Motif ID: LEF1_TCF7_TCF7L1,2.p2

Z-value: 1.267


Transcription factors associated with LEF1_TCF7_TCF7L1,2.p2:

Gene SymbolEntrez IDGene Name
LEF1 51176 lymphoid enhancer-binding factor 1
TCF7 6932 transcription factor 7 (T-cell specific, HMG-box)
TCF7L1 83439 transcription factor 7-like 1 (T-cell specific, HMG-box)
TCF7L2 6934 transcription factor 7-like 2 (T-cell specific, HMG-box)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TCF7L2chr10_+_1146999530.514.5e-02Click!
TCF7chr5_+_133479196-0.467.6e-02Click!
LEF1chr4_-_109308893-0.302.7e-01Click!
TCF7L1chr2_+_852138840.107.2e-01Click!


Activity profile for motif LEF1_TCF7_TCF7L1,2.p2.

activity profile for motif LEF1_TCF7_TCF7L1,2.p2


Sorted Z-values histogram for motif LEF1_TCF7_TCF7L1,2.p2

Sorted Z-values for motif LEF1_TCF7_TCF7L1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LEF1_TCF7_TCF7L1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_91632525 1.153 NM_001161528
LOC401387
leucine-rich repeat and death domain-containing protein
chr4_-_187114407 1.093 SORBS2
sorbin and SH3 domain containing 2
chr6_-_128883125 0.987 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr20_-_13919256 0.943 NM_025229
SEL1L2
sel-1 suppressor of lin-12-like 2 (C. elegans)
chr14_-_22521544 0.912 NM_032876
JUB
jub, ajuba homolog (Xenopus laevis)
chr2_+_69093641 0.905 NM_018153
NM_032208
NM_053034
ANTXR1


anthrax toxin receptor 1


chr7_-_27186400 0.845 NM_153715
HOXA10
homeobox A10
chr2_+_11597530 0.792 NM_148903
GREB1
growth regulation by estrogen in breast cancer 1
chr1_-_116184846 0.786 NM_001111061
NHLH2
nescient helix loop helix 2
chr2_+_171280046 0.784 NM_001003845
SP5
Sp5 transcription factor
chr10_+_53744043 0.777 NM_012242
DKK1
dickkopf homolog 1 (Xenopus laevis)
chr3_+_134239906 0.771 TMEM108
transmembrane protein 108
chr10_+_114699953 0.748 NM_001146274
NM_001146283
NM_001146284
NM_001146285
NM_001146286
NM_001198525
NM_001198526
NM_001198527
NM_001198528
NM_001198529
NM_001198530
NM_001198531
NM_030756
TCF7L2












transcription factor 7-like 2 (T-cell specific, HMG-box)












chr2_+_11600287 0.729 NM_033090
GREB1
growth regulation by estrogen in breast cancer 1
chr7_-_19778928 0.711 NM_152774
TMEM196
transmembrane protein 196
chr17_-_36376663 0.704 NM_213656
KRT39
keratin 39
chr8_+_22075112 0.698 NM_001172357
NM_001172410
NM_003018
SFTPC


surfactant protein C


chr8_-_121892877 0.696 SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr2_+_204509698 0.678 NM_012092
ICOS
inducible T-cell co-stimulator
chrX_-_105169370 0.674 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr14_-_20572783 0.668 NM_001012264
RNASE13
ribonuclease, RNase A family, 13 (non-active)
chr15_-_63457378 0.668 NM_004884
IGDCC3
immunoglobulin superfamily, DCC subclass, member 3
chr10_-_52315390 0.652 A1CF
APOBEC1 complementation factor
chr6_-_11887265 0.641 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr2_+_11600238 0.632 GREB1
growth regulation by estrogen in breast cancer 1
chr18_-_24011349 0.626 NM_001792
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr2_-_241484245 0.602 NM_001085437
C2orf54
chromosome 2 open reading frame 54
chr7_-_27180398 0.596 NM_018951
HOXA10
homeobox A10
chr3_+_134239860 0.595 NM_001136469
NM_023943
TMEM108

transmembrane protein 108

chr1_+_93686154 0.592 NM_001024948
NM_001164473
NM_017737
FNBP1L


formin binding protein 1-like


chr5_+_149526533 0.589 NM_001804
CDX1
caudal type homeobox 1
chr5_-_58370693 0.588 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr2_-_75641587 0.569 NM_001135032
FAM176A
family with sequence similarity 176, member A
chr17_-_61253122 0.567 NM_001037325
CCDC46
coiled-coil domain containing 46
chr15_+_48261649 0.563 NM_001159629
NM_003645
SLC27A2

solute carrier family 27 (fatty acid transporter), member 2

chr14_-_20642214 0.549


chr1_+_16203317 0.532 NM_178840
C1orf64
chromosome 1 open reading frame 64
chr20_+_30019465 0.528 NM_001011718
XKR7
XK, Kell blood group complex subunit-related family, member 7
chr2_-_75641535 0.527 FAM176A
family with sequence similarity 176, member A
chr13_-_71339313 0.522 NM_004392
NM_080759
NM_080760
DACH1


dachshund homolog 1 (Drosophila)


chr12_-_120781002 0.521 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr6_+_167624792 0.506 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr5_-_16989371 0.504 NM_012334
MYO10
myosin X
chr2_+_219354948 0.504 CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr17_-_45427565 0.497 NM_005220
DLX3
distal-less homeobox 3
chr17_-_60986905 0.491 AXIN2
axin 2
chr13_+_75108450 0.482 LMO7
LIM domain 7
chr7_+_29200636 0.481 NM_004067
CHN2
chimerin (chimaerin) 2
chr18_-_24010944 0.480 CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr3_+_152970904 0.475 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr1_+_48460943 0.474 NM_001011547
NM_001135181
SLC5A9

solute carrier family 5 (sodium/glucose cotransporter), member 9

chr9_-_73715666 0.472 FAM108B1
family with sequence similarity 108, member B1
chr13_+_75232797 0.470 NM_015842
LMO7
LIM domain 7
chr11_+_46697312 0.469 NM_000506
F2
coagulation factor II (thrombin)
chr10_+_7785331 0.467 ITIH2
inter-alpha (globulin) inhibitor H2
chr11_+_46697345 0.460 F2
coagulation factor II (thrombin)
chr7_+_139750311 0.459 NM_001008749
RAB19
RAB19, member RAS oncogene family
chr14_-_34413831 0.458 BAZ1A
bromodomain adjacent to zinc finger domain, 1A
chr16_-_12805194 0.455 NM_001099455
NM_018340
CPPED1

calcineurin-like phosphoesterase domain containing 1

chr9_-_14858974 0.453 FREM1
FRAS1 related extracellular matrix 1
chr15_+_37330176 0.451 NM_207445
C15orf54
chromosome 15 open reading frame 54
chr4_+_113372287 0.448 NM_001128426
NM_018569
AP1AR

adaptor-related protein complex 1 associated regulatory protein

chr10_+_7785347 0.445 ITIH2
inter-alpha (globulin) inhibitor H2
chr2_+_47449951 0.445 EPCAM
epithelial cell adhesion molecule
chr3_-_147696411 0.444 NM_020359
PLSCR2
phospholipid scramblase 2
chr17_-_40348378 0.443 NM_001131019
NM_002055
GFAP

glial fibrillary acidic protein

chr9_-_35640852 0.441 NM_014450
SIT1
signaling threshold regulating transmembrane adaptor 1
chr10_-_118755077 0.436 NM_001127211
NM_018330
KIAA1598

KIAA1598

chr17_-_60988077 0.434 NM_004655
AXIN2
axin 2
chr4_-_184480572 0.428 NM_001185149
CLDN24
claudin 24
chr2_+_101680594 0.427 NM_004834
NM_145686
NM_145687
MAP4K4


mitogen-activated protein kinase kinase kinase kinase 4


chr17_-_60988226 0.424 AXIN2
axin 2
chr4_-_120462705 0.424 NM_000134
FABP2
fatty acid binding protein 2, intestinal
chr1_+_15957832 0.419 NM_017556
FBLIM1
filamin binding LIM protein 1
chr6_+_131190237 0.418 NM_001195597
LOC285733
hypothetical LOC285733
chr10_+_7785360 0.417 ITIH2
inter-alpha (globulin) inhibitor H2
chr2_+_228386800 0.413 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr9_-_21229975 0.412 NM_002172
IFNA14
interferon, alpha 14
chr1_-_172153087 0.409 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr5_-_16791346 0.407 MYO10
myosin X
chr20_-_42249146 0.406 JPH2
junctophilin 2
chr17_-_10313600 0.406 NM_017533
MYH4
myosin, heavy chain 4, skeletal muscle
chr16_+_49139694 0.403 NM_033119
NKD1
naked cuticle homolog 1 (Drosophila)
chr2_+_204440753 0.401 NM_001037631
NM_005214
CTLA4

cytotoxic T-lymphocyte-associated protein 4

chr20_-_42457717 0.397


chr15_+_21361546 0.395 NM_005664
MKRN3
makorin ring finger protein 3
chr11_+_101488380 0.393 NM_001195045
YAP1
Yes-associated protein 1
chr16_-_12805133 0.389 CPPED1
calcineurin-like phosphoesterase domain containing 1
chr3_+_125296217 0.386 NM_001024660
NM_003947
KALRN

kalirin, RhoGEF kinase

chr6_+_44076281 0.385 NM_001171992
NM_153246
C6orf223

chromosome 6 open reading frame 223

chr17_+_72047709 0.382 NM_001077620
PRCD
progressive rod-cone degeneration
chr10_+_7785235 0.381 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chr7_+_94130752 0.381 PEG10
paternally expressed 10
chr6_-_138935359 0.378 NM_020464
NHSL1
NHS-like 1
chr12_+_52713098 0.374 NM_018953
HOXC5
homeobox C5
chr15_-_53667800 0.373 PYGO1
pygopus homolog 1 (Drosophila)
chr1_-_165754325 0.368 NM_000734
NM_198053
CD247

CD247 molecule

chr17_+_69939806 0.367 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr13_+_28496746 0.364 NM_001033602
MTUS2
microtubule associated tumor suppressor candidate 2
chr14_-_20642629 0.364 NM_001102454
ZNF219
zinc finger protein 219
chr6_-_27548438 0.364 NM_007149
ZNF184
zinc finger protein 184
chr1_-_3437834 0.364 MEGF6
multiple EGF-like-domains 6
chr3_-_150422474 0.362 NM_000096
CP
ceruloplasmin (ferroxidase)
chr3_-_79899748 0.359 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr2_+_102744921 0.357 NM_144632
TMEM182
transmembrane protein 182
chr3_-_126136261 0.356 NM_033049
MUC13
mucin 13, cell surface associated
chr17_+_7900926 0.355


chr2_+_135312655 0.354 NM_138326
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr1_+_59535074 0.352 NM_001113411
NM_018291
FGGY

FGGY carbohydrate kinase domain containing

chr2_-_98714020 0.350 NM_012214
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr1_+_17719405 0.349 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr2_+_10101081 0.348 NM_003597
NM_001177716
KLF11

Kruppel-like factor 11

chr11_-_124311106 0.345 HEPACAM
hepatic and glial cell adhesion molecule
chr9_-_110658030 0.344 NM_006686
ACTL7B
actin-like 7B
chr12_-_15833383 0.342 EPS8
epidermal growth factor receptor pathway substrate 8
chr3_-_150858274 0.340 NM_001168280
NM_015472
WWTR1

WW domain containing transcription regulator 1

chr8_-_121893196 0.338


chr10_+_7785290 0.338 ITIH2
inter-alpha (globulin) inhibitor H2
chr5_+_140714951 0.337 NM_018917
NM_032053
PCDHGA4

protocadherin gamma subfamily A, 4

chr5_+_34720368 0.337 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr2_+_171280182 0.335


chr3_+_142569988 0.332 ZBTB38
zinc finger and BTB domain containing 38
chr15_-_76890626 0.330 NM_014272
ADAMTS7
ADAM metallopeptidase with thrombospondin type 1 motif, 7
chr7_-_64088848 0.329 NM_015852
ZNF117
zinc finger protein 117
chr2_+_97696462 0.326 NM_001079
ZAP70
zeta-chain (TCR) associated protein kinase 70kDa
chr11_+_69165065 0.326 CCND1
cyclin D1
chr10_-_52315436 0.325 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr6_-_128263868 0.320 NM_001010923
NM_001164685
THEMIS

thymocyte selection associated

chr9_-_103187082 0.313 NM_001701
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr7_+_94130673 0.311 PEG10
paternally expressed 10
chr7_+_29486010 0.310 NM_001039936
CHN2
chimerin (chimaerin) 2
chr16_+_70646008 0.310 NM_001126102
NM_005143
HP

haptoglobin

chr6_-_52736231 0.309 NM_000846
GSTA2
glutathione S-transferase alpha 2
chr7_-_139523187 0.309 NM_030647
JHDM1D
jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae)
chr17_-_53849888 0.308 RNF43
ring finger protein 43
chr3_+_139550134 0.308 NM_001085049
MRAS
muscle RAS oncogene homolog
chr11_-_110888273 0.307 NM_017589
BTG4
B-cell translocation gene 4
chr14_+_38720085 0.306 PNN
pinin, desmosome associated protein
chr1_-_172153024 0.302 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr11_+_69165018 0.300 NM_053056
CCND1
cyclin D1
chr11_+_69165119 0.300 CCND1
cyclin D1
chr4_-_10295412 0.299 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chr9_+_88086932 0.298


chr4_+_78297356 0.298 NM_004354
CCNG2
cyclin G2
chr11_+_56224436 0.295 NM_001005213
NM_001013358
OR9G1
OR9G9
olfactory receptor, family 9, subfamily G, member 1
olfactory receptor, family 9, subfamily G, member 9
chr14_-_22947320 0.294 NM_002471
MYH6
myosin, heavy chain 6, cardiac muscle, alpha
chr8_-_17624009 0.292 NM_001001931
MTUS1
microtubule associated tumor suppressor 1
chr9_+_96806235 0.290 C9orf3
chromosome 9 open reading frame 3
chr2_+_47449790 0.290 NM_002354
EPCAM
epithelial cell adhesion molecule
chr11_+_74548472 0.289 NM_001145211
SLCO2B1
solute carrier organic anion transporter family, member 2B1
chr6_+_144649142 0.289 UTRN
utrophin
chr9_-_26995649 0.285 NM_022901
LRRC19
leucine rich repeat containing 19
chr1_+_99884018 0.283 NM_017734
PALMD
palmdelphin
chr7_-_142434340 0.282 NM_001001658
OR9A2
olfactory receptor, family 9, subfamily A, member 2
chr19_-_18578577 0.281 CRLF1
cytokine receptor-like factor 1
chr14_+_73555802 0.279 NM_025057
C14orf45
chromosome 14 open reading frame 45
chr13_+_30404809 0.277 NM_152325
C13orf26
chromosome 13 open reading frame 26
chr13_+_95541093 0.276 NM_153456
HS6ST3
heparan sulfate 6-O-sulfotransferase 3
chr12_+_15366712 0.275 NM_002848
NM_030667
PTPRO

protein tyrosine phosphatase, receptor type, O

chr19_-_18578467 0.274 CRLF1
cytokine receptor-like factor 1
chr6_+_123152044 0.272 SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr9_-_98185613 0.270 NM_007001
SLC35D2
solute carrier family 35, member D2
chr17_+_35075124 0.270 NM_003673
TCAP
titin-cap (telethonin)
chr10_-_101831579 0.270 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr10_-_116434364 0.270 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr2_+_219432789 0.269 NM_006522
WNT6
wingless-type MMTV integration site family, member 6
chr20_-_35586366 0.269 NM_001167823
BLCAP
bladder cancer associated protein
chr1_-_32574185 0.269 NM_023009
MARCKSL1
MARCKS-like 1
chr14_+_20283938 0.267 NM_006683
EDDM3A
epididymal protein 3A
chr3_+_46423682 0.266 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chr18_+_3439972 0.266 NM_173209
NM_173208
NM_003244
TGIF1


TGFB-induced factor homeobox 1


chr13_+_100902942 0.260 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr11_+_64878857 0.260 NM_145719
TIGD3
tigger transposable element derived 3
chr14_-_30746431 0.259 NM_015382
HECTD1
HECT domain containing 1
chr4_-_152316105 0.259 NM_001128924
SH3D19
SH3 domain containing 19
chr5_-_58607673 0.258 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr14_+_20048451 0.258 NM_001012975
RNASE10
ribonuclease, RNase A family, 10 (non-active)
chr9_-_21340885 0.257 NM_021002
IFNA6
interferon, alpha 6
chr10_-_91285290 0.257 NM_213606
SLC16A12
solute carrier family 16, member 12 (monocarboxylic acid transporter 12)
chr19_-_18578631 0.257 NM_004750
CRLF1
cytokine receptor-like factor 1
chr13_-_32658215 0.255 NM_178007
STARD13
StAR-related lipid transfer (START) domain containing 13
chr2_+_218992053 0.254 NM_007127
VIL1
villin 1
chr17_+_28279040 0.254 NM_001033504
NM_015544
TMEM98

transmembrane protein 98

chr1_-_116185215 0.252 NM_005599
NHLH2
nescient helix loop helix 2
chr4_-_158111504 0.252 PDGFC
platelet derived growth factor C
chr4_-_7991992 0.252 NM_001134647
NM_198595
AFAP1

actin filament associated protein 1

chr4_-_111777956 0.252 NM_153426
NM_153427
PITX2

paired-like homeodomain 2

chr17_-_68600427 0.251 NM_001159770
NM_139177
SLC39A11

solute carrier family 39 (metal ion transporter), member 11

chr4_+_69996780 0.251 NM_001074
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr5_-_83052606 0.248 NM_001884
HAPLN1
hyaluronan and proteoglycan link protein 1
chr2_+_38009405 0.247 NM_001170792
FAM82A1
family with sequence similarity 82, member A1
chr20_+_42399039 0.246 NM_178491
R3HDML
R3H domain containing-like
chr17_+_54652609 0.246 NM_001165993
NM_001165994
NM_182569
GDPD1


glycerophosphodiester phosphodiesterase domain containing 1


chr8_-_33544184 0.246 NM_024787
RNF122
ring finger protein 122
chr14_+_105012106 0.246 NM_001312
CRIP2
cysteine-rich protein 2
chr15_+_77362200 0.245 NM_001146341
ANKRD34C
ankyrin repeat domain 34C
chr14_-_93924663 0.245 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr6_+_28032997 0.244 NM_012367
OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr5_+_54434230 0.243 NM_006144
GZMA
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
chr4_-_158111995 0.243 NM_016205
PDGFC
platelet derived growth factor C

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.