Motif ID: NKX2-2,8.p2

Z-value: 0.561


Transcription factors associated with NKX2-2,8.p2:

Gene SymbolEntrez IDGene Name
NKX2-2 4821 NK2 homeobox 2
NKX2-8 26257 NK2 homeobox 8

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-8chr14_-_36121536-0.702.8e-03Click!
NKX2-2chr20_-_21442663-0.591.7e-02Click!


Activity profile for motif NKX2-2,8.p2.

activity profile for motif NKX2-2,8.p2


Sorted Z-values histogram for motif NKX2-2,8.p2

Sorted Z-values for motif NKX2-2,8.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-2,8.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_88021644 1.789 ZNF292
zinc finger protein 292
chr3_-_15814678 1.464 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr2_+_228064531 1.378 AGFG1
ArfGAP with FG repeats 1
chr12_-_101115677 1.292 NM_002674
PMCH
pro-melanin-concentrating hormone
chr3_-_153541468 1.275 NM_001123228
TMEM14E
transmembrane protein 14E
chr2_-_225078931 1.228 CUL3
cullin 3
chr1_+_144198658 1.228 LIX1L
Lix1 homolog (mouse)-like
chr10_-_98326435 1.197 TM9SF3
transmembrane 9 superfamily member 3
chr11_+_65023038 1.187 MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr7_+_111879348 1.159 NM_001197079
IFRD1
interferon-related developmental regulator 1
chrX_+_108665665 1.091 NM_018698
NXT2
nuclear transport factor 2-like export factor 2
chr4_-_83566045 1.057


chr13_-_40454188 1.016 ELF1
E74-like factor 1 (ets domain transcription factor)
chr15_+_22778233 0.988 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr2_+_183290912 0.972 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr9_+_122923864 0.951 CEP110
centrosomal protein 110kDa
chr3_+_160473729 0.933 NM_001197107
NM_001197108
NM_014575
SCHIP1


schwannomin interacting protein 1


chr18_+_17607633 0.922 MIB1
mindbomb homolog 1 (Drosophila)
chr6_+_142552320 0.911 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr7_-_122130201 0.910 NM_198085
RNF148
ring finger protein 148
chr11_-_11331411 0.908 CSNK2A1P
casein kinase 2, alpha 1 polypeptide pseudogene
chr1_-_195436258 0.860 NM_194314
ZBTB41
zinc finger and BTB domain containing 41
chrX_+_11687655 0.853 NM_006800
MSL3
male-specific lethal 3 homolog (Drosophila)
chr6_-_138862273 0.847


chr9_-_99001551 0.837 NM_199005
ZNF322B
ZNF322A
zinc finger protein 322B
zinc finger protein 322A
chr5_-_160044844 0.834 ATP10B
ATPase, class V, type 10B
chr13_+_100902942 0.829 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr3_-_102194938 0.810 NM_015429
ABI3BP
ABI family, member 3 (NESH) binding protein
chr3_+_153499883 0.805 NM_207293
NM_207294
NM_207295
NM_207296
NM_207297
MBNL1




muscleblind-like (Drosophila)




chr7_-_107667728 0.796 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr5_+_128468785 0.786 ISOC1
isochorismatase domain containing 1
chr4_-_140280031 0.763 NM_201999
ELF2
E74-like factor 2 (ets domain transcription factor)
chr1_-_115060956 0.759 NM_002524
NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr2_-_151052391 0.754 NM_005168
RND3
Rho family GTPase 3
chr5_+_159781454 0.748 PTTG1
pituitary tumor-transforming 1
chr17_+_55098280 0.737 CLTC
clathrin, heavy chain (Hc)
chr1_-_115060857 0.730 NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr3_-_44464722 0.729


chr10_+_112334066 0.725 SMC3
structural maintenance of chromosomes 3
chr6_-_152744143 0.723 SYNE1
spectrin repeat containing, nuclear envelope 1
chr12_-_88573949 0.711 NM_001001323
NM_001682
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chr12_-_9913199 0.706 CLEC2B
C-type lectin domain family 2, member B
chr3_-_71262426 0.702 FOXP1
forkhead box P1
chr15_-_53350383 0.696 NM_183236
RAB27A
RAB27A, member RAS oncogene family
chr10_+_124660206 0.694 NM_001029888
FAM24A
family with sequence similarity 24, member A
chr2_-_225086564 0.693 CUL3
cullin 3
chr1_-_115060904 0.692 NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr4_+_95595419 0.692 PDLIM5
PDZ and LIM domain 5
chr14_-_74669864 0.685 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr4_-_279943 0.685 NM_001137608
ZNF732
zinc finger protein 732
chr12_+_63090008 0.680 XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr5_+_159781413 0.678 NM_004219
PTTG1
pituitary tumor-transforming 1
chr5_+_162862808 0.663 NM_182796
MAT2B
methionine adenosyltransferase II, beta
chr1_+_169747788 0.662 PRRC2C
proline-rich coiled-coil 2C
chrX_-_44287032 0.659 NM_173794
FUNDC1
FUN14 domain containing 1
chr1_-_242073094 0.658 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chr1_-_118123033 0.655


chr2_-_20375497 0.653 PUM2
pumilio homolog 2 (Drosophila)
chr2_-_192419896 0.651 SDPR
serum deprivation response
chr2_-_61566477 0.651 XPO1
exportin 1 (CRM1 homolog, yeast)
chr6_-_99957253 0.650 SFRS18
splicing factor, arginine/serine-rich 18
chr1_-_74971679 0.649 NM_001130042
NM_001130043
NM_001134759
NM_001889
CRYZ



crystallin, zeta (quinone reductase)



chr5_-_96544639 0.648 RIOK2
RIO kinase 2 (yeast)
chr14_-_19871267 0.647 NM_021178
NM_182849
CCNB1IP1

cyclin B1 interacting protein 1, E3 ubiquitin protein ligase

chr11_+_65027721 0.643


chrX_-_118610880 0.631 NM_001173488
NKRF
NFKB repressing factor
chr19_-_16103996 0.631


chr12_-_11230809 0.630 NM_181429
TAS2R42
taste receptor, type 2, member 42
chr18_+_31488530 0.620 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr8_+_17874128 0.619 PCM1
pericentriolar material 1
chr21_+_34112456 0.618 ITSN1
intersectin 1 (SH3 domain protein)
chr3_+_88270951 0.613 NM_018293
ZNF654
zinc finger protein 654
chr17_-_26648375 0.612 NM_002544
OMG
oligodendrocyte myelin glycoprotein
chr3_-_56673113 0.611 NM_015224
C3orf63
chromosome 3 open reading frame 63
chr19_-_57100052 0.611 NM_023074
ZNF649
zinc finger protein 649
chr12_+_21481804 0.609 NM_024854
PYROXD1
pyridine nucleotide-disulphide oxidoreductase domain 1
chr13_-_106018445 0.609 NM_018011
ARGLU1
arginine and glutamate rich 1
chr14_-_81069865 0.608 SEL1L
sel-1 suppressor of lin-12-like (C. elegans)
chr5_+_54491702 0.604 NM_001008397
GPX8
glutathione peroxidase 8 (putative)
chr1_-_56750235 0.604 PPAP2B
phosphatidic acid phosphatase type 2B
chr8_+_17866373 0.602 PCM1
pericentriolar material 1
chr5_-_95044415 0.599 NM_031952
SPATA9
spermatogenesis associated 9
chr12_-_85756766 0.599 NM_013244
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr9_-_14076901 0.599 NFIB
nuclear factor I/B
chr5_-_98290117 0.594 NM_001270
CHD1
chromodomain helicase DNA binding protein 1
chrX_-_19898302 0.593 NM_198279
CXorf23
chromosome X open reading frame 23
chr18_-_29273979 0.592 NM_001105528
C18orf34
chromosome 18 open reading frame 34
chr1_-_197173159 0.591 LOC100131234
familial acute myelogenous leukemia related factor
chr6_-_76027286 0.589 TMEM30A
transmembrane protein 30A
chr4_+_86918870 0.585 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr16_+_54158084 0.581 NM_032330
CAPNS2
calpain, small subunit 2
chr1_+_213245507 0.577 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chr11_-_47467094 0.576 NM_001025596
NM_001172640
CELF1

CUGBP, Elav-like family member 1

chr5_-_43550891 0.575 NM_198566
C5orf34
chromosome 5 open reading frame 34
chr15_-_58477407 0.564 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chr12_+_84792203 0.564 NM_006183
NTS
neurotensin
chrX_-_55225668 0.561 NM_001190708
MTRNR2L10
MT-RNR2-like 10
chr14_+_95915774 0.556 NM_016472
C14orf129
chromosome 14 open reading frame 129
chr5_-_96544694 0.556 RIOK2
RIO kinase 2 (yeast)
chr7_-_138444933 0.553 NM_020119
NM_024625
ZC3HAV1

zinc finger CCCH-type, antiviral 1

chr1_+_74971423 0.535 NM_001162916
NM_138467
TYW3

tRNA-yW synthesizing protein 3 homolog (S. cerevisiae)

chr1_+_84402962 0.535 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr12_-_10846435 0.534 NM_023919
TAS2R7
taste receptor, type 2, member 7
chr14_-_81069951 0.531 NM_005065
SEL1L
sel-1 suppressor of lin-12-like (C. elegans)
chr2_-_216008689 0.530 FN1
fibronectin 1
chr1_+_144374513 0.525 RNF115
ring finger protein 115
chrX_+_107569671 0.522 NM_000495
NM_033380
COL4A5

collagen, type IV, alpha 5

chr10_-_27569269 0.520 NM_145698
ACBD5
acyl-CoA binding domain containing 5
chr3_-_33675484 0.515 CLASP2
cytoplasmic linker associated protein 2
chr5_+_71538456 0.513 MAP1B
microtubule-associated protein 1B
chr6_+_28357292 0.512 NM_001184743
NM_032507
PGBD1

piggyBac transposable element derived 1

chr15_-_74963246 0.510 NM_020843
SCAPER
S-phase cyclin A-associated protein in the ER
chr10_-_64698831 0.509 NM_004241
JMJD1C
jumonji domain containing 1C
chr10_+_13668944 0.503 NM_003675
PRPF18
PRP18 pre-mRNA processing factor 18 homolog (S. cerevisiae)
chr12_+_76749199 0.502 NM_014903
NAV3
neuron navigator 3
chr15_-_53440069 0.495 CCPG1
cell cycle progression 1
chr12_-_15706340 0.492 EPS8
epidermal growth factor receptor pathway substrate 8
chrX_+_122923279 0.489 STAG2
stromal antigen 2
chr4_+_114433551 0.488 ANK2
ankyrin 2, neuronal
chr8_+_66744659 0.488 NM_001145838
MTFR1
mitochondrial fission regulator 1
chr2_+_170074457 0.486 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr11_+_12917369 0.485 TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr14_+_88130482 0.484 NM_207662
ZC3H14
zinc finger CCCH-type containing 14
chr11_-_82460518 0.484 RAB30
RAB30, member RAS oncogene family
chr1_-_23568854 0.483 NM_001077195
ZNF436
zinc finger protein 436
chr1_+_201862845 0.482 ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr19_+_46503524 0.481 HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr10_-_98315090 0.481 TM9SF3
transmembrane 9 superfamily member 3
chr22_-_39587944 0.479 NM_145174
DNAJB7
DnaJ (Hsp40) homolog, subfamily B, member 7
chr9_+_102380156 0.478 NM_001018116
MURC
muscle-related coiled-coil protein
chr21_+_29322100 0.477 USP16
ubiquitin specific peptidase 16
chr12_-_110410730 0.472 ATXN2
ataxin 2
chr18_+_54039730 0.472 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr4_+_53975597 0.470 FIP1L1
FIP1 like 1 (S. cerevisiae)
chr7_+_104468614 0.467 MLL5
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
chr5_-_96544719 0.466 NM_001159749
NM_018343
RIOK2

RIO kinase 2 (yeast)

chr2_+_58127155 0.465 NM_001130480
NM_001130482
NM_001130483
NM_006296
NM_001130481
VRK2




vaccinia related kinase 2




chr12_+_28301399 0.461 NM_018318
CCDC91
coiled-coil domain containing 91
chr2_-_144991556 0.460 ZEB2
zinc finger E-box binding homeobox 2
chrX_+_107174855 0.456 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr7_+_115650240 0.455 NM_152829
TES
testis derived transcript (3 LIM domains)
chr3_-_152403636 0.454 NM_013308
GPR171
G protein-coupled receptor 171
chr6_-_152744022 0.453 SYNE1
spectrin repeat containing, nuclear envelope 1
chr9_+_119506446 0.449 TLR4
toll-like receptor 4
chr1_+_161305019 0.449 NM_001102445
RGS4
regulator of G-protein signaling 4
chr4_+_129021514 0.447 NM_001190801
PLK4
polo-like kinase 4
chr22_-_37211467 0.445 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr2_+_102320148 0.442 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chrX_+_103297891 0.440 NM_207318
FAM199X
family with sequence similarity 199, X-linked
chr5_-_139662864 0.437 NM_002622
PFDN1
prefoldin subunit 1
chr1_+_61642287 0.435 NFIA
nuclear factor I/A
chr9_-_3213007 0.430


chr1_+_92405196 0.430 NM_015237
KIAA1107
KIAA1107
chr2_+_201464884 0.429 NM_001142356
NIF3L1
NIF3 NGG1 interacting factor 3-like 1 (S. pombe)
chr8_+_107807415 0.427 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr1_+_100099353 0.423 NM_000645
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr9_-_74735669 0.423 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr16_+_24475129 0.418 RBBP6
retinoblastoma binding protein 6
chr3_-_57301749 0.416 NM_001142733
ASB14
ankyrin repeat and SOCS box containing 14
chr19_+_11837843 0.415 NM_152262
ZNF439
zinc finger protein 439
chr9_+_19280748 0.415 NM_017925
DENND4C
DENN/MADD domain containing 4C
chr8_-_66863841 0.414 NM_002603
PDE7A
phosphodiesterase 7A
chr18_+_27925815 0.413 NM_016271
RNF138
ring finger protein 138
chr20_-_35586366 0.410 NM_001167823
BLCAP
bladder cancer associated protein
chr8_+_26206648 0.409 NM_001177591
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr11_+_93916653 0.408 NM_002033
PIWIL4
FUT4
piwi-like 4 (Drosophila)
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr3_+_120495906 0.406 NM_020754
ARHGAP31
Rho GTPase activating protein 31
chr18_+_30812205 0.406 NM_001143827
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr22_-_22422951 0.403 NM_021916
ZNF70
zinc finger protein 70
chr12_-_10870134 0.402 NM_023921
TAS2R10
taste receptor, type 2, member 10
chr4_+_113958652 0.401 NM_001127493
ANK2
ankyrin 2, neuronal
chr3_+_133798770 0.401 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr1_-_177106702 0.398 NM_004673
ANGPTL1
angiopoietin-like 1
chr12_-_52305900 0.397 ATF7
activating transcription factor 7
chr3_+_25444837 0.396 NM_000965
RARB
retinoic acid receptor, beta
chr15_-_53996597 0.396 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr11_-_5657947 0.395 TRIM5
tripartite motif containing 5
chr3_-_122862447 0.394 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr13_-_40454360 0.393 NM_001145353
ELF1
E74-like factor 1 (ets domain transcription factor)
chr1_-_245902965 0.393 NM_001005487
OR13G1
olfactory receptor, family 13, subfamily G, member 1
chr15_-_53349775 0.390 NM_183234
NM_004580
RAB27A

RAB27A, member RAS oncogene family

chr2_-_37397669 0.387 NM_005813
PRKD3
protein kinase D3
chr1_-_109957195 0.385 NM_005272
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr8_-_38324809 0.384 WHSC1L1
Wolf-Hirschhorn syndrome candidate 1-like 1
chr19_+_54530485 0.383 NM_001040031
NM_001774
CD37

CD37 molecule

chr9_-_15500209 0.383 NM_021144
PSIP1
PC4 and SFRS1 interacting protein 1
chr1_-_156657279 0.382 NM_001004476
OR10K2
olfactory receptor, family 10, subfamily K, member 2
chr4_-_153493133 0.382 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr1_-_108536885 0.380 NM_213651
SLC25A24
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
chr10_-_93992982 0.379 NM_001178137
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr17_-_1195096 0.379 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr3_-_130373241 0.378 CNBP
CCHC-type zinc finger, nucleic acid binding protein
chr1_-_20374273 0.378 NM_001105572
PLA2G2C
phospholipase A2, group IIC
chr17_+_50333021 0.377 NM_005486
TOM1L1
target of myb1 (chicken)-like 1
chr14_+_50069549 0.376 NM_001127713
ATL1
atlastin GTPase 1
chr18_+_27925859 0.375 RNF138
ring finger protein 138
chr9_+_119506428 0.374 TLR4
toll-like receptor 4
chr6_-_138862271 0.374 NM_001144060
NHSL1
NHS-like 1
chr2_+_28892366 0.373 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr10_+_5478521 0.373 NM_005863
NET1
neuroepithelial cell transforming 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.17 2.44e-02 GO:0065007 biological regulation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.22 3.51e-02 GO:0046930 pore complex

Nothing significant found in function category.