Motif ID: NKX2-1,4.p2

Z-value: 0.715


Transcription factors associated with NKX2-1,4.p2:

Gene SymbolEntrez IDGene Name
NKX2-1 7080 NK2 homeobox 1
NKX2-4 644524 NK2 homeobox 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-4chr20_-_213260460.273.2e-01Click!
NKX2-1chr14_-_360586480.243.7e-01Click!


Activity profile for motif NKX2-1,4.p2.

activity profile for motif NKX2-1,4.p2


Sorted Z-values histogram for motif NKX2-1,4.p2

Sorted Z-values for motif NKX2-1,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-1,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_7846636 0.645 NM_000180
GUCY2D
guanylate cyclase 2D, membrane (retina-specific)
chr3_+_190831909 0.490 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chr1_+_180836050 0.474


chr8_-_7308438 0.467 NM_016512
NM_058200
NM_058201
NM_058202
NM_058203
SPAG11B




SPAG11A
sperm associated antigen 11B




sperm associated antigen 11A
chr2_-_160764819 0.466 NM_000888
ITGB6
integrin, beta 6
chr11_+_34599227 0.427 EHF
ets homologous factor
chr1_+_31814712 0.411 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr1_+_226462363 0.382 NM_001098623
NM_052843
OBSCN

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

chr16_+_11966464 0.377 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr11_+_34599163 0.372 NM_012153
EHF
ets homologous factor
chr7_+_129720209 0.343 NM_001163446
NM_016352
CPA4

carboxypeptidase A4

chr1_+_31814709 0.338 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr12_-_46883341 0.319 NM_001004134
OR10AD1
olfactory receptor, family 10, subfamily AD, member 1
chr1_-_207891264 0.282 NM_001017402
LAMB3
laminin, beta 3
chrX_+_78087484 0.258 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr6_+_132901119 0.256 NM_175057
TAAR9
trace amine associated receptor 9 (gene/pseudogene)
chr1_-_238842071 0.249 NM_022469
GREM2
gremlin 2
chr8_+_9990471 0.240 NM_001135671
MSRA
methionine sulfoxide reductase A
chr5_-_22248630 0.240 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr2_-_37727472 0.240 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr3_-_74652952 0.237 NM_020872
CNTN3
contactin 3 (plasmacytoma associated)
chr2_+_178893216 0.234 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr12_-_51173238 0.231 NM_005554
KRT6A
keratin 6A
chr22_-_27787793 0.224 NM_015370
C22orf31
chromosome 22 open reading frame 31
chr10_-_108448990 0.219 SORCS1
sortilin-related VPS10 domain containing receptor 1
chr19_+_42689881 0.218 ZNF793
zinc finger protein 793
chr15_+_38437703 0.213 NM_033510
DISP2
dispatched homolog 2 (Drosophila)
chr17_+_20048890 0.211 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr4_+_22303645 0.207 NM_001128432
NM_020973
GBA3

glucosidase, beta, acid 3 (cytosolic)

chr1_+_150749943 0.205 NM_178438
LCE5A
late cornified envelope 5A
chr1_+_31814672 0.202 NM_022164
TINAGL1
tubulointerstitial nephritis antigen-like 1
chr14_+_38772870 0.201 NM_054024
MIA2
melanoma inhibitory activity 2
chr8_+_124263932 0.201 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chr3_+_191588354 0.199 NM_006580
CLDN16
claudin 16
chr6_+_83129641 0.196 NM_006670
TPBG
trophoblast glycoprotein
chr14_-_19553191 0.195 NM_001004712
OR4K14
olfactory receptor, family 4, subfamily K, member 14
chr19_+_16691786 0.194 NM_001007525
NWD1
NACHT and WD repeat domain containing 1
chr12_-_53064565 0.192 ZNF385A
zinc finger protein 385A
chr8_+_124264054 0.191 FAM83A
family with sequence similarity 83, member A
chr11_-_119499188 0.188 TRIM29
tripartite motif containing 29
chr12_-_7739591 0.181 NM_020634
GDF3
growth differentiation factor 3
chr12_-_53064723 0.176 NM_015481
ZNF385A
zinc finger protein 385A
chr11_-_102331643 0.176 NM_002427
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr14_-_64359565 0.175 NM_000347
NM_001024858
SPTB

spectrin, beta, erythrocytic

chr9_+_6231677 0.175 NM_033439
IL33
interleukin 33
chr11_+_117452936 0.172 NM_001083947
NM_001173551
NM_001173552
NM_019894
TMPRSS4



transmembrane protease, serine 4



chr9_-_21472311 0.171 NM_176891
IFNE
interferon, epsilon
chr2_+_1397186 0.166 NM_175721
NM_175722
TPO

thyroid peroxidase

chr5_+_139485703 0.157 NM_001007189
C5orf53
chromosome 5 open reading frame 53
chr2_-_160765008 0.154 ITGB6
integrin, beta 6
chr17_+_69875140 0.148 NM_181790
GPR142
G protein-coupled receptor 142
chr10_+_24538094 0.146 KIAA1217
KIAA1217
chr5_+_147423727 0.146 NM_001127698
NM_001127699
NM_006846
SPINK5


serine peptidase inhibitor, Kazal type 5


chr4_+_111053488 0.144 NM_001178130
NM_001178131
NM_001963
EGF


epidermal growth factor


chr14_-_20694023 0.144 NM_001004731
OR5AU1
olfactory receptor, family 5, subfamily AU, member 1
chr19_+_8702315 0.142 NM_001004699
OR2Z1
olfactory receptor, family 2, subfamily Z, member 1
chr11_+_118259684 0.142 NM_001716
CXCR5
chemokine (C-X-C motif) receptor 5
chr2_-_166359016 0.140 NM_004482
GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr10_-_123343320 0.136 NM_001144913
NM_001144914
FGFR2

fibroblast growth factor receptor 2

chrX_+_48427103 0.133 NM_000377
WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr2_+_28469864 0.132 FOSL2
FOS-like antigen 2
chr11_-_6600385 0.130 DCHS1
dachsous 1 (Drosophila)
chr7_+_129634935 0.129 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr17_-_51155073 0.129 NM_018286
TMEM100
transmembrane protein 100
chr16_-_69876262 0.125 FTSJD1
FtsJ methyltransferase domain containing 1
chr8_+_7742811 0.121 NM_058203
NM_001081552
SPAG11B
SPAG11A
sperm associated antigen 11B
sperm associated antigen 11A
chr1_-_13325242 0.121 NM_001099854
PRAMEF14
PRAME family member 14
chr18_-_26876622 0.120 NM_001941
NM_024423
DSC3

desmocollin 3

chrX_-_110542040 0.119 NM_178151
NM_001195553
NM_178152
NM_178153
DCX



doublecortin



chr1_+_156590109 0.115 NM_001042583
NM_001042584
NM_001042585
NM_001042586
NM_001042587
NM_001185107
NM_001185108
NM_001185110
NM_001185112
NM_001185113
NM_001185114
NM_001185115
NM_030893
CD1E












CD1e molecule












chr3_-_127810087 0.115 NM_001039783
TXNRD3IT1
thioredoxin reductase 3 intronic transcript 1
chr19_-_60458915 0.115 PPP6R1
protein phosphatase 6, regulatory subunit 1
chr16_+_74901235 0.114 NM_138994
CNTNAP4
contactin associated protein-like 4
chr2_+_28469850 0.113 FOSL2
FOS-like antigen 2
chr4_-_68793928 0.110 NM_182502
TMPRSS11B
transmembrane protease, serine 11B
chr17_+_71235324 0.109 ITGB4
integrin, beta 4
chr11_+_55776251 0.108 NM_001004747
OR5T3
olfactory receptor, family 5, subfamily T, member 3
chr5_+_140215778 0.108 NM_018901
NM_031859
NM_031860
PCDHA10


protocadherin alpha 10


chr20_+_4650499 0.107 NM_012409
PRND
prion protein 2 (dublet)
chrX_-_138617994 0.106 NM_001099855
NM_001171876
MCF2

MCF.2 cell line derived transforming sequence

chr3_+_98641143 0.106 NM_173655
EPHA6
EPH receptor A6
chr2_-_133256097 0.106 NCKAP5
NCK-associated protein 5
chr19_-_15906669 0.106 NM_001128932
NM_021187
CYP4F11

cytochrome P450, family 4, subfamily F, polypeptide 11

chr2_+_28469199 0.104 FOSL2
FOS-like antigen 2
chr7_-_16471817 0.103 NM_015464
SOSTDC1
sclerostin domain containing 1
chr15_+_92700167 0.103 NM_001159644
MCTP2
multiple C2 domains, transmembrane 2
chr8_+_74369647 0.103 NM_172037
RDH10
retinol dehydrogenase 10 (all-trans)
chr4_-_123761615 0.101 NM_021803
IL21
interleukin 21
chr1_+_24522116 0.101 NM_021180
GRHL3
grainyhead-like 3 (Drosophila)
chr19_-_53950458 0.101 NM_000148
FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr11_-_123799976 0.100 NM_001005196
OR8B4
olfactory receptor, family 8, subfamily B, member 4
chr14_+_63752424 0.098 NM_182910
SYNE2
spectrin repeat containing, nuclear envelope 2
chr11_-_4675524 0.096 NM_030774
OR51E2
olfactory receptor, family 51, subfamily E, member 2
chr17_-_53961709 0.096 NM_004574
SEPT4
septin 4
chr2_+_1396239 0.095 NM_000547
NM_175719
TPO

thyroid peroxidase

chr1_-_47179729 0.094 NM_000778
CYP4A11
CYP4A22
cytochrome P450, family 4, subfamily A, polypeptide 11
cytochrome P450, family 4, subfamily A, polypeptide 22
chr6_+_43373986 0.093 SLC22A7
solute carrier family 22 (organic anion transporter), member 7
chr1_-_158948176 0.093 NM_001778
CD48
CD48 molecule
chrX_+_128966844 0.092 NM_021946
BCORL1
BCL6 corepressor-like 1
chr15_+_79304694 0.091 NM_172217
IL16
interleukin 16 (lymphocyte chemoattractant factor)
chr9_-_111230926 0.091 NM_001145371
NM_001145372
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr1_-_151852128 0.091 NM_080388
S100A16
S100 calcium binding protein A16
chr6_-_136829705 0.090 NM_001198615
MAP7
microtubule-associated protein 7
chr1_-_240679380 0.088 NM_001195811
NM_001195812
PLD5

phospholipase D family, member 5

chr6_-_31196174 0.088 NM_001264
CDSN
corneodesmosin
chr6_+_35373632 0.088 DEF6
differentially expressed in FDCP 6 homolog (mouse)
chr17_-_64649608 0.087 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr5_-_150663519 0.086 NM_001145017
NM_181774
SLC36A3

solute carrier family 36 (proton/amino acid symporter), member 3

chr10_-_123343761 0.084 NM_001144916
FGFR2
fibroblast growth factor receptor 2
chr17_-_53761119 0.082 NM_004758
NM_024418
BZRAP1

benzodiazapine receptor (peripheral) associated protein 1

chr5_+_131424245 0.081 NM_000588
IL3
interleukin 3 (colony-stimulating factor, multiple)
chr8_-_110726921 0.080 NM_001099751
NM_001099752
SYBU

syntabulin (syntaxin-interacting)

chr4_-_123596921 0.080 NM_000586
IL2
interleukin 2
chr8_+_67201684 0.080 NM_033058
NM_184085
NM_184086
NM_184087
TRIM55



tripartite motif containing 55



chr5_-_134810696 0.080 NM_130848
C5orf20
chromosome 5 open reading frame 20
chr6_-_136889436 0.079 NM_001198614
NM_001198618
NM_001198619
MAP7


microtubule-associated protein 7


chr1_+_43508251 0.079 NM_144626
TMEM125
transmembrane protein 125
chr9_+_108726257 0.078 ZNF462
zinc finger protein 462
chr20_+_43784401 0.078 NM_178455
SPINT4
serine peptidase inhibitor, Kunitz type 4
chr6_-_11887265 0.077 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr5_+_125786975 0.077 GRAMD3
GRAM domain containing 3
chr11_-_16380967 0.076 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr12_+_8866416 0.075 NM_144670
A2ML1
alpha-2-macroglobulin-like 1
chr10_+_24537725 0.075 NM_001098501
NM_019590
KIAA1217

KIAA1217

chr3_+_46386636 0.075 NM_000579
NM_001100168
CCR5

chemokine (C-C motif) receptor 5

chr19_+_45797413 0.074 LTBP4
latent transforming growth factor beta binding protein 4
chr2_-_242205556 0.074 NM_001164356
THAP4
THAP domain containing 4
chr15_+_72253077 0.074 NM_005545
ISLR
immunoglobulin superfamily containing leucine-rich repeat
chr17_-_3408038 0.074 NM_145068
TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr5_-_39306465 0.073 FYB
FYN binding protein
chr11_-_128279670 0.073 C11orf45
chromosome 11 open reading frame 45
chr12_-_10853940 0.073 NM_023917
TAS2R9
taste receptor, type 2, member 9
chr1_-_148175383 0.073 NM_001145862
MTMR11
myotubularin related protein 11
chr19_-_45132372 0.071 NM_003890
FCGBP
Fc fragment of IgG binding protein
chr6_-_116488458 0.071 NM_002031
FRK
fyn-related kinase
chr5_+_145297490 0.071 SH3RF2
SH3 domain containing ring finger 2
chr14_-_75517198 0.071 TGFB3
transforming growth factor, beta 3
chr17_-_3407780 0.070 TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr19_+_46312176 0.070 NM_000774
CYP2F1
cytochrome P450, family 2, subfamily F, polypeptide 1
chr4_-_102487506 0.070 PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chrX_+_21960841 0.070 NM_000444
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr1_-_201586910 0.070 NM_002023
FMOD
fibromodulin
chrX_+_144716619 0.069 NM_004709
CXorf1
chromosome X open reading frame 1
chr18_-_42490993 0.069 NM_144612
LOXHD1
lipoxygenase homology domains 1
chr4_-_24590867 0.069 NM_173463
CCDC149
coiled-coil domain containing 149
chr6_-_136889302 0.069 MAP7
microtubule-associated protein 7
chr11_-_89181390 0.069 NM_020358
TRIM49
tripartite motif containing 49
chr8_-_82536312 0.068 NM_001080526
FABP9
fatty acid binding protein 9, testis
chr20_+_2224612 0.068 NM_003245
TGM3
transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
chrX_-_84250629 0.067 NM_001012980
SATL1
spermidine/spermine N1-acetyl transferase-like 1
chrX_-_72351381 0.067 NAP1L2
nucleosome assembly protein 1-like 2
chr6_-_76838944 0.067 NM_001563
IMPG1
interphotoreceptor matrix proteoglycan 1
chr11_-_7906784 0.067 NM_001004461
OR10A6
olfactory receptor, family 10, subfamily A, member 6
chrX_-_72351392 0.066 NM_021963
NAP1L2
nucleosome assembly protein 1-like 2
chrX_+_69371229 0.066 NM_001013579
AWAT1
acyl-CoA wax alcohol acyltransferase 1
chr1_-_43168247 0.065 SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
chr20_+_51023159 0.064 TSHZ2
teashirt zinc finger homeobox 2
chr1_-_156937065 0.063 NM_001005279
OR6K2
olfactory receptor, family 6, subfamily K, member 2
chr6_+_101953389 0.063 GRIK2
glutamate receptor, ionotropic, kainate 2
chr7_-_115458047 0.063 TFEC
transcription factor EC
chr10_-_49152918 0.063 NM_001018071
FRMPD2
FERM and PDZ domain containing 2
chr15_+_30721161 0.063 NM_001144757
NM_003020
SCG5

secretogranin V (7B2 protein)

chr16_-_79811475 0.062 NM_001076780
NM_052892
PKD1L2

polycystic kidney disease 1-like 2

chr10_-_91092410 0.062 LIPA
lipase A, lysosomal acid, cholesterol esterase
chr13_-_102144854 0.062 NM_001010977
METTL21C
methyltransferase like 21C
chr6_+_30212488 0.062 NM_138700
TRIM40
tripartite motif containing 40
chr5_-_156468614 0.061 NM_032782
HAVCR2
hepatitis A virus cellular receptor 2
chr4_-_77547481 0.061 NM_001042784
CCDC158
coiled-coil domain containing 158
chrX_+_48427137 0.060 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr5_+_76284435 0.060 NM_001882
CRHBP
corticotropin releasing hormone binding protein
chr3_+_187840842 0.060 NM_014375
FETUB
fetuin B
chr17_-_53961533 0.060 SEPT4
septin 4
chr3_-_121445831 0.060 NM_001168271
NM_153002
GPR156

G protein-coupled receptor 156

chr18_-_27594696 0.060 NM_001034172
MCART2
mitochondrial carrier triple repeat 2
chr13_+_48178620 0.059 NM_020377
CYSLTR2
cysteinyl leukotriene receptor 2
chr4_-_77147625 0.058 NM_002416
CXCL9
chemokine (C-X-C motif) ligand 9
chr9_-_76692829 0.058 NM_017662
TRPM6
transient receptor potential cation channel, subfamily M, member 6
chr3_+_188397967 0.056 NM_153708
RTP1
receptor (chemosensory) transporter protein 1
chr12_+_48737753 0.056 NM_001095
NM_020039
ACCN2

amiloride-sensitive cation channel 2, neuronal

chr1_-_201321711 0.056 MYOG
myogenin (myogenic factor 4)
chr5_-_88004891 0.056 LOC645323
hypothetical LOC645323
chr20_-_1298493 0.055 FKBP1A
FK506 binding protein 1A, 12kDa
chrX_-_108611940 0.055 NM_001522
GUCY2F
guanylate cyclase 2F, retinal
chr2_-_37752272 0.055 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr15_-_72287447 0.055 NM_001199041
STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr9_-_94284571 0.054 NM_001193335
NM_017680
ASPN

asporin

chr3_-_109958723 0.054 NM_032579
RETNLB
resistin like beta
chr7_-_99170651 0.053 NM_000765
CYP3A7
cytochrome P450, family 3, subfamily A, polypeptide 7
chrX_-_48101044 0.052 NM_021014
NM_175711
SSX3

synovial sarcoma, X breakpoint 3

chr12_-_94914133 0.052 NM_002108
HAL
histidine ammonia-lyase
chr3_+_63403792 0.052 NM_144642
SYNPR
synaptoporin
chr10_-_80990147 0.052 NM_001098668
SFTPA1
SFTPA2
surfactant protein A1
surfactant protein A2
chr2_+_36777336 0.051 NM_001177969
NM_001177970
NM_001177971
NM_001177972
NM_053276
VIT




vitrin




chrX_-_137649180 0.051 NM_033642
FGF13
fibroblast growth factor 13
chr7_-_104696678 0.051 NM_182691
SRPK2
SRSF protein kinase 2
chr1_-_12929992 0.050 NM_001010889
PRAMEF9
PRAMEF6
PRAME family member 9
PRAME family member 6
chr1_-_158883666 0.050 NM_003037
SLAMF1
signaling lymphocytic activation molecule family member 1
chr1_+_89602023 0.050 NM_198460
GBP6
guanylate binding protein family, member 6
chr13_+_77007809 0.050 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr19_-_51979838 0.050 NM_001145145
SLC1A5
solute carrier family 1 (neutral amino acid transporter), member 5

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.94 5.17e-05 GO:0001775 cell activation
3.71 3.98e-04 GO:0045321 leukocyte activation
1.39 1.50e-03 GO:0032501 multicellular organismal process
3.74 4.96e-03 GO:0046649 lymphocyte activation
1.31 1.82e-02 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.81 7.12e-06 GO:0005576 extracellular region
2.21 1.20e-05 GO:0044421 extracellular region part
1.45 1.59e-04 GO:0071944 cell periphery
1.45 2.01e-04 GO:0005886 plasma membrane
2.16 9.85e-04 GO:0005615 extracellular space
1.26 1.57e-02 GO:0044425 membrane part
2.48 2.13e-02 GO:0031012 extracellular matrix
1.28 4.15e-02 GO:0031224 intrinsic to membrane
2.53 4.75e-02 GO:0005578 proteinaceous extracellular matrix

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.82 1.81e-04 GO:0004872 receptor activity
1.68 8.04e-04 GO:0004871 signal transducer activity
1.68 8.04e-04 GO:0060089 molecular transducer activity
1.88 1.71e-03 GO:0004888 transmembrane receptor activity
2.07 4.19e-03 GO:0004930 G-protein coupled receptor activity