Motif ID: NKX2-1,4.p2

Z-value: 0.715


Transcription factors associated with NKX2-1,4.p2:

Gene SymbolEntrez IDGene Name
NKX2-1 7080 NK2 homeobox 1
NKX2-4 644524 NK2 homeobox 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-4chr20_-_213260460.273.2e-01Click!
NKX2-1chr14_-_360586480.243.7e-01Click!


Activity profile for motif NKX2-1,4.p2.

activity profile for motif NKX2-1,4.p2


Sorted Z-values histogram for motif NKX2-1,4.p2

Sorted Z-values for motif NKX2-1,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-1,4.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_7846636 0.645 NM_000180
 GUCY2D
guanylate cyclase 2D, membrane (retina-specific)
chr3_+_190831909 0.490 NM_001114978
NM_001114979
NM_003722
 TP63


tumor protein p63


chr1_+_180836050 0.474


chr8_-_7308438 0.467 NM_016512
NM_058200
NM_058201
NM_058202
NM_058203
 SPAG11B




SPAG11A
sperm associated antigen 11B




sperm associated antigen 11A
chr2_-_160764819 0.466 NM_000888
 ITGB6
integrin, beta 6
chr11_+_34599227 0.427 EHF
ets homologous factor
chr1_+_31814712 0.411 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr1_+_226462363 0.382 NM_001098623
NM_052843
 OBSCN

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

chr16_+_11966464 0.377 NM_001192
 TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr11_+_34599163 0.372 NM_012153
 EHF
ets homologous factor
chr7_+_129720209 0.343 NM_001163446
NM_016352
 CPA4

carboxypeptidase A4

chr1_+_31814709 0.338 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr12_-_46883341 0.319 NM_001004134
 OR10AD1
olfactory receptor, family 10, subfamily AD, member 1
chr1_-_207891264 0.282 NM_001017402
 LAMB3
laminin, beta 3
chrX_+_78087484 0.258 NM_014499
NM_198333
 P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr6_+_132901119 0.256 NM_175057
 TAAR9
trace amine associated receptor 9 (gene/pseudogene)
chr1_-_238842071 0.249 NM_022469
 GREM2
gremlin 2
chr8_+_9990471 0.240 NM_001135671
 MSRA
methionine sulfoxide reductase A
chr5_-_22248630 0.240 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr2_-_37727472 0.240 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 5 of 5 entries
enrichment   p-value GO term description
3.74 4.96e-03 GO:0046649 lymphocyte activation
3.71 3.98e-04 GO:0045321 leukocyte activation
2.94 5.17e-05 GO:0001775 cell activation
1.39 1.50e-03 GO:0032501 multicellular organismal process
1.31 1.82e-02 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
2.53 4.75e-02 GO:0005578 proteinaceous extracellular matrix
2.48 2.13e-02 GO:0031012 extracellular matrix
2.21 1.20e-05 GO:0044421 extracellular region part
2.16 9.85e-04 GO:0005615 extracellular space
1.81 7.12e-06 GO:0005576 extracellular region
1.45 1.59e-04 GO:0071944 cell periphery
1.45 2.01e-04 GO:0005886 plasma membrane
1.28 4.15e-02 GO:0031224 intrinsic to membrane
1.26 1.57e-02 GO:0044425 membrane part

Gene overrepresentation in function category:

Showing 1 to 5 of 5 entries
enrichment   p-value GO term description
2.07 4.19e-03 GO:0004930 G-protein coupled receptor activity
1.88 1.71e-03 GO:0004888 transmembrane receptor activity
1.82 1.81e-04 GO:0004872 receptor activity
1.68 8.04e-04 GO:0004871 signal transducer activity
1.68 8.04e-04 GO:0060089 molecular transducer activity