• All motifs sorted by activity significance
• All samples sorted alphabetically
• Mean activities

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
• Download the whole report

Motif ID: NHLH1,2.p2

Z-value: 1.512

---

Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr17_-_36533903	2.837	NM_031854	KRTAP4-12	keratin associated protein 4-12
chr2_+_109112428	1.313	NM_001099289	SH3RF3	SH3 domain containing ring finger 3
chr17_+_36515166	1.297	NM_001146041	KRTAP4-9	keratin associated protein 4-9
chr12_-_74710741	1.201		PHLDA1	pleckstrin homology-like domain, family A, member 1
chr3_-_87122936	1.198	NM_016206	VGLL3	vestigial like 3 (Drosophila)
chr2_-_229844198	1.159	NM_001100818 NM_017933	PID1	phosphotyrosine interaction domain containing 1
chr14_-_88090641	1.128	NM_007039	PTPN21	protein tyrosine phosphatase, non-receptor type 21
chr17_-_36594652	1.089	NM_033060	KRTAP4-1	keratin associated protein 4-1
chr17_+_56832492	1.044		TBX2	T-box 2
chr13_-_35603513	1.025	NM_004734	DCLK1	doublecortin-like kinase 1
chr13_+_113546841	1.017	NM_000820	GAS6	growth arrest-specific 6
chr14_-_59001804	0.987	NM_022571	GPR135	G protein-coupled receptor 135
chr3_-_73756668	0.940	NM_015009	PDZRN3	PDZ domain containing ring finger 3
chr13_+_113546897	0.903		GAS6	growth arrest-specific 6
chr10_+_72642274	0.901	NM_170744	UNC5B	unc-5 homolog B (C. elegans)
chr9_-_130980359	0.900	NM_203434	IER5L	immediate early response 5-like
chr13_-_35603432	0.900		DCLK1	doublecortin-like kinase 1
chr10_+_99463446	0.897	NM_031484	MARVELD1	MARVEL domain containing 1
chr9_-_71476917	0.888	NM_001163	APBA1	amyloid beta (A4) precursor protein-binding, family A, member 1
chr15_+_90738108	0.886	NM_006011	ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr1_+_31658549	0.875	NM_178865	SERINC2	serine incorporator 2
chr3_-_87122958	0.866		VGLL3	vestigial like 3 (Drosophila)
chr6_+_133604203	0.863		EYA4	eyes absent homolog 4 (Drosophila)
chr10_+_99463468	0.859		MARVELD1	MARVEL domain containing 1
chr2_-_220144254	0.858		OBSL1	obscurin-like 1
chr13_+_113546943	0.850		GAS6	growth arrest-specific 6
chr11_+_110916629	0.840		LAYN	layilin
chr8_+_22078622	0.829		BMP1	bone morphogenetic protein 1
chr9_-_21549696	0.815		LOC554202	hypothetical LOC554202
chr12_-_53099277	0.807	NM_002205	ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr12_-_53099203	0.805		ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr22_+_22652248	0.801	NM_000854	GSTT2 GSTT2B	glutathione S-transferase theta 2 glutathione S-transferase theta 2B (gene/pseudogene)
chr2_-_220144427	0.799		OBSL1	obscurin-like 1
chr17_-_36559579	0.798	NM_033188	KRTAP4-5	keratin associated protein 4-5
chr1_-_27212035	0.789		FAM46B	family with sequence similarity 46, member B
chr1_-_59020875	0.785		JUN	jun proto-oncogene
chr12_-_53099269	0.785		ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr11_-_65841077	0.776	NM_020404	CD248	CD248 molecule, endosialin
chr1_+_238321794	0.775	NM_020066	FMN2	formin 2
chr2_-_37752731	0.772	NM_006449	CDC42EP3	CDC42 effector protein (Rho GTPase binding) 3
chr6_-_105691675	0.771		BVES	blood vessel epicardial substance
chr9_-_83493415	0.770	NM_005077	TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr18_-_21185968	0.763		ZNF521	zinc finger protein 521
chr7_+_17304707	0.763	NM_001621	AHR	aryl hydrocarbon receptor
chr8_+_22078817	0.757		BMP1	bone morphogenetic protein 1
chr1_+_77520315	0.755	NM_174858	AK5	adenylate kinase 5
chr16_-_4105703	0.755		ADCY9	adenylate cyclase 9
chr17_+_78630793	0.753	NM_001004431	METRNL	meteorin, glial cell differentiation regulator-like
chr2_+_29191711	0.750	NM_024692	CLIP4	CAP-GLY domain containing linker protein family, member 4
chr8_+_104452877	0.750		CTHRC1	collagen triple helix repeat containing 1
chr13_-_98536640	0.747	NM_001130049 NM_015296	DOCK9	dedicator of cytokinesis 9
chr1_-_33420213	0.733	NM_018207	TRIM62	tripartite motif containing 62
chr11_+_61032847	0.723	NM_001145077	LRRC10B	leucine rich repeat containing 10B
chr1_-_84237316	0.716	NM_024686	TTLL7	tubulin tyrosine ligase-like family, member 7
chr5_-_178704934	0.716		ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif, 2
chr3_-_187025501	0.714	NM_001007225 NM_006548	IGF2BP2	insulin-like growth factor 2 mRNA binding protein 2
chr12_-_29827952	0.710	NM_001193451	TMTC1	transmembrane and tetratricopeptide repeat containing 1
chr2_-_220144511	0.701	NM_001173408 NM_001173431 NM_015311	OBSL1	obscurin-like 1
chr2_-_1727247	0.696		PXDN	peroxidasin homolog (Drosophila)
chr2_-_227371698	0.696	NM_005544	IRS1	insulin receptor substrate 1
chr7_+_55054416	0.690		EGFR	epidermal growth factor receptor
chr12_-_1573591	0.690	NM_152441	FBXL14	F-box and leucine-rich repeat protein 14
chr10_+_17311282	0.685		VIM	vimentin
chr5_+_159276317	0.681	NM_000679	ADRA1B	adrenergic, alpha-1B-, receptor
chr12_+_50342814	0.677	NM_001177984	SCN8A	sodium channel, voltage gated, type VIII, alpha subunit
chr6_-_105691235	0.671	NM_007073	BVES	blood vessel epicardial substance
chr7_+_137182230	0.648
chr1_-_56817717	0.648		PPAP2B	phosphatidic acid phosphatase type 2B
chr11_-_6298284	0.645	NM_145040	PRKCDBP	protein kinase C, delta binding protein
chr21_+_46226072	0.643	NM_001848	COL6A1	collagen, type VI, alpha 1
chr1_-_31154023	0.642	NM_014654	SDC3	syndecan 3
chr1_-_115682374	0.641	NM_002506	NGF	nerve growth factor (beta polypeptide)
chr6_-_119079712	0.632	NM_001042475 NM_206921	C6orf204	chromosome 6 open reading frame 204
chr6_-_46246543	0.629	NM_021572	ENPP5	ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)
chr14_+_22375753	0.622		MMP14	matrix metallopeptidase 14 (membrane-inserted)
chr14_-_59113301	0.615	NM_001164399	C14orf38	chromosome 14 open reading frame 38
chr1_+_116320641	0.613	NM_018420	SLC22A15	solute carrier family 22, member 15
chr19_+_4255590	0.613	NM_024333	FSD1	fibronectin type III and SPRY domain containing 1
chr6_+_129245978	0.608	NM_000426 NM_001079823	LAMA2	laminin, alpha 2
chr12_+_64504835	0.605		HMGA2	high mobility group AT-hook 2
chr1_+_68070573	0.605
chr9_-_35679902	0.598	NM_003289 NM_213674	TPM2	tropomyosin 2 (beta)
chr1_+_216586199	0.592		TGFB2	transforming growth factor, beta 2
chr14_-_59001603	0.587		GPR135	G protein-coupled receptor 135
chrX_-_154341451	0.585	NM_001007523 NM_001007524 NM_012151	F8A2 F8A3 F8A1	coagulation factor VIII-associated (intronic transcript) 2 coagulation factor VIII-associated (intronic transcript) 3 coagulation factor VIII-associated (intronic transcript) 1
chr8_+_104452961	0.575	NM_138455	CTHRC1	collagen triple helix repeat containing 1
chr5_+_129268352	0.573	NM_175856	CHSY3	chondroitin sulfate synthase 3
chr3_-_45162865	0.568		CDCP1	CUB domain containing protein 1
chr10_-_13083576	0.567	NM_031455	CCDC3	coiled-coil domain containing 3
chr5_-_178705036	0.567	NM_014244 NM_021599	ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif, 2
chr6_-_153494076	0.564	NM_012419	RGS17	regulator of G-protein signaling 17
chr3_-_45162901	0.560	NM_022842 NM_178181	CDCP1	CUB domain containing protein 1
chr10_+_17311347	0.559		VIM	vimentin
chr17_+_56832255	0.553		TBX2	T-box 2
chr17_-_19711580	0.551	NM_001142610 NM_014683	ULK2	unc-51-like kinase 2 (C. elegans)
chr11_+_12355600	0.546	NM_018222	PARVA	parvin, alpha
chrX_+_117513899	0.537	NM_144658	DOCK11	dedicator of cytokinesis 11
chr1_+_22909916	0.536	NM_004442 NM_017449	EPHB2	EPH receptor B2
chr7_+_72486044	0.535	NM_003508	FZD9	frizzled homolog 9 (Drosophila)
chr2_+_202607554	0.529	NM_003507	FZD7	frizzled homolog 7 (Drosophila)
chr2_-_19421852	0.529	NM_145260	OSR1	odd-skipped related 1 (Drosophila)
chr10_+_112247614	0.527	NM_004419	DUSP5	dual specificity phosphatase 5
chr10_+_124211353	0.525		HTRA1	HtrA serine peptidase 1
chrX_+_73557809	0.525	NM_006517	SLC16A2	solute carrier family 16, member 2 (monocarboxylic acid transporter 8)
chr13_+_113546912	0.524		GAS6	growth arrest-specific 6
chr1_-_22136263	0.518	NM_005529	HSPG2	heparan sulfate proteoglycan 2
chr5_+_172000793	0.516	NM_001142651	NEURL1B	neuralized homolog 1B (Drosophila)
chr3_-_45162847	0.516		CDCP1	CUB domain containing protein 1
chr2_+_56264627	0.513	NM_001080433	CCDC85A	coiled-coil domain containing 85A
chr4_-_86106567	0.509	NM_014991	WDFY3	WD repeat and FYVE domain containing 3
chr17_+_3486510	0.506	NM_001031681 NM_004937	CTNS	cystinosis, nephropathic
chr2_+_149895274	0.506	NM_194317	LYPD6	LY6/PLAUR domain containing 6
chr9_+_17124974	0.505	NM_001114395 NM_017738	CNTLN	centlein, centrosomal protein
chr10_+_17311283	0.503		VIM	vimentin
chr12_-_45759691	0.502	NM_001143668 NM_181847	AMIGO2	adhesion molecule with Ig-like domain 2
chr9_-_137731139	0.501	NM_001012415 NM_001101677	SOHLH1	spermatogenesis and oogenesis specific basic helix-loop-helix 1
chr4_-_177427252	0.500	NM_080874	ASB5	ankyrin repeat and SOCS box containing 5
chr4_-_81213333	0.499	NM_001145794 NM_058172	ANTXR2	anthrax toxin receptor 2
chr1_-_234096842	0.493	NM_000081	LYST	lysosomal trafficking regulator
chr16_-_3131348	0.491
chr3_-_187025438	0.491		IGF2BP2	insulin-like growth factor 2 mRNA binding protein 2
chr9_-_21999270	0.491	NM_004936 NM_078487	CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
chr10_+_17311242	0.490		VIM	vimentin
chr1_-_48710263	0.486		SPATA6	spermatogenesis associated 6
chr14_+_58174489	0.484	NM_001079520 NM_016651	DACT1	dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)
chr8_-_82186832	0.483	NM_018440	PAG1	phosphoprotein associated with glycosphingolipid microdomains 1
chr10_+_17311307	0.481		VIM	vimentin
chr12_+_51730101	0.480	NM_170754	TENC1	tensin like C1 domain containing phosphatase (tensin 2)
chr4_-_2390050	0.478	NM_001172656 NM_001172657 NM_001172658 NM_020972	ZFYVE28	zinc finger, FYVE domain containing 28
chr1_+_1157485	0.478	NM_080605	B3GALT6	UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6
chr7_-_130891861	0.476	NM_001018111 NM_005397	PODXL	podocalyxin-like
chr13_-_25523164	0.476	NM_001007538	SHISA2	shisa homolog 2 (Xenopus laevis)
chr9_+_89530793	0.473	NM_001912 NM_145918	CTSL1	cathepsin L1
chr1_+_116320698	0.471		SLC22A15	solute carrier family 22, member 15
chrX_+_49013243	0.470	NM_001184745 NM_033215	PPP1R3F	protein phosphatase 1, regulatory (inhibitor) subunit 3F
chr11_+_12987455	0.469	NM_001080521	RASSF10	Ras association (RalGDS/AF-6) domain family (N-terminal) member 10
chr10_-_80875097	0.468	NM_153367	ZCCHC24	zinc finger, CCHC domain containing 24
chr16_-_30929217	0.465	NM_052874	STX1B	syntaxin 1B
chr12_-_74711474	0.463		PHLDA1	pleckstrin homology-like domain, family A, member 1
chr5_+_176493752	0.461		NSD1	nuclear receptor binding SET domain protein 1
chr7_-_137182125	0.460	NM_004717	DGKI	diacylglycerol kinase, iota
chr13_-_35603466	0.459		DCLK1	doublecortin-like kinase 1
chr19_+_43502301	0.458	NM_004823	KCNK6	potassium channel, subfamily K, member 6
chr11_+_46255737	0.458	NM_052854	CREB3L1	cAMP responsive element binding protein 3-like 1
chr4_-_957269	0.457		DGKQ	diacylglycerol kinase, theta 110kDa
chr7_-_45927263	0.457	NM_000598 NM_001013398	IGFBP3	insulin-like growth factor binding protein 3
chr14_-_51605461	0.455		NID2	nidogen 2 (osteonidogen)
chr18_-_53621277	0.454	NM_005603	ATP8B1	ATPase, aminophospholipid transporter, class I, type 8B, member 1
chr21_+_45318861	0.454	NM_001112 NM_001160230 NM_015833 NM_015834	ADARB1	adenosine deaminase, RNA-specific, B1
chr6_-_75972473	0.450		COL12A1	collagen, type XII, alpha 1
chr13_+_31318828	0.449		EEF1DP3	eukaryotic translation elongation factor 1 delta pseudogene 3
chr9_+_89530838	0.447		CTSL1	cathepsin L1
chr11_+_46256161	0.444		CREB3L1	cAMP responsive element binding protein 3-like 1
chr6_-_18230829	0.444	NM_198586	NHLRC1	NHL repeat containing 1
chr2_+_238060602	0.443	NM_001042467 NM_024101	MLPH	melanophilin
chr18_+_32131628	0.443	NM_025135	FHOD3	formin homology 2 domain containing 3
chr14_-_51605487	0.442		NID2	nidogen 2 (osteonidogen)
chr10_-_48058981	0.441	NM_004962	GDF10	growth differentiation factor 10
chr8_+_22078589	0.441	NM_001199 NM_006129	BMP1	bone morphogenetic protein 1
chr10_+_93160066	0.438	NM_173497 NM_182765	HECTD2	HECT domain containing 2
chr14_-_29466562	0.438	NM_002742	PRKD1	protein kinase D1
chr3_+_30623376	0.438		TGFBR2	transforming growth factor, beta receptor II (70/80kDa)
chr11_+_124539814	0.436		PKNOX2	PBX/knotted 1 homeobox 2
chr17_-_24973940	0.435		CORO6	coronin 6
chr3_-_51971915	0.435	NM_033010	PCBP4	poly(rC) binding protein 4
chr6_-_75972286	0.432	NM_004370 NM_080645	COL12A1	collagen, type XII, alpha 1
chr6_-_82518576	0.432		FAM46A	family with sequence similarity 46, member A
chr13_-_76358370	0.430		KCTD12	potassium channel tetramerisation domain containing 12
chr2_-_1727220	0.428		PXDN	peroxidasin homolog (Drosophila)
chr12_-_74711642	0.426	NM_007350	PHLDA1	pleckstrin homology-like domain, family A, member 1
chrX_-_106846253	0.421	NM_001015881	TSC22D3	TSC22 domain family, member 3
chr7_+_129919157	0.421	NM_002402	MEST	mesoderm specific transcript homolog (mouse)
chr5_+_92946348	0.420		NR2F1	nuclear receptor subfamily 2, group F, member 1
chr19_+_10597167	0.420	NM_020428	SLC44A2	solute carrier family 44, member 2
chr1_-_158091296	0.420		C1orf204	chromosome 1 open reading frame 204
chr5_-_58370693	0.419	NM_001197221 NM_001197222	PDE4D	phosphodiesterase 4D, cAMP-specific
chr7_+_129919330	0.418		MEST	mesoderm specific transcript homolog (mouse)
chr4_-_140696740	0.416	NM_030648	SETD7	SET domain containing (lysine methyltransferase) 7
chr10_-_27026559	0.415
chr17_+_36642240	0.414	NM_031962	KRTAP9-9 KRTAP9-3	keratin associated protein 9-9 keratin associated protein 9-3
chr7_-_100009205	0.413	NM_001168682	SAP25	sin3A-binding protein 25
chr1_-_39877928	0.412	NM_014571	HEYL	hairy/enhancer-of-split related with YRPW motif-like
chr13_-_43259032	0.411	NM_017993	ENOX1	ecto-NOX disulfide-thiol exchanger 1
chr19_+_43446937	0.411	NM_001166103 NM_021102	SPINT2	serine peptidase inhibitor, Kunitz type, 2
chr11_-_129803515	0.411		ADAMTS8	ADAM metallopeptidase with thrombospondin type 1 motif, 8
chr16_+_27320983	0.410	NM_181078 NM_181079	IL21R	interleukin 21 receptor
chr6_-_159341180	0.407	NM_031924	RSPH3	radial spoke 3 homolog (Chlamydomonas)
chr4_-_81212737	0.407		ANTXR2	anthrax toxin receptor 2
chr18_-_21186107	0.404	NM_015461	ZNF521	zinc finger protein 521
chr9_-_35679799	0.404		TPM2	tropomyosin 2 (beta)
chr1_-_85703321	0.401	NM_012137	DDAH1	dimethylarginine dimethylaminohydrolase 1
chr5_-_136862317	0.401		SPOCK1	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr16_+_53522611	0.398	NM_005853	IRX5	iroquois homeobox 5
chr11_+_46256130	0.397		CREB3L1	cAMP responsive element binding protein 3-like 1
chr7_+_100037817	0.397	NM_002593	PCOLCE	procollagen C-endopeptidase enhancer
chr19_-_50964336	0.396	NM_175875	SIX5	SIX homeobox 5
chr14_+_22375747	0.396		MMP14	matrix metallopeptidase 14 (membrane-inserted)
chr14_+_49229572	0.394	NM_172193	KLHDC1	kelch domain containing 1
chr17_+_75808685	0.394	NM_001166347 NM_001166348 NM_001166349 NM_173626	SLC26A11	solute carrier family 26, member 11
chr9_-_139060285	0.392		NPDC1	neural proliferation, differentiation and control, 1

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.44	8.79e-08	GO:0048468	cell development
1.33	2.27e-07	GO:0009653	anatomical structure morphogenesis
1.18	3.40e-06	GO:0023052	signaling
1.19	5.66e-06	GO:0007165	signal transduction
1.55	6.39e-06	GO:0000904	cell morphogenesis involved in differentiation
1.48	7.19e-06	GO:0032989	cellular component morphogenesis
1.29	3.12e-05	GO:0007399	nervous system development
1.47	3.62e-05	GO:0000902	cell morphogenesis
1.45	5.26e-05	GO:0007167	enzyme linked receptor protein signaling pathway
1.11	6.09e-05	GO:0050794	regulation of cellular process
1.23	7.32e-05	GO:0048869	cellular developmental process
1.54	7.54e-05	GO:0048812	neuron projection morphogenesis
1.54	7.79e-05	GO:0048667	cell morphogenesis involved in neuron differentiation
1.23	1.10e-04	GO:0030154	cell differentiation
1.26	1.33e-04	GO:0023051	regulation of signaling
1.50	1.43e-04	GO:0048858	cell projection morphogenesis
1.36	1.87e-04	GO:0022008	neurogenesis
1.50	1.96e-04	GO:0031175	neuron projection development
1.22	2.02e-04	GO:0048523	negative regulation of cellular process
1.48	2.68e-04	GO:0032990	cell part morphogenesis
1.19	2.80e-04	GO:0048731	system development
1.53	2.90e-04	GO:0007409	axonogenesis
1.18	3.32e-04	GO:0048856	anatomical structure development
1.27	4.90e-04	GO:0009966	regulation of signal transduction
1.16	6.08e-04	GO:0007275	multicellular organismal development
1.35	6.55e-04	GO:0048699	generation of neurons
1.41	9.43e-04	GO:0030030	cell projection organization
1.59	1.04e-03	GO:0022603	regulation of anatomical structure morphogenesis
1.37	1.06e-03	GO:2000026	regulation of multicellular organismal development
1.35	1.40e-03	GO:0051128	regulation of cellular component organization
1.15	1.69e-03	GO:0032502	developmental process
1.09	1.73e-03	GO:0050789	regulation of biological process
1.14	3.05e-03	GO:0051716	cellular response to stimulus
1.19	4.07e-03	GO:0048519	negative regulation of biological process
1.22	4.14e-03	GO:0007166	cell surface receptor linked signaling pathway
1.29	4.39e-03	GO:0010646	regulation of cell communication
1.08	4.81e-03	GO:0065007	biological regulation
1.40	5.04e-03	GO:0048666	neuron development
1.43	5.59e-03	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
1.52	7.96e-03	GO:0007411	axon guidance
1.48	1.34e-02	GO:0090066	regulation of anatomical structure size
1.24	2.39e-02	GO:0051239	regulation of multicellular organismal process
1.49	2.62e-02	GO:0032535	regulation of cellular component size
1.33	3.60e-02	GO:0030182	neuron differentiation
1.29	4.03e-02	GO:0050793	regulation of developmental process

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.10	3.22e-07	GO:0005737	cytoplasm
1.75	2.06e-03	GO:0005912	adherens junction
1.36	3.15e-03	GO:0030054	cell junction
1.63	8.28e-03	GO:0031252	cell leading edge
1.05	1.14e-02	GO:0044424	intracellular part
1.16	1.52e-02	GO:0044459	plasma membrane part
1.64	1.67e-02	GO:0070161	anchoring junction
1.04	2.74e-02	GO:0005622	intracellular
1.38	3.89e-02	GO:0045202	synapse
1.40	4.21e-02	GO:0031012	extracellular matrix
1.08	4.97e-02	GO:0044444	cytoplasmic part

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.10	1.09e-05	GO:0005515	protein binding
1.49	5.14e-03	GO:0003779	actin binding