Motif ID: NHLH1,2.p2

Z-value: 1.512


Transcription factors associated with NHLH1,2.p2:

Gene SymbolEntrez IDGene Name
NHLH1 4807 nescient helix loop helix 1
NHLH2 4808 nescient helix loop helix 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NHLH2chr1_+_116181927-0.107.2e-01Click!
NHLH1chr1_+_158603480-0.001.0e+00Click!


Activity profile for motif NHLH1,2.p2.

activity profile for motif NHLH1,2.p2


Sorted Z-values histogram for motif NHLH1,2.p2

Sorted Z-values for motif NHLH1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NHLH1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_36533903 2.837 NM_031854
KRTAP4-12
keratin associated protein 4-12
chr2_+_109112428 1.313 NM_001099289
SH3RF3
SH3 domain containing ring finger 3
chr17_+_36515166 1.297 NM_001146041
KRTAP4-9
keratin associated protein 4-9
chr12_-_74710741 1.201 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr3_-_87122936 1.198 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr2_-_229844198 1.159 NM_001100818
NM_017933
PID1

phosphotyrosine interaction domain containing 1

chr14_-_88090641 1.128 NM_007039
PTPN21
protein tyrosine phosphatase, non-receptor type 21
chr17_-_36594652 1.089 NM_033060
KRTAP4-1
keratin associated protein 4-1
chr17_+_56832492 1.044 TBX2
T-box 2
chr13_-_35603513 1.025 NM_004734
DCLK1
doublecortin-like kinase 1
chr13_+_113546841 1.017 NM_000820
GAS6
growth arrest-specific 6
chr14_-_59001804 0.987 NM_022571
GPR135
G protein-coupled receptor 135
chr3_-_73756668 0.940 NM_015009
PDZRN3
PDZ domain containing ring finger 3
chr13_+_113546897 0.903 GAS6
growth arrest-specific 6
chr10_+_72642274 0.901 NM_170744
UNC5B
unc-5 homolog B (C. elegans)
chr9_-_130980359 0.900 NM_203434
IER5L
immediate early response 5-like
chr13_-_35603432 0.900 DCLK1
doublecortin-like kinase 1
chr10_+_99463446 0.897 NM_031484
MARVELD1
MARVEL domain containing 1
chr9_-_71476917 0.888 NM_001163
APBA1
amyloid beta (A4) precursor protein-binding, family A, member 1
chr15_+_90738108 0.886 NM_006011
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 45 entries
enrichment   p-value GO term description
1.59 1.04e-03 GO:0022603 regulation of anatomical structure morphogenesis
1.55 6.39e-06 GO:0000904 cell morphogenesis involved in differentiation
1.54 7.54e-05 GO:0048812 neuron projection morphogenesis
1.54 7.79e-05 GO:0048667 cell morphogenesis involved in neuron differentiation
1.53 2.90e-04 GO:0007409 axonogenesis
1.52 7.96e-03 GO:0007411 axon guidance
1.50 1.43e-04 GO:0048858 cell projection morphogenesis
1.50 1.96e-04 GO:0031175 neuron projection development
1.49 2.62e-02 GO:0032535 regulation of cellular component size
1.48 7.19e-06 GO:0032989 cellular component morphogenesis
1.48 2.68e-04 GO:0032990 cell part morphogenesis
1.48 1.34e-02 GO:0090066 regulation of anatomical structure size
1.47 3.62e-05 GO:0000902 cell morphogenesis
1.45 5.26e-05 GO:0007167 enzyme linked receptor protein signaling pathway
1.44 8.79e-08 GO:0048468 cell development
1.43 5.59e-03 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.41 9.43e-04 GO:0030030 cell projection organization
1.40 5.04e-03 GO:0048666 neuron development
1.37 1.06e-03 GO:2000026 regulation of multicellular organismal development
1.36 1.87e-04 GO:0022008 neurogenesis

Gene overrepresentation in compartment category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
1.75 2.06e-03 GO:0005912 adherens junction
1.64 1.67e-02 GO:0070161 anchoring junction
1.63 8.28e-03 GO:0031252 cell leading edge
1.40 4.21e-02 GO:0031012 extracellular matrix
1.38 3.89e-02 GO:0045202 synapse
1.36 3.15e-03 GO:0030054 cell junction
1.16 1.52e-02 GO:0044459 plasma membrane part
1.10 3.22e-07 GO:0005737 cytoplasm
1.08 4.97e-02 GO:0044444 cytoplasmic part
1.05 1.14e-02 GO:0044424 intracellular part
1.04 2.74e-02 GO:0005622 intracellular

Gene overrepresentation in function category:

Showing 1 to 2 of 2 entries
enrichment   p-value GO term description
1.49 5.14e-03 GO:0003779 actin binding
1.10 1.09e-05 GO:0005515 protein binding