Motif ID: HSF1,2.p2

Z-value: 1.103


Transcription factors associated with HSF1,2.p2:

Gene SymbolEntrez IDGene Name
HSF1 3297 heat shock transcription factor 1
HSF2 3298 heat shock transcription factor 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HSF1chr8_+_1454862450.721.6e-03Click!
HSF2chr6_+_122762449-0.562.5e-02Click!


Activity profile for motif HSF1,2.p2.

activity profile for motif HSF1,2.p2


Sorted Z-values histogram for motif HSF1,2.p2

Sorted Z-values for motif HSF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HSF1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_44234525 1.710 NM_007058
 CAPN11
calpain 11
chr12_+_118100977 1.552 NM_014365
 HSPB8
heat shock 22kDa protein 8
chr5_-_110090264 1.466 NM_001039763
 TMEM232
transmembrane protein 232
chr3_-_36756355 1.453 NM_033403
 DCLK3
doublecortin-like kinase 3
chr5_-_112798436 1.331 NM_032028
 TSSK1B
testis-specific serine kinase 1B
chr11_+_12265022 1.288 NM_032867
 MICALCL
MICAL C-terminal like
chr6_-_31890765 1.248 NM_005527
 HSPA1L
heat shock 70kDa protein 1-like
chr9_-_90983501 1.230 NM_016848
 SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr2_+_210152609 1.225 NM_002374
NM_031845
NM_031847
 MAP2


microtubule-associated protein 2


chr1_+_12757570 1.200 NM_001080830
 PRAMEF12
PRAME family member 12
chr19_+_40298571 1.180 NM_001136007
NM_001136008
NM_001136009
NM_001136010
NM_001136011
NM_001136012
NM_005971
NM_021910
 FXYD3







FXYD domain containing ion transport regulator 3







chr14_-_21108714 1.157 NM_001005465
 OR10G3
olfactory receptor, family 10, subfamily G, member 3
chr12_-_12994584 1.096 NM_018654
 GPRC5D
G protein-coupled receptor, family C, group 5, member D
chr20_+_31334601 1.092 NM_033197
 C20orf114
chromosome 20 open reading frame 114
chr11_+_68818175 1.077 NM_138768
 MYEOV
myeloma overexpressed (in a subset of t(11;14) positive multiple myelomas)
chr7_-_75876830 1.074 NM_080744
 SRCRB4D
scavenger receptor cysteine rich domain containing, group B (4 domains)
chr6_+_54281161 1.036 NM_014464
 TINAG
tubulointerstitial nephritis antigen
chr22_+_22907443 1.035 NM_019601
 SUSD2
sushi domain containing 2
chr6_+_29472310 1.006 NM_013936
 OR12D2
olfactory receptor, family 12, subfamily D, member 2
chr2_-_113259441 0.990 NM_000575
 IL1A
interleukin 1, alpha

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 26 entries
enrichment   p-value GO term description
6.64 7.51e-03 GO:0060600 dichotomous subdivision of an epithelial terminal unit
2.87 9.37e-03 GO:0048762 mesenchymal cell differentiation
2.03 3.44e-02 GO:0030855 epithelial cell differentiation
1.87 4.16e-04 GO:0060429 epithelium development
1.82 5.25e-03 GO:0007389 pattern specification process
1.73 5.37e-03 GO:0007608 sensory perception of smell
1.71 2.14e-06 GO:0007155 cell adhesion
1.71 2.14e-06 GO:0022610 biological adhesion
1.70 4.95e-04 GO:0006928 cellular component movement
1.65 1.51e-02 GO:0007606 sensory perception of chemical stimulus
1.56 3.15e-04 GO:0040011 locomotion
1.54 8.16e-04 GO:0009888 tissue development
1.49 8.98e-03 GO:0007600 sensory perception
1.48 4.45e-02 GO:2000026 regulation of multicellular organismal development
1.44 3.54e-05 GO:0009653 anatomical structure morphogenesis
1.43 8.00e-06 GO:0003008 system process
1.41 8.59e-04 GO:0050877 neurological system process
1.38 2.08e-03 GO:0007399 nervous system development
1.34 1.03e-06 GO:0048731 system development
1.34 1.75e-03 GO:0048513 organ development

Gene overrepresentation in compartment category:

Showing 1 to 13 of 13 entries
enrichment   p-value GO term description
2.18 2.98e-02 GO:0044420 extracellular matrix part
2.15 2.10e-09 GO:0031012 extracellular matrix
2.12 2.07e-07 GO:0005578 proteinaceous extracellular matrix
1.67 5.19e-10 GO:0044421 extracellular region part
1.50 8.49e-04 GO:0005615 extracellular space
1.45 6.24e-10 GO:0005576 extracellular region
1.31 2.68e-11 GO:0005886 plasma membrane
1.30 3.64e-11 GO:0071944 cell periphery
1.29 5.28e-04 GO:0044459 plasma membrane part
1.18 3.03e-05 GO:0031224 intrinsic to membrane
1.17 1.38e-05 GO:0044425 membrane part
1.17 1.50e-04 GO:0016021 integral to membrane
1.12 9.45e-04 GO:0016020 membrane

Gene overrepresentation in function category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
1.76 2.86e-02 GO:0005261 cation channel activity
1.74 1.68e-03 GO:0004984 olfactory receptor activity
1.50 1.18e-02 GO:0005509 calcium ion binding
1.45 4.63e-02 GO:0043565 sequence-specific DNA binding
1.42 2.96e-04 GO:0004888 transmembrane receptor activity
1.41 3.18e-02 GO:0004930 G-protein coupled receptor activity
1.38 4.14e-05 GO:0004872 receptor activity
1.31 3.28e-04 GO:0004871 signal transducer activity
1.31 3.28e-04 GO:0060089 molecular transducer activity