Motif ID: IKZF2.p2

Z-value: 0.490


Transcription factors associated with IKZF2.p2:

Gene SymbolEntrez IDGene Name
IKZF2 22807 IKAROS family zinc finger 2 (Helios)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
IKZF2chr2_-_213723298-0.117.0e-01Click!


Activity profile for motif IKZF2.p2.

activity profile for motif IKZF2.p2


Sorted Z-values histogram for motif IKZF2.p2

Sorted Z-values for motif IKZF2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of IKZF2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_161305558 0.989 NM_001113381
RGS4
regulator of G-protein signaling 4
chr12_+_7348194 0.969 NM_001080454
ACSM4
acyl-CoA synthetase medium-chain family member 4
chr8_-_30826074 0.903 NM_031271
TEX15
testis expressed 15
chr14_-_34660902 0.880 PPP2R3C
protein phosphatase 2, regulatory subunit B'', gamma
chr7_+_123353144 0.846 NM_001174045
NM_001174046
SPAM1

sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)

chr2_-_144994349 0.840 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr12_+_91654395 0.831 NM_001004330
PLEKHG7
pleckstrin homology domain containing, family G (with RhoGef domain) member 7
chr1_-_232810111 0.812 IRF2BP2
interferon regulatory factor 2 binding protein 2
chr4_-_100431093 0.802 NM_000667
ADH1A
alcohol dehydrogenase 1A (class I), alpha polypeptide
chr1_+_100089118 0.797 NM_000646
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chrX_-_114158388 0.783 NM_000640
IL13RA2
interleukin 13 receptor, alpha 2
chr9_-_94226380 0.781 NM_005014
OMD
osteomodulin
chr1_-_194844061 0.767 NM_198503
KCNT2
potassium channel, subfamily T, member 2
chr7_-_122130201 0.761 NM_198085
RNF148
ring finger protein 148
chrX_-_153698930 0.709 HMGN1P37
high-mobility group nucleosome binding domain 1 pseudogene 37
chr7_-_63660889 0.705 NM_001130022
NM_178558
ZNF680

zinc finger protein 680

chr21_-_31995972 0.689 SCAF4
SR-related CTD-associated factor 4
chrX_-_74292800 0.683 NM_004299
ABCB7
ATP-binding cassette, sub-family B (MDR/TAP), member 7
chr1_+_40399618 0.664 NM_012421
RLF
rearranged L-myc fusion
chrX_-_102828238 0.660 NM_001142418
NM_001142423
NM_001142424
NM_001142425
NM_001142426
NM_001142429
NM_001142430
NM_012286
MORF4L2







mortality factor 4 like 2







chr11_-_5178505 0.652 NM_001004760
OR51V1
olfactory receptor, family 51, subfamily V, member 1
chr1_+_40399642 0.652 RLF
rearranged L-myc fusion
chr4_+_170817787 0.643 CLCN3
chloride channel 3
chr15_-_47700342 0.636 NM_152647
C15orf33
chromosome 15 open reading frame 33
chr15_-_53440069 0.634 CCPG1
cell cycle progression 1
chr2_+_168383427 0.631 NM_020981
B3GALT1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr20_+_1132097 0.629 NM_001009612
C20orf202
chromosome 20 open reading frame 202
chr14_+_38720085 0.629 PNN
pinin, desmosome associated protein
chr3_+_1109619 0.623 NM_014461
CNTN6
contactin 6
chr4_-_174774368 0.607 NM_006792
MORF4
mortality factor 4
chr14_+_55148488 0.606 KTN1
kinectin 1 (kinesin receptor)
chrX_-_102829621 0.596 NM_001142419
NM_001142420
NM_001142421
NM_001142422
NM_001142427
NM_001142428
NM_001142431
NM_001142432
MORF4L2







mortality factor 4 like 2







chrX_-_76824726 0.594 ATRX
alpha thalassemia/mental retardation syndrome X-linked
chr9_+_79158164 0.589 VPS13A
vacuolar protein sorting 13 homolog A (S. cerevisiae)
chr1_+_99884018 0.585 NM_017734
PALMD
palmdelphin
chr7_-_63660766 0.584 ZNF680
zinc finger protein 680
chr5_+_148711419 0.580 GRPEL2
GrpE-like 2, mitochondrial (E. coli)
chr18_-_35634247 0.573 LOC647946
hypothetical LOC647946
chr7_-_91632525 0.573 NM_001161528
LOC401387
leucine-rich repeat and death domain-containing protein
chr1_-_109201228 0.569 NM_152763
AKNAD1
AKNA domain containing 1
chrX_-_102829595 0.560 MORF4L2
mortality factor 4 like 2
chr5_-_86739683 0.558 CCNH
cyclin H
chr1_-_109957195 0.556 NM_005272
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr7_+_120415958 0.545 NM_024913
C7orf58
chromosome 7 open reading frame 58
chr4_+_159662349 0.530 NM_021634
RXFP1
relaxin/insulin-like family peptide receptor 1
chr8_-_15140162 0.530 NM_139167
SGCZ
sarcoglycan, zeta
chr7_-_64088848 0.530 NM_015852
ZNF117
zinc finger protein 117
chr2_+_101874765 0.517 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr9_+_109131814 0.516 RAD23B
RAD23 homolog B (S. cerevisiae)
chr7_+_93388951 0.515 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr2_-_55413253 0.515 CCDC88A
coiled-coil domain containing 88A
chr4_-_174491270 0.512 NM_001130689
HMGB2
high-mobility group box 2
chr7_+_120416103 0.512 C7orf58
chromosome 7 open reading frame 58
chr9_-_14912419 0.504


chrX_+_56772391 0.502 LOC550643
hypothetical LOC550643
chr1_-_195436258 0.502 NM_194314
ZBTB41
zinc finger and BTB domain containing 41
chr7_-_110989582 0.500 NM_032549
IMMP2L
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr6_-_49712483 0.499 NM_000324
RHAG
Rh-associated glycoprotein
chr6_-_68655708 0.499


chr1_+_19807168 0.497


chrX_-_118610880 0.496 NM_001173488
NKRF
NFKB repressing factor
chr14_-_54720101 0.496 DLGAP5
discs, large (Drosophila) homolog-associated protein 5
chr11_-_55757236 0.492 NM_001004746
OR5T2
olfactory receptor, family 5, subfamily T, member 2
chr2_+_190248955 0.487 NM_144708
ANKAR
ankyrin and armadillo repeat containing
chr11_+_65026382 0.486


chr2_-_142605739 0.486 NM_018557
LRP1B
low density lipoprotein receptor-related protein 1B
chr2_+_99344060 0.485 EIF5B
eukaryotic translation initiation factor 5B
chr5_+_170143289 0.485 NM_014211
GABRP
gamma-aminobutyric acid (GABA) A receptor, pi
chr2_+_101874809 0.483 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr12_-_54607925 0.482 WIBG
within bgcn homolog (Drosophila)
chr8_+_90839336 0.475 RIPK2
receptor-interacting serine-threonine kinase 2
chrX_-_138742050 0.474 NM_001010986
NM_173694
ATP11C

ATPase, class VI, type 11C

chr1_+_93317374 0.474 NM_001164391
NM_001164392
NM_001164393
NM_007358
MTF2



metal response element binding transcription factor 2



chr14_+_38719462 0.470 PNN
pinin, desmosome associated protein
chr10_+_62208094 0.464 NM_001170406
NM_001170407
NM_001786
NM_033379
CDK1



cyclin-dependent kinase 1



chr1_+_61642287 0.463 NFIA
nuclear factor I/A
chr1_-_172228673 0.462 NM_172071
RC3H1
ring finger and CCCH-type domains 1
chrX_-_135783496 0.460


chr7_-_16471817 0.460 NM_015464
SOSTDC1
sclerostin domain containing 1
chrX_+_77889861 0.460 NM_005296
LPAR4
lysophosphatidic acid receptor 4
chr7_+_117651947 0.460 NM_019644
ANKRD7
ankyrin repeat domain 7
chr1_+_184532027 0.458 NM_001127708
NM_001127709
NM_001127710
NM_005807
PRG4



proteoglycan 4



chr9_+_70046658 0.456 NM_201453
CBWD5
CBWD3
CBWD1
CBWD6
COBW domain containing 5
COBW domain containing 3
COBW domain containing 1
COBW domain containing 6
chr5_+_60969392 0.456 NM_173667
FLJ37543
hypothetical protein FLJ37543
chr6_-_134415311 0.445 NM_145176
SLC2A12
solute carrier family 2 (facilitated glucose transporter), member 12
chr9_-_92444886 0.442 NM_017594
DIRAS2
DIRAS family, GTP-binding RAS-like 2
chr1_+_42773146 0.439 NM_001080850
CCDC30
coiled-coil domain containing 30
chr7_+_102340579 0.437 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr6_-_97452481 0.436 NM_014165
NDUFAF4
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4
chr1_-_143786993 0.435 NM_022359
PDE4DIP
phosphodiesterase 4D interacting protein
chr1_+_239882202 0.433 NM_144625
WDR64
WD repeat domain 64
chr6_+_31731647 0.432 NM_019101
APOM
apolipoprotein M
chr13_+_19430881 0.431 ZMYM2
zinc finger, MYM-type 2
chr7_+_111879348 0.430 NM_001197079
IFRD1
interferon-related developmental regulator 1
chr8_-_92122219 0.427 NM_018710
TMEM55A
transmembrane protein 55A
chr13_+_48582389 0.425 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr4_-_104217618 0.421 NM_178833
NHEDC2
Na+/H+ exchanger domain containing 2
chr18_+_30544193 0.421 NM_001198941
NM_032978
DTNA

dystrobrevin, alpha

chr2_-_127817143 0.418 NM_006609
MAP3K2
mitogen-activated protein kinase kinase kinase 2
chr1_-_110752068 0.416 NM_006402
HBXIP
hepatitis B virus x interacting protein
chrX_+_119622570 0.415 NM_001137554
MCTS1
malignant T cell amplified sequence 1
chr2_+_157822355 0.410 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr2_-_174538675 0.409 NM_001172712
NM_003111
SP3

Sp3 transcription factor

chr2_+_128644510 0.407 UGGT1
UDP-glucose glycoprotein glucosyltransferase 1
chr1_-_115070413 0.407 CSDE1
cold shock domain containing E1, RNA-binding
chr1_+_160002746 0.407 ATF6
activating transcription factor 6
chr14_+_51396799 0.406 NM_053064
GNG2
guanine nucleotide binding protein (G protein), gamma 2
chr1_+_15858950 0.404 NM_006511
RSC1A1
regulatory solute carrier protein, family 1, member 1
chr1_+_78888064 0.403 NM_006417
IFI44
interferon-induced protein 44
chr1_+_39569396 0.403 NM_033044
MACF1
microtubule-actin crosslinking factor 1
chr6_+_147568795 0.402 STXBP5
syntaxin binding protein 5 (tomosyn)
chr6_+_31731667 0.402 APOM
apolipoprotein M
chr2_+_114390975 0.400 ACTR3
ARP3 actin-related protein 3 homolog (yeast)
chr1_-_47428310 0.400 NM_005764
PDZK1IP1
PDZK1 interacting protein 1
chr14_+_51397134 0.399 GNG2
guanine nucleotide binding protein (G protein), gamma 2
chr5_+_109053507 0.398 MAN2A1
mannosidase, alpha, class 2A, member 1
chr4_-_164473107 0.398 NM_000909
NPY1R
neuropeptide Y receptor Y1
chr12_+_49922592 0.394 DAZAP2
DAZ associated protein 2
chr4_+_144654526 0.393


chr4_-_80079393 0.390 NM_001040202
PAQR3
progestin and adipoQ receptor family member III
chrX_+_119622012 0.390 MCTS1
malignant T cell amplified sequence 1
chr1_-_178100204 0.390


chr1_-_47428190 0.386 PDZK1IP1
PDZK1 interacting protein 1
chr6_-_46933901 0.385 GPR116
G protein-coupled receptor 116
chrX_+_123062143 0.384 STAG2
stromal antigen 2
chr6_+_88024152 0.384 ZNF292
zinc finger protein 292
chr11_-_5819702 0.382 NM_001005167
OR52E6
olfactory receptor, family 52, subfamily E, member 6
chr3_+_99465777 0.382 NM_001005479
OR5H6
olfactory receptor, family 5, subfamily H, member 6
chr16_+_20682812 0.382 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chr6_-_117096594 0.377 NM_145062
ZUFSP
zinc finger with UFM1-specific peptidase domain
chr1_+_151117421 0.377 NM_030663
SMCP
sperm mitochondria-associated cysteine-rich protein
chr11_+_109468734 0.376 ZC3H12C
zinc finger CCCH-type containing 12C
chr6_+_142510094 0.375 NM_016485
VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr6_-_135860479 0.375 AHI1
Abelson helper integration site 1
chr1_+_67923660 0.374 GADD45A
growth arrest and DNA-damage-inducible, alpha
chr1_-_143075560 0.372 NM_178230
NM_001143883
NM_001135789
PPIAL4A
PPIAL4G
PPIAL4B
PPIAL4C
peptidylprolyl isomerase A (cyclophilin A)-like 4A
peptidylprolyl isomerase A (cyclophilin A)-like 4G
peptidylprolyl isomerase A (cyclophilin A)-like 4B
peptidylprolyl isomerase A (cyclophilin A)-like 4C
chr8_+_39561243 0.372 NM_001190956
NM_014237
ADAM18

ADAM metallopeptidase domain 18

chr1_+_143807748 0.371 NM_004892
SEC22B
SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
chr11_-_5419358 0.371 NM_001005288
OR51I1
olfactory receptor, family 51, subfamily I, member 1
chr21_-_26867138 0.371 NM_052954
CYYR1
cysteine/tyrosine-rich 1
chr3_-_197293331 0.370 TFRC
transferrin receptor (p90, CD71)
chr7_+_111850367 0.370 NM_001007245
NM_001197080
IFRD1

interferon-related developmental regulator 1

chr6_-_99955987 0.369 SFRS18
splicing factor, arginine/serine-rich 18
chr20_-_30703219 0.368 NM_182584
C20orf203
chromosome 20 open reading frame 203
chr22_-_37211467 0.367 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr1_+_170768635 0.366 NM_014283
C1orf9
chromosome 1 open reading frame 9
chr3_-_197293355 0.365 NM_003234
TFRC
transferrin receptor (p90, CD71)
chr14_+_31615922 0.365 ARHGAP5
Rho GTPase activating protein 5
chr6_+_76367944 0.364 SENP6
SUMO1/sentrin specific peptidase 6
chr16_+_10430225 0.363 NM_024997
ATF7IP2
activating transcription factor 7 interacting protein 2
chr1_-_191422346 0.363 NM_003783
B3GALT2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr12_+_67366989 0.362 NM_020401
NUP107
nucleoporin 107kDa
chr3_+_25445071 0.362 RARB
retinoic acid receptor, beta
chr1_+_245779018 0.361 NM_145278
C1orf150
chromosome 1 open reading frame 150
chr4_-_153493133 0.361 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr3_-_197293394 0.357 NM_001128148
TFRC
transferrin receptor (p90, CD71)
chr10_+_111957292 0.355 NM_130439
MXI1
MAX interactor 1
chr14_+_95915774 0.354 NM_016472
C14orf129
chromosome 14 open reading frame 129
chr1_-_239865724 0.354 NM_001821
CHML
choroideremia-like (Rab escort protein 2)
chr10_+_96433240 0.353 NM_000772
NM_001128925
CYP2C18

cytochrome P450, family 2, subfamily C, polypeptide 18

chr17_+_63338500 0.353 BPTF
bromodomain PHD finger transcription factor
chr4_-_88531353 0.352 NM_016245
HSD17B11
hydroxysteroid (17-beta) dehydrogenase 11
chr11_+_11820096 0.352 USP47
ubiquitin specific peptidase 47
chr6_+_142510075 0.352 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr7_+_32501665 0.351 NM_015060
AVL9
AVL9 homolog (S. cerevisiase)
chr4_+_25931745 0.350 RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr5_+_27508139 0.349 LOC643401
hypothetical protein LOC643401
chr1_+_246432954 0.349 NM_001004689
OR2M3
olfactory receptor, family 2, subfamily M, member 3
chr5_-_43550891 0.348 NM_198566
C5orf34
chromosome 5 open reading frame 34
chr2_-_99412694 0.347 REV1
REV1 homolog (S. cerevisiae)
chr2_-_162808123 0.347 NM_004460
FAP
fibroblast activation protein, alpha
chr13_+_96592051 0.346 MBNL2
muscleblind-like 2 (Drosophila)
chrX_-_102396704 0.345 NM_001006684
NM_153333
TCEAL8

transcription elongation factor A (SII)-like 8

chr11_+_65027721 0.343


chrX_+_119621933 0.342 MCTS1
malignant T cell amplified sequence 1
chr4_+_90252990 0.341 NM_145715
TIGD2
tigger transposable element derived 2
chr15_-_75259714 0.341 PEAK1
NKF3 kinase family member
chr6_-_76027286 0.340 TMEM30A
transmembrane protein 30A
chr11_+_27019084 0.340 NM_003986
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr2_+_48649662 0.340 NM_172311
STON1-GTF2A1L
STON1-GTF2A1L readthrough
chr4_-_88531245 0.338 HSD17B11
hydroxysteroid (17-beta) dehydrogenase 11
chrX_-_31194867 0.336 NM_004015
NM_004016
NM_004017
NM_004018
NM_004019
DMD




dystrophin




chrX_-_132947141 0.335 GPC3
glypican 3
chr7_+_123272458 0.333 NM_012269
HYAL4
hyaluronoglucosaminidase 4
chr12_+_74160779 0.332 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr12_-_88573949 0.331 NM_001001323
NM_001682
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chr2_-_152538694 0.330 NM_001005747
CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr7_+_141124710 0.330 NM_016944
TAS2R4
taste receptor, type 2, member 4
chr2_+_122229590 0.330 NM_004622
TSN
translin
chr4_-_101658094 0.330 NM_001159694
NM_016242
EMCN

endomucin

chr3_+_143858428 0.329 NM_001172312
PLS1
plastin 1
chr4_+_124537334 0.329 NM_199327
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr4_-_140280031 0.327 NM_201999
ELF2
E74-like factor 2 (ets domain transcription factor)
chr7_-_7724762 0.327 NM_002947
RPA3
replication protein A3, 14kDa
chr12_-_68379331 0.326 NM_032735
BEST3
bestrophin 3
chr13_-_101852028 0.326 NM_175929
FGF14
fibroblast growth factor 14
chr3_-_25658829 0.325 TOP2B
topoisomerase (DNA) II beta 180kDa
chr1_-_232810443 0.325


chr1_-_191341866 0.324 NM_016066
GLRX2
glutaredoxin 2
chr5_-_42847716 0.323 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.26 4.04e-03 GO:0090304 nucleic acid metabolic process
1.56 5.40e-03 GO:0016071 mRNA metabolic process
1.66 7.01e-03 GO:0006397 mRNA processing
1.74 1.04e-02 GO:0008380 RNA splicing

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.56 4.36e-04 GO:0005694 chromosome
1.23 4.68e-03 GO:0043233 organelle lumen
1.22 4.98e-03 GO:0031974 membrane-enclosed lumen
1.99 1.60e-02 GO:0005681 spliceosomal complex
1.06 1.73e-02 GO:0044424 intracellular part
1.24 2.11e-02 GO:0031981 nuclear lumen
1.12 2.51e-02 GO:0005634 nucleus
1.21 2.87e-02 GO:0044428 nuclear part
1.16 2.88e-02 GO:0032991 macromolecular complex
1.21 3.07e-02 GO:0070013 intracellular organelle lumen
1.05 3.96e-02 GO:0005622 intracellular

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.09 3.62e-02 GO:0005515 protein binding