Motif ID: IKZF1.p2

Z-value: 1.257


Transcription factors associated with IKZF1.p2:

Gene SymbolEntrez IDGene Name
IKZF1 10320 IKAROS family zinc finger 1 (Ikaros)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
IKZF1chr7_+_50314801-0.165.6e-01Click!


Activity profile for motif IKZF1.p2.

activity profile for motif IKZF1.p2


Sorted Z-values histogram for motif IKZF1.p2

Sorted Z-values for motif IKZF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of IKZF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_47545816 1.206 NM_014470
RND1
Rho family GTPase 1
chr20_+_55569542 1.102 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr19_-_10558906 0.993 NM_005498
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr1_+_117253882 0.885 NM_020440
PTGFRN
prostaglandin F2 receptor negative regulator
chr14_+_38772870 0.800 NM_054024
MIA2
melanoma inhibitory activity 2
chr6_+_132901119 0.671 NM_175057
TAAR9
trace amine associated receptor 9 (gene/pseudogene)
chr21_-_30460841 0.668 NM_012131
CLDN17
claudin 17
chr2_-_238164452 0.660 NM_022449
RAB17
RAB17, member RAS oncogene family
chr1_+_3378030 0.634 ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr1_-_109651140 0.631 NM_001010985
MYBPHL
myosin binding protein H-like
chr3_-_185578621 0.630 NM_000460
NM_001177597
NM_001177598
THPO


thrombopoietin


chr4_-_155753207 0.625 FGG
fibrinogen gamma chain
chr8_+_124263932 0.602 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chr1_+_6767968 0.600 NM_001195563
NM_015215
CAMTA1

calmodulin binding transcription activator 1

chr1_+_26728846 0.599 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr4_-_155753332 0.591 NM_000509
NM_021870
FGG

fibrinogen gamma chain

chr1_+_26728827 0.583 NM_002953
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr2_+_47449790 0.576 NM_002354
EPCAM
epithelial cell adhesion molecule
chr22_-_17892859 0.569 NM_001130861
NM_003277
CLDN5

claudin 5

chr1_+_26728839 0.567 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr1_+_33124658 0.565 NM_002143
HPCA
hippocalcin
chr2_-_220144254 0.560 OBSL1
obscurin-like 1
chr12_-_56447090 0.557 NM_000785
CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr2_-_21120398 0.553 APOB
apolipoprotein B (including Ag(x) antigen)
chr1_+_31814712 0.551 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr8_-_145881968 0.548 ARHGAP39
Rho GTPase activating protein 39
chr11_-_123182266 0.547 NM_001005325
OR6M1
olfactory receptor, family 6, subfamily M, member 1
chr22_+_27609889 0.545 NM_032173
ZNRF3
zinc and ring finger 3
chr7_-_142695392 0.545


chr3_+_46594079 0.543 NM_003212
TDGF1
teratocarcinoma-derived growth factor 1
chr1_-_228916486 0.536 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr4_-_155753249 0.535 FGG
fibrinogen gamma chain
chr4_-_155753287 0.524 FGG
fibrinogen gamma chain
chr1_-_2451543 0.524 NM_001010926
HES5
hairy and enhancer of split 5 (Drosophila)
chr2_+_241279934 0.523 NM_198998
AQP12A
AQP12B
aquaporin 12A
aquaporin 12B
chr14_-_23106779 0.519 AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr12_-_51585004 0.518 NM_002273
KRT8
keratin 8
chr1_-_117011824 0.516 NM_001007237
NM_001542
IGSF3

immunoglobulin superfamily, member 3

chr4_-_155753272 0.512 FGG
fibrinogen gamma chain
chr19_-_6643953 0.511 C3
complement component 3
chr17_+_54652609 0.509 NM_001165993
NM_001165994
NM_182569
GDPD1


glycerophosphodiester phosphodiesterase domain containing 1


chr1_-_228916470 0.508 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr2_+_95303947 0.507 PROM2
prominin 2
chr2_-_238164042 0.498 RAB17
RAB17, member RAS oncogene family
chr17_+_77478858 0.497 LOC92659
hypothetical LOC92659
chr18_+_3441589 0.493 NM_170695
NM_173210
TGIF1

TGFB-induced factor homeobox 1

chr10_-_97190885 0.487 NM_001034954
NM_001034955
NM_001034956
NM_001034957
NM_006434
SORBS1




sorbin and SH3 domain containing 1




chr3_-_44464722 0.484


chr2_-_241270982 0.479 NM_001102467
AQP12A
AQP12B
aquaporin 12A
aquaporin 12B
chr1_+_153366559 0.477 EFNA1
ephrin-A1
chr1_+_31814709 0.473 TINAGL1
tubulointerstitial nephritis antigen-like 1
chrX_-_133620103 0.473 NM_021796
PLAC1
placenta-specific 1
chr1_+_153513810 0.471 NM_020897
HCN3
hyperpolarization activated cyclic nucleotide-gated potassium channel 3
chr10_-_21825879 0.470 C10orf114
chromosome 10 open reading frame 114
chr1_-_228916559 0.468 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr7_-_75876830 0.468 NM_080744
SRCRB4D
scavenger receptor cysteine rich domain containing, group B (4 domains)
chr11_-_5130174 0.465 NM_012375
OR52A1
olfactory receptor, family 52, subfamily A, member 1
chr2_-_21120314 0.457 APOB
apolipoprotein B (including Ag(x) antigen)
chr18_+_7221136 0.453 NM_001105581
LRRC30
leucine rich repeat containing 30
chr1_-_207892420 0.452 NM_000228
LAMB3
laminin, beta 3
chr5_+_175231098 0.444 NM_001008220
CPLX2
complexin 2
chr1_-_31942206 0.443 NM_001856
COL16A1
collagen, type XVI, alpha 1
chr1_-_26553168 0.442 NM_001039775
AIM1L
absent in melanoma 1-like
chr14_-_20642214 0.440


chr5_+_176726918 0.436 RGS14
regulator of G-protein signaling 14
chr16_+_3036682 0.432 NM_022468
MMP25
matrix metallopeptidase 25
chr12_-_32940931 0.429 NM_001005242
NM_004572
PKP2

plakophilin 2

chr12_-_52980984 0.429 NM_001136023
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr11_-_66245288 0.427 NM_006946
SPTBN2
spectrin, beta, non-erythrocytic 2
chr1_+_31814672 0.426 NM_022164
TINAGL1
tubulointerstitial nephritis antigen-like 1
chr11_+_73034870 0.424 NM_001130033
NM_021200
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr12_-_52980914 0.422 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr2_+_95303922 0.418 NM_001165977
NM_001165978
NM_144707
PROM2


prominin 2


chrX_+_130984912 0.418 NM_001042453
NM_016542
MST4

serine/threonine protein kinase MST4

chr14_+_23527866 0.417 NM_198083
DHRS4
DHRS4L2
dehydrogenase/reductase (SDR family) member 4
dehydrogenase/reductase (SDR family) member 4 like 2
chr11_+_46697345 0.415 F2
coagulation factor II (thrombin)
chr6_-_33276416 0.414 RXRB
retinoid X receptor, beta
chr19_-_40693176 0.414 NM_001126059
DMKN
dermokine
chr17_-_37181636 0.413 JUP
junction plakoglobin
chr14_-_23107106 0.413 NM_003917
AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr1_-_37872874 0.406 RSPO1
R-spondin homolog (Xenopus laevis)
chr20_-_31055892 0.402 NM_080675
SUN5
Sad1 and UNC84 domain containing 5
chr12_+_47009029 0.402 NM_181788
H1FNT
H1 histone family, member N, testis-specific
chr17_-_53973177 0.401 NM_001198713
SEPT4
septin 4
chr2_+_27163114 0.398 NM_000221
NM_006488
KHK

ketohexokinase (fructokinase)

chr9_-_5620070 0.391 C9orf46
chromosome 9 open reading frame 46
chr1_-_151855413 0.385 NM_020672
S100A14
S100 calcium binding protein A14
chr8_+_95722516 0.385 NM_001034915
NM_001122825
NM_001122826
NM_001122827
NM_017697
ESRP1




epithelial splicing regulatory protein 1




chr1_-_207892296 0.384 NM_001127641
LAMB3
laminin, beta 3
chr2_-_165133239 0.383 GRB14
growth factor receptor-bound protein 14
chr4_+_1764802 0.382 NM_000142
NM_001163213
NM_022965
FGFR3


fibroblast growth factor receptor 3


chr7_-_96471544 0.382 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chr14_-_23493169 0.374 C14orf167
chromosome 14 open reading frame 167
chr18_-_26935883 0.373 NM_004949
NM_024422
DSC2

desmocollin 2

chr10_-_74384569 0.372 PLA2G12B
phospholipase A2, group XIIB
chr1_+_196153122 0.371 NM_020204
LHX9
LIM homeobox 9
chr3_-_12561962 0.370 NM_001195279
LOC100129480
hypothetical protein LOC100129480
chr19_+_40431122 0.370 LSR
lipolysis stimulated lipoprotein receptor
chr16_-_65510230 0.367 NM_004062
CDH16
cadherin 16, KSP-cadherin
chr5_+_140509803 0.365 NM_018939
PCDHB6
protocadherin beta 6
chr10_-_21826192 0.363 C10orf114
chromosome 10 open reading frame 114
chr14_+_64240996 0.362 PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr10_-_21826211 0.362 NM_001010911
C10orf114
chromosome 10 open reading frame 114
chr5_-_131591380 0.361 NM_001017974
NM_001142598
NM_001142599
P4HA2


prolyl 4-hydroxylase, alpha polypeptide II


chr11_+_20000938 0.360 NAV2
neuron navigator 2
chr19_+_43446937 0.358 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr14_+_64240902 0.357 NM_015549
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr7_-_103417198 0.349 NM_005045
NM_173054
RELN

reelin

chr1_+_203740391 0.348 CDK18
cyclin-dependent kinase 18
chr10_-_74384485 0.347 NM_032562
PLA2G12B
phospholipase A2, group XIIB
chr6_+_31190505 0.346 NM_014068
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr7_-_99536852 0.345 MCM7
minichromosome maintenance complex component 7
chr19_+_43447262 0.342 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr19_+_43447078 0.341 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr8_+_95722575 0.341 ESRP1
epithelial splicing regulatory protein 1
chr1_+_15123165 0.338 NM_001018000
KAZN
kazrin, periplakin interacting protein
chr6_+_35856798 0.338 NM_001010886
C6orf127
chromosome 6 open reading frame 127
chr6_-_30188845 0.335 NM_007028
TRIM31
tripartite motif containing 31
chr19_-_56147971 0.334 NM_001077491
NM_001077492
NM_012427
KLK5


kallikrein-related peptidase 5


chr17_+_53769659 0.332 LOC100506779
hypothetical LOC100506779
chr11_-_18214891 0.331 NM_006512
SAA4
serum amyloid A4, constitutive
chr1_-_95472096 0.330


chr20_+_41621119 0.327 SGK2
serum/glucocorticoid regulated kinase 2
chr19_+_54314292 0.322 NM_003660
PPFIA3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr11_+_384199 0.320 NM_007183
PKP3
plakophilin 3
chr9_+_129951552 0.320 NM_005564
LCN2
lipocalin 2
chr6_-_109521969 0.320 NM_014454
SESN1
sestrin 1
chr19_+_50004134 0.319 NM_001013257
NM_005581
BCAM

basal cell adhesion molecule (Lutheran blood group)

chr18_+_3443771 0.319 NM_173211
TGIF1
TGFB-induced factor homeobox 1
chr20_+_41621079 0.317 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr16_+_3102556 0.317 NM_001042428
NM_003456
ZNF205

zinc finger protein 205

chr17_+_23818922 0.313


chr1_+_207915282 0.307 NM_015714
G0S2
G0/G1switch 2
chr3_+_46423682 0.306 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chr17_+_50333021 0.302 NM_005486
TOM1L1
target of myb1 (chicken)-like 1
chr5_+_109052984 0.302


chr1_+_160599396 0.301 NM_001126060
NOS1AP
nitric oxide synthase 1 (neuronal) adaptor protein
chr16_-_69277194 0.301 MTSS1L
metastasis suppressor 1-like
chr19_-_17217022 0.299 NM_005234
NR2F6
nuclear receptor subfamily 2, group F, member 6
chr16_+_2742684 0.296 SRRM2
serine/arginine repetitive matrix 2
chr22_+_18447732 0.285 NM_001190326
NM_022720
DGCR8

DiGeorge syndrome critical region gene 8

chr17_-_37181626 0.283


chr1_+_32992131 0.283


chr6_-_2696152 0.281 NM_001012418
MYLK4
myosin light chain kinase family, member 4
chr8_-_17787342 0.280 FGL1
fibrinogen-like 1
chr4_+_128773529 0.276 NM_015693
INTU
inturned planar cell polarity effector homolog (Drosophila)
chr2_+_96295715 0.275 CIAO1
cytosolic iron-sulfur protein assembly 1
chr14_-_68424653 0.274 ACTN1
actinin, alpha 1
chr22_-_28492933 0.274 NM_001003692
NM_019103
ZMAT5

zinc finger, matrin-type 5

chr7_-_50600536 0.273 NM_001082971
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr22_+_40347263 0.273 XRCC6
X-ray repair complementing defective repair in Chinese hamster cells 6
chr1_+_12627152 0.272 NM_001013630
AADACL4
arylacetamide deacetylase-like 4
chr8_+_95722448 0.271 ESRP1
epithelial splicing regulatory protein 1
chr12_+_50913220 0.269 NM_005556
KRT7
keratin 7
chr6_+_150505849 0.269 NM_030949
PPP1R14C
protein phosphatase 1, regulatory (inhibitor) subunit 14C
chr17_+_7457988 0.269 SHBG
sex hormone-binding globulin
chr8_-_7718769 0.268 NM_152250
NM_001040703
DEFB105A
DEFB105B
defensin, beta 105A
defensin, beta 105B
chr2_-_110665188 0.268 NM_033514
LIMS3-LOC440895
LIMS3
LIMS3-LOC440895 read-through
LIM and senescent cell antigen-like domains 3
chr17_+_53769562 0.267 LOC100506779
hypothetical LOC100506779
chr17_+_69781980 0.267 NM_001172810
NM_023036
DNAI2

dynein, axonemal, intermediate chain 2

chr2_-_21081694 0.265 APOB
apolipoprotein B (including Ag(x) antigen)
chr3_-_140148671 0.265 NM_023067
FOXL2
forkhead box L2
chr5_-_150441150 0.264 NM_006058
TNIP1
TNFAIP3 interacting protein 1
chr1_-_232962369 0.262 PP2672
hypothetical LOC100130249
chr21_+_44534575 0.261 NM_000658
AIRE
autoimmune regulator
chr3_+_195336631 0.257 HES1
hairy and enhancer of split 1, (Drosophila)
chr11_-_16992524 0.255 NM_175058
PLEKHA7
pleckstrin homology domain containing, family A member 7
chr19_+_59062962 0.254 MYADM
myeloid-associated differentiation marker
chr1_-_208046011 0.254 NM_006147
IRF6
interferon regulatory factor 6
chr11_+_5466490 0.254 NM_001005163
OR52D1
olfactory receptor, family 52, subfamily D, member 1
chr17_-_58877276 0.253 NM_001017916
NM_001915
CYB561

cytochrome b-561

chr1_-_110108048 0.253 NM_024526
NM_133181
NM_139053
EPS8L3


EPS8-like 3


chr2_+_17585462 0.252 VSNL1
visinin-like 1
chr11_+_6216905 0.250 NM_001037329
CNGA4
cyclic nucleotide gated channel alpha 4
chr2_+_17585287 0.250 NM_003385
VSNL1
visinin-like 1
chr10_-_52315390 0.249 A1CF
APOBEC1 complementation factor
chr19_-_50779914 0.248 OPA3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr8_+_38007147 0.248 NM_004095
EIF4EBP1
eukaryotic translation initiation factor 4E binding protein 1
chr19_-_50618471 0.248 ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr20_+_58064360 0.248 NM_173644
C20orf197
chromosome 20 open reading frame 197
chr17_+_24079924 0.247 NM_178170
NEK8
NIMA (never in mitosis gene a)- related kinase 8
chr5_+_137447479 0.246 NM_058244
WNT8A
wingless-type MMTV integration site family, member 8A
chr1_+_168381811 0.246 NM_001136107
METTL11B
methyltransferase like 11B
chr14_+_22845851 0.246 NM_004050
BCL2L2-PABPN1
BCL2L2
BCL2L2-PABPN1 read-through transcript
BCL2-like 2
chr17_-_31882135 0.246 NM_001001418
NM_001040282
TBC1D3C
TBC1D3G
TBC1D3
TBC1 domain family, member 3C
TBC1 domain family, member 3G
TBC1 domain family, member 3
chr2_+_28572441 0.245 NM_001170585
NM_153021
PLB1

phospholipase B1

chr17_-_77411707 0.244 P4HB
prolyl 4-hydroxylase, beta polypeptide
chr1_+_35020425 0.243 NM_001005752
GJB3
gap junction protein, beta 3, 31kDa
chr22_+_38720881 0.242 NM_138435
FAM83F
family with sequence similarity 83, member F
chr5_+_66160359 0.242 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr14_+_22633728 0.242 C14orf119
chromosome 14 open reading frame 119
chr6_-_15356865 0.241


chr1_-_153514124 0.241 CLK2
CDC-like kinase 2
chr11_+_22646229 0.240 NM_177553
GAS2
growth arrest-specific 2
chr6_-_47117951 0.240 NM_025048
NM_153840
GPR110

G protein-coupled receptor 110

chr2_-_227372574 0.240 IRS1
insulin receptor substrate 1
chr6_-_31812049 0.239 CLIC1
chloride intracellular channel 1
chr17_-_77411659 0.239 P4HB
prolyl 4-hydroxylase, beta polypeptide
chr6_-_31812214 0.239 CLIC1
chloride intracellular channel 1
chr20_-_1113116 0.239 NM_018354
C20orf46
chromosome 20 open reading frame 46

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.09 5.34e-05 GO:0009987 cellular process
1.13 1.01e-02 GO:0044237 cellular metabolic process
1.12 1.19e-02 GO:0008152 metabolic process

Nothing significant found in compartment category.

Nothing significant found in function category.