Motif ID: NFKB1_REL_RELA.p2

Z-value: 1.272


Transcription factors associated with NFKB1_REL_RELA.p2:

Gene SymbolEntrez IDGene Name
NFKB1 4790 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
REL 5966 v-rel reticuloendotheliosis viral oncogene homolog (avian)
RELA 5970 v-rel reticuloendotheliosis viral oncogene homolog A (avian)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFKB1chr4_+_1036418540.639.5e-03Click!
RELAchr11_-_651828010.411.2e-01Click!
RELchr2_+_609622790.097.4e-01Click!


Activity profile for motif NFKB1_REL_RELA.p2.

activity profile for motif NFKB1_REL_RELA.p2


Sorted Z-values histogram for motif NFKB1_REL_RELA.p2

Sorted Z-values for motif NFKB1_REL_RELA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFKB1_REL_RELA.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_4180494 1.635 NM_005755
EBI3
Epstein-Barr virus induced 3
chr14_-_95250155 1.487 NM_001098725
NM_021966
TCL1A

T-cell leukemia/lymphoma 1A

chr19_+_50196526 1.303 NM_006509
RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr10_+_12431714 1.224 CAMK1D
calcium/calmodulin-dependent protein kinase ID
chr10_+_104145421 1.128 NM_002502
NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr8_-_70909754 1.080 NM_030958
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr17_-_16816113 1.041 NM_012452
TNFRSF13B
tumor necrosis factor receptor superfamily, member 13B
chr2_+_219453487 1.022 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr10_+_104144218 1.016 NM_001077493
NM_001077494
NFKB2

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

chr22_-_35875890 0.958 NM_000878
IL2RB
interleukin 2 receptor, beta
chr16_+_84490267 0.945 NM_002163
IRF8
interferon regulatory factor 8
chr5_+_10617431 0.924 NM_001164440
ANKRD33B
ankyrin repeat domain 33B
chr19_+_3087026 0.911 NM_002068
GNA15
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
chr19_-_6542012 0.905 CD70
CD70 molecule
chr1_-_24386324 0.870 NM_170743
NM_173064
NM_173065
IL28RA


interleukin 28 receptor, alpha (interferon, lambda receptor)


chr19_-_7672978 0.863 NM_002002
FCER2
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr2_-_162883062 0.851 NM_022168
IFIH1
interferon induced with helicase C domain 1
chr11_+_120828058 0.846 NM_003105
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr9_-_139235595 0.834 NM_031297
RNF208
ring finger protein 208
chr19_-_17819773 0.829 JAK3
Janus kinase 3
chr4_-_147079018 0.818 NM_178835
ZNF827
zinc finger protein 827
chr2_+_233633348 0.809 INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
chr2_-_231498184 0.784 NM_005683
GPR55
G protein-coupled receptor 55
chr22_-_35970230 0.779 NM_002872
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr20_+_44180296 0.772 NM_001250
NM_152854
CD40

CD40 molecule, TNF receptor superfamily member 5

chr7_+_68702252 0.762 AUTS2
autism susceptibility candidate 2
chr12_-_53268538 0.759 NM_006741
PPP1R1A
protein phosphatase 1, regulatory (inhibitor) subunit 1A
chr17_+_62804036 0.752 PITPNC1
phosphatidylinositol transfer protein, cytoplasmic 1
chr20_-_24986501 0.735 ACSS1
acyl-CoA synthetase short-chain family member 1
chr22_+_38720881 0.732 NM_138435
FAM83F
family with sequence similarity 83, member F
chr6_-_31432934 0.724 HLA-B
major histocompatibility complex, class I, B
chr6_+_32713160 0.715 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr11_+_101693403 0.712 NM_001165
NM_182962
BIRC3

baculoviral IAP repeat containing 3

chr19_+_47073029 0.681 NM_001783
NM_021601
CD79A

CD79a molecule, immunoglobulin-associated alpha

chr13_-_110011866 0.676 NM_017817
RAB20
RAB20, member RAS oncogene family
chr11_+_120828275 0.657 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr12_-_53661888 0.639 NM_001098815
KIAA0748
KIAA0748
chr8_-_11361594 0.633 NM_053279
FAM167A
family with sequence similarity 167, member A
chr2_+_237143118 0.630 NM_020311
CXCR7
chemokine (C-X-C motif) receptor 7
chr5_-_141318810 0.629 NM_016580
PCDH12
protocadherin 12
chr20_+_44180355 0.621 CD40
CD40 molecule, TNF receptor superfamily member 5
chr2_+_233633279 0.618 NM_001017915
NM_005541
INPP5D

inositol polyphosphate-5-phosphatase, 145kDa

chr1_+_152644668 0.617 IL6R
interleukin 6 receptor
chrX_-_30505804 0.614 NM_025159
CXorf21
chromosome X open reading frame 21
chr15_+_83724743 0.609 NM_006738
NM_007200
AKAP13

A kinase (PRKA) anchor protein 13

chr19_-_6542082 0.600 CD70
CD70 molecule
chr14_-_23686269 0.591 PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr3_-_115258053 0.591 NM_020817
KIAA1407
KIAA1407
chr16_+_49333461 0.591 NM_001042355
NM_015247
CYLD

cylindromatosis (turban tumor syndrome)

chr16_+_49333513 0.591 NM_001042412
CYLD
cylindromatosis (turban tumor syndrome)
chr10_+_12431477 0.589 NM_020397
NM_153498
CAMK1D

calcium/calmodulin-dependent protein kinase ID

chr6_+_116798791 0.587 NM_013352
DSE
dermatan sulfate epimerase
chr8_-_139995417 0.571 NM_152888
COL22A1
collagen, type XXII, alpha 1
chr6_-_32659958 0.564 HLA-DRB1
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 5
chr5_-_149772469 0.562 NM_001025159
NM_004355
NM_001025158
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr6_+_14225932 0.555 CD83
CD83 molecule
chr7_-_44985084 0.552 MYO1G
myosin IG
chr19_-_48976852 0.547 KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr12_+_6925997 0.542 NM_080548
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr5_+_110587546 0.541 NM_001744
CAMK4
calcium/calmodulin-dependent protein kinase IV
chr20_-_4743768 0.540 NM_170774
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr19_-_48977247 0.534 NM_002250
KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr6_+_106640903 0.533 PRDM1
PR domain containing 1, with ZNF domain
chr19_-_17819814 0.532 NM_000215
JAK3
Janus kinase 3
chr6_+_32919873 0.532


chr3_-_113334657 0.532 NM_001190259
NM_001190260
NM_152785
GCET2


germinal center expressed transcript 2


chr22_-_32646325 0.530 NM_004737
NM_133642
LARGE

like-glycosyltransferase

chr17_-_33178987 0.530 HNF1B
HNF1 homeobox B
chr6_-_132764257 0.528 NM_015529
MOXD1
monooxygenase, DBH-like 1
chr7_-_99899829 0.527 NM_001004323
C7orf61
chromosome 7 open reading frame 61
chrX_+_14457340 0.522 NM_001118885
NM_001118886
NM_001171942
NM_002063
GLRA2



glycine receptor, alpha 2



chr5_-_168660293 0.522 NM_003062
SLIT3
slit homolog 3 (Drosophila)
chr6_+_149109841 0.521 NM_005715
UST
uronyl-2-sulfotransferase
chr21_+_25933459 0.515 NM_021219
JAM2
junctional adhesion molecule 2
chr1_-_37873077 0.512 NM_001038633
RSPO1
R-spondin homolog (Xenopus laevis)
chrX_+_18353623 0.511 NM_003159
CDKL5
cyclin-dependent kinase-like 5
chrX_+_130019896 0.511 NM_144967
ARHGAP36
Rho GTPase activating protein 36
chrX_+_12795111 0.506 NM_016562
TLR7
toll-like receptor 7
chrX_+_78087484 0.504 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr1_-_207892420 0.498 NM_000228
LAMB3
laminin, beta 3
chr5_+_177473071 0.496 NM_015111
N4BP3
NEDD4 binding protein 3
chr22_-_36212160 0.496 NM_001166343
NM_002405
MFNG

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

chr17_-_31231421 0.496 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr1_-_157003095 0.495 NM_001005185
OR6N1
olfactory receptor, family 6, subfamily N, member 1
chr19_-_4289750 0.487 NM_001013841
NM_017720
STAP2

signal transducing adaptor family member 2

chr1_-_1614005 0.485 SLC35E2B
solute carrier family 35, member E2B
chr15_+_79376295 0.485 NM_004513
IL16
interleukin 16 (lymphocyte chemoattractant factor)
chr13_+_52500830 0.482 NM_006418
OLFM4
olfactomedin 4
chr4_-_174327377 0.482


chr12_+_6926014 0.477 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr19_+_43502301 0.477 NM_004823
KCNK6
potassium channel, subfamily K, member 6
chr1_-_85235210 0.476 NM_153259
MCOLN2
mucolipin 2
chr22_-_35970133 0.476 RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr2_-_235070431 0.474 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chrX_-_111970662 0.472 NM_133265
AMOT
angiomotin
chr1_-_153107084 0.471


chr13_+_23051426 0.470 NM_018647
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr11_+_66580884 0.470 RHOD
ras homolog gene family, member D
chr11_+_66580861 0.468 NM_014578
RHOD
ras homolog gene family, member D
chr4_+_103641762 0.467 NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr1_+_40193424 0.466 MFSD2A
major facilitator superfamily domain containing 2A
chr14_+_102313566 0.465 NM_003300
NM_145725
NM_145726
TRAF3


TNF receptor-associated factor 3


chr8_+_73612179 0.459 NM_004770
KCNB2
potassium voltage-gated channel, Shab-related subfamily, member 2
chr17_+_26742903 0.458 RAB11FIP4
RAB11 family interacting protein 4 (class II)
chr1_-_164402700 0.458 FAM78B
family with sequence similarity 78, member B
chr11_+_65740789 0.457 PACS1
phosphofurin acidic cluster sorting protein 1
chr19_+_17723285 0.457 NM_001161359
NM_015122
FCHO1

FCH domain only 1

chr3_-_58175437 0.452 NM_004944
DNASE1L3
deoxyribonuclease I-like 3
chr1_-_207891264 0.451 NM_001017402
LAMB3
laminin, beta 3
chr1_-_200396354 0.450 NM_002832
PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr17_+_60563917 0.450 NM_001081955
NM_001165933
NM_003835
RGS9


regulator of G-protein signaling 9


chr2_+_95055155 0.447 NM_002371
NM_022438
NM_022439
NM_022440
MAL



mal, T-cell differentiation protein



chr15_+_71131877 0.446 NM_001172623
NM_001172624
NM_002499
NEO1


neogenin 1


chr10_-_134940315 0.446 NM_001109
NM_001164489
NM_001164490
ADAM8


ADAM metallopeptidase domain 8


chr5_-_149772563 0.445 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr19_-_4133495 0.439 NM_001193285
NM_016539
SIRT6

sirtuin 6

chr15_+_74139325 0.436 NM_152335
C15orf27
chromosome 15 open reading frame 27
chrX_+_103243762 0.431 NM_001143978
ZCCHC18
zinc finger, CCHC domain containing 18
chr1_-_164402575 0.428 NM_001017961
FAM78B
family with sequence similarity 78, member B
chr7_+_68702516 0.428 AUTS2
autism susceptibility candidate 2
chr11_-_57092332 0.425 UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr9_-_131555111 0.425 NM_004878
PTGES
prostaglandin E synthase
chr6_+_106640881 0.424 NM_001198
PRDM1
PR domain containing 1, with ZNF domain
chr2_+_68815416 0.423 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr19_+_43502591 0.423 KCNK6
potassium channel, subfamily K, member 6
chr17_-_59172852 0.423 STRADA
STE20-related kinase adaptor alpha
chr12_-_56447090 0.422 NM_000785
CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr4_+_103641854 0.422 NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr14_-_23106779 0.422 AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr1_-_180840016 0.421 NM_002928
RGS16
regulator of G-protein signaling 16
chr17_+_69974116 0.420 NM_007261
CD300A
CD300a molecule
chr10_-_105427898 0.419 SH3PXD2A
SH3 and PX domains 2A
chr8_-_11096257 0.419 NM_173683
XKR6
XK, Kell blood group complex subunit-related family, member 6
chr19_-_44427446 0.418 NM_172139
IL28B
interleukin 28B (interferon, lambda 3)
chr17_-_36451189 0.418 NM_030967
KRTAP1-3
KRTAP1-1
keratin associated protein 1-3
keratin associated protein 1-1
chr17_+_60563963 0.411 RGS9
regulator of G-protein signaling 9
chr6_+_31648071 0.409 NM_000595
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr17_+_43328514 0.409 NM_003110
SP2
Sp2 transcription factor
chr7_-_44985202 0.409 NM_033054
MYO1G
myosin IG
chr4_+_103641511 0.408 NM_001165412
NM_003998
NFKB1

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

chr14_+_102313585 0.404 TRAF3
TNF receptor-associated factor 3
chr11_-_57092028 0.398 NM_198183
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr1_-_27834210 0.398 NM_005248
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr2_+_228386800 0.397 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr13_+_44813479 0.397 LOC100190939
hypothetical LOC100190939
chr19_+_2427122 0.396 NM_015675
GADD45B
growth arrest and DNA-damage-inducible, beta
chr1_+_152644471 0.394 IL6R
interleukin 6 receptor
chr19_-_11549441 0.394 ACP5
acid phosphatase 5, tartrate resistant
chr14_-_64040072 0.388 NM_006977
ZBTB25
zinc finger and BTB domain containing 25
chr19_+_1018536 0.387 HMHA1
histocompatibility (minor) HA-1
chr16_+_49288550 0.386 NM_022162
NOD2
nucleotide-binding oligomerization domain containing 2
chr18_+_22060383 0.384 NM_005640
TAF4B
TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
chr6_-_32919751 0.382 NM_148919
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr12_+_129212955 0.381 NM_007197
FZD10
frizzled homolog 10 (Drosophila)
chr16_+_55580910 0.379 NM_032206
NLRC5
NLR family, CARD domain containing 5
chr2_-_74522563 0.377 NM_001015055
RTKN
rhotekin
chr15_-_72804763 0.375 NM_000499
CYP1A1
cytochrome P450, family 1, subfamily A, polypeptide 1
chr5_-_171547844 0.374 STK10
serine/threonine kinase 10
chr9_-_138236775 0.373 NM_178138
LHX3
LIM homeobox 3
chr1_+_152644292 0.371 NM_000565
NM_181359
IL6R

interleukin 6 receptor

chr12_-_51476047 0.371 NM_057088
KRT3
keratin 3
chr3_+_123279439 0.369 NM_006889
CD86
CD86 molecule
chr20_+_29526751 0.369 NM_014012
REM1
RAS (RAD and GEM)-like GTP-binding 1
chr7_+_150376537 0.364 NM_004769
NM_020321
NM_020322
ACCN3


amiloride-sensitive cation channel 3


chr19_-_46551670 0.364 NM_000660
TGFB1
transforming growth factor, beta 1
chr17_+_35728039 0.361 RARA
retinoic acid receptor, alpha
chr17_-_7531456 0.361 NM_000546
NM_001126112
NM_001126113
NM_001126114
TP53



tumor protein p53



chr17_-_23151601 0.360 NM_000625
NOS2
nitric oxide synthase 2, inducible
chr11_+_128266460 0.360 NM_000890
KCNJ5
potassium inwardly-rectifying channel, subfamily J, member 5
chr5_-_171547700 0.357 STK10
serine/threonine kinase 10
chr19_+_54786723 0.356 NM_020719
PRR12
proline rich 12
chr10_-_133645301 0.353 NM_004052
BNIP3
BCL2/adenovirus E1B 19kDa interacting protein 3
chrX_+_28515479 0.353 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr17_+_63713171 0.353


chr6_-_33016561 0.352 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr5_+_169465478 0.351 NM_012188
NM_144769
FOXI1

forkhead box I1

chr19_-_55071645 0.351 AKT1S1
AKT1 substrate 1 (proline-rich)
chr1_-_37872874 0.350 RSPO1
R-spondin homolog (Xenopus laevis)
chr1_-_158182006 0.350 NM_001135050
NM_020789
IGSF9

immunoglobulin superfamily, member 9

chr1_+_159959072 0.345 NM_001002901
FCRLB
Fc receptor-like B
chr14_+_69148066 0.345 KIAA0247
KIAA0247
chr1_-_202730135 0.343 PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr11_-_76800525 0.339 PAK1
p21 protein (Cdc42/Rac)-activated kinase 1
chr14_+_18623364 0.339 NM_001005356
POTEG
POTE ankyrin domain family, member G
chr19_-_6542136 0.338 NM_001252
CD70
CD70 molecule
chr7_-_44985175 0.337 MYO1G
myosin IG
chr20_-_62181231 0.337 NM_005873
RGS19
regulator of G-protein signaling 19
chr5_+_167651063 0.336 NM_001161661
NM_001161662
NM_015238
WWC1


WW and C2 domain containing 1


chr6_-_31246159 0.335 NM_002701
POU5F1
POU5F1B
POU5F1P3
POU class 5 homeobox 1
POU class 5 homeobox 1B
POU class 5 homeobox 1 pseudogene 3
chr17_-_1874927 0.335 NM_178568
RTN4RL1
reticulon 4 receptor-like 1
chr15_+_57517564 0.335 NM_152450
FAM81A
family with sequence similarity 81, member A
chr17_+_35727998 0.335 NM_001145301
NM_001145302
RARA

retinoic acid receptor, alpha

chr17_+_4795128 0.334 NM_001193503
NM_001976
NM_053013
ENO3


enolase 3 (beta, muscle)


chr14_-_23878871 0.332 NM_006871
RIPK3
receptor-interacting serine-threonine kinase 3
chr12_-_108231407 0.332 NM_213596
FOXN4
forkhead box N4
chr5_-_171547925 0.330 NM_005990
STK10
serine/threonine kinase 10
chr6_-_143307976 0.327 NM_006734
HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr16_-_73798539 0.322 NM_001025200
CTRB1
CTRB2
chymotrypsinogen B1
chymotrypsinogen B2
chr7_+_143402207 0.322 NM_001004488
OR2A25
olfactory receptor, family 2, subfamily A, member 25
chr9_+_35739321 0.320 RGP1
RGP1 retrograde golgi transport homolog (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.74 7.32e-07 GO:0006955 immune response
1.53 5.37e-06 GO:0002376 immune system process
1.36 6.88e-06 GO:0048522 positive regulation of cellular process
1.32 3.48e-05 GO:0048518 positive regulation of biological process
1.67 8.57e-05 GO:0002682 regulation of immune system process
1.24 2.54e-04 GO:0023052 signaling
1.25 5.14e-04 GO:0007165 signal transduction
1.35 1.31e-03 GO:0048583 regulation of response to stimulus
2.13 1.40e-03 GO:0051249 regulation of lymphocyte activation
1.40 3.31e-03 GO:0035556 intracellular signal transduction
1.20 4.91e-03 GO:0051716 cellular response to stimulus
1.43 5.83e-03 GO:0010604 positive regulation of macromolecule metabolic process
1.38 5.95e-03 GO:0009966 regulation of signal transduction
1.72 6.22e-03 GO:0002684 positive regulation of immune system process
1.51 7.72e-03 GO:0006952 defense response
2.16 8.56e-03 GO:0045088 regulation of innate immune response
1.14 8.78e-03 GO:0050794 regulation of cellular process
2.17 1.03e-02 GO:0051251 positive regulation of lymphocyte activation
1.97 1.05e-02 GO:0002694 regulation of leukocyte activation
1.15 1.09e-02 GO:0050896 response to stimulus
1.76 1.41e-02 GO:0045087 innate immune response
1.94 1.43e-02 GO:0050865 regulation of cell activation
1.39 2.00e-02 GO:0009893 positive regulation of metabolic process
1.80 2.27e-02 GO:0031347 regulation of defense response
1.33 2.31e-02 GO:0023051 regulation of signaling
2.07 2.42e-02 GO:0002696 positive regulation of leukocyte activation
1.08 2.55e-02 GO:0009987 cellular process
1.12 2.85e-02 GO:0065007 biological regulation
1.26 3.15e-02 GO:0048519 negative regulation of biological process
1.97 3.24e-02 GO:0071345 cellular response to cytokine stimulus
1.12 3.28e-02 GO:0050789 regulation of biological process
2.04 3.68e-02 GO:0050867 positive regulation of cell activation
1.52 3.75e-02 GO:0045595 regulation of cell differentiation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.29 3.24e-02 GO:0032587 ruffle membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.12 4.25e-03 GO:0005515 protein binding
3.51 6.03e-03 GO:0003823 antigen binding