Motif ID: MTF1.p2

Z-value: 2.034


Transcription factors associated with MTF1.p2:

Gene SymbolEntrez IDGene Name
MTF1 4520 metal-regulatory transcription factor 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MTF1chr1_-_38097811-0.312.4e-01Click!


Activity profile for motif MTF1.p2.

activity profile for motif MTF1.p2


Sorted Z-values histogram for motif MTF1.p2

Sorted Z-values for motif MTF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MTF1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_105012106 4.952 NM_001312
 CRIP2
cysteine-rich protein 2
chr9_+_136358145 4.802 RXRA
retinoid X receptor, alpha
chr16_+_1143738 4.243 CACNA1H
calcium channel, voltage-dependent, T type, alpha 1H subunit
chr9_+_136358134 3.918 NM_002957
 RXRA
retinoid X receptor, alpha
chr9_+_115958051 3.638 NM_032888
 COL27A1
collagen, type XXVII, alpha 1
chr15_-_76890626 3.618 NM_014272
 ADAMTS7
ADAM metallopeptidase with thrombospondin type 1 motif, 7
chr1_-_32002222 3.565 NM_001703
 BAI2
brain-specific angiogenesis inhibitor 2
chr10_+_124211353 3.246 HTRA1
HtrA serine peptidase 1
chr6_-_170441493 3.124 NM_005618
 DLL1
delta-like 1 (Drosophila)
chr20_-_60228665 3.115 NM_007232
 HRH3
histamine receptor H3
chr13_-_105985313 3.096 NM_004093
 EFNB2
ephrin-B2
chr19_+_38377329 2.998 NM_002333
 LRP3
low density lipoprotein receptor-related protein 3
chr11_+_125279481 2.983 NM_013264
 DDX25
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
chr17_+_70495318 2.965 NM_014603
 CDR2L
cerebellar degeneration-related protein 2-like
chr15_-_23659329 2.857 NM_024490
 ATP10A
ATPase, class V, type 10A
chr3_-_135575925 2.851 NM_016201
 AMOTL2
angiomotin like 2
chr2_+_100087812 2.804


chr22_-_23318829 2.784 NM_207644
 C22orf36
chromosome 22 open reading frame 36
chr2_+_28469172 2.749 FOSL2
FOS-like antigen 2
chr9_+_90796169 2.748 NM_005226
 S1PR3
sphingosine-1-phosphate receptor 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 208 entries
enrichment   p-value GO term description
3.89 1.18e-02 GO:0060411 cardiac septum morphogenesis
3.38 9.11e-03 GO:0003279 cardiac septum development
3.02 1.36e-04 GO:0050772 positive regulation of axonogenesis
2.89 2.14e-02 GO:0050771 negative regulation of axonogenesis
2.80 1.22e-08 GO:0050770 regulation of axonogenesis
2.53 1.40e-04 GO:0050768 negative regulation of neurogenesis
2.52 1.16e-03 GO:0032412 regulation of ion transmembrane transporter activity
2.43 3.34e-03 GO:0022898 regulation of transmembrane transporter activity
2.41 1.17e-05 GO:0050769 positive regulation of neurogenesis
2.39 9.35e-05 GO:0010721 negative regulation of cell development
2.38 3.68e-03 GO:0034765 regulation of ion transmembrane transport
2.30 1.90e-03 GO:0042326 negative regulation of phosphorylation
2.23 3.05e-03 GO:0010563 negative regulation of phosphorus metabolic process
2.23 3.05e-03 GO:0045936 negative regulation of phosphate metabolic process
2.23 3.05e-03 GO:0048638 regulation of developmental growth
2.22 5.26e-07 GO:0010975 regulation of neuron projection development
2.22 1.51e-02 GO:0032409 regulation of transporter activity
2.18 1.20e-06 GO:0010769 regulation of cell morphogenesis involved in differentiation
2.18 2.12e-03 GO:0030178 negative regulation of Wnt receptor signaling pathway
2.17 1.79e-06 GO:0022604 regulation of cell morphogenesis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 25 entries
enrichment   p-value GO term description
2.25 1.00e-02 GO:0005905 coated pit
1.88 4.04e-02 GO:0030139 endocytic vesicle
1.76 2.29e-03 GO:0005912 adherens junction
1.73 1.76e-03 GO:0070161 anchoring junction
1.70 2.40e-02 GO:0034703 cation channel complex
1.69 1.83e-03 GO:0031252 cell leading edge
1.58 4.41e-06 GO:0045202 synapse
1.52 1.15e-04 GO:0043005 neuron projection
1.52 1.88e-03 GO:0005578 proteinaceous extracellular matrix
1.51 3.36e-04 GO:0031012 extracellular matrix
1.47 2.11e-02 GO:0044456 synapse part
1.46 8.26e-06 GO:0030054 cell junction
1.35 9.08e-05 GO:0042995 cell projection
1.31 1.78e-11 GO:0044459 plasma membrane part
1.23 9.57e-03 GO:0031226 intrinsic to plasma membrane
1.22 2.17e-02 GO:0005887 integral to plasma membrane
1.21 6.08e-03 GO:0012505 endomembrane system
1.15 1.31e-05 GO:0005886 plasma membrane
1.15 1.61e-05 GO:0071944 cell periphery
1.09 4.12e-05 GO:0005737 cytoplasm

Gene overrepresentation in function category:

Showing 1 to 20 of 26 entries
enrichment   p-value GO term description
2.79 1.12e-02 GO:0005158 insulin receptor binding
2.45 4.23e-03 GO:0008013 beta-catenin binding
2.21 1.64e-04 GO:0019199 transmembrane receptor protein kinase activity
2.11 1.90e-02 GO:0004714 transmembrane receptor protein tyrosine kinase activity
1.89 1.49e-02 GO:0016566 specific transcriptional repressor activity
1.85 1.55e-02 GO:0019838 growth factor binding
1.59 2.07e-02 GO:0000975 regulatory region DNA binding
1.59 2.07e-02 GO:0001067 regulatory region nucleic acid binding
1.59 2.07e-02 GO:0044212 transcription regulatory region DNA binding
1.59 3.50e-02 GO:0010843 promoter binding
1.51 9.57e-03 GO:0008134 transcription factor binding
1.50 9.35e-03 GO:0016564 transcription repressor activity
1.45 3.32e-02 GO:0003779 actin binding
1.41 1.88e-05 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.41 6.12e-05 GO:0043565 sequence-specific DNA binding
1.39 3.72e-05 GO:0016301 kinase activity
1.39 3.41e-02 GO:0004674 protein serine/threonine kinase activity
1.38 2.43e-03 GO:0004672 protein kinase activity
1.36 2.01e-02 GO:0008092 cytoskeletal protein binding
1.34 6.39e-05 GO:0001071 nucleic acid binding transcription factor activity