Motif ID: IRF1,2,7.p3

Z-value: 4.882


Transcription factors associated with IRF1,2,7.p3:

Gene SymbolEntrez IDGene Name
IRF1 3659 interferon regulatory factor 1
IRF2 3660 interferon regulatory factor 2
IRF7 3665 interferon regulatory factor 7

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
IRF2chr4_-_1856326100.448.9e-02Click!
IRF1chr5_-_1318543250.439.4e-02Click!
IRF7chr11_-_6059200.253.6e-01Click!


Activity profile for motif IRF1,2,7.p3.

activity profile for motif IRF1,2,7.p3


Sorted Z-values histogram for motif IRF1,2,7.p3

Sorted Z-values for motif IRF1,2,7.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of IRF1,2,7.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_78858675 10.476 NM_006820
 IFI44L
interferon-induced protein 44-like
chr12_+_111900650 8.604 NM_001032731
NM_002535
NM_016817
 OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr10_+_91077581 5.910 NM_001549
 IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr21_+_41655786 5.343 NM_002463
 LOC100131190
MX2
hypothetical protein LOC100131190
myxovirus (influenza virus) resistance 2 (mouse)
chr12_+_25096755 5.249 LRMP
lymphoid-restricted membrane protein
chr10_+_91082218 4.866 NM_001031683
 IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr10_+_91142301 4.410 NM_001548
 IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr1_-_27871306 3.911 NM_002038
NM_022872
NM_022873
 IFI6


interferon, alpha-inducible protein 6


chr1_-_27871287 3.858 IFI6
interferon, alpha-inducible protein 6
chr1_-_27871245 3.805 IFI6
interferon, alpha-inducible protein 6
chr17_-_37518213 3.721 NM_024119
 DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr22_+_17012841 3.560 USP18
ubiquitin specific peptidase 18
chr1_+_938709 3.542 NM_005101
 ISG15
ISG15 ubiquitin-like modifier
chr7_+_73826244 3.532 NM_000265
 NCF1
NCF1B
NCF1C
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1B pseudogene
neutrophil cytosolic factor 1C pseudogene
chr4_+_142777172 3.421 NM_000585
NM_172174
 IL15

interleukin 15

chr22_+_17012704 3.393 NM_017414
 USP18
ubiquitin specific peptidase 18
chr19_-_7672978 3.283 NM_002002
 FCER2
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr12_+_93066370 3.243 NM_005761
 PLXNC1
plexin C1
chr1_+_78888064 3.170 NM_006417
 IFI44
interferon-induced protein 44
chr7_+_150013716 3.136 NM_015660
 GIMAP2
GTPase, IMAP family member 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 51 entries
enrichment   p-value GO term description
13.44 1.06e-03 GO:0019883 antigen processing and presentation of endogenous antigen
9.65 6.20e-04 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
9.10 5.48e-24 GO:0060337 type I interferon-mediated signaling pathway
9.10 5.48e-24 GO:0071357 cellular response to type I interferon
8.96 1.20e-23 GO:0034340 response to type I interferon
8.62 1.61e-05 GO:0048002 antigen processing and presentation of peptide antigen
8.36 1.01e-08 GO:0060338 regulation of type I interferon-mediated signaling pathway
5.23 2.39e-02 GO:0032480 negative regulation of type I interferon production
4.81 1.25e-05 GO:0001959 regulation of cytokine-mediated signaling pathway
4.73 1.68e-05 GO:0060759 regulation of response to cytokine stimulus
4.58 3.50e-15 GO:0009615 response to virus
4.57 2.55e-03 GO:0032479 regulation of type I interferon production
4.43 3.80e-17 GO:0019221 cytokine-mediated signaling pathway
4.28 2.73e-03 GO:0019882 antigen processing and presentation
4.15 1.90e-16 GO:0071345 cellular response to cytokine stimulus
4.15 3.87e-04 GO:0071346 cellular response to interferon-gamma
4.05 2.73e-03 GO:0060333 interferon-gamma-mediated signaling pathway
3.92 2.27e-04 GO:0034341 response to interferon-gamma
3.49 3.00e-19 GO:0045087 innate immune response
3.34 2.64e-07 GO:0045088 regulation of innate immune response

Gene overrepresentation in compartment category:

Showing 1 to 1 of 1 entries
enrichment   p-value GO term description
1.13 9.16e-03 GO:0005737 cytoplasm

Gene overrepresentation in function category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
11.76 9.15e-04 GO:0005132 interferon-alpha/beta receptor binding
2.80 3.69e-05 GO:0005126 cytokine receptor binding
2.36 5.27e-03 GO:0005125 cytokine activity