Motif ID: JUN.p2

Z-value: 1.475


Transcription factors associated with JUN.p2:

Gene SymbolEntrez IDGene Name
JUN 3725 jun oncogene
JUNB 3726 jun B proto-oncogene
JUND 3727 jun D proto-oncogene

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
JUNchr1_-_590208750.495.1e-02Click!
JUNBchr19_+_12763295,
chr19_+_12763285
0.312.5e-01Click!
JUNDchr19_-_182534130.224.1e-01Click!


Activity profile for motif JUN.p2.

activity profile for motif JUN.p2


Sorted Z-values histogram for motif JUN.p2

Sorted Z-values for motif JUN.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of JUN.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_-_42589543 8.120 NM_014351
SULT4A1
sulfotransferase family 4A, member 1
chr12_-_121946581 4.736 VPS37B
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr12_-_121946635 4.337 NM_024667
VPS37B
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr1_+_26368969 3.469 NM_015871
ZNF593
zinc finger protein 593
chr6_+_139497933 3.404 NM_016217
HECA
headcase homolog (Drosophila)
chr11_-_1549719 2.906 NM_004420
DUSP8
dual specificity phosphatase 8
chr4_-_111763655 2.618 NM_000325
PITX2
paired-like homeodomain 2
chr20_+_32610161 2.429 NM_032514
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr7_-_100595552 2.219 NM_003378
VGF
VGF nerve growth factor inducible
chr10_-_131652364 2.208 EBF3
early B-cell factor 3
chr12_+_131194967 2.202 NOC4L
nucleolar complex associated 4 homolog (S. cerevisiae)
chr10_+_134060681 2.197 NM_001098637
NM_138499
PWWP2B

PWWP domain containing 2B

chr19_+_55671600 2.184 C19orf63
chromosome 19 open reading frame 63
chr9_-_139473606 2.063 NM_001130969
NM_001130970
NM_001130971
NM_001178064
NM_015537
NELF




nasal embryonic LHRH factor




chr19_+_55671594 2.055 C19orf63
chromosome 19 open reading frame 63
chr12_+_131194931 2.043 NM_024078
NOC4L
nucleolar complex associated 4 homolog (S. cerevisiae)
chr19_+_55671584 2.041 C19orf63
chromosome 19 open reading frame 63
chr6_+_39868126 2.036 DAAM2
dishevelled associated activator of morphogenesis 2
chr12_-_121946561 2.031


chr19_+_50663089 2.029 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr7_-_45095017 1.997 NM_001146334
NACAD
NAC alpha domain containing
chr2_+_10969513 1.979 NM_002236
KCNF1
potassium voltage-gated channel, subfamily F, member 1
chr11_+_12652427 1.964 NM_021961
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr20_+_19863716 1.960 RIN2
Ras and Rab interactor 2
chr16_+_85101605 1.953 NM_001451
FOXF1
forkhead box F1
chr2_+_28469172 1.877 FOSL2
FOS-like antigen 2
chr17_-_13445942 1.863 NM_006042
HS3ST3A1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
chr17_+_38831874 1.862 NM_001661
ARL4D
ADP-ribosylation factor-like 4D
chr14_+_100362204 1.861 MEG3
maternally expressed 3 (non-protein coding)
chr6_+_39868116 1.850


chr19_+_55671468 1.757 NM_175063
NM_206538
C19orf63

chromosome 19 open reading frame 63

chr19_+_53801811 1.750 NM_133498
SPACA4
sperm acrosome associated 4
chr11_-_68537243 1.688 NM_001098515
NM_145015
MRGPRF

MAS-related GPR, member F

chr19_-_7459867 1.674 NM_080662
PEX11G
peroxisomal biogenesis factor 11 gamma
chr12_+_52665196 1.661 NM_017409
HOXC10
homeobox C10
chr4_+_658250 1.632 MYL5
myosin, light chain 5, regulatory
chr19_-_55671814 1.632 NM_138411
FAM71E1
family with sequence similarity 71, member E1
chr7_+_5598964 1.621 FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr2_-_237987509 1.616 COL6A3
collagen, type VI, alpha 3
chr6_+_135860631 1.586 NCRNA00271
non-protein coding RNA 271
chr19_-_50779861 1.583 OPA3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr3_+_50272648 1.569


chr2_+_28469275 1.565 NM_005253
FOSL2
FOS-like antigen 2
chr19_-_50779924 1.548 NM_001017989
NM_025136
OPA3

optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)

chr7_+_5598979 1.544 NM_003088
FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr2_-_237987554 1.526 COL6A3
collagen, type VI, alpha 3
chr18_+_52965290 1.525 BOD1P
biorientation of chromosomes in cell division 1 pseudogene
chr12_+_131194962 1.523


chr19_-_55671273 1.511 FAM71E1
family with sequence similarity 71, member E1
chr2_-_237987579 1.509 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr16_+_66252296 1.495 NM_001037281
NM_016948
PARD6A

par-6 partitioning defective 6 homolog alpha (C. elegans)

chr3_+_158026769 1.486 NM_001004316
NM_001193283
LEKR1

leucine, glutamate and lysine rich 1

chr3_+_11242666 1.459 NM_001098211
HRH1
histamine receptor H1
chr11_-_2149591 1.453 NM_000360
NM_199292
NM_199293
TH


tyrosine hydroxylase


chr8_-_95343716 1.439 NM_005261
NM_181702
GEM

GTP binding protein overexpressed in skeletal muscle

chr8_-_95343696 1.437 GEM
GTP binding protein overexpressed in skeletal muscle
chr7_+_44612705 1.430 OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr6_-_56515640 1.418


chr7_+_65596078 1.380


chr1_-_1283770 1.377 NM_032348
MXRA8
matrix-remodelling associated 8
chr14_-_49399317 1.377 RN7SL2
RNA, 7SL, cytoplasmic 2
chr2_-_26554413 1.356 NM_004802
NM_194322
NM_194323
OTOF


otoferlin


chr19_-_45611110 1.343 NM_020956
NM_181882
PRX

periaxin

chr3_-_64186151 1.337 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr4_-_111777584 1.336 PITX2
paired-like homeodomain 2
chrX_+_153325684 1.334 FAM50A
family with sequence similarity 50, member A
chr11_+_18676913 1.333 NM_153347
TMEM86A
transmembrane protein 86A
chr14_+_100362236 1.311 MEG3
maternally expressed 3 (non-protein coding)
chr1_-_16355013 1.295 NM_004431
EPHA2
EPH receptor A2
chr4_-_186693574 1.288 NM_001114107
NM_014476
PDLIM3

PDZ and LIM domain 3

chr5_+_174084137 1.287 NM_002449
MSX2
msh homeobox 2
chr19_-_5291700 1.285 NM_002850
NM_130853
NM_130854
NM_130855
PTPRS



protein tyrosine phosphatase, receptor type, S



chr2_-_224175339 1.279 SCG2
secretogranin II
chr12_-_13147839 1.274 NM_001080554
NM_001080555
GSG1

germ cell associated 1

chr9_-_139473569 1.257 NELF
nasal embryonic LHRH factor
chr2_-_224175293 1.257 SCG2
secretogranin II
chr10_-_128199986 1.249 NM_001004298
C10orf90
chromosome 10 open reading frame 90
chr1_+_99502655 1.240 LPPR4
lipid phosphate phosphatase-related protein type 4
chr2_+_219991342 1.235 NM_001927
DES
desmin
chr9_+_139152595 1.224 GRIN1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
chr4_+_145786622 1.217 NM_022475
HHIP
hedgehog interacting protein
chr11_-_66367279 1.215


chr3_+_8518539 1.214 LMCD1
LIM and cysteine-rich domains 1
chr6_+_35335278 1.207 ZNF76
zinc finger protein 76
chr19_+_1892157 1.207 NM_001319
CSNK1G2
casein kinase 1, gamma 2
chr11_+_18676857 1.197 TMEM86A
transmembrane protein 86A
chr21_-_43903755 1.192 NM_007031
HSF2BP
heat shock transcription factor 2 binding protein
chr6_-_91063181 1.190 NM_021813
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr19_+_1892184 1.189 CSNK1G2
casein kinase 1, gamma 2
chr22_+_40286957 1.189 NM_014460
CSDC2
cold shock domain containing C2, RNA binding
chr12_-_6103945 1.171 NM_000552
VWF
von Willebrand factor
chr2_-_224175386 1.167 NM_003469
SCG2
secretogranin II
chr6_+_117693413 1.166 NM_153453
NM_182645
VGLL2

vestigial like 2 (Drosophila)

chr16_+_85101734 1.165 FOXF1
forkhead box F1
chr11_-_62146144 1.164 B3GAT3
beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
chr19_+_50041387 1.163 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr1_+_99502435 1.163 NM_001166252
NM_014839
LPPR4

lipid phosphate phosphatase-related protein type 4

chr1_-_26571812 1.158 NM_001114759
NM_173574
ZNF683

zinc finger protein 683

chr9_-_98421894 1.153 NM_003671
NM_033331
CDC14B

CDC14 cell division cycle 14 homolog B (S. cerevisiae)

chr19_+_50041400 1.145 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr9_+_34980266 1.135 NM_001135005
DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr12_+_12935619 1.127 GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr3_-_188946168 1.122 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr1_+_1207351 1.116 NM_001130413
NM_002978
SCNN1D

sodium channel, nonvoltage-gated 1, delta

chr9_+_27099138 1.116 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr8_-_144694722 1.116 ZC3H3
zinc finger CCCH-type containing 3
chr22_+_48870434 1.111 NM_001164104
NM_018995
MOV10L1

Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)

chr11_-_35503720 1.098 NM_001001991
NM_015430
PAMR1

peptidase domain containing associated with muscle regeneration 1

chr21_+_46369606 1.098 COL6A2
collagen, type VI, alpha 2
chr6_-_127822227 1.096 NM_014702
KIAA0408
KIAA0408
chr10_+_99069007 1.090 NM_005479
FRAT1
frequently rearranged in advanced T-cell lymphomas
chr16_+_415630 1.089 NM_014700
RAB11FIP3
RAB11 family interacting protein 3 (class II)
chr2_-_237987545 1.077 COL6A3
collagen, type VI, alpha 3
chr8_-_26780665 1.068 ADRA1A
adrenergic, alpha-1A-, receptor
chr4_-_111777651 1.062 PITX2
paired-like homeodomain 2
chr2_+_28469199 1.061 FOSL2
FOS-like antigen 2
chr2_-_237987553 1.060 COL6A3
collagen, type VI, alpha 3
chr9_-_139473433 1.059 NELF
nasal embryonic LHRH factor
chr9_+_138341752 1.058 NM_001145638
NM_015597
GPSM1

G-protein signaling modulator 1

chr14_+_75521806 1.056 NM_001102564
NM_052873
C14orf179

chromosome 14 open reading frame 179

chr7_+_28415495 1.054 LOC401317
hypothetical LOC401317
chr3_-_8518327 1.048 LOC100288428
hypothetical LOC100288428
chr6_-_91063301 1.041 NM_001170794
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr21_+_46369911 1.040 COL6A2
collagen, type VI, alpha 2
chrX_-_83644054 1.040 NM_001177478
NM_001177479
NM_144657
HDX


highly divergent homeobox


chr19_+_40811774 1.033 RBM42
RNA binding motif protein 42
chr18_+_75540786 1.030 NM_004715
NM_048368
CTDP1

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1

chr16_+_415606 1.029 RAB11FIP3
RAB11 family interacting protein 3 (class II)
chr4_+_658312 1.026 MYL5
myosin, light chain 5, regulatory
chr5_+_99898922 1.026 NM_198507
FAM174A
family with sequence similarity 174, member A
chr19_+_40716153 1.026 NM_014364
GAPDHS
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr18_+_75540831 1.026 CTDP1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
chr17_+_30472710 1.025 NM_017559
FNDC8
fibronectin type III domain containing 8
chrX_+_153325643 1.019 NM_004699
FAM50A
family with sequence similarity 50, member A
chr5_-_95794416 1.018 NM_000439
PCSK1
proprotein convertase subtilisin/kexin type 1
chr17_+_4590067 0.998 NM_001136046
NM_032265
ZMYND15

zinc finger, MYND-type containing 15

chr19_-_52308848 0.993 NM_015168
ZC3H4
zinc finger CCCH-type containing 4
chr9_-_34387786 0.985 NM_032596
C9orf24
chromosome 9 open reading frame 24
chr11_+_124539814 0.983 PKNOX2
PBX/knotted 1 homeobox 2
chr2_-_96899396 0.980 NM_017789
SEMA4C
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
chr22_+_17539198 0.980


chr10_-_105208634 0.980 NM_001001412
CALHM1
calcium homeostasis modulator 1
chr17_-_76064842 0.970 NM_002522
NPTX1
neuronal pentraxin I
chr9_-_128924819 0.968 NM_012098
ANGPTL2
angiopoietin-like 2
chr19_+_53814359 0.957 NM_020126
SPHK2
sphingosine kinase 2
chr22_+_36927884 0.954 NM_001161572
NM_001161574
NM_012323
MAFF


v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)


chr1_-_226670928 0.951 TRIM17
tripartite motif containing 17
chr2_-_241408296 0.951 NM_004321
KIF1A
kinesin family member 1A
chr3_-_48489474 0.947 SHISA5
shisa homolog 5 (Xenopus laevis)
chr3_+_129690735 0.947


chr1_+_29435534 0.942 NM_001195001
NM_005704
NM_133177
NM_133178
PTPRU



protein tyrosine phosphatase, receptor type, U



chr8_-_98359347 0.937 NM_033512
TSPYL5
TSPY-like 5
chr9_-_19023183 0.936 NM_153707
FAM154A
family with sequence similarity 154, member A
chr19_-_48791967 0.935 NM_001007561
IRGQ
immunity-related GTPase family, Q
chr11_-_118740069 0.935 NM_171997
USP2
ubiquitin specific peptidase 2
chr14_+_95792299 0.932 NM_000710
BDKRB1
bradykinin receptor B1
chr10_-_31360778 0.931 NM_001143766
NM_001143767
NM_001143768
NM_001143770
NM_001143771
NM_182755
ZNF438





zinc finger protein 438





chr16_-_78192111 0.931 NM_001031804
NM_005360
MAF

v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)

chr11_-_65550425 0.930 NM_053054
CATSPER1
cation channel, sperm associated 1
chr19_+_50041424 0.925 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr22_+_36928011 0.924 MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr1_+_156229686 0.923 NM_018240
KIRREL
kin of IRRE like (Drosophila)
chr9_+_36159384 0.922 NM_005893
CCIN
calicin
chr11_+_65945050 0.919 NM_178864
NPAS4
neuronal PAS domain protein 4
chr11_+_110916629 0.919 LAYN
layilin
chr20_-_43853945 0.917 NM_080614
WFDC3
WAP four-disulfide core domain 3
chr2_+_5750229 0.917 NM_003108
SOX11
SRY (sex determining region Y)-box 11
chr4_+_119732338 0.914 LOC729218
hypothetical LOC729218
chr7_-_41709191 0.911 NM_002192
INHBA
inhibin, beta A
chr20_+_33667160 0.910 NM_003116
SPAG4
sperm associated antigen 4
chr3_+_141136896 0.904 CLSTN2
calsyntenin 2
chr17_+_32368611 0.898 NM_005568
LHX1
LIM homeobox 1
chr9_+_129518163 0.896 NM_144965
TTC16
tetratricopeptide repeat domain 16
chr9_+_34979674 0.893 NM_001135004
NM_012266
DNAJB5

DnaJ (Hsp40) homolog, subfamily B, member 5

chr1_+_165330710 0.889 NM_001080426
DUSP27
dual specificity phosphatase 27 (putative)
chr2_+_241023703 0.885 NM_002081
GPC1
glypican 1
chr8_-_29263714 0.884 NM_001394
DUSP4
dual specificity phosphatase 4
chr9_-_129517740 0.883 NM_001002913
PTRH1
peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae)
chr15_+_79080341 0.881 NM_022566
MESDC1
mesoderm development candidate 1
chr10_-_90957028 0.881 NM_003956
CH25H
cholesterol 25-hydroxylase
chr8_-_98359248 0.880 TSPYL5
TSPY-like 5
chr19_-_50779914 0.879 OPA3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr12_-_51734434 0.878 LOC283335
hypothetical LOC283335
chr11_-_62145952 0.875 NM_012200
B3GAT3
beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
chr4_-_171161486 0.873 NM_001009554
MFAP3L
microfibrillar-associated protein 3-like
chr19_-_13978096 0.873 NM_002918
RFX1
regulatory factor X, 1 (influences HLA class II expression)
chr2_-_27967458 0.871 LOC100302650
hypothetical LOC100302650
chr2_-_96899326 0.870 SEMA4C
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
chr3_-_188945921 0.867 BCL6
B-cell CLL/lymphoma 6
chr1_-_160613203 0.866 NM_182581
C1orf111
chromosome 1 open reading frame 111
chr17_-_40923864 0.866 PLEKHM1
pleckstrin homology domain containing, family M (with RUN domain) member 1
chr7_+_44612745 0.866 OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr3_-_10042989 0.865 CIDECP
cell death-inducing DFFA-like effector c pseudogene
chr5_-_99898788 0.862


chr20_+_55718619 0.862


chr20_-_33489383 0.862 NM_000557
GDF5
growth differentiation factor 5
chr10_+_102782151 0.861 SFXN3
sideroflexin 3
chr14_+_60517682 0.860 SLC38A6
solute carrier family 38, member 6
chr17_+_56884560 0.858 TBX4
T-box 4
chr19_+_10388448 0.854 PDE4A
phosphodiesterase 4A, cAMP-specific

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.44 4.00e-08 GO:0048731 system development
1.37 4.54e-07 GO:0007275 multicellular organismal development
1.39 4.77e-07 GO:0048856 anatomical structure development
1.35 6.53e-07 GO:0032502 developmental process
1.26 5.69e-06 GO:0032501 multicellular organismal process
1.44 8.06e-05 GO:0030154 cell differentiation
1.41 2.83e-04 GO:0048869 cellular developmental process
1.64 3.54e-04 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.46 2.92e-03 GO:0009653 anatomical structure morphogenesis
1.40 3.55e-03 GO:0048513 organ development
1.91 8.88e-03 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.82 1.01e-02 GO:0072358 cardiovascular system development
1.82 1.01e-02 GO:0072359 circulatory system development
1.66 1.17e-02 GO:0030182 neuron differentiation
1.76 1.37e-02 GO:0045892 negative regulation of transcription, DNA-dependent
1.75 1.40e-02 GO:0051253 negative regulation of RNA metabolic process
1.54 3.43e-02 GO:0022008 neurogenesis
1.62 3.43e-02 GO:0009890 negative regulation of biosynthetic process
1.41 3.67e-02 GO:0007399 nervous system development
1.64 3.92e-02 GO:0010558 negative regulation of macromolecule biosynthetic process
1.66 4.70e-02 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.65 5.00e-02 GO:2000113 negative regulation of cellular macromolecule biosynthetic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.62 3.03e-03 GO:0043292 contractile fiber
2.66 3.33e-03 GO:0030016 myofibril
2.76 6.84e-03 GO:0030017 sarcomere
2.51 2.09e-02 GO:0044449 contractile fiber part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.80 1.09e-08 GO:0001071 nucleic acid binding transcription factor activity
1.80 1.09e-08 GO:0003700 sequence-specific DNA binding transcription factor activity
1.93 1.58e-07 GO:0043565 sequence-specific DNA binding
1.68 4.23e-06 GO:0030528 transcription regulator activity
2.09 6.81e-04 GO:0008134 transcription factor binding
1.09 8.92e-04 GO:0005488 binding
1.15 1.63e-03 GO:0005515 protein binding
3.59 4.65e-02 GO:0008307 structural constituent of muscle