Motif ID: MSX1,2.p2

Z-value: 1.050


Transcription factors associated with MSX1,2.p2:

Gene SymbolEntrez IDGene Name
MSX1 4487 msh homeobox 1
MSX2 4488 msh homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MSX2chr5_+_174084137-0.582.0e-02Click!
MSX1chr4_+_49122720.448.9e-02Click!


Activity profile for motif MSX1,2.p2.

activity profile for motif MSX1,2.p2


Sorted Z-values histogram for motif MSX1,2.p2

Sorted Z-values for motif MSX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MSX1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_96471544 1.423 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chr10_+_7785360 1.069 ITIH2
inter-alpha (globulin) inhibitor H2
chr10_+_7785331 1.003 ITIH2
inter-alpha (globulin) inhibitor H2
chr9_-_115880372 0.972 AMBP
alpha-1-microglobulin/bikunin precursor
chr10_-_74384569 0.961 PLA2G12B
phospholipase A2, group XIIB
chr4_+_89115862 0.844 SPP1
secreted phosphoprotein 1
chr4_+_71096830 0.787 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr2_-_77602843 0.772 NM_001134745
NM_024993
LRRTM4

leucine rich repeat transmembrane neuronal 4

chr12_+_70119785 0.769 LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr4_+_89115825 0.763 NM_000582
NM_001040058
NM_001040060
SPP1


secreted phosphoprotein 1


chr1_-_145163520 0.752 FMO5
flavin containing monooxygenase 5
chr2_-_180135559 0.739 NM_001113398
ZNF385B
zinc finger protein 385B
chr4_+_89115892 0.709 SPP1
secreted phosphoprotein 1
chr11_-_40272239 0.671 NM_020929
LRRC4C
leucine rich repeat containing 4C
chr9_-_126309510 0.650 NM_004959
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr9_-_115880281 0.638 AMBP
alpha-1-microglobulin/bikunin precursor
chr9_-_115880425 0.605 AMBP
alpha-1-microglobulin/bikunin precursor
chr2_-_237987553 0.603 COL6A3
collagen, type VI, alpha 3
chr10_-_74384485 0.601 NM_032562
PLA2G12B
phospholipase A2, group XIIB
chr1_-_108032645 0.562 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr3_+_52803823 0.540 NM_002217
ITIH3
inter-alpha (globulin) inhibitor H3
chr2_-_192420168 0.539 NM_004657
SDPR
serum deprivation response
chr17_-_61655915 0.537 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr11_+_7574992 0.522 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr10_+_7785347 0.518 ITIH2
inter-alpha (globulin) inhibitor H2
chr13_+_100902942 0.506 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr6_-_48186868 0.470 C6orf138
chromosome 6 open reading frame 138
chr10_+_7785290 0.458 ITIH2
inter-alpha (globulin) inhibitor H2
chr1_+_200246370 0.447 ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr4_+_89115923 0.426 SPP1
secreted phosphoprotein 1
chr2_-_237987509 0.405 COL6A3
collagen, type VI, alpha 3
chr3_-_150422474 0.404 NM_000096
CP
ceruloplasmin (ferroxidase)
chr2_+_114916368 0.403 NM_020868
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr16_-_29817841 0.394 NM_001114099
NM_001114100
NM_012410
NM_201575
SEZ6L2



seizure related 6 homolog (mouse)-like 2



chr2_-_237987554 0.378 COL6A3
collagen, type VI, alpha 3
chr10_-_44794146 0.375 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr9_-_96395828 0.373 NM_003837
FBP2
fructose-1,6-bisphosphatase 2
chr4_-_159311959 0.358 FAM198B
family with sequence similarity 198, member B
chr2_-_192419896 0.356 SDPR
serum deprivation response
chr2_-_237987579 0.350 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr9_+_135491305 0.337 NM_000787
DBH
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
chr2_-_237987545 0.318 COL6A3
collagen, type VI, alpha 3
chrX_+_128966844 0.316 NM_021946
BCORL1
BCL6 corepressor-like 1
chr2_+_216695062 0.309 XRCC5
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
chr3_-_127810087 0.307 NM_001039783
TXNRD3IT1
thioredoxin reductase 3 intronic transcript 1
chr9_-_115880366 0.307 AMBP
alpha-1-microglobulin/bikunin precursor
chr4_+_155703581 0.300 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr6_-_28591542 0.297 NM_182701
GPX6
glutathione peroxidase 6 (olfactory)
chr17_-_36113502 0.289 NM_019016
KRT24
keratin 24
chr10_-_51678318 0.289 NM_001143974
NM_019893
ASAH2

N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2

chr2_-_165133239 0.284 GRB14
growth factor receptor-bound protein 14
chr6_+_154373323 0.282 NM_001145279
NM_001145280
NM_001145281
OPRM1


opioid receptor, mu 1


chr7_+_94377145 0.278 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory (inhibitor) subunit 9A


chr21_+_44729875 0.278


chr8_+_76614757 0.273 NM_004133
HNF4G
hepatocyte nuclear factor 4, gamma
chr3_-_167037946 0.267 NM_000055
BCHE
butyrylcholinesterase
chr3_+_129690735 0.257


chr6_+_16237264 0.251 NM_013262
MYLIP
myosin regulatory light chain interacting protein
chr3_-_167037861 0.248 BCHE
butyrylcholinesterase
chr12_+_56114724 0.242 NM_005538
INHBC
inhibin, beta C
chr16_+_64958060 0.238 CDH5
cadherin 5, type 2 (vascular endothelium)
chr11_-_114593838 0.233 CADM1
cell adhesion molecule 1
chr2_-_162638174 0.233 DPP4
dipeptidyl-peptidase 4
chr9_+_133295353 0.232


chr4_-_186970366 0.231 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr6_+_127940011 0.223 NM_001010905
C6orf58
chromosome 6 open reading frame 58
chr4_-_155753332 0.223 NM_000509
NM_021870
FGG

fibrinogen gamma chain

chr1_-_149245503 0.222 NM_001163259
NM_001163260
NM_001040217
FAM63A


family with sequence similarity 63, member A


chr12_+_108038774 0.219 ACACB
acetyl-CoA carboxylase beta
chr1_-_229071957 0.218 NM_001136494
C1orf198
chromosome 1 open reading frame 198
chr2_+_138438277 0.216 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr10_+_7785235 0.211 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chr2_-_68952006 0.208 NM_014482
BMP10
bone morphogenetic protein 10
chr12_+_49605010 0.207 METTL7A
methyltransferase like 7A
chr17_-_25685175 0.205 NM_206832
TMIGD1
transmembrane and immunoglobulin domain containing 1
chr15_-_38185865 0.204 NM_033503
BMF
Bcl2 modifying factor
chr3_+_189425886 0.200 NM_001167671
LPP
LIM domain containing preferred translocation partner in lipoma
chr20_-_29360048 0.198 NM_001037731
DEFB116
defensin, beta 116
chr16_+_64958086 0.197 CDH5
cadherin 5, type 2 (vascular endothelium)
chr3_-_121884091 0.196 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr4_-_68793928 0.194 NM_182502
TMPRSS11B
transmembrane protease, serine 11B
chr1_+_200246312 0.192 NM_001114309
NM_004433
ELF3

E74-like factor 3 (ets domain transcription factor, epithelial-specific )

chr3_-_121883647 0.191 HGD
homogentisate 1,2-dioxygenase
chr2_-_21081694 0.189 APOB
apolipoprotein B (including Ag(x) antigen)
chr3_-_150578023 0.181 TM4SF1
transmembrane 4 L six family member 1
chr16_+_64958025 0.176 NM_001795
CDH5
cadherin 5, type 2 (vascular endothelium)
chr3_-_101316038 0.175 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chr6_-_26038817 0.169 NM_005835
SLC17A2
solute carrier family 17 (sodium phosphate), member 2
chr6_-_24491498 0.168 NM_001195610
DCDC2
doublecortin domain containing 2
chr7_+_143437539 0.167 NM_001005480
OR2A2
olfactory receptor, family 2, subfamily A, member 2
chr11_-_85074848 0.166 NM_152723
CCDC89
coiled-coil domain containing 89
chr11_+_6823458 0.164 NM_178168
OR10A5
olfactory receptor, family 10, subfamily A, member 5
chr3_-_152585226 0.162 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr5_-_160211623 0.159 NM_025153
ATP10B
ATPase, class V, type 10B
chr3_-_71625318 0.157 FOXP1
forkhead box P1
chr2_+_219453487 0.157 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr17_-_1195096 0.156 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr2_+_88148413 0.155 NM_198274
SMYD1
SET and MYND domain containing 1
chr10_+_124020810 0.154 NM_144587
BTBD16
BTB (POZ) domain containing 16
chr10_-_50269912 0.154 NM_001080520
DRGX
dorsal root ganglia homeobox
chr7_+_120415958 0.153 NM_024913
C7orf58
chromosome 7 open reading frame 58
chr3_+_12367993 0.152 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr22_+_34109095 0.149 HMOX1
heme oxygenase (decycling) 1
chr10_+_685887 0.144 C10orf108
chromosome 10 open reading frame 108
chr3_+_187866464 0.144 NM_000412
HRG
histidine-rich glycoprotein
chr4_-_41579325 0.143


chr20_+_31613800 0.143 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr3_-_150578148 0.141 TM4SF1
transmembrane 4 L six family member 1
chr16_+_31105579 0.141


chr2_-_21087435 0.140 APOB
apolipoprotein B (including Ag(x) antigen)
chr20_+_43283423 0.138 NM_003008
SEMG2
semenogelin II
chr9_-_115880494 0.138 NM_001633
AMBP
alpha-1-microglobulin/bikunin precursor
chr6_+_16237300 0.137 MYLIP
myosin regulatory light chain interacting protein
chr2_+_228064531 0.136 AGFG1
ArfGAP with FG repeats 1
chr19_-_17236522 0.135 NM_031941
USHBP1
Usher syndrome 1C binding protein 1
chr5_-_42847716 0.135 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr8_-_15140162 0.132 NM_139167
SGCZ
sarcoglycan, zeta
chr2_-_215957927 0.131 FN1
fibronectin 1
chr8_-_145613034 0.130 SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr2_+_162908828 0.129 NM_012198
GCA
grancalcin, EF-hand calcium binding protein
chr5_+_109052984 0.129


chr3_+_9919295 0.128 NM_153483
IL17RE
interleukin 17 receptor E
chr6_-_123999640 0.128 NM_006073
TRDN
triadin
chr19_-_14030970 0.128 NM_001145028
PALM3
paralemmin 3
chr3_+_8518539 0.128 LMCD1
LIM and cysteine-rich domains 1
chr5_-_22248630 0.127 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr17_+_65582981 0.126 NM_018658
NM_170741
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr9_+_110664366 0.126 NM_006687
ACTL7A
actin-like 7A
chr17_+_38306339 0.125 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr3_+_101720753 0.124 TMEM45A
transmembrane protein 45A
chr6_-_114490701 0.123 NM_153612
HS3ST5
heparan sulfate (glucosamine) 3-O-sulfotransferase 5
chr3_-_71262426 0.123 FOXP1
forkhead box P1
chr12_-_15757114 0.122 EPS8
epidermal growth factor receptor pathway substrate 8
chr4_-_77176163 0.122 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr22_+_33792125 0.122 NM_001008494
ISX
intestine-specific homeobox
chr5_+_169713458 0.122 NM_001034838
KCNIP1
Kv channel interacting protein 1
chr1_-_85816520 0.120 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr8_-_145613058 0.119 NM_130849
SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr18_+_3584056 0.118 FLJ35776
hypothetical LOC649446
chr11_+_56512922 0.117 NM_001005323
OR5AK2
olfactory receptor, family 5, subfamily AK, member 2
chr14_-_23752875 0.115 NM_014169
CHMP4A
chromatin modifying protein 4A
chr11_-_6870306 0.115 NM_003700
OR2D2
olfactory receptor, family 2, subfamily D, member 2
chr13_-_45577144 0.115 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr2_+_233029076 0.114 NM_001631
ALPI
alkaline phosphatase, intestinal
chr20_+_19985289 0.114 NM_001167816
C20orf26
chromosome 20 open reading frame 26
chrX_+_54963953 0.114 NM_001039705
NM_016157
NM_177556
TRO


trophinin


chr7_+_21434818 0.113


chr7_-_86433139 0.112 NM_152748
KIAA1324L
KIAA1324-like
chr16_-_11918019 0.111 NM_001130007
GSPT1
G1 to S phase transition 1
chr5_+_140494971 0.111 NM_015669
PCDHB5
protocadherin beta 5
chr21_-_30720100 0.111 NM_181622
KRTAP13-3
keratin associated protein 13-3
chr4_+_71330797 0.109 NM_001145006
MUC7
mucin 7, secreted
chr4_-_89963177 0.108 NM_001015045
FAM13A
family with sequence similarity 13, member A
chr3_+_185300660 0.108 NM_182589
HTR3E
5-hydroxytryptamine (serotonin) receptor 3, family member E
chr4_+_114190233 0.106 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr21_-_31049566 0.106 NM_181619
KRTAP21-1
keratin associated protein 21-1
chr1_+_162795328 0.105 NM_002585
PBX1
pre-B-cell leukemia homeobox 1
chr3_-_123584747 0.104 NM_001017928
CCDC58
coiled-coil domain containing 58
chr11_-_64484184 0.104 NM_001037225
C11orf85
chromosome 11 open reading frame 85
chr17_-_15109315 0.103 NM_000304
PMP22
peripheral myelin protein 22
chr21_-_30460841 0.101 NM_012131
CLDN17
claudin 17
chr16_+_80626459 0.099 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr3_-_150578207 0.098 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr12_+_52105131 0.096 AMHR2
anti-Mullerian hormone receptor, type II
chr16_-_21197072 0.096 CRYM
crystallin, mu
chr5_+_109052945 0.094 MAN2A1
mannosidase, alpha, class 2A, member 1
chr16_+_80626456 0.093 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr17_+_46176105 0.092 LUC7L3
LUC7-like 3 (S. cerevisiae)
chr1_+_36545283 0.092 NM_024676
SH3D21
SH3 domain containing 21
chr16_+_80626402 0.091 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr7_+_80069439 0.091 NM_001001547
CD36
CD36 molecule (thrombospondin receptor)
chr9_+_1040367 0.090 DMRT2
doublesex and mab-3 related transcription factor 2
chr2_-_239987629 0.090 HDAC4
histone deacetylase 4
chr6_+_132901119 0.089 NM_175057
TAAR9
trace amine associated receptor 9 (gene/pseudogene)
chr16_+_52037186 0.089 RBL2
retinoblastoma-like 2 (p130)
chrX_+_115481848 0.088 SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chrX_-_129347101 0.088 NM_178471
GPR119
G protein-coupled receptor 119
chr12_-_69837831 0.087 TSPAN8
tetraspanin 8
chr9_+_115970599 0.086 COL27A1
collagen, type XXVII, alpha 1
chr3_-_71262405 0.086 FOXP1
forkhead box P1
chr11_+_64950402 0.085


chr9_+_133295297 0.084 NM_013318
PRRC2B
proline-rich coiled-coil 2B
chr20_+_42644633 0.084 PKIG
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chr6_-_33085290 0.084 HLA-DOA
major histocompatibility complex, class II, DO alpha
chr7_+_143423073 0.081 NM_001004135
OR2A12
olfactory receptor, family 2, subfamily A, member 12
chr17_+_67628749 0.081 NM_000346
SOX9
SRY (sex determining region Y)-box 9
chr12_-_89922875 0.081 EPYC
epiphycan
chr5_+_140790141 0.081 PCDHGA12
protocadherin gamma subfamily A, 12
chr17_+_67628763 0.078 SOX9
SRY (sex determining region Y)-box 9
chr12_-_89922888 0.077 NM_004950
EPYC
epiphycan
chr21_-_36774257 0.075 NM_001146079
NM_144492
CLDN14

claudin 14

chr14_-_67353046 0.075 NM_015346
ZFYVE26
zinc finger, FYVE domain containing 26
chr16_-_74055998 0.075 TMEM170A
transmembrane protein 170A
chrX_-_100920493 0.074 GK
glycerol kinase
chr19_-_51109875 0.073 NM_001029861
NANOS2
nanos homolog 2 (Drosophila)
chr3_+_50119261 0.072 RBM5
RNA binding motif protein 5
chr11_+_101488380 0.072 NM_001195045
YAP1
Yes-associated protein 1
chr17_-_30909219 0.072 NM_001129820
SLFN14
schlafen family member 14
chr12_-_14024187 0.071 NM_000834
GRIN2B
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
chr6_-_31938572 0.071 NM_000434
NEU1
sialidase 1 (lysosomal sialidase)

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
7.42 9.23e-03 GO:0031983 vesicle lumen
2.16 1.19e-02 GO:0005626 insoluble fraction
2.25 1.36e-02 GO:0016023 cytoplasmic membrane-bounded vesicle
2.16 1.60e-02 GO:0005624 membrane fraction
2.21 1.87e-02 GO:0031988 membrane-bounded vesicle
1.41 2.39e-02 GO:0071944 cell periphery
1.91 3.60e-02 GO:0000267 cell fraction
2.12 3.79e-02 GO:0031410 cytoplasmic vesicle
23.62 4.45e-02 GO:0005577 fibrinogen complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
18.37 1.23e-02 GO:0042301 phosphate binding