Motif ID: NKX2-3_NKX2-5.p2

Z-value: 0.893


Transcription factors associated with NKX2-3_NKX2-5.p2:

Gene SymbolEntrez IDGene Name
NKX2-3 159296 NK2 transcription factor related, locus 3 (Drosophila)
NKX2-5 1482 NK2 transcription factor related, locus 5 (Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-3chr10_+_1012826790.731.4e-03Click!
NKX2-5chr5_-_1725946910.351.9e-01Click!


Activity profile for motif NKX2-3_NKX2-5.p2.

activity profile for motif NKX2-3_NKX2-5.p2


Sorted Z-values histogram for motif NKX2-3_NKX2-5.p2

Sorted Z-values for motif NKX2-3_NKX2-5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-3_NKX2-5.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_152517204 1.403 NM_023915
 GPR87
G protein-coupled receptor 87
chr7_-_13992351 1.312 NM_001163150
NM_001163151
NM_001163152
 ETV1


ets variant 1


chr7_-_27171673 1.215 NM_152739
 HOXA9
homeobox A9
chr7_-_27171648 1.186 HOXA9
homeobox A9
chr3_+_89239494 1.150 EPHA3
EPH receptor A3
chr18_+_27152049 1.090 NM_001942
 DSG1
desmoglein 1
chr13_-_102517196 1.081 NM_000452
 SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter family), member 2
chr3_-_57209319 1.056 NM_003865
 HESX1
HESX homeobox 1
chr4_+_71713324 1.010 NM_031889
 ENAM
enamelin
chr12_-_51173238 1.010 NM_005554
 KRT6A
keratin 6A
chrX_-_110541029 0.995 NM_000555
 DCX
doublecortin
chr10_-_105835525 0.969 COL17A1
collagen, type XVII, alpha 1
chr8_+_104900591 0.888 NM_014677
 RIMS2
regulating synaptic membrane exocytosis 2
chr9_+_108726257 0.875 ZNF462
zinc finger protein 462
chrX_+_28515479 0.829 NM_014271
 IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr4_-_38710376 0.805 NM_024943
 TMEM156
transmembrane protein 156
chr6_+_50789215 0.804 NM_172238
 TFAP2D
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chrX_-_15243647 0.786 NM_080873
 ASB11
ankyrin repeat and SOCS box containing 11
chr2_+_174907914 0.763 NM_001145250
 SP9
Sp9 transcription factor homolog (mouse)
chr2_+_210152609 0.762 NM_002374
NM_031845
NM_031847
 MAP2


microtubule-associated protein 2



Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 18 of 18 entries
enrichment   p-value GO term description
3.79 2.76e-02 GO:0042472 inner ear morphogenesis
3.66 1.11e-02 GO:0042471 ear morphogenesis
3.22 6.43e-04 GO:0007156 homophilic cell adhesion
3.07 2.29e-02 GO:0043583 ear development
2.97 2.11e-12 GO:0007608 sensory perception of smell
2.78 1.50e-11 GO:0007606 sensory perception of chemical stimulus
2.72 2.33e-02 GO:0048562 embryonic organ morphogenesis
2.34 1.06e-12 GO:0007600 sensory perception
2.21 1.84e-02 GO:0016337 cell-cell adhesion
1.96 1.18e-11 GO:0050877 neurological system process
1.92 3.43e-14 GO:0003008 system process
1.82 1.21e-03 GO:0007155 cell adhesion
1.82 1.21e-03 GO:0022610 biological adhesion
1.76 5.69e-03 GO:0007267 cell-cell signaling
1.76 5.99e-03 GO:0006955 immune response
1.70 8.59e-03 GO:0009888 tissue development
1.45 1.99e-15 GO:0032501 multicellular organismal process
1.23 2.67e-04 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 17 of 17 entries
enrichment   p-value GO term description
6.70 3.30e-03 GO:0001533 cornified envelope
3.96 1.20e-04 GO:0045095 keratin filament
3.27 1.30e-06 GO:0005882 intermediate filament
2.83 4.25e-05 GO:0045111 intermediate filament cytoskeleton
1.82 4.85e-05 GO:0005615 extracellular space
1.80 1.36e-06 GO:0044421 extracellular region part
1.79 2.00e-14 GO:0005576 extracellular region
1.79 3.18e-03 GO:0030054 cell junction
1.57 3.80e-19 GO:0071944 cell periphery
1.57 9.33e-19 GO:0005886 plasma membrane
1.49 9.59e-03 GO:0031226 intrinsic to plasma membrane
1.49 1.22e-02 GO:0005887 integral to plasma membrane
1.46 5.08e-05 GO:0044459 plasma membrane part
1.32 9.03e-09 GO:0031224 intrinsic to membrane
1.30 3.25e-07 GO:0016021 integral to membrane
1.27 4.96e-08 GO:0044425 membrane part
1.21 1.86e-06 GO:0016020 membrane

Gene overrepresentation in function category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
2.97 2.06e-12 GO:0004984 olfactory receptor activity
2.26 2.59e-12 GO:0004930 G-protein coupled receptor activity
1.98 3.11e-12 GO:0004888 transmembrane receptor activity
1.82 3.79e-12 GO:0004872 receptor activity
1.74 6.26e-03 GO:0005509 calcium ion binding
1.70 2.96e-11 GO:0004871 signal transducer activity
1.70 2.96e-11 GO:0060089 molecular transducer activity