.80 2.65e-14 GO:0007608 sensory perception of smell
3.93 7.47e-13 GO:0007600 sensory perception
3.08 2.15e-12 GO:0050877 neurological system process
2.64 2.71e-10 GO:0003008 system process
1.51 3.13e-04 GO:0032501 multicellular organismal process
1.40 3.07e-03 GO:0050896 response to stimulus
28.77 6.56e-03 GO:0032645 regulation of granulocyte macrophage colony-stimulating factor production
2.45 2.11e-02 GO:0007267 cell-cell signaling
2.98 2.13e-02 GO:0050776 regulation of immune response

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.65 3.51e-06 GO:0005886 plasma membrane
1.62 7.46e-06 GO:0071944 cell periphery
1.45 1.92e-04 GO:0016021 integral to membrane
1.44 2.88e-04 GO:0031224 intrinsic to membrane
1.35 2.37e-03 GO:0044425 membrane part
5.67 3.04e-02 GO:0045095 keratin filament

Gene overrepresentation in function category:

enrichment   p-value GO term description
6.25 1.43e-16 GO:0004984 olfactory receptor activity
3.62 1.15e-11 GO:0004930 G-protein coupled receptor activity
2.99 1.61e-11 GO:0004888 transmembrane receptor activity
2.62 4.58e-11 GO:0004872 receptor activity
2.24 1.31e-08 GO:0004871 signal transducer activity
2.24 1.31e-08 GO:0060089 molecular transducer activity