Motif ID: NKX2-3_NKX2-5.p2

Z-value: 0.893


Transcription factors associated with NKX2-3_NKX2-5.p2:

Gene SymbolEntrez IDGene Name
NKX2-3 159296 NK2 transcription factor related, locus 3 (Drosophila)
NKX2-5 1482 NK2 transcription factor related, locus 5 (Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-3chr10_+_1012826790.731.4e-03Click!
NKX2-5chr5_-_1725946910.351.9e-01Click!


Activity profile for motif NKX2-3_NKX2-5.p2.

activity profile for motif NKX2-3_NKX2-5.p2


Sorted Z-values histogram for motif NKX2-3_NKX2-5.p2

Sorted Z-values for motif NKX2-3_NKX2-5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-3_NKX2-5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_152517204 1.403 NM_023915
GPR87
G protein-coupled receptor 87
chr7_-_13992351 1.312 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr7_-_27171673 1.215 NM_152739
HOXA9
homeobox A9
chr7_-_27171648 1.186 HOXA9
homeobox A9
chr3_+_89239494 1.150 EPHA3
EPH receptor A3
chr18_+_27152049 1.090 NM_001942
DSG1
desmoglein 1
chr13_-_102517196 1.081 NM_000452
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter family), member 2
chr3_-_57209319 1.056 NM_003865
HESX1
HESX homeobox 1
chr4_+_71713324 1.010 NM_031889
ENAM
enamelin
chr12_-_51173238 1.010 NM_005554
KRT6A
keratin 6A
chrX_-_110541029 0.995 NM_000555
DCX
doublecortin
chr10_-_105835525 0.969 COL17A1
collagen, type XVII, alpha 1
chr8_+_104900591 0.888 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chr9_+_108726257 0.875 ZNF462
zinc finger protein 462
chrX_+_28515479 0.829 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr4_-_38710376 0.805 NM_024943
TMEM156
transmembrane protein 156
chr6_+_50789215 0.804 NM_172238
TFAP2D
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chrX_-_15243647 0.786 NM_080873
ASB11
ankyrin repeat and SOCS box containing 11
chr2_+_174907914 0.763 NM_001145250
SP9
Sp9 transcription factor homolog (mouse)
chr2_+_210152609 0.762 NM_002374
NM_031845
NM_031847
MAP2


microtubule-associated protein 2


chr11_-_102081654 0.758 NM_022122
MMP27
matrix metallopeptidase 27
chr3_-_121445831 0.745 NM_001168271
NM_153002
GPR156

G protein-coupled receptor 156

chr11_+_91724909 0.732 NM_001008781
FAT3
FAT tumor suppressor homolog 3 (Drosophila)
chr12_-_86947276 0.720 NM_152589
C12orf50
chromosome 12 open reading frame 50
chr7_-_27171600 0.718 HOXA9
homeobox A9
chr6_+_134800533 0.713 LOC154092
hypothetical LOC154092
chr10_-_105835609 0.711 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr13_-_85271329 0.705 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr6_-_39398293 0.681 NM_001135105
NM_001135106
NM_001135107
NM_032115
KCNK16



potassium channel, subfamily K, member 16



chr13_-_93929719 0.671 NM_001129889
NM_001922
DCT

dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)

chr9_+_129066576 0.639 NM_032293
GARNL3
GTPase activating Rap/RanGAP domain-like 3
chr6_+_50894397 0.638 NM_003221
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chr1_+_156229686 0.630 NM_018240
KIRREL
kin of IRRE like (Drosophila)
chr1_+_151209751 0.619 NM_173080
SPRR4
small proline-rich protein 4
chr2_+_225973845 0.612 NM_020864
KIAA1486
KIAA1486
chr12_-_28016182 0.611 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr5_-_168204430 0.609


chr5_+_140166842 0.601 NM_018907
NM_031500
PCDHA4

protocadherin alpha 4

chr13_-_34948758 0.597 NM_005584
MAB21L1
mab-21-like 1 (C. elegans)
chr12_+_9871343 0.587 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr7_+_113842284 0.581 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chrX_-_18600108 0.573 NM_000330
RS1
retinoschisin 1
chr6_-_25679197 0.571


chr9_+_12683385 0.569 NM_000550
TYRP1
tyrosinase-related protein 1
chr10_+_26545241 0.564 NM_000818
NM_001134366
GAD2

glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)

chr2_+_161980865 0.556 NM_006593
TBR1
T-box, brain, 1
chr7_-_27133163 0.550 NM_153631
HOXA3
homeobox A3
chr6_+_132915522 0.549 NM_053278
TAAR8
trace amine associated receptor 8
chr12_-_51200347 0.546 NM_000424
KRT5
keratin 5
chr12_-_51233001 0.546 NM_033448
KRT71
keratin 71
chr12_+_40117751 0.537 NM_013377
PDZRN4
PDZ domain containing ring finger 4
chr3_-_152173475 0.532 NM_001195794
NM_174878
CLRN1

clarin 1

chr1_+_207823667 0.527 NM_020439
CAMK1G
calcium/calmodulin-dependent protein kinase IG
chr15_-_64108718 0.526


chr1_+_207944807 0.526 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr2_+_161981138 0.524 TBR1
T-box, brain, 1
chr1_+_154297588 0.521 NM_020387
RAB25
RAB25, member RAS oncogene family
chr10_-_5436781 0.517 NM_001171864
NM_024803
TUBAL3

tubulin, alpha-like 3

chr10_+_95507555 0.516 NM_005097
LGI1
leucine-rich, glioma inactivated 1
chr14_+_91858677 0.513 NM_153648
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr3_+_89239363 0.510 NM_005233
NM_182644
EPHA3

EPH receptor A3

chr9_-_205892 0.509 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr17_-_36456949 0.507 NM_001123387
KRTAP2-1
keratin associated protein 2-1
chr11_+_34599227 0.505 EHF
ets homologous factor
chr11_+_89032112 0.503 NM_153696
FOLH1B
folate hydrolase 1B
chr4_+_77575276 0.501 NM_020859
SHROOM3
shroom family member 3
chr5_+_176744037 0.499 NM_001167579
NM_003052
SLC34A1

solute carrier family 34 (sodium phosphate), member 1

chr10_-_123346148 0.495 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr20_-_33489383 0.492 NM_000557
GDF5
growth differentiation factor 5
chr4_+_71142893 0.485 NM_005212
CSN3
casein kappa
chr1_+_84540921 0.480 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chrX_+_50044279 0.475 NM_033031
NM_033670
CCNB3

cyclin B3

chr2_+_17861266 0.473 NM_001105569
MSGN1
mesogenin 1
chr11_-_104411065 0.471 NM_001223
NM_033292
NM_033293
NM_033294
NM_033295
CASP1




caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)




chr12_-_10173947 0.470 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr11_-_16454493 0.468 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr11_-_57173823 0.467 NM_145008
YPEL4
yippee-like 4 (Drosophila)
chr1_-_150398327 0.466 NM_001122965
RPTN
repetin
chr9_+_108665168 0.461 NM_021224
ZNF462
zinc finger protein 462
chr12_-_10853940 0.460 NM_023917
TAS2R9
taste receptor, type 2, member 9
chr5_-_22889487 0.458 NM_004061
CDH12
cadherin 12, type 2 (N-cadherin 2)
chr7_+_141054621 0.456 NM_001105558
WEE2
WEE1 homolog 2 (S. pombe)
chr7_+_139175420 0.455 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr1_+_168381811 0.453 NM_001136107
METTL11B
methyltransferase like 11B
chr22_-_36836620 0.452 NM_025045
BAIAP2L2
BAI1-associated protein 2-like 2
chr20_-_7869068 0.451 NM_017545
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr4_+_88939725 0.448 NM_004967
IBSP
integrin-binding sialoprotein
chr2_-_99238001 0.445 NM_175735
LYG2
lysozyme G-like 2
chr8_+_55691179 0.445 NM_006269
RP1
retinitis pigmentosa 1 (autosomal dominant)
chr4_+_68995761 0.444 NM_014058
TMPRSS11E
transmembrane protease, serine 11E
chr3_+_14835472 0.442 NM_152536
FGD5
FYVE, RhoGEF and PH domain containing 5
chr1_-_155336223 0.438 NM_001004341
ETV3L
ets variant 3-like
chr4_+_94969064 0.434 NM_005172
ATOH1
atonal homolog 1 (Drosophila)
chr13_-_45323757 0.434 NM_198849
SIAH3
seven in absentia homolog 3 (Drosophila)
chr13_+_77007809 0.434 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr15_-_96875133 0.431 NM_182562
FAM169B
family with sequence similarity 169, member B
chr3_+_162697289 0.427 NM_001080440
OTOL1
otolin 1 homolog (zebrafish)
chr5_+_31229609 0.426 CDH6
cadherin 6, type 2, K-cadherin (fetal kidney)
chr17_-_36877002 0.425 NM_002278
KRT32
keratin 32
chrX_+_153101278 0.420 NM_000513
NM_001048181
OPN1MW
OPN1MW2
opsin 1 (cone pigments), medium-wave-sensitive
opsin 1 (cone pigments), medium-wave-sensitive 2
chr12_+_8866416 0.419 NM_144670
A2ML1
alpha-2-macroglobulin-like 1
chr13_-_37070862 0.419 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr7_-_115458010 0.418 NM_001018058
NM_012252
TFEC

transcription factor EC

chr2_+_234490781 0.416 NM_024080
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr8_-_40874485 0.415 NM_001135731
NM_024645
ZMAT4

zinc finger, matrin-type 4

chr12_-_6103945 0.409 NM_000552
VWF
von Willebrand factor
chr8_-_102872354 0.409 NCALD
neurocalcin delta
chr12_-_51086330 0.409 NM_033033
KRT82
keratin 82
chr7_-_36991189 0.408 NM_001039459
ELMO1
engulfment and cell motility 1
chr12_-_16650687 0.404 LMO3
LIM domain only 3 (rhombotin-like 2)
chr7_-_13996166 0.403 NM_001163147
NM_004956
ETV1

ets variant 1

chr5_+_140583098 0.395 NM_018934
PCDHB14
protocadherin beta 14
chr5_+_140703784 0.391 NM_018916
NM_032011
PCDHGA3

protocadherin gamma subfamily A, 3

chr11_-_46364681 0.386 NM_000741
CHRM4
cholinergic receptor, muscarinic 4
chr5_-_22248630 0.386 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr4_+_9094611 0.385 NM_001040071
LOC650293
seven transmembrane helix receptor
chr1_+_117098579 0.384 NM_001767
CD2
CD2 molecule
chr9_+_124173049 0.383 NM_000962
NM_080591
PTGS1

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

chr4_+_30331289 0.381 PCDH7
protocadherin 7
chr6_+_136214495 0.376 NM_018945
PDE7B
phosphodiesterase 7B
chr3_+_85858321 0.376 NM_153184
CADM2
cell adhesion molecule 2
chr17_-_64649608 0.374 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr13_+_52500830 0.365 NM_006418
OLFM4
olfactomedin 4
chr3_+_190990142 0.365 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chrX_-_106033202 0.360 NM_001171706
NM_138382
RIPPLY1

ripply1 homolog (zebrafish)

chr5_+_140848905 0.359 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr21_-_32879617 0.359 NM_144659
TCP10L
t-complex 10 (mouse)-like
chr15_+_92700167 0.358 NM_001159644
MCTP2
multiple C2 domains, transmembrane 2
chr15_+_56217686 0.356 NM_020980
AQP9
aquaporin 9
chr10_-_21475493 0.355 NM_001010896
NM_001177483
C10orf113

chromosome 10 open reading frame 113

chr10_+_98054074 0.352 NM_001017520
NM_004088
DNTT

deoxynucleotidyltransferase, terminal

chr1_-_154665807 0.350 NM_006365
C1orf61
chromosome 1 open reading frame 61
chr13_-_60887655 0.350 NM_022843
PCDH20
protocadherin 20
chr4_+_75393053 0.349 NM_001013442
EPGN
epithelial mitogen homolog (mouse)
chrX_+_90976314 0.349 NM_014522
NM_032968
NM_032969
PCDH11X


protocadherin 11 X-linked


chr5_-_39255335 0.347 NM_001465
NM_199335
FYB

FYN binding protein

chr1_-_224993498 0.346 NM_002221
ITPKB
inositol 1,4,5-trisphosphate 3-kinase B
chr2_-_207291364 0.345 NM_001093730
DYTN
dystrotelin
chr10_-_50066386 0.342 NM_001010863
C10orf128
chromosome 10 open reading frame 128
chr2_+_234266250 0.342 NM_001072
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr19_+_7874701 0.340 MAP2K7
mitogen-activated protein kinase kinase 7
chr1_+_145841569 0.338 NM_005267
GJA8
gap junction protein, alpha 8, 50kDa
chr11_+_128067598 0.336 NM_001167681
FLI1
Friend leukemia virus integration 1
chr21_-_31175722 0.334 NM_175858
KRTAP11-1
keratin associated protein 11-1
chr17_-_36347197 0.331 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr11_-_123353607 0.330 NM_001004474
OR10S1
olfactory receptor, family 10, subfamily S, member 1
chr1_+_151240846 0.328 NM_001097589
NM_005416
SPRR3

small proline-rich protein 3

chr20_+_62266217 0.327 MYT1
myelin transcription factor 1
chr1_+_74473672 0.326 NM_015978
TNNI3K
TNNI3 interacting kinase
chr17_-_76064842 0.324 NM_002522
NPTX1
neuronal pentraxin I
chr11_-_56166490 0.324 NM_001002925
OR5AP2
olfactory receptor, family 5, subfamily AP, member 2
chr3_-_74652952 0.323 NM_020872
CNTN3
contactin 3 (plasmacytoma associated)
chr17_-_39191658 0.322 NM_025237
SOST
sclerostin
chr8_-_20084892 0.322 NM_001135691
NM_001142324
NM_001142325
NM_003053
SLC18A1



solute carrier family 18 (vesicular monoamine), member 1



chr17_-_19290745 0.321


chr3_+_46370578 0.321 CCR2
chemokine (C-C motif) receptor 2
chr6_-_136888771 0.320 NM_001198608
NM_001198609
NM_001198611
MAP7


microtubule-associated protein 7


chr2_+_161981046 0.319 TBR1
T-box, brain, 1
chr6_-_155818728 0.319 NM_015718
NOX3
NADPH oxidase 3
chr14_+_91859289 0.319 NM_153647
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr10_+_102212787 0.319 NM_003393
WNT8B
wingless-type MMTV integration site family, member 8B
chr4_-_70547962 0.316 NM_006798
UGT2A1
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
chr16_-_4792857 0.315 ROGDI
rogdi homolog (Drosophila)
chr19_-_3723208 0.314 NM_032753
RAX2
retina and anterior neural fold homeobox 2
chr5_-_1935764 0.313 NM_016358
IRX4
iroquois homeobox 4
chr9_-_70345549 0.312 NM_153237
C9orf71
chromosome 9 open reading frame 71
chr13_+_45174446 0.312 NM_152719
SPERT
spermatid associated
chr6_+_29187565 0.310 NM_001005216
OR2J3
olfactory receptor, family 2, subfamily J, member 3
chr7_-_97457286 0.310 NM_006188
OCM2
oncomodulin 2
chr11_+_4799126 0.310 NM_001004753
OR51F2
olfactory receptor, family 51, subfamily F, member 2
chr13_-_19703371 0.310 NM_006783
GJB6
gap junction protein, beta 6, 30kDa
chr16_+_65938753 0.308 NM_001161575
LRRC36
leucine rich repeat containing 36
chr14_-_56342097 0.308 NM_172337
OTX2
orthodenticle homeobox 2
chr15_-_48345453 0.307 NM_002112
HDC
histidine decarboxylase
chr14_-_56346849 0.306 NM_021728
OTX2
orthodenticle homeobox 2
chrX_+_30158473 0.305 NM_002365
MAGEB3
melanoma antigen family B, 3
chr2_+_210152399 0.305 MAP2
microtubule-associated protein 2
chr5_+_140187746 0.303 NM_018909
NM_031848
NM_031849
PCDHA6


protocadherin alpha 6


chr2_-_73373956 0.301 NM_001965
EGR4
early growth response 4
chr7_-_31347032 0.300 NM_022728
NEUROD6
neurogenic differentiation 6
chr11_-_83071084 0.299 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr17_+_71232370 0.298 NM_001005619
ITGB4
integrin, beta 4
chrX_-_128616594 0.298 NM_017413
APLN
apelin
chr8_-_72436832 0.295 EYA1
eyes absent homolog 1 (Drosophila)
chr2_+_166034402 0.294 NM_001172173
CSRNP3
cysteine-serine-rich nuclear protein 3
chrX_+_102852492 0.294 NM_182541
TMEM31
transmembrane protein 31
chr21_+_39117064 0.293 ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr3_-_188492163 0.292 NM_001031849
NM_001879
NM_139125
MASP1


mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)


chr14_-_100105883 0.289 NM_020836
BEGAIN
brain-enriched guanylate kinase-associated homolog (rat)
chr5_-_149649380 0.288 CAMK2A
calcium/calmodulin-dependent protein kinase II alpha
chr3_+_160269836 0.288 IQCJ
IQ motif containing J
chr11_+_34599163 0.285 NM_012153
EHF
ets homologous factor
chr17_+_56843893 0.285 NM_203425
C17orf82
chromosome 17 open reading frame 82
chr7_-_41709191 0.285 NM_002192
INHBA
inhibin, beta A
chr14_+_19473606 0.285 NM_001004063
OR4K1
olfactory receptor, family 4, subfamily K, member 1
chr11_-_16380967 0.282 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chrX_-_48212683 0.280 SLC38A5
solute carrier family 38, member 5
chr5_-_149649593 0.279 NM_015981
NM_171825
CAMK2A

calcium/calmodulin-dependent protein kinase II alpha

chr11_+_88550687 0.279 NM_000372
TYR
tyrosinase (oculocutaneous albinism IA)
chr14_-_36121536 0.276 NM_014360
NKX2-8
NK2 homeobox 8

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.45 1.99e-15 GO:0032501 multicellular organismal process
1.92 3.43e-14 GO:0003008 system process
2.34 1.06e-12 GO:0007600 sensory perception
2.97 2.11e-12 GO:0007608 sensory perception of smell
1.96 1.18e-11 GO:0050877 neurological system process
2.78 1.50e-11 GO:0007606 sensory perception of chemical stimulus
1.23 2.67e-04 GO:0050896 response to stimulus
3.22 6.43e-04 GO:0007156 homophilic cell adhesion
1.82 1.21e-03 GO:0007155 cell adhesion
1.82 1.21e-03 GO:0022610 biological adhesion
1.76 5.69e-03 GO:0007267 cell-cell signaling
1.76 5.99e-03 GO:0006955 immune response
1.70 8.59e-03 GO:0009888 tissue development
3.66 1.11e-02 GO:0042471 ear morphogenesis
2.21 1.84e-02 GO:0016337 cell-cell adhesion
3.07 2.29e-02 GO:0043583 ear development
2.72 2.33e-02 GO:0048562 embryonic organ morphogenesis
3.79 2.76e-02 GO:0042472 inner ear morphogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.57 3.80e-19 GO:0071944 cell periphery
1.57 9.33e-19 GO:0005886 plasma membrane
1.79 2.00e-14 GO:0005576 extracellular region
1.32 9.03e-09 GO:0031224 intrinsic to membrane
1.27 4.96e-08 GO:0044425 membrane part
1.30 3.25e-07 GO:0016021 integral to membrane
3.27 1.30e-06 GO:0005882 intermediate filament
1.80 1.36e-06 GO:0044421 extracellular region part
1.21 1.86e-06 GO:0016020 membrane
2.83 4.25e-05 GO:0045111 intermediate filament cytoskeleton
1.82 4.85e-05 GO:0005615 extracellular space
1.46 5.08e-05 GO:0044459 plasma membrane part
3.96 1.20e-04 GO:0045095 keratin filament
1.79 3.18e-03 GO:0030054 cell junction
6.70 3.30e-03 GO:0001533 cornified envelope
1.49 9.59e-03 GO:0031226 intrinsic to plasma membrane
1.49 1.22e-02 GO:0005887 integral to plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.97 2.06e-12 GO:0004984 olfactory receptor activity
2.26 2.59e-12 GO:0004930 G-protein coupled receptor activity
1.98 3.11e-12 GO:0004888 transmembrane receptor activity
1.82 3.79e-12 GO:0004872 receptor activity
1.70 2.96e-11 GO:0004871 signal transducer activity
1.70 2.96e-11 GO:0060089 molecular transducer activity
1.74 6.26e-03 GO:0005509 calcium ion binding