Motif ID: LHX3,4.p2

Z-value: 1.230


Transcription factors associated with LHX3,4.p2:

Gene SymbolEntrez IDGene Name
LHX3 8022 LIM homeobox 3
LHX4 89884 LIM homeobox 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
LHX3chr9_-_1382347070.467.2e-02Click!
LHX4chr1_+_1784660640.116.7e-01Click!


Activity profile for motif LHX3,4.p2.

activity profile for motif LHX3,4.p2


Sorted Z-values histogram for motif LHX3,4.p2

Sorted Z-values for motif LHX3,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LHX3,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_57209319 1.696 NM_003865
HESX1
HESX homeobox 1
chr13_-_83354425 1.164 SLITRK1
SLIT and NTRK-like family, member 1
chr13_+_112349358 1.156 NM_207440
C13orf35
chromosome 13 open reading frame 35
chr9_-_137671206 1.120 NM_182974
GLT6D1
glycosyltransferase 6 domain containing 1
chr7_-_25234582 1.048 NM_022150
NPVF
neuropeptide VF precursor
chr22_+_38627031 1.007 NM_004810
GRAP2
GRB2-related adaptor protein 2
chr19_-_56612653 0.957 NM_001171156
NM_001171157
NM_001171158
NM_001171159
NM_001171160
NM_001171161
NM_033130
SIGLEC10






sialic acid binding Ig-like lectin 10






chr11_-_30910074 0.940 NM_020869
DCDC5
doublecortin domain containing 5
chr4_+_68995761 0.887 NM_014058
TMPRSS11E
transmembrane protease, serine 11E
chr4_-_189263395 0.859 NM_173553
TRIML2
tripartite motif family-like 2
chr7_-_36991189 0.851 NM_001039459
ELMO1
engulfment and cell motility 1
chr4_+_119174947 0.836 NM_004784
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr5_-_1935764 0.827 NM_016358
IRX4
iroquois homeobox 4
chr18_-_13905534 0.811 NM_000529
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chr1_+_196874839 0.810 PTPRC
protein tyrosine phosphatase, receptor type, C
chr16_+_11966464 0.795 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr18_+_59767567 0.779 NM_001123366
HMSD
histocompatibility (minor) serpin domain containing
chr2_-_99238001 0.718 NM_175735
LYG2
lysozyme G-like 2
chr6_+_132915522 0.716 NM_053278
TAAR8
trace amine associated receptor 8
chr11_-_102081654 0.713 NM_022122
MMP27
matrix metallopeptidase 27
chr18_+_28023984 0.708 NM_005925
MEP1B
meprin A, beta
chr13_+_52500830 0.706 NM_006418
OLFM4
olfactomedin 4
chr10_+_91142301 0.700 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr11_+_22646229 0.695 NM_177553
GAS2
growth arrest-specific 2
chr19_+_14554895 0.686 NM_207390
CLEC17A
C-type lectin domain family 17, member A
chr2_-_215711313 0.676 NM_173076
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr7_-_44547382 0.660 NM_001101648
NM_013389
NPC1L1

NPC1 (Niemann-Pick disease, type C1, gene)-like 1

chr15_+_92700167 0.654 NM_001159644
MCTP2
multiple C2 domains, transmembrane 2
chr20_+_56919233 0.645 GNAS
GNAS complex locus
chr11_-_117628211 0.645 NM_198275
MPZL3
myelin protein zero-like 3
chr1_-_92725017 0.642 NM_005263
GFI1
growth factor independent 1 transcription repressor
chr13_-_45323757 0.636 NM_198849
SIAH3
seven in absentia homolog 3 (Drosophila)
chr22_-_38619739 0.627 NM_152512
ENTHD1
ENTH domain containing 1
chr14_-_94306104 0.621 NM_173849
GSC
goosecoid homeobox
chr15_-_96875133 0.611 NM_182562
FAM169B
family with sequence similarity 169, member B
chr18_-_72857665 0.607 MBP
myelin basic protein
chr2_+_161980865 0.587 NM_006593
TBR1
T-box, brain, 1
chr3_-_54937001 0.579 NM_020678
LRTM1
leucine-rich repeats and transmembrane domains 1
chr6_+_12825818 0.571 NM_030948
PHACTR1
phosphatase and actin regulator 1
chr18_+_59733724 0.567 NM_005024
SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr7_-_122627235 0.567 NM_022444
SLC13A1
solute carrier family 13 (sodium/sulfate symporters), member 1
chr2_+_161981046 0.558 TBR1
T-box, brain, 1
chr8_+_98772537 0.557 MTDH
metadherin
chrX_-_55074125 0.546 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chr1_-_158815895 0.536 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr3_+_99733432 0.531 NM_005290
GPR15
G protein-coupled receptor 15
chr13_-_83354474 0.529 NM_052910
SLITRK1
SLIT and NTRK-like family, member 1
chrX_-_138552517 0.526 NM_001171877
NM_001171878
NM_001171879
NM_005369
MCF2



MCF.2 cell line derived transforming sequence



chr1_-_114215768 0.523 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chrX_-_110542040 0.520 NM_178151
NM_001195553
NM_178152
NM_178153
DCX



doublecortin



chr20_+_16676997 0.516 NM_020157
OTOR
otoraplin
chrX_+_78313124 0.513 NM_032553
GPR174
G protein-coupled receptor 174
chr10_+_118073929 0.513 NM_198515
C10orf96
chromosome 10 open reading frame 96
chr2_-_80385227 0.512 LRRTM1
leucine rich repeat transmembrane neuronal 1
chr10_+_102212787 0.503 NM_003393
WNT8B
wingless-type MMTV integration site family, member 8B
chr22_+_38627129 0.501 GRAP2
GRB2-related adaptor protein 2
chr12_-_10173947 0.496 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr11_+_59979857 0.491 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr15_-_64108718 0.490


chr6_-_25679197 0.487


chrX_-_18600108 0.482 NM_000330
RS1
retinoschisin 1
chr16_-_70168449 0.480 NM_000353
TAT
tyrosine aminotransferase
chr4_+_140806536 0.480 MGST2
microsomal glutathione S-transferase 2
chr8_-_102872354 0.478 NCALD
neurocalcin delta
chrX_-_102418329 0.476 NM_001012979
TCEAL5
transcription elongation factor A (SII)-like 5
chr17_-_36209672 0.475 NM_181535
KRT28
keratin 28
chr1_-_159191184 0.473 NM_080878
ITLN2
intelectin 2
chr13_-_102517196 0.469 NM_000452
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter family), member 2
chr6_-_26216299 0.469 NM_005323
HIST1H1T
histone cluster 1, H1t
chr1_-_149004916 0.468 NM_004079
CTSS
cathepsin S
chr2_-_158008763 0.467 NM_004288
CYTIP
cytohesin 1 interacting protein
chr8_-_110762409 0.464 NM_001099745
NM_001099746
SYBU

syntabulin (syntaxin-interacting)

chr11_-_20138445 0.461 NM_001029865
DBX1
developing brain homeobox 1
chr10_-_50066386 0.455 NM_001010863
C10orf128
chromosome 10 open reading frame 128
chr18_+_27210737 0.455 NM_001134453
NM_177986
DSG4

desmoglein 4

chr1_+_196874867 0.452 PTPRC
protein tyrosine phosphatase, receptor type, C
chr12_-_101398429 0.447 IGF1
insulin-like growth factor 1 (somatomedin C)
chr21_+_42492867 0.445 NM_207627
NM_207628
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chr7_-_37454933 0.444 NM_014800
ELMO1
engulfment and cell motility 1
chr11_-_56166490 0.441 NM_001002925
OR5AP2
olfactory receptor, family 5, subfamily AP, member 2
chr1_+_246682699 0.437 NM_001004136
OR2T2
olfactory receptor, family 2, subfamily T, member 2
chr21_-_31107431 0.437 NM_175857
KRTAP8-1
keratin associated protein 8-1
chr17_+_71975224 0.436 NM_001088
AANAT
aralkylamine N-acetyltransferase
chr6_-_2580296 0.434 NM_152554
C6orf195
chromosome 6 open reading frame 195
chr7_+_128802719 0.433 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr5_+_59819761 0.432 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr3_-_143230124 0.432 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr1_-_149004852 0.423 CTSS
cathepsin S
chr12_+_52697160 0.422 HOXC5
HOXC6
homeobox C5
homeobox C6
chr6_+_31538934 0.422 NM_006674
HCP5
HLA complex P5
chrX_-_107569256 0.418 NM_001847
COL4A6
collagen, type IV, alpha 6
chr12_-_14982708 0.412 NM_152321
ERP27
endoplasmic reticulum protein 27
chr9_+_12683385 0.411 NM_000550
TYRP1
tyrosinase-related protein 1
chr5_+_140207540 0.410 NM_014005
NM_031857
PCDHA9

protocadherin alpha 9

chr5_-_88155360 0.410 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr14_-_46882144 0.409 NM_182830
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chrX_-_131089552 0.408 NM_194277
FRMD7
FERM domain containing 7
chr13_-_34948758 0.407 NM_005584
MAB21L1
mab-21-like 1 (C. elegans)
chrX_+_37524250 0.404 CYBB
cytochrome b-245, beta polypeptide
chr2_+_158559936 0.401 NM_001135098
UPP2
uridine phosphorylase 2
chrX_+_50044279 0.401 NM_033031
NM_033670
CCNB3

cyclin B3

chrX_+_37524190 0.400 NM_000397
CYBB
cytochrome b-245, beta polypeptide
chr11_-_74478405 0.400 NM_001005285
OR2AT4
olfactory receptor, family 2, subfamily AT, member 4
chr4_-_68511738 0.400 NM_001114387
NM_182606
TMPRSS11A

transmembrane protease, serine 11A

chr15_+_100175888 0.400 NM_001001674
OR4F15
olfactory receptor, family 4, subfamily F, member 15
chr10_+_57028755 0.397 NM_001190478
MTRNR2L5
MT-RNR2-like 5
chr5_-_160211623 0.395 NM_025153
ATP10B
ATPase, class V, type 10B
chr7_-_38279757 0.391 NM_001003799
NM_001003806
TARP

TRGV9
TCR gamma alternate reading frame protein

T cell receptor gamma variable 9
chr11_+_61794205 0.390 NM_002411
SCGB2A2
secretoglobin, family 2A, member 2
chr9_-_35962454 0.386 YBX1
Y box binding protein 1
chr11_-_89181390 0.383 NM_020358
TRIM49
tripartite motif containing 49
chr4_+_88748704 0.380 NM_014208
DSPP
dentin sialophosphoprotein
chr1_-_151587645 0.380 NM_020393
PGLYRP4
peptidoglycan recognition protein 4
chr12_+_91620749 0.378 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr8_-_59575249 0.378 NM_000780
CYP7A1
cytochrome P450, family 7, subfamily A, polypeptide 1
chr8_-_102872372 0.373 NCALD
neurocalcin delta
chr12_+_130004404 0.372 NM_198827
GPR133
G protein-coupled receptor 133
chr17_-_36347197 0.370 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr1_-_245942679 0.370 NM_001005286
OR6F1
olfactory receptor, family 6, subfamily F, member 1
chr6_+_31604717 0.367 NM_001011700
MCCD1
mitochondrial coiled-coil domain 1
chr5_-_156705250 0.366 NM_001001343
FNDC9
fibronectin type III domain containing 9
chr3_+_82117978 0.366


chrX_+_48978875 0.364 CCDC22
coiled-coil domain containing 22
chr21_-_31175722 0.364 NM_175858
KRTAP11-1
keratin associated protein 11-1
chr20_+_5935897 0.361 NM_001127458
CRLS1
cardiolipin synthase 1
chr6_-_50045296 0.361 NM_001037729
DEFB113
defensin, beta 113
chr1_-_203592538 0.360 NM_018203
KLHDC8A
kelch domain containing 8A
chr22_+_35290271 0.355


chr9_+_92603832 0.354 NM_001135052
NM_003177
SYK

spleen tyrosine kinase

chr8_-_110730183 0.354 NM_001099747
NM_001099748
NM_001099749
NM_001099750
NM_017786
SYBU




syntabulin (syntaxin-interacting)




chr12_-_101396459 0.353 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr17_-_9863929 0.353 GAS7
growth arrest-specific 7
chr8_+_124032830 0.353 ZHX2
zinc fingers and homeoboxes 2
chr6_+_167504070 0.352 NM_001145121
TCP10L2
TCP10
t-complex 10-like 2 (mouse)
t-complex 10 homolog (mouse)
chr10_-_21825879 0.348 C10orf114
chromosome 10 open reading frame 114
chr12_+_52696908 0.345 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr14_-_106084519 0.345 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr16_-_79811475 0.341 NM_001076780
NM_052892
PKD1L2

polycystic kidney disease 1-like 2

chr3_-_152517204 0.341 NM_023915
GPR87
G protein-coupled receptor 87
chr10_-_48426868 0.340 NM_001042357
NM_001042389
PTPN20B
PTPN20A
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20A
chr1_-_149004879 0.340 CTSS
cathepsin S
chr15_+_32048380 0.339 NM_012125
CHRM5
cholinergic receptor, muscarinic 5
chr5_-_22889192 0.339 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr11_+_89032112 0.339 NM_153696
FOLH1B
folate hydrolase 1B
chr2_+_161981138 0.338 TBR1
T-box, brain, 1
chr19_-_40995606 0.337 PRODH2
proline dehydrogenase (oxidase) 2
chrX_+_85404626 0.335 NM_001139515
DACH2
dachshund homolog 2 (Drosophila)
chr12_+_52634950 0.332 NM_173860
HOXC12
homeobox C12
chr20_-_7869068 0.330 NM_017545
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr1_+_173111306 0.329 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr18_+_27281729 0.329 NM_001944
DSG3
desmoglein 3
chr8_+_92330691 0.328 NM_052832
NM_134266
SLC26A7

solute carrier family 26, member 7

chr6_-_136829705 0.327 NM_001198615
MAP7
microtubule-associated protein 7
chr17_-_9635325 0.327 NM_001105571
DHRS7C
dehydrogenase/reductase (SDR family) member 7C
chr8_-_7710547 0.327 NM_001037668
NM_001040705
DEFB107A
DEFB107B
defensin, beta 107A
defensin, beta 107B
chr15_+_70477707 0.326 NM_001080462
TMEM202
transmembrane protein 202
chr5_+_156628929 0.326 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr1_+_190394214 0.323 NM_130782
RGS18
regulator of G-protein signaling 18
chr21_-_30460841 0.322 NM_012131
CLDN17
claudin 17
chr6_-_167717907 0.317 NM_004610
TCP10
t-complex 10 homolog (mouse)
chr12_-_16321885 0.315 NM_001170798
SLC15A5
solute carrier family 15, member 5
chr4_+_74497998 0.315 ALB
albumin
chrX_+_115215985 0.311 NM_000686
AGTR2
angiotensin II receptor, type 2
chr1_-_157014048 0.311 NM_001005278
OR6N2
olfactory receptor, family 6, subfamily N, member 2
chrX_+_107174855 0.309 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr2_-_207291364 0.308 NM_001093730
DYTN
dystrotelin
chr11_-_123182266 0.305 NM_001005325
OR6M1
olfactory receptor, family 6, subfamily M, member 1
chr8_-_7200278 0.304 FAM66B
family with sequence similarity 66, member B
chrX_-_24600661 0.302 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chrX_-_142432884 0.301 NM_001009609
SPANXN3
SPANX family, member N3
chr10_+_90511142 0.301 NM_001102469
LIPN
lipase, family member N
chrX_+_140810117 0.300 NM_177456
MAGEC3
melanoma antigen family C, 3
chr6_-_33016561 0.298 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr7_+_147918589 0.298 NM_145304
C7orf33
chromosome 7 open reading frame 33
chr1_+_117345894 0.298 NM_004258
CD101
CD101 molecule
chr2_-_134042500 0.296 NM_207363
NM_207481
NCKAP5

NCK-associated protein 5

chrX_-_13744933 0.296 GPM6B
glycoprotein M6B
chrX_+_134803450 0.293 NM_018666
SAGE1
sarcoma antigen 1
chrX_+_28515479 0.293 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr6_+_12825022 0.289 PHACTR1
phosphatase and actin regulator 1
chr14_+_61532293 0.288 NM_031914
SYT16
synaptotagmin XVI
chr6_+_12824873 0.287 PHACTR1
phosphatase and actin regulator 1
chr15_-_70838703 0.287


chr7_+_37689903 0.286


chr6_+_55300225 0.286 NM_207410
GFRAL
GDNF family receptor alpha like
chr2_+_234490781 0.284 NM_024080
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr1_+_196874759 0.282 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr1_-_151549790 0.282 NM_052891
PGLYRP3
peptidoglycan recognition protein 3
chr6_-_29635680 0.280 NM_006398
UBD
ubiquitin D
chr14_-_105997732 0.280 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_+_94097513 0.279 NM_006215
SERPINA4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
chr20_+_31334601 0.278 NM_033197
C20orf114
chromosome 20 open reading frame 114
chr4_+_74498042 0.278 ALB
albumin
chr9_+_129066576 0.277 NM_032293
GARNL3
GTPase activating Rap/RanGAP domain-like 3
chr2_+_73864823 0.274 NM_001080474
C2orf78
chromosome 2 open reading frame 78
chrX_-_138875342 0.274 NM_001013403
CXorf66
chromosome X open reading frame 66
chr4_-_47678187 0.273 NM_001142564
CNGA1
cyclic nucleotide gated channel alpha 1
chr1_+_111634996 0.272 NM_021797
NM_201653
CHIA

chitinase, acidic

chr2_+_95621492 0.272 NM_138800
TRIM43
tripartite motif containing 43
chr10_-_21826192 0.271 C10orf114
chromosome 10 open reading frame 114

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.77 1.80e-08 GO:0007608 sensory perception of smell
2.57 1.46e-07 GO:0007606 sensory perception of chemical stimulus
1.34 1.33e-06 GO:0032501 multicellular organismal process
2.01 8.36e-06 GO:0007600 sensory perception
1.66 9.68e-06 GO:0003008 system process
1.72 4.48e-05 GO:0050877 neurological system process
1.23 1.69e-03 GO:0050896 response to stimulus
1.78 6.75e-03 GO:0006952 defense response

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.35 6.70e-09 GO:0016021 integral to membrane
1.42 1.35e-08 GO:0005886 plasma membrane
1.34 2.05e-08 GO:0031224 intrinsic to membrane
1.41 2.42e-08 GO:0071944 cell periphery
1.25 1.99e-05 GO:0044425 membrane part
1.52 3.61e-05 GO:0005576 extracellular region
1.16 9.16e-03 GO:0016020 membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.37 2.19e-12 GO:0004930 G-protein coupled receptor activity
1.97 3.19e-10 GO:0004888 transmembrane receptor activity
1.81 4.63e-10 GO:0004872 receptor activity
2.90 6.98e-10 GO:0004984 olfactory receptor activity
1.59 8.59e-07 GO:0004871 signal transducer activity
1.59 8.59e-07 GO:0060089 molecular transducer activity
7.22 8.76e-04 GO:0001608 nucleotide receptor activity, G-protein coupled
7.22 8.76e-04 GO:0045028 purinergic nucleotide receptor activity, G-protein coupled
5.64 8.78e-03 GO:0001614 purinergic nucleotide receptor activity
5.64 8.78e-03 GO:0016502 nucleotide receptor activity
5.01 2.46e-02 GO:0035586 purinergic receptor activity