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Motif ID: NKX2-3_NKX2-5.p2

Z-value: 0.893

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr3_-_152517204	1.403	NM_023915	GPR87	G protein-coupled receptor 87
chr7_-_13992351	1.312	NM_001163150 NM_001163151 NM_001163152	ETV1	ets variant 1
chr7_-_27171673	1.215	NM_152739	HOXA9	homeobox A9
chr7_-_27171648	1.186		HOXA9	homeobox A9
chr3_+_89239494	1.150		EPHA3	EPH receptor A3
chr18_+_27152049	1.090	NM_001942	DSG1	desmoglein 1
chr13_-_102517196	1.081	NM_000452	SLC10A2	solute carrier family 10 (sodium/bile acid cotransporter family), member 2
chr3_-_57209319	1.056	NM_003865	HESX1	HESX homeobox 1
chr4_+_71713324	1.010	NM_031889	ENAM	enamelin
chr12_-_51173238	1.010	NM_005554	KRT6A	keratin 6A
chrX_-_110541029	0.995	NM_000555	DCX	doublecortin
chr10_-_105835525	0.969		COL17A1	collagen, type XVII, alpha 1
chr8_+_104900591	0.888	NM_014677	RIMS2	regulating synaptic membrane exocytosis 2
chr9_+_108726257	0.875		ZNF462	zinc finger protein 462
chrX_+_28515479	0.829	NM_014271	IL1RAPL1	interleukin 1 receptor accessory protein-like 1
chr4_-_38710376	0.805	NM_024943	TMEM156	transmembrane protein 156
chr6_+_50789215	0.804	NM_172238	TFAP2D	transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chrX_-_15243647	0.786	NM_080873	ASB11	ankyrin repeat and SOCS box containing 11
chr2_+_174907914	0.763	NM_001145250	SP9	Sp9 transcription factor homolog (mouse)
chr2_+_210152609	0.762	NM_002374 NM_031845 NM_031847	MAP2	microtubule-associated protein 2
chr11_-_102081654	0.758	NM_022122	MMP27	matrix metallopeptidase 27
chr3_-_121445831	0.745	NM_001168271 NM_153002	GPR156	G protein-coupled receptor 156
chr11_+_91724909	0.732	NM_001008781	FAT3	FAT tumor suppressor homolog 3 (Drosophila)
chr12_-_86947276	0.720	NM_152589	C12orf50	chromosome 12 open reading frame 50
chr7_-_27171600	0.718		HOXA9	homeobox A9
chr6_+_134800533	0.713		LOC154092	hypothetical LOC154092
chr10_-_105835609	0.711	NM_000494	COL17A1	collagen, type XVII, alpha 1
chr13_-_85271329	0.705	NM_032229	SLITRK6	SLIT and NTRK-like family, member 6
chr6_-_39398293	0.681	NM_001135105 NM_001135106 NM_001135107 NM_032115	KCNK16	potassium channel, subfamily K, member 16
chr13_-_93929719	0.671	NM_001129889 NM_001922	DCT	dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)
chr9_+_129066576	0.639	NM_032293	GARNL3	GTPase activating Rap/RanGAP domain-like 3
chr6_+_50894397	0.638	NM_003221	TFAP2B	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chr1_+_156229686	0.630	NM_018240	KIRREL	kin of IRRE like (Drosophila)
chr1_+_151209751	0.619	NM_173080	SPRR4	small proline-rich protein 4
chr2_+_225973845	0.612	NM_020864	KIAA1486	KIAA1486
chr12_-_28016182	0.611	NM_002820 NM_198965	PTHLH	parathyroid hormone-like hormone
chr5_-_168204430	0.609
chr5_+_140166842	0.601	NM_018907 NM_031500	PCDHA4	protocadherin alpha 4
chr13_-_34948758	0.597	NM_005584	MAB21L1	mab-21-like 1 (C. elegans)
chr12_+_9871343	0.587	NM_016523	KLRF1	killer cell lectin-like receptor subfamily F, member 1
chr7_+_113842284	0.581	NM_001172766 NM_014491 NM_148898 NM_148900	FOXP2	forkhead box P2
chrX_-_18600108	0.573	NM_000330	RS1	retinoschisin 1
chr6_-_25679197	0.571
chr9_+_12683385	0.569	NM_000550	TYRP1	tyrosinase-related protein 1
chr10_+_26545241	0.564	NM_000818 NM_001134366	GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr2_+_161980865	0.556	NM_006593	TBR1	T-box, brain, 1
chr7_-_27133163	0.550	NM_153631	HOXA3	homeobox A3
chr6_+_132915522	0.549	NM_053278	TAAR8	trace amine associated receptor 8
chr12_-_51200347	0.546	NM_000424	KRT5	keratin 5
chr12_-_51233001	0.546	NM_033448	KRT71	keratin 71
chr12_+_40117751	0.537	NM_013377	PDZRN4	PDZ domain containing ring finger 4
chr3_-_152173475	0.532	NM_001195794 NM_174878	CLRN1	clarin 1
chr1_+_207823667	0.527	NM_020439	CAMK1G	calcium/calmodulin-dependent protein kinase IG
chr15_-_64108718	0.526
chr1_+_207944807	0.526	NM_005525	HSD11B1	hydroxysteroid (11-beta) dehydrogenase 1
chr2_+_161981138	0.524		TBR1	T-box, brain, 1
chr1_+_154297588	0.521	NM_020387	RAB25	RAB25, member RAS oncogene family
chr10_-_5436781	0.517	NM_001171864 NM_024803	TUBAL3	tubulin, alpha-like 3
chr10_+_95507555	0.516	NM_005097	LGI1	leucine-rich, glioma inactivated 1
chr14_+_91858677	0.513	NM_153648	SLC24A4	solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr3_+_89239363	0.510	NM_005233 NM_182644	EPHA3	EPH receptor A3
chr9_-_205892	0.509	NM_152569	C9orf66	chromosome 9 open reading frame 66
chr17_-_36456949	0.507	NM_001123387	KRTAP2-1	keratin associated protein 2-1
chr11_+_34599227	0.505		EHF	ets homologous factor
chr11_+_89032112	0.503	NM_153696	FOLH1B	folate hydrolase 1B
chr4_+_77575276	0.501	NM_020859	SHROOM3	shroom family member 3
chr5_+_176744037	0.499	NM_001167579 NM_003052	SLC34A1	solute carrier family 34 (sodium phosphate), member 1
chr10_-_123346148	0.495	NM_001144915	FGFR2	fibroblast growth factor receptor 2
chr20_-_33489383	0.492	NM_000557	GDF5	growth differentiation factor 5
chr4_+_71142893	0.485	NM_005212	CSN3	casein kappa
chr1_+_84540921	0.480	NM_001134664	SAMD13	sterile alpha motif domain containing 13
chrX_+_50044279	0.475	NM_033031 NM_033670	CCNB3	cyclin B3
chr2_+_17861266	0.473	NM_001105569	MSGN1	mesogenin 1
chr11_-_104411065	0.471	NM_001223 NM_033292 NM_033293 NM_033294 NM_033295	CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr12_-_10173947	0.470	NM_022570 NM_197947 NM_197948 NM_197949 NM_197950 NM_197954	CLEC7A	C-type lectin domain family 7, member A
chr11_-_16454493	0.468	NM_033326	SOX6	SRY (sex determining region Y)-box 6
chr11_-_57173823	0.467	NM_145008	YPEL4	yippee-like 4 (Drosophila)
chr1_-_150398327	0.466	NM_001122965	RPTN	repetin
chr9_+_108665168	0.461	NM_021224	ZNF462	zinc finger protein 462
chr12_-_10853940	0.460	NM_023917	TAS2R9	taste receptor, type 2, member 9
chr5_-_22889487	0.458	NM_004061	CDH12	cadherin 12, type 2 (N-cadherin 2)
chr7_+_141054621	0.456	NM_001105558	WEE2	WEE1 homolog 2 (S. pombe)
chr7_+_139175420	0.455	NM_001061 NM_001166253 NM_030984	TBXAS1	thromboxane A synthase 1 (platelet)
chr1_+_168381811	0.453	NM_001136107	METTL11B	methyltransferase like 11B
chr22_-_36836620	0.452	NM_025045	BAIAP2L2	BAI1-associated protein 2-like 2
chr20_-_7869068	0.451	NM_017545	HAO1	hydroxyacid oxidase (glycolate oxidase) 1
chr4_+_88939725	0.448	NM_004967	IBSP	integrin-binding sialoprotein
chr2_-_99238001	0.445	NM_175735	LYG2	lysozyme G-like 2
chr8_+_55691179	0.445	NM_006269	RP1	retinitis pigmentosa 1 (autosomal dominant)
chr4_+_68995761	0.444	NM_014058	TMPRSS11E	transmembrane protease, serine 11E
chr3_+_14835472	0.442	NM_152536	FGD5	FYVE, RhoGEF and PH domain containing 5
chr1_-_155336223	0.438	NM_001004341	ETV3L	ets variant 3-like
chr4_+_94969064	0.434	NM_005172	ATOH1	atonal homolog 1 (Drosophila)
chr13_-_45323757	0.434	NM_198849	SIAH3	seven in absentia homolog 3 (Drosophila)
chr13_+_77007809	0.434	NM_001160706 NM_003843 NM_144777	SCEL	sciellin
chr15_-_96875133	0.431	NM_182562	FAM169B	family with sequence similarity 169, member B
chr3_+_162697289	0.427	NM_001080440	OTOL1	otolin 1 homolog (zebrafish)
chr5_+_31229609	0.426		CDH6	cadherin 6, type 2, K-cadherin (fetal kidney)
chr17_-_36877002	0.425	NM_002278	KRT32	keratin 32
chrX_+_153101278	0.420	NM_000513 NM_001048181	OPN1MW OPN1MW2	opsin 1 (cone pigments), medium-wave-sensitive opsin 1 (cone pigments), medium-wave-sensitive 2
chr12_+_8866416	0.419	NM_144670	A2ML1	alpha-2-macroglobulin-like 1
chr13_-_37070862	0.419	NM_001135934 NM_001135935 NM_001135936 NM_006475	POSTN	periostin, osteoblast specific factor
chr7_-_115458010	0.418	NM_001018058 NM_012252	TFEC	transcription factor EC
chr2_+_234490781	0.416	NM_024080	TRPM8	transient receptor potential cation channel, subfamily M, member 8
chr8_-_40874485	0.415	NM_001135731 NM_024645	ZMAT4	zinc finger, matrin-type 4
chr12_-_6103945	0.409	NM_000552	VWF	von Willebrand factor
chr8_-_102872354	0.409		NCALD	neurocalcin delta
chr12_-_51086330	0.409	NM_033033	KRT82	keratin 82
chr7_-_36991189	0.408	NM_001039459	ELMO1	engulfment and cell motility 1
chr12_-_16650687	0.404		LMO3	LIM domain only 3 (rhombotin-like 2)
chr7_-_13996166	0.403	NM_001163147 NM_004956	ETV1	ets variant 1
chr5_+_140583098	0.395	NM_018934	PCDHB14	protocadherin beta 14
chr5_+_140703784	0.391	NM_018916 NM_032011	PCDHGA3	protocadherin gamma subfamily A, 3
chr11_-_46364681	0.386	NM_000741	CHRM4	cholinergic receptor, muscarinic 4
chr5_-_22248630	0.386		CDH12	cadherin 12, type 2 (N-cadherin 2)
chr4_+_9094611	0.385	NM_001040071	LOC650293	seven transmembrane helix receptor
chr1_+_117098579	0.384	NM_001767	CD2	CD2 molecule
chr9_+_124173049	0.383	NM_000962 NM_080591	PTGS1	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr4_+_30331289	0.381		PCDH7	protocadherin 7
chr6_+_136214495	0.376	NM_018945	PDE7B	phosphodiesterase 7B
chr3_+_85858321	0.376	NM_153184	CADM2	cell adhesion molecule 2
chr17_-_64649608	0.374	NM_080284	ABCA6	ATP-binding cassette, sub-family A (ABC1), member 6
chr13_+_52500830	0.365	NM_006418	OLFM4	olfactomedin 4
chr3_+_190990142	0.365	NM_001114980 NM_001114981 NM_001114982	TP63	tumor protein p63
chrX_-_106033202	0.360	NM_001171706 NM_138382	RIPPLY1	ripply1 homolog (zebrafish)
chr5_+_140848905	0.359	NM_018929 NM_032407	PCDHGC5	protocadherin gamma subfamily C, 5
chr21_-_32879617	0.359	NM_144659	TCP10L	t-complex 10 (mouse)-like
chr15_+_92700167	0.358	NM_001159644	MCTP2	multiple C2 domains, transmembrane 2
chr15_+_56217686	0.356	NM_020980	AQP9	aquaporin 9
chr10_-_21475493	0.355	NM_001010896 NM_001177483	C10orf113	chromosome 10 open reading frame 113
chr10_+_98054074	0.352	NM_001017520 NM_004088	DNTT	deoxynucleotidyltransferase, terminal
chr1_-_154665807	0.350	NM_006365	C1orf61	chromosome 1 open reading frame 61
chr13_-_60887655	0.350	NM_022843	PCDH20	protocadherin 20
chr4_+_75393053	0.349	NM_001013442	EPGN	epithelial mitogen homolog (mouse)
chrX_+_90976314	0.349	NM_014522 NM_032968 NM_032969	PCDH11X	protocadherin 11 X-linked
chr5_-_39255335	0.347	NM_001465 NM_199335	FYB	FYN binding protein
chr1_-_224993498	0.346	NM_002221	ITPKB	inositol 1,4,5-trisphosphate 3-kinase B
chr2_-_207291364	0.345	NM_001093730	DYTN	dystrotelin
chr10_-_50066386	0.342	NM_001010863	C10orf128	chromosome 10 open reading frame 128
chr2_+_234266250	0.342	NM_001072	UGT1A6	UDP glucuronosyltransferase 1 family, polypeptide A6
chr19_+_7874701	0.340		MAP2K7	mitogen-activated protein kinase kinase 7
chr1_+_145841569	0.338	NM_005267	GJA8	gap junction protein, alpha 8, 50kDa
chr11_+_128067598	0.336	NM_001167681	FLI1	Friend leukemia virus integration 1
chr21_-_31175722	0.334	NM_175858	KRTAP11-1	keratin associated protein 11-1
chr17_-_36347197	0.331	NM_015515	KRT23	keratin 23 (histone deacetylase inducible)
chr11_-_123353607	0.330	NM_001004474	OR10S1	olfactory receptor, family 10, subfamily S, member 1
chr1_+_151240846	0.328	NM_001097589 NM_005416	SPRR3	small proline-rich protein 3
chr20_+_62266217	0.327		MYT1	myelin transcription factor 1
chr1_+_74473672	0.326	NM_015978	TNNI3K	TNNI3 interacting kinase
chr17_-_76064842	0.324	NM_002522	NPTX1	neuronal pentraxin I
chr11_-_56166490	0.324	NM_001002925	OR5AP2	olfactory receptor, family 5, subfamily AP, member 2
chr3_-_74652952	0.323	NM_020872	CNTN3	contactin 3 (plasmacytoma associated)
chr17_-_39191658	0.322	NM_025237	SOST	sclerostin
chr8_-_20084892	0.322	NM_001135691 NM_001142324 NM_001142325 NM_003053	SLC18A1	solute carrier family 18 (vesicular monoamine), member 1
chr17_-_19290745	0.321
chr3_+_46370578	0.321		CCR2	chemokine (C-C motif) receptor 2
chr6_-_136888771	0.320	NM_001198608 NM_001198609 NM_001198611	MAP7	microtubule-associated protein 7
chr2_+_161981046	0.319		TBR1	T-box, brain, 1
chr6_-_155818728	0.319	NM_015718	NOX3	NADPH oxidase 3
chr14_+_91859289	0.319	NM_153647	SLC24A4	solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr10_+_102212787	0.319	NM_003393	WNT8B	wingless-type MMTV integration site family, member 8B
chr4_-_70547962	0.316	NM_006798	UGT2A1	UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
chr16_-_4792857	0.315		ROGDI	rogdi homolog (Drosophila)
chr19_-_3723208	0.314	NM_032753	RAX2	retina and anterior neural fold homeobox 2
chr5_-_1935764	0.313	NM_016358	IRX4	iroquois homeobox 4
chr9_-_70345549	0.312	NM_153237	C9orf71	chromosome 9 open reading frame 71
chr13_+_45174446	0.312	NM_152719	SPERT	spermatid associated
chr6_+_29187565	0.310	NM_001005216	OR2J3	olfactory receptor, family 2, subfamily J, member 3
chr7_-_97457286	0.310	NM_006188	OCM2	oncomodulin 2
chr11_+_4799126	0.310	NM_001004753	OR51F2	olfactory receptor, family 51, subfamily F, member 2
chr13_-_19703371	0.310	NM_006783	GJB6	gap junction protein, beta 6, 30kDa
chr16_+_65938753	0.308	NM_001161575	LRRC36	leucine rich repeat containing 36
chr14_-_56342097	0.308	NM_172337	OTX2	orthodenticle homeobox 2
chr15_-_48345453	0.307	NM_002112	HDC	histidine decarboxylase
chr14_-_56346849	0.306	NM_021728	OTX2	orthodenticle homeobox 2
chrX_+_30158473	0.305	NM_002365	MAGEB3	melanoma antigen family B, 3
chr2_+_210152399	0.305		MAP2	microtubule-associated protein 2
chr5_+_140187746	0.303	NM_018909 NM_031848 NM_031849	PCDHA6	protocadherin alpha 6
chr2_-_73373956	0.301	NM_001965	EGR4	early growth response 4
chr7_-_31347032	0.300	NM_022728	NEUROD6	neurogenic differentiation 6
chr11_-_83071084	0.299	NM_001142702	DLG2	discs, large homolog 2 (Drosophila)
chr17_+_71232370	0.298	NM_001005619	ITGB4	integrin, beta 4
chrX_-_128616594	0.298	NM_017413	APLN	apelin
chr8_-_72436832	0.295		EYA1	eyes absent homolog 1 (Drosophila)
chr2_+_166034402	0.294	NM_001172173	CSRNP3	cysteine-serine-rich nuclear protein 3
chrX_+_102852492	0.294	NM_182541	TMEM31	transmembrane protein 31
chr21_+_39117064	0.293		ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr3_-_188492163	0.292	NM_001031849 NM_001879 NM_139125	MASP1	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
chr14_-_100105883	0.289	NM_020836	BEGAIN	brain-enriched guanylate kinase-associated homolog (rat)
chr5_-_149649380	0.288		CAMK2A	calcium/calmodulin-dependent protein kinase II alpha
chr3_+_160269836	0.288		IQCJ	IQ motif containing J
chr11_+_34599163	0.285	NM_012153	EHF	ets homologous factor
chr17_+_56843893	0.285	NM_203425	C17orf82	chromosome 17 open reading frame 82
chr7_-_41709191	0.285	NM_002192	INHBA	inhibin, beta A
chr14_+_19473606	0.285	NM_001004063	OR4K1	olfactory receptor, family 4, subfamily K, member 1
chr11_-_16380967	0.282	NM_001145819 NM_017508	SOX6	SRY (sex determining region Y)-box 6
chrX_-_48212683	0.280		SLC38A5	solute carrier family 38, member 5
chr5_-_149649593	0.279	NM_015981 NM_171825	CAMK2A	calcium/calmodulin-dependent protein kinase II alpha
chr11_+_88550687	0.279	NM_000372	TYR	tyrosinase (oculocutaneous albinism IA)
chr14_-_36121536	0.276	NM_014360	NKX2-8	NK2 homeobox 8

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.45	1.99e-15	GO:0032501	multicellular organismal process
1.92	3.43e-14	GO:0003008	system process
2.34	1.06e-12	GO:0007600	sensory perception
2.97	2.11e-12	GO:0007608	sensory perception of smell
1.96	1.18e-11	GO:0050877	neurological system process
2.78	1.50e-11	GO:0007606	sensory perception of chemical stimulus
1.23	2.67e-04	GO:0050896	response to stimulus
3.22	6.43e-04	GO:0007156	homophilic cell adhesion
1.82	1.21e-03	GO:0007155	cell adhesion
1.82	1.21e-03	GO:0022610	biological adhesion
1.76	5.69e-03	GO:0007267	cell-cell signaling
1.76	5.99e-03	GO:0006955	immune response
1.70	8.59e-03	GO:0009888	tissue development
3.66	1.11e-02	GO:0042471	ear morphogenesis
2.21	1.84e-02	GO:0016337	cell-cell adhesion
3.07	2.29e-02	GO:0043583	ear development
2.72	2.33e-02	GO:0048562	embryonic organ morphogenesis
3.79	2.76e-02	GO:0042472	inner ear morphogenesis

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.57	3.80e-19	GO:0071944	cell periphery
1.57	9.33e-19	GO:0005886	plasma membrane
1.79	2.00e-14	GO:0005576	extracellular region
1.32	9.03e-09	GO:0031224	intrinsic to membrane
1.27	4.96e-08	GO:0044425	membrane part
1.30	3.25e-07	GO:0016021	integral to membrane
3.27	1.30e-06	GO:0005882	intermediate filament
1.80	1.36e-06	GO:0044421	extracellular region part
1.21	1.86e-06	GO:0016020	membrane
2.83	4.25e-05	GO:0045111	intermediate filament cytoskeleton
1.82	4.85e-05	GO:0005615	extracellular space
1.46	5.08e-05	GO:0044459	plasma membrane part
3.96	1.20e-04	GO:0045095	keratin filament
1.79	3.18e-03	GO:0030054	cell junction
6.70	3.30e-03	GO:0001533	cornified envelope
1.49	9.59e-03	GO:0031226	intrinsic to plasma membrane
1.49	1.22e-02	GO:0005887	integral to plasma membrane

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
2.97	2.06e-12	GO:0004984	olfactory receptor activity
2.26	2.59e-12	GO:0004930	G-protein coupled receptor activity
1.98	3.11e-12	GO:0004888	transmembrane receptor activity
1.82	3.79e-12	GO:0004872	receptor activity
1.70	2.96e-11	GO:0004871	signal transducer activity
1.70	2.96e-11	GO:0060089	molecular transducer activity
1.74	6.26e-03	GO:0005509	calcium ion binding