Motif ID: NFIX.p2

Z-value: 1.543


Transcription factors associated with NFIX.p2:

Gene SymbolEntrez IDGene Name
NFIX 4784 nuclear factor I/X (CCAAT-binding transcription factor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFIXchr19_+_130669560.702.4e-03Click!


Activity profile for motif NFIX.p2.

activity profile for motif NFIX.p2


Sorted Z-values histogram for motif NFIX.p2

Sorted Z-values for motif NFIX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFIX.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_50271283 1.318 NM_014191
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr10_+_17311962 1.314 VIM
vimentin
chr4_-_99798563 1.174 NM_005723
TSPAN5
tetraspanin 5
chr7_-_80386602 1.106 NM_006379
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr3_+_185762233 1.046 NM_004443
EPHB3
EPH receptor B3
chr11_+_61491793 1.044 LOC399900
hypothetical LOC399900
chr7_-_80386258 1.024 SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr6_-_109868400 1.004 PPIL6
peptidylprolyl isomerase (cyclophilin)-like 6
chr2_+_241023703 0.997 NM_002081
GPC1
glypican 1
chr22_+_44828338 0.979


chr10_-_17311961 0.972


chr10_+_124210980 0.945 NM_002775
HTRA1
HtrA serine peptidase 1
chr1_+_199975674 0.933 NAV1
neuron navigator 1
chr5_-_169340321 0.917 NM_001129891
FAM196B
family with sequence similarity 196, member B
chr10_+_102782151 0.893 SFXN3
sideroflexin 3
chr1_+_199975563 0.891 NM_001167738
NAV1
neuron navigator 1
chr14_-_99842519 0.885 NM_001039355
SLC25A29
solute carrier family 25, member 29
chr5_+_148941228 0.866 NM_001001669
ARHGEF37
Rho guanine nucleotide exchange factor (GEF) 37
chr14_+_51025604 0.864 NM_001042481
FRMD6
FERM domain containing 6
chr1_-_6243621 0.863 NM_207370
GPR153
G protein-coupled receptor 153
chr15_-_76890626 0.858 NM_014272
ADAMTS7
ADAM metallopeptidase with thrombospondin type 1 motif, 7
chr9_-_21549696 0.853 LOC554202
hypothetical LOC554202
chr5_-_156935283 0.852


chr21_-_27139563 0.798 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr12_+_54611212 0.786 NM_001345
DGKA
diacylglycerol kinase, alpha 80kDa
chr1_+_238321794 0.771 NM_020066
FMN2
formin 2
chr19_-_1188840 0.767 NM_152769
C19orf26
chromosome 19 open reading frame 26
chr12_+_26239755 0.751 NM_005086
SSPN
sarcospan (Kras oncogene-associated gene)
chr8_-_41286088 0.733 NM_003012
SFRP1
secreted frizzled-related protein 1
chr1_-_2312850 0.732 NM_024848
MORN1
MORN repeat containing 1
chr16_+_3010311 0.728 NM_016639
TNFRSF12A
tumor necrosis factor receptor superfamily, member 12A
chr4_-_143987053 0.723 NM_001101669
NM_003866
INPP4B

inositol polyphosphate-4-phosphatase, type II, 105kDa

chr12_+_26239535 0.715 NM_001135823
SSPN
sarcospan (Kras oncogene-associated gene)
chr3_-_49916304 0.714 NM_002447
MST1R
macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
chr4_+_166097548 0.693 NM_153027
C4orf39
chromosome 4 open reading frame 39
chr1_-_206484258 0.689 NM_025179
PLXNA2
plexin A2
chr12_+_48641545 0.687 NM_001651
AQP5
aquaporin 5
chr5_+_122452739 0.682 NM_001136239
PRDM6
PR domain containing 6
chr1_-_27565412 0.681 MAP3K6
mitogen-activated protein kinase kinase kinase 6
chr6_-_150285838 0.675 NM_001001788
RAET1G
retinoic acid early transcript 1G
chr1_+_891739 0.673 NM_001160184
NM_032129
PLEKHN1

pleckstrin homology domain containing, family N member 1

chr21_+_44941514 0.673 NM_198699
KRTAP10-12
keratin associated protein 10-12
chr1_+_20788027 0.668 NM_001785
CDA
cytidine deaminase
chr5_-_156935317 0.662 NM_033274
ADAM19
ADAM metallopeptidase domain 19
chr15_+_72253940 0.661 NM_201526
ISLR
immunoglobulin superfamily containing leucine-rich repeat
chr11_+_71613472 0.640 NM_001567
INPPL1
inositol polyphosphate phosphatase-like 1
chr19_-_18246166 0.633 NM_001145304
NM_001145305
NM_025249
KIAA1683


KIAA1683


chr4_+_166097579 0.628 C4orf39
chromosome 4 open reading frame 39
chr7_-_100262971 0.627 NM_004444
EPHB4
EPH receptor B4
chr3_-_46710137 0.620 NM_001190707
NM_147129
ALS2CL

ALS2 C-terminal like

chr5_+_15553288 0.619 NM_012304
FBXL7
F-box and leucine-rich repeat protein 7
chr3_-_197103848 0.619 TNK2
tyrosine kinase, non-receptor, 2
chr10_-_100164877 0.617 NM_032709
PYROXD2
pyridine nucleotide-disulphide oxidoreductase domain 2
chr5_-_43075904 0.616 NM_001014279
C5orf39
chromosome 5 open reading frame 39
chr14_+_58174489 0.606 NM_001079520
NM_016651
DACT1

dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)

chr1_+_43769065 0.605 NM_002840
NM_130440
PTPRF

protein tyrosine phosphatase, receptor type, F

chr9_-_100057809 0.597 NM_018421
TBC1D2
TBC1 domain family, member 2
chr1_+_1250152 0.595


chr9_-_112840801 0.588 LPAR1
lysophosphatidic acid receptor 1
chr5_+_140767953 0.577 NM_018926
NM_032100
PCDHGB6

protocadherin gamma subfamily B, 6

chr3_-_162305319 0.574 NM_033169
NM_001038628
NM_003781
NM_033167
NM_033168
B3GALNT1




beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)




chr9_-_25668230 0.573 TUSC1
tumor suppressor candidate 1
chr10_+_89409332 0.559 NM_001015880
NM_004670
PAPSS2

3'-phosphoadenosine 5'-phosphosulfate synthase 2

chr11_-_46678736 0.559 ARHGAP1
Rho GTPase activating protein 1
chr19_+_45807909 0.557


chr21_+_44871467 0.555 NM_198690
KRTAP10-9
keratin associated protein 10-9
chr19_+_7505037 0.550 NM_006702
NM_001166112
PNPLA6

patatin-like phospholipase domain containing 6

chr1_-_6448737 0.548 NM_001039664
NM_003790
NM_148965
NM_148966
NM_148967
NM_148970
TNFRSF25





tumor necrosis factor receptor superfamily, member 25





chr3_+_49211936 0.547 NM_001135197
CCDC36
coiled-coil domain containing 36
chr21_-_44795769 0.531 NM_198693
KRTAP10-2
keratin associated protein 10-2
chr9_-_100057313 0.530 TBC1D2
TBC1 domain family, member 2
chr21_-_27139143 0.524 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chrX_+_71047344 0.523 NM_001013627
NHSL2
NHS-like 2
chr14_-_104507862 0.513 AHNAK2
AHNAK nucleoprotein 2
chr3_-_46481346 0.508 NM_002343
LTF
lactotransferrin
chr7_-_123460722 0.504 NM_001136002
TMEM229A
transmembrane protein 229A
chr10_+_88718167 0.504 NM_006829
C10orf116
chromosome 10 open reading frame 116
chr17_-_5428491 0.504 NM_001033053
NM_014922
NM_033004
NM_033006
NM_033007
NLRP1




NLR family, pyrin domain containing 1




chr1_+_1250115 0.503 GLTPD1
glycolipid transfer protein domain containing 1
chr2_-_56266408 0.502 LOC100129434
hypothetical LOC100129434
chr11_-_46678691 0.501 NM_004308
ARHGAP1
Rho GTPase activating protein 1
chr17_+_18069593 0.501 NM_004140
LLGL1
lethal giant larvae homolog 1 (Drosophila)
chr10_+_122206455 0.500 NM_001030059
PPAPDC1A
phosphatidic acid phosphatase type 2 domain containing 1A
chr9_+_5440455 0.499 NM_014143
CD274
CD274 molecule
chr13_-_76358433 0.498 NM_138444
KCTD12
potassium channel tetramerisation domain containing 12
chr1_+_77105746 0.498 NM_030965
ST6GALNAC5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr7_+_142723340 0.493 NM_000083
CLCN1
chloride channel 1, skeletal muscle
chr5_+_15553539 0.489 FBXL7
F-box and leucine-rich repeat protein 7
chr12_+_54612055 0.481 NM_201444
NM_201445
NM_201554
DGKA


diacylglycerol kinase, alpha 80kDa


chr13_-_76358370 0.480 KCTD12
potassium channel tetramerisation domain containing 12
chr1_+_77105709 0.475 ST6GALNAC5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr11_-_11986704 0.472 NM_001018057
DKK3
dickkopf homolog 3 (Xenopus laevis)
chr4_+_3264509 0.466 RGS12
regulator of G-protein signaling 12
chr6_+_150326802 0.465 NM_025218
ULBP1
UL16 binding protein 1
chr9_-_25668855 0.457 NM_001004125
TUSC1
tumor suppressor candidate 1
chr3_-_195835197 0.452 TMEM44
transmembrane protein 44
chr8_+_104452961 0.447 NM_138455
CTHRC1
collagen triple helix repeat containing 1
chr20_+_1194959 0.447 NM_014723
SNPH
syntaphilin
chr6_+_109868736 0.446 SMPD2
sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
chr14_-_19973640 0.446 NM_001109997
KLHL33
kelch-like 33 (Drosophila)
chr5_+_148766632 0.438 LOC728264
hypothetical LOC728264
chr5_+_15553768 0.434 FBXL7
F-box and leucine-rich repeat protein 7
chr1_-_68470585 0.432 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr5_+_15553736 0.431 FBXL7
F-box and leucine-rich repeat protein 7
chr2_+_241023908 0.429 GPC1
glypican 1
chr2_-_40532651 0.429 SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr19_+_52908412 0.429 NM_014601
EHD2
EH-domain containing 2
chr3_+_139550368 0.425 MRAS
muscle RAS oncogene homolog
chr16_-_69277355 0.418 NM_138383
MTSS1L
metastasis suppressor 1-like
chr19_-_44722599 0.412 NM_153232
EID2
EP300 interacting inhibitor of differentiation 2
chr10_+_17311788 0.410 VIM
vimentin
chr12_+_48303607 0.410 NM_012272
PRPF40B
PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)
chr10_+_124211353 0.408 HTRA1
HtrA serine peptidase 1
chr3_+_156280129 0.399 NM_000902
MME
membrane metallo-endopeptidase
chr1_-_205272619 0.399 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr11_-_56761250 0.396 NM_005161
APLNR
apelin receptor
chr17_+_19221606 0.392 NM_139032
NM_139033
MAPK7

mitogen-activated protein kinase 7

chr21_+_44890758 0.390 NM_198692
KRTAP10-11
keratin associated protein 10-11
chr4_-_83938920 0.387 NM_001037582
NM_024906
SCD5

stearoyl-CoA desaturase 5

chr19_-_14467939 0.385 NM_005716
NM_202467
NM_202468
NM_202469
NM_202470
NM_202494
GIPC1





GIPC PDZ domain containing family, member 1





chr1_+_31659246 0.384 NM_001199039
NM_018565
SERINC2

serine incorporator 2

chr17_+_35587767 0.384 NM_016339
RAPGEFL1
Rap guanine nucleotide exchange factor (GEF)-like 1
chr4_-_111777584 0.380 PITX2
paired-like homeodomain 2
chr16_-_674357 0.379 NM_001005920
JMJD8
jumonji domain containing 8
chr15_+_65145215 0.379 SMAD3
SMAD family member 3
chr12_+_106236281 0.377 NM_001018072
BTBD11
BTB (POZ) domain containing 11
chr12_+_6179736 0.373 NM_001769
CD9
CD9 molecule
chr22_+_38720881 0.373 NM_138435
FAM83F
family with sequence similarity 83, member F
chr3_-_195835298 0.371 NM_001011655
NM_001166305
NM_001166306
NM_138399
TMEM44



transmembrane protein 44



chr1_+_29011240 0.370 NM_000911
OPRD1
opioid receptor, delta 1
chr9_-_129656413 0.368 ENG
endoglin
chr5_+_34692239 0.364 RAI14
retinoic acid induced 14
chr11_-_118286822 0.363 NM_182557
BCL9L
B-cell CLL/lymphoma 9-like
chr19_-_4016467 0.363 ZBTB7A
zinc finger and BTB domain containing 7A
chr8_+_104452877 0.360 CTHRC1
collagen triple helix repeat containing 1
chr17_-_4831388 0.359 NM_001171167
NM_001171168
CAMTA2

calmodulin binding transcription activator 2

chrX_+_154264931 0.359 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated (intronic transcript) 2
coagulation factor VIII-associated (intronic transcript) 3
coagulation factor VIII-associated (intronic transcript) 1
chr16_-_1086244 0.358 NM_207419
C1QTNF8
C1q and tumor necrosis factor related protein 8
chr1_+_199884072 0.356 NM_020443
NAV1
neuron navigator 1
chr5_+_94981735 0.355 NM_199243
GPR150
G protein-coupled receptor 150
chr11_-_67163600 0.353 NM_005995
TBX10
T-box 10
chr21_-_44836811 0.352 NM_198688
KRTAP10-6
keratin associated protein 10-6
chr3_-_188903038 0.351 NM_001004312
RTP2
receptor (chemosensory) transporter protein 2
chr1_+_199884152 0.351 NAV1
neuron navigator 1
chr17_+_17952744 0.349 NM_016239
MYO15A
myosin XVA
chr10_-_31360778 0.349 NM_001143766
NM_001143767
NM_001143768
NM_001143770
NM_001143771
NM_182755
ZNF438





zinc finger protein 438





chr4_+_148621518 0.349 NM_001166055
NM_001957
EDNRA

endothelin receptor type A

chr9_+_35595339 0.346 TESK1
testis-specific kinase 1
chr9_-_129656581 0.346 ENG
endoglin
chr1_+_156417302 0.345 CD1D
CD1d molecule
chr2_+_17923404 0.344 NM_002252
KCNS3
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
chr17_-_40750109 0.344 NM_003954
MAP3K14
mitogen-activated protein kinase kinase kinase 14
chr15_+_65145248 0.342 NM_005902
SMAD3
SMAD family member 3
chr1_+_115198977 0.342 NM_003176
SYCP1
synaptonemal complex protein 1
chr3_-_50371934 0.341 NM_007024
TMEM115
transmembrane protein 115
chr19_-_14467890 0.341 GIPC1
GIPC PDZ domain containing family, member 1
chr11_-_68537243 0.341 NM_001098515
NM_145015
MRGPRF

MAS-related GPR, member F

chr21_+_32706615 0.339 NM_058187
C21orf63
chromosome 21 open reading frame 63
chr4_-_25473528 0.338 NM_015187
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr12_-_46439127 0.336 NM_001098531
RAPGEF3
Rap guanine nucleotide exchange factor (GEF) 3
chr8_-_142307854 0.335 NM_001080431
SLC45A4
solute carrier family 45, member 4
chr5_-_33928049 0.335 ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr17_+_21220260 0.333 NM_021012
KCNJ12
potassium inwardly-rectifying channel, subfamily J, member 12
chr17_-_76064842 0.331 NM_002522
NPTX1
neuronal pentraxin I
chr21_+_33364316 0.329 NM_138983
OLIG1
oligodendrocyte transcription factor 1
chr5_+_34692352 0.329 NM_001145520
RAI14
retinoic acid induced 14
chr1_-_158182006 0.328 NM_001135050
NM_020789
IGSF9

immunoglobulin superfamily, member 9

chr2_-_222871577 0.328 NM_000438
NM_001127366
NM_013942
NM_181457
NM_181458
NM_181459
NM_181460
NM_181461
PAX3







paired box 3







chr1_-_150233337 0.325 NM_002966
S100A10
S100 calcium binding protein A10
chr5_+_34692124 0.325 NM_001145522
NM_015577
RAI14

retinoic acid induced 14

chr3_-_50371896 0.325 TMEM115
transmembrane protein 115
chr4_-_140443061 0.324 NM_001184987
NM_001184988
NM_001184989
NM_001184990
NDUFC1



NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa



chr17_+_6495694 0.320 NM_001105520
C17orf100
chromosome 17 open reading frame 100
chr9_+_35595275 0.317 NM_006285
TESK1
testis-specific kinase 1
chr9_-_129707392 0.317 LOC100131355
ST6GALNAC6
hypothetical protein LOC100131355
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr10_+_11824361 0.316 NM_024693
ECHDC3
enoyl CoA hydratase domain containing 3
chr8_+_143778529 0.316 NM_001160354
NM_001160355
NM_017527
LY6K


lymphocyte antigen 6 complex, locus K


chr16_+_2016807 0.314 NM_001130012
NM_004785
SLC9A3R2

solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2

chr9_-_129656778 0.313 ENG
endoglin
chr5_-_157011949 0.311 NM_007017
NM_178424
SOX30

SRY (sex determining region Y)-box 30

chr17_+_19222651 0.309 MAPK7
mitogen-activated protein kinase 7
chrX_+_106955737 0.308 NM_012216
NM_052817
MID2

midline 2

chr3_-_50371960 0.305 TMEM115
transmembrane protein 115
chr3_+_129117007 0.301 KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr2_-_232103352 0.301 NM_006056
NMUR1
neuromedin U receptor 1
chr17_+_70495318 0.299 NM_014603
CDR2L
cerebellar degeneration-related protein 2-like
chr22_-_16020153 0.298 CECR5
cat eye syndrome chromosome region, candidate 5
chr11_-_64284762 0.297 NM_001164716
NM_005609
PYGM

phosphorylase, glycogen, muscle

chr9_+_129951552 0.297 NM_005564
LCN2
lipocalin 2
chr11_+_696607 0.297 EPS8L2
EPS8-like 2
chr10_+_73393998 0.295 NM_004273
CHST3
carbohydrate (chondroitin 6) sulfotransferase 3
chr1_+_208568811 0.295 NM_001170587
NM_001170588
NM_018194
HHAT


hedgehog acyltransferase


chr19_-_59385226 0.294 MBOAT7
membrane bound O-acyltransferase domain containing 7
chr15_-_70455153 0.293 HEXA
hexosaminidase A (alpha polypeptide)
chr3_+_158026769 0.292 NM_001004316
NM_001193283
LEKR1

leucine, glutamate and lysine rich 1

chr1_+_31658549 0.291 NM_178865
SERINC2
serine incorporator 2
chr22_-_16020168 0.290 NM_033070
CECR5
cat eye syndrome chromosome region, candidate 5
chr6_+_86216020 0.290 NM_002526
NT5E
5'-nucleotidase, ecto (CD73)
chr5_-_157011665 0.289


chr1_-_150232900 0.289 S100A10
S100 calcium binding protein A10

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.44 2.37e-02 GO:0009966 regulation of signal transduction
1.40 2.98e-02 GO:0023051 regulation of signaling

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.20 1.51e-02 GO:0071944 cell periphery
1.20 1.78e-02 GO:0005886 plasma membrane
3.01 2.17e-02 GO:0042383 sarcolemma

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.54 3.87e-02 GO:0008201 heparin binding