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Motif ID: NKX2-1,4.p2

Z-value: 0.715

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr17_+_7846636	0.645	NM_000180	GUCY2D	guanylate cyclase 2D, membrane (retina-specific)
chr3_+_190831909	0.490	NM_001114978 NM_001114979 NM_003722	TP63	tumor protein p63
chr1_+_180836050	0.474
chr8_-_7308438	0.467	NM_016512 NM_058200 NM_058201 NM_058202 NM_058203	SPAG11B SPAG11A	sperm associated antigen 11B sperm associated antigen 11A
chr2_-_160764819	0.466	NM_000888	ITGB6	integrin, beta 6
chr11_+_34599227	0.427		EHF	ets homologous factor
chr1_+_31814712	0.411		TINAGL1	tubulointerstitial nephritis antigen-like 1
chr1_+_226462363	0.382	NM_001098623 NM_052843	OBSCN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
chr16_+_11966464	0.377	NM_001192	TNFRSF17	tumor necrosis factor receptor superfamily, member 17
chr11_+_34599163	0.372	NM_012153	EHF	ets homologous factor
chr7_+_129720209	0.343	NM_001163446 NM_016352	CPA4	carboxypeptidase A4
chr1_+_31814709	0.338		TINAGL1	tubulointerstitial nephritis antigen-like 1
chr12_-_46883341	0.319	NM_001004134	OR10AD1	olfactory receptor, family 10, subfamily AD, member 1
chr1_-_207891264	0.282	NM_001017402	LAMB3	laminin, beta 3
chrX_+_78087484	0.258	NM_014499 NM_198333	P2RY10	purinergic receptor P2Y, G-protein coupled, 10
chr6_+_132901119	0.256	NM_175057	TAAR9	trace amine associated receptor 9 (gene/pseudogene)
chr1_-_238842071	0.249	NM_022469	GREM2	gremlin 2
chr8_+_9990471	0.240	NM_001135671	MSRA	methionine sulfoxide reductase A
chr5_-_22248630	0.240		CDH12	cadherin 12, type 2 (N-cadherin 2)
chr2_-_37727472	0.240		CDC42EP3	CDC42 effector protein (Rho GTPase binding) 3
chr3_-_74652952	0.237	NM_020872	CNTN3	contactin 3 (plasmacytoma associated)
chr2_+_178893216	0.234	NM_145739	OSBPL6	oxysterol binding protein-like 6
chr12_-_51173238	0.231	NM_005554	KRT6A	keratin 6A
chr22_-_27787793	0.224	NM_015370	C22orf31	chromosome 22 open reading frame 31
chr10_-_108448990	0.219		SORCS1	sortilin-related VPS10 domain containing receptor 1
chr19_+_42689881	0.218		ZNF793	zinc finger protein 793
chr15_+_38437703	0.213	NM_033510	DISP2	dispatched homolog 2 (Drosophila)
chr17_+_20048890	0.211		SPECC1	sperm antigen with calponin homology and coiled-coil domains 1
chr4_+_22303645	0.207	NM_001128432 NM_020973	GBA3	glucosidase, beta, acid 3 (cytosolic)
chr1_+_150749943	0.205	NM_178438	LCE5A	late cornified envelope 5A
chr1_+_31814672	0.202	NM_022164	TINAGL1	tubulointerstitial nephritis antigen-like 1
chr14_+_38772870	0.201	NM_054024	MIA2	melanoma inhibitory activity 2
chr8_+_124263932	0.201	NM_032899 NM_207006	FAM83A	family with sequence similarity 83, member A
chr3_+_191588354	0.199	NM_006580	CLDN16	claudin 16
chr6_+_83129641	0.196	NM_006670	TPBG	trophoblast glycoprotein
chr14_-_19553191	0.195	NM_001004712	OR4K14	olfactory receptor, family 4, subfamily K, member 14
chr19_+_16691786	0.194	NM_001007525	NWD1	NACHT and WD repeat domain containing 1
chr12_-_53064565	0.192		ZNF385A	zinc finger protein 385A
chr8_+_124264054	0.191		FAM83A	family with sequence similarity 83, member A
chr11_-_119499188	0.188		TRIM29	tripartite motif containing 29
chr12_-_7739591	0.181	NM_020634	GDF3	growth differentiation factor 3
chr12_-_53064723	0.176	NM_015481	ZNF385A	zinc finger protein 385A
chr11_-_102331643	0.176	NM_002427	MMP13	matrix metallopeptidase 13 (collagenase 3)
chr14_-_64359565	0.175	NM_000347 NM_001024858	SPTB	spectrin, beta, erythrocytic
chr9_+_6231677	0.175	NM_033439	IL33	interleukin 33
chr11_+_117452936	0.172	NM_001083947 NM_001173551 NM_001173552 NM_019894	TMPRSS4	transmembrane protease, serine 4
chr9_-_21472311	0.171	NM_176891	IFNE	interferon, epsilon
chr2_+_1397186	0.166	NM_175721 NM_175722	TPO	thyroid peroxidase
chr5_+_139485703	0.157	NM_001007189	C5orf53	chromosome 5 open reading frame 53
chr2_-_160765008	0.154		ITGB6	integrin, beta 6
chr17_+_69875140	0.148	NM_181790	GPR142	G protein-coupled receptor 142
chr10_+_24538094	0.146		KIAA1217	KIAA1217
chr5_+_147423727	0.146	NM_001127698 NM_001127699 NM_006846	SPINK5	serine peptidase inhibitor, Kazal type 5
chr4_+_111053488	0.144	NM_001178130 NM_001178131 NM_001963	EGF	epidermal growth factor
chr14_-_20694023	0.144	NM_001004731	OR5AU1	olfactory receptor, family 5, subfamily AU, member 1
chr19_+_8702315	0.142	NM_001004699	OR2Z1	olfactory receptor, family 2, subfamily Z, member 1
chr11_+_118259684	0.142	NM_001716	CXCR5	chemokine (C-X-C motif) receptor 5
chr2_-_166359016	0.140	NM_004482	GALNT3	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr10_-_123343320	0.136	NM_001144913 NM_001144914	FGFR2	fibroblast growth factor receptor 2
chrX_+_48427103	0.133	NM_000377	WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr2_+_28469864	0.132		FOSL2	FOS-like antigen 2
chr11_-_6600385	0.130		DCHS1	dachsous 1 (Drosophila)
chr7_+_129634935	0.129	NM_145268	C7orf45	chromosome 7 open reading frame 45
chr17_-_51155073	0.129	NM_018286	TMEM100	transmembrane protein 100
chr16_-_69876262	0.125		FTSJD1	FtsJ methyltransferase domain containing 1
chr8_+_7742811	0.121	NM_058203 NM_001081552	SPAG11B SPAG11A	sperm associated antigen 11B sperm associated antigen 11A
chr1_-_13325242	0.121	NM_001099854	PRAMEF14	PRAME family member 14
chr18_-_26876622	0.120	NM_001941 NM_024423	DSC3	desmocollin 3
chrX_-_110542040	0.119	NM_178151 NM_001195553 NM_178152 NM_178153	DCX	doublecortin
chr1_+_156590109	0.115	NM_001042583 NM_001042584 NM_001042585 NM_001042586 NM_001042587 NM_001185107 NM_001185108 NM_001185110 NM_001185112 NM_001185113 NM_001185114 NM_001185115 NM_030893	CD1E	CD1e molecule
chr3_-_127810087	0.115	NM_001039783	TXNRD3IT1	thioredoxin reductase 3 intronic transcript 1
chr19_-_60458915	0.115		PPP6R1	protein phosphatase 6, regulatory subunit 1
chr16_+_74901235	0.114	NM_138994	CNTNAP4	contactin associated protein-like 4
chr2_+_28469850	0.113		FOSL2	FOS-like antigen 2
chr4_-_68793928	0.110	NM_182502	TMPRSS11B	transmembrane protease, serine 11B
chr17_+_71235324	0.109		ITGB4	integrin, beta 4
chr11_+_55776251	0.108	NM_001004747	OR5T3	olfactory receptor, family 5, subfamily T, member 3
chr5_+_140215778	0.108	NM_018901 NM_031859 NM_031860	PCDHA10	protocadherin alpha 10
chr20_+_4650499	0.107	NM_012409	PRND	prion protein 2 (dublet)
chrX_-_138617994	0.106	NM_001099855 NM_001171876	MCF2	MCF.2 cell line derived transforming sequence
chr3_+_98641143	0.106	NM_173655	EPHA6	EPH receptor A6
chr2_-_133256097	0.106		NCKAP5	NCK-associated protein 5
chr19_-_15906669	0.106	NM_001128932 NM_021187	CYP4F11	cytochrome P450, family 4, subfamily F, polypeptide 11
chr2_+_28469199	0.104		FOSL2	FOS-like antigen 2
chr7_-_16471817	0.103	NM_015464	SOSTDC1	sclerostin domain containing 1
chr15_+_92700167	0.103	NM_001159644	MCTP2	multiple C2 domains, transmembrane 2
chr8_+_74369647	0.103	NM_172037	RDH10	retinol dehydrogenase 10 (all-trans)
chr4_-_123761615	0.101	NM_021803	IL21	interleukin 21
chr1_+_24522116	0.101	NM_021180	GRHL3	grainyhead-like 3 (Drosophila)
chr19_-_53950458	0.101	NM_000148	FUT1	fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr11_-_123799976	0.100	NM_001005196	OR8B4	olfactory receptor, family 8, subfamily B, member 4
chr14_+_63752424	0.098	NM_182910	SYNE2	spectrin repeat containing, nuclear envelope 2
chr11_-_4675524	0.096	NM_030774	OR51E2	olfactory receptor, family 51, subfamily E, member 2
chr17_-_53961709	0.096	NM_004574	SEPT4	septin 4
chr2_+_1396239	0.095	NM_000547 NM_175719	TPO	thyroid peroxidase
chr1_-_47179729	0.094	NM_000778	CYP4A11 CYP4A22	cytochrome P450, family 4, subfamily A, polypeptide 11 cytochrome P450, family 4, subfamily A, polypeptide 22
chr6_+_43373986	0.093		SLC22A7	solute carrier family 22 (organic anion transporter), member 7
chr1_-_158948176	0.093	NM_001778	CD48	CD48 molecule
chrX_+_128966844	0.092	NM_021946	BCORL1	BCL6 corepressor-like 1
chr15_+_79304694	0.091	NM_172217	IL16	interleukin 16 (lymphocyte chemoattractant factor)
chr9_-_111230926	0.091	NM_001145371 NM_001145372	PTPN3	protein tyrosine phosphatase, non-receptor type 3
chr1_-_151852128	0.091	NM_080388	S100A16	S100 calcium binding protein A16
chr6_-_136829705	0.090	NM_001198615	MAP7	microtubule-associated protein 7
chr1_-_240679380	0.088	NM_001195811 NM_001195812	PLD5	phospholipase D family, member 5
chr6_-_31196174	0.088	NM_001264	CDSN	corneodesmosin
chr6_+_35373632	0.088		DEF6	differentially expressed in FDCP 6 homolog (mouse)
chr17_-_64649608	0.087	NM_080284	ABCA6	ATP-binding cassette, sub-family A (ABC1), member 6
chr5_-_150663519	0.086	NM_001145017 NM_181774	SLC36A3	solute carrier family 36 (proton/amino acid symporter), member 3
chr10_-_123343761	0.084	NM_001144916	FGFR2	fibroblast growth factor receptor 2
chr17_-_53761119	0.082	NM_004758 NM_024418	BZRAP1	benzodiazapine receptor (peripheral) associated protein 1
chr5_+_131424245	0.081	NM_000588	IL3	interleukin 3 (colony-stimulating factor, multiple)
chr8_-_110726921	0.080	NM_001099751 NM_001099752	SYBU	syntabulin (syntaxin-interacting)
chr4_-_123596921	0.080	NM_000586	IL2	interleukin 2
chr8_+_67201684	0.080	NM_033058 NM_184085 NM_184086 NM_184087	TRIM55	tripartite motif containing 55
chr5_-_134810696	0.080	NM_130848	C5orf20	chromosome 5 open reading frame 20
chr6_-_136889436	0.079	NM_001198614 NM_001198618 NM_001198619	MAP7	microtubule-associated protein 7
chr1_+_43508251	0.079	NM_144626	TMEM125	transmembrane protein 125
chr9_+_108726257	0.078		ZNF462	zinc finger protein 462
chr20_+_43784401	0.078	NM_178455	SPINT4	serine peptidase inhibitor, Kunitz type 4
chr6_-_11887265	0.077	NM_001143948 NM_032744	C6orf105	chromosome 6 open reading frame 105
chr5_+_125786975	0.077		GRAMD3	GRAM domain containing 3
chr11_-_16380967	0.076	NM_001145819 NM_017508	SOX6	SRY (sex determining region Y)-box 6
chr12_+_8866416	0.075	NM_144670	A2ML1	alpha-2-macroglobulin-like 1
chr10_+_24537725	0.075	NM_001098501 NM_019590	KIAA1217	KIAA1217
chr3_+_46386636	0.075	NM_000579 NM_001100168	CCR5	chemokine (C-C motif) receptor 5
chr19_+_45797413	0.074		LTBP4	latent transforming growth factor beta binding protein 4
chr2_-_242205556	0.074	NM_001164356	THAP4	THAP domain containing 4
chr15_+_72253077	0.074	NM_005545	ISLR	immunoglobulin superfamily containing leucine-rich repeat
chr17_-_3408038	0.074	NM_145068	TRPV3	transient receptor potential cation channel, subfamily V, member 3
chr5_-_39306465	0.073		FYB	FYN binding protein
chr11_-_128279670	0.073		C11orf45	chromosome 11 open reading frame 45
chr12_-_10853940	0.073	NM_023917	TAS2R9	taste receptor, type 2, member 9
chr1_-_148175383	0.073	NM_001145862	MTMR11	myotubularin related protein 11
chr19_-_45132372	0.071	NM_003890	FCGBP	Fc fragment of IgG binding protein
chr6_-_116488458	0.071	NM_002031	FRK	fyn-related kinase
chr5_+_145297490	0.071		SH3RF2	SH3 domain containing ring finger 2
chr14_-_75517198	0.071		TGFB3	transforming growth factor, beta 3
chr17_-_3407780	0.070		TRPV3	transient receptor potential cation channel, subfamily V, member 3
chr19_+_46312176	0.070	NM_000774	CYP2F1	cytochrome P450, family 2, subfamily F, polypeptide 1
chr4_-_102487506	0.070		PPP3CA	protein phosphatase 3, catalytic subunit, alpha isozyme
chrX_+_21960841	0.070	NM_000444	PHEX	phosphate regulating endopeptidase homolog, X-linked
chr1_-_201586910	0.070	NM_002023	FMOD	fibromodulin
chrX_+_144716619	0.069	NM_004709	CXorf1	chromosome X open reading frame 1
chr18_-_42490993	0.069	NM_144612	LOXHD1	lipoxygenase homology domains 1
chr4_-_24590867	0.069	NM_173463	CCDC149	coiled-coil domain containing 149
chr6_-_136889302	0.069		MAP7	microtubule-associated protein 7
chr11_-_89181390	0.069	NM_020358	TRIM49	tripartite motif containing 49
chr8_-_82536312	0.068	NM_001080526	FABP9	fatty acid binding protein 9, testis
chr20_+_2224612	0.068	NM_003245	TGM3	transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
chrX_-_84250629	0.067	NM_001012980	SATL1	spermidine/spermine N1-acetyl transferase-like 1
chrX_-_72351381	0.067		NAP1L2	nucleosome assembly protein 1-like 2
chr6_-_76838944	0.067	NM_001563	IMPG1	interphotoreceptor matrix proteoglycan 1
chr11_-_7906784	0.067	NM_001004461	OR10A6	olfactory receptor, family 10, subfamily A, member 6
chrX_-_72351392	0.066	NM_021963	NAP1L2	nucleosome assembly protein 1-like 2
chrX_+_69371229	0.066	NM_001013579	AWAT1	acyl-CoA wax alcohol acyltransferase 1
chr1_-_43168247	0.065		SLC2A1	solute carrier family 2 (facilitated glucose transporter), member 1
chr20_+_51023159	0.064		TSHZ2	teashirt zinc finger homeobox 2
chr1_-_156937065	0.063	NM_001005279	OR6K2	olfactory receptor, family 6, subfamily K, member 2
chr6_+_101953389	0.063		GRIK2	glutamate receptor, ionotropic, kainate 2
chr7_-_115458047	0.063		TFEC	transcription factor EC
chr10_-_49152918	0.063	NM_001018071	FRMPD2	FERM and PDZ domain containing 2
chr15_+_30721161	0.063	NM_001144757 NM_003020	SCG5	secretogranin V (7B2 protein)
chr16_-_79811475	0.062	NM_001076780 NM_052892	PKD1L2	polycystic kidney disease 1-like 2
chr10_-_91092410	0.062		LIPA	lipase A, lysosomal acid, cholesterol esterase
chr13_-_102144854	0.062	NM_001010977	METTL21C	methyltransferase like 21C
chr6_+_30212488	0.062	NM_138700	TRIM40	tripartite motif containing 40
chr5_-_156468614	0.061	NM_032782	HAVCR2	hepatitis A virus cellular receptor 2
chr4_-_77547481	0.061	NM_001042784	CCDC158	coiled-coil domain containing 158
chrX_+_48427137	0.060		WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr5_+_76284435	0.060	NM_001882	CRHBP	corticotropin releasing hormone binding protein
chr3_+_187840842	0.060	NM_014375	FETUB	fetuin B
chr17_-_53961533	0.060		SEPT4	septin 4
chr3_-_121445831	0.060	NM_001168271 NM_153002	GPR156	G protein-coupled receptor 156
chr18_-_27594696	0.060	NM_001034172	MCART2	mitochondrial carrier triple repeat 2
chr13_+_48178620	0.059	NM_020377	CYSLTR2	cysteinyl leukotriene receptor 2
chr4_-_77147625	0.058	NM_002416	CXCL9	chemokine (C-X-C motif) ligand 9
chr9_-_76692829	0.058	NM_017662	TRPM6	transient receptor potential cation channel, subfamily M, member 6
chr3_+_188397967	0.056	NM_153708	RTP1	receptor (chemosensory) transporter protein 1
chr12_+_48737753	0.056	NM_001095 NM_020039	ACCN2	amiloride-sensitive cation channel 2, neuronal
chr1_-_201321711	0.056		MYOG	myogenin (myogenic factor 4)
chr5_-_88004891	0.056		LOC645323	hypothetical LOC645323
chr20_-_1298493	0.055		FKBP1A	FK506 binding protein 1A, 12kDa
chrX_-_108611940	0.055	NM_001522	GUCY2F	guanylate cyclase 2F, retinal
chr2_-_37752272	0.055		CDC42EP3	CDC42 effector protein (Rho GTPase binding) 3
chr15_-_72287447	0.055	NM_001199041	STRA6	stimulated by retinoic acid gene 6 homolog (mouse)
chr9_-_94284571	0.054	NM_001193335 NM_017680	ASPN	asporin
chr3_-_109958723	0.054	NM_032579	RETNLB	resistin like beta
chr7_-_99170651	0.053	NM_000765	CYP3A7	cytochrome P450, family 3, subfamily A, polypeptide 7
chrX_-_48101044	0.052	NM_021014 NM_175711	SSX3	synovial sarcoma, X breakpoint 3
chr12_-_94914133	0.052	NM_002108	HAL	histidine ammonia-lyase
chr3_+_63403792	0.052	NM_144642	SYNPR	synaptoporin
chr10_-_80990147	0.052	NM_001098668	SFTPA1 SFTPA2	surfactant protein A1 surfactant protein A2
chr2_+_36777336	0.051	NM_001177969 NM_001177970 NM_001177971 NM_001177972 NM_053276	VIT	vitrin
chrX_-_137649180	0.051	NM_033642	FGF13	fibroblast growth factor 13
chr7_-_104696678	0.051	NM_182691	SRPK2	SRSF protein kinase 2
chr1_-_12929992	0.050	NM_001010889	PRAMEF9 PRAMEF6	PRAME family member 9 PRAME family member 6
chr1_-_158883666	0.050	NM_003037	SLAMF1	signaling lymphocytic activation molecule family member 1
chr1_+_89602023	0.050	NM_198460	GBP6	guanylate binding protein family, member 6
chr13_+_77007809	0.050	NM_001160706 NM_003843 NM_144777	SCEL	sciellin
chr19_-_51979838	0.050	NM_001145145	SLC1A5	solute carrier family 1 (neutral amino acid transporter), member 5

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
2.94	5.17e-05	GO:0001775	cell activation
3.71	3.98e-04	GO:0045321	leukocyte activation
1.39	1.50e-03	GO:0032501	multicellular organismal process
3.74	4.96e-03	GO:0046649	lymphocyte activation
1.31	1.82e-02	GO:0050896	response to stimulus

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.81	7.12e-06	GO:0005576	extracellular region
2.21	1.20e-05	GO:0044421	extracellular region part
1.45	1.59e-04	GO:0071944	cell periphery
1.45	2.01e-04	GO:0005886	plasma membrane
2.16	9.85e-04	GO:0005615	extracellular space
1.26	1.57e-02	GO:0044425	membrane part
2.48	2.13e-02	GO:0031012	extracellular matrix
1.28	4.15e-02	GO:0031224	intrinsic to membrane
2.53	4.75e-02	GO:0005578	proteinaceous extracellular matrix

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.82	1.81e-04	GO:0004872	receptor activity
1.68	8.04e-04	GO:0004871	signal transducer activity
1.68	8.04e-04	GO:0060089	molecular transducer activity
1.88	1.71e-03	GO:0004888	transmembrane receptor activity
2.07	4.19e-03	GO:0004930	G-protein coupled receptor activity