Motif ID: NKX3-1.p2

Z-value: 1.265


Transcription factors associated with NKX3-1.p2:

Gene SymbolEntrez IDGene Name
NKX3-1 4824 NK3 homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX3-1chr8_-_235963460.136.3e-01Click!


Activity profile for motif NKX3-1.p2.

activity profile for motif NKX3-1.p2


Sorted Z-values histogram for motif NKX3-1.p2

Sorted Z-values for motif NKX3-1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_132000134 3.649 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr17_-_61655915 1.932 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr17_-_53847937 1.896 RNF43
ring finger protein 43
chr20_+_30160952 1.621 NM_014742
TM9SF4
transmembrane 9 superfamily protein member 4
chr5_+_156628929 1.518 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr4_+_89115892 1.394 SPP1
secreted phosphoprotein 1
chr14_-_105681377 1.383 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr20_+_30161173 1.383 TM9SF4
transmembrane 9 superfamily protein member 4
chr20_+_12937616 1.360 NM_018327
SPTLC3
serine palmitoyltransferase, long chain base subunit 3
chr12_+_130004404 1.342 NM_198827
GPR133
G protein-coupled receptor 133
chr4_+_89115923 1.308 SPP1
secreted phosphoprotein 1
chr4_+_89115825 1.296 NM_000582
NM_001040058
NM_001040060
SPP1


secreted phosphoprotein 1


chr4_+_74520796 1.199 NM_001134
AFP
alpha-fetoprotein
chr4_+_89115862 1.166 SPP1
secreted phosphoprotein 1
chr12_-_14982708 1.104 NM_152321
ERP27
endoplasmic reticulum protein 27
chr4_-_10295412 1.098 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chr15_+_57691382 1.094 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chrX_-_131401319 1.077 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chr17_-_18890963 1.058 NM_006613
GRAP
GRB2-related adaptor protein
chr8_-_17787342 1.050 FGL1
fibrinogen-like 1
chr2_-_21106291 1.003 APOB
apolipoprotein B (including Ag(x) antigen)
chr6_+_30238961 0.989 NM_033229
TRIM15
tripartite motif containing 15
chr4_+_74488947 0.907 ALB
albumin
chr2_-_207291364 0.906 NM_001093730
DYTN
dystrotelin
chr15_+_92700167 0.896 NM_001159644
MCTP2
multiple C2 domains, transmembrane 2
chr6_+_167445284 0.884 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr8_-_16094591 0.872 NM_002445
NM_138715
NM_138716
MSR1


macrophage scavenger receptor 1


chr4_+_74488835 0.854 NM_000477
ALB
albumin
chr9_-_124981125 0.814 STRBP
spermatid perinuclear RNA binding protein
chr8_-_17797127 0.803 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr15_+_57691272 0.799 NM_004751
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr3_-_198784590 0.776 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr11_-_30910074 0.758 NM_020869
DCDC5
doublecortin domain containing 5
chr2_+_102294393 0.754 NM_016232
IL18R1
IL1RL1
interleukin 18 receptor 1
interleukin 1 receptor-like 1
chr17_+_50698169 0.727 HLF
hepatic leukemia factor
chr1_+_158975662 0.725 NM_021181
SLAMF7
SLAM family member 7
chr7_+_94377145 0.720 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory (inhibitor) subunit 9A


chr6_+_153060722 0.717 NM_025107
MYCT1
myc target 1
chr9_-_35860316 0.712 NM_001004487
OR13J1
olfactory receptor, family 13, subfamily J, member 1
chr14_-_20098929 0.702 NM_001001673
NM_001110356
NM_001110357
NM_001110358
NM_001110359
NM_001110360
NM_001110361
RNASE9






ribonuclease, RNase A family, 9 (non-active)






chr14_+_38772870 0.666 NM_054024
MIA2
melanoma inhibitory activity 2
chrX_-_2892288 0.664 NM_000047
ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr2_+_102744921 0.661 NM_144632
TMEM182
transmembrane protein 182
chrX_+_107569671 0.636 NM_000495
NM_033380
COL4A5

collagen, type IV, alpha 5

chr2_+_228064531 0.630 AGFG1
ArfGAP with FG repeats 1
chr14_+_38804226 0.616 NM_203354
CTAGE5
CTAGE family, member 5
chr18_+_27210737 0.611 NM_001134453
NM_177986
DSG4

desmoglein 4

chrX_+_57329834 0.604 NM_174912
FAAH2
fatty acid amide hydrolase 2
chr2_+_61225710 0.594 NM_001143960
C2orf74
chromosome 2 open reading frame 74
chr4_-_186934059 0.591 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr12_-_78608873 0.585 NM_002583
PAWR
PRKC, apoptosis, WT1, regulator
chr20_-_51633042 0.585 NM_006526
ZNF217
zinc finger protein 217
chr12_-_5925658 0.585 NM_020373
ANO2
anoctamin 2
chr4_-_84254932 0.584 NM_001130715
NM_016619
PLAC8

placenta-specific 8

chr2_-_77602843 0.571 NM_001134745
NM_024993
LRRTM4

leucine rich repeat transmembrane neuronal 4

chr14_+_87541220 0.569 NM_003608
GPR65
G protein-coupled receptor 65
chr14_+_94148466 0.564 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr4_+_152417774 0.564 NM_183375
PRSS48
protease, serine, 48
chr20_-_1298493 0.559 FKBP1A
FK506 binding protein 1A, 12kDa
chr20_+_58146916 0.559 LOC284757
hypothetical protein LOC284757
chr9_-_103237851 0.556 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr2_+_115538716 0.554 NM_001178037
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr9_+_95273241 0.552 FAM120A
family with sequence similarity 120A
chr14_-_19553191 0.550 NM_001004712
OR4K14
olfactory receptor, family 4, subfamily K, member 14
chr3_-_156876798 0.545 NM_001130960
NM_001130961
PLCH1

phospholipase C, eta 1

chr10_-_74384485 0.540 NM_032562
PLA2G12B
phospholipase A2, group XIIB
chr17_-_16816113 0.538 NM_012452
TNFRSF13B
tumor necrosis factor receptor superfamily, member 13B
chr3_+_99288706 0.537 NM_054106
OR5AC2
olfactory receptor, family 5, subfamily AC, member 2
chr4_+_39084936 0.532 KLB
klotho beta
chr10_-_14856901 0.527 NM_031453
FAM107B
family with sequence similarity 107, member B
chr8_-_59575249 0.524 NM_000780
CYP7A1
cytochrome P450, family 7, subfamily A, polypeptide 1
chr6_+_144654565 0.517 NM_007124
UTRN
utrophin
chr3_-_42892195 0.515 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chrX_-_130792297 0.511 LOC286467
hypothetical LOC286467
chr2_-_99412694 0.511 REV1
REV1 homolog (S. cerevisiae)
chr12_-_242255 0.507 NM_001190997
NM_016615
SLC6A13

solute carrier family 6 (neurotransmitter transporter, GABA), member 13

chr11_+_89507465 0.504 NM_005467
NAALAD2
N-acetylated alpha-linked acidic dipeptidase 2
chr6_-_76259976 0.503 NM_015687
FILIP1
filamin A interacting protein 1
chr2_+_64534774 0.502 NM_014181
HSPC159
galectin-related protein
chr9_-_94206648 0.501 NM_014057
NM_033014
OGN

osteoglycin

chr19_-_56612653 0.500 NM_001171156
NM_001171157
NM_001171158
NM_001171159
NM_001171160
NM_001171161
NM_033130
SIGLEC10






sialic acid binding Ig-like lectin 10






chr12_-_101835510 0.496 NM_000277
PAH
phenylalanine hydroxylase
chr4_-_186969041 0.496 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr4_+_74488910 0.491 ALB
albumin
chr1_-_246869181 0.487 NM_001001827
OR2T35
olfactory receptor, family 2, subfamily T, member 35
chr10_-_7722747 0.484 ITIH5
inter-alpha (globulin) inhibitor H5
chr9_+_106496480 0.484 NM_001004484
OR13D1
olfactory receptor, family 13, subfamily D, member 1
chr10_-_11614279 0.484 NM_001080491
USP6NL
USP6 N-terminal like
chr20_-_31055892 0.484 NM_080675
SUN5
Sad1 and UNC84 domain containing 5
chr4_-_68793928 0.482 NM_182502
TMPRSS11B
transmembrane protease, serine 11B
chr16_+_80626459 0.478 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr11_+_55362802 0.478 NM_001005496
OR5D16
olfactory receptor, family 5, subfamily D, member 16
chr17_+_23818922 0.476


chrX_-_107569256 0.466 NM_001847
COL4A6
collagen, type IV, alpha 6
chr16_+_80626331 0.454 NM_002153
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chrX_+_105823723 0.452 NM_024539
RNF128
ring finger protein 128
chr10_-_69267774 0.450 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr5_-_78317444 0.450 NM_198709
ARSB
arylsulfatase B
chr13_+_23042722 0.448 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr21_-_30460841 0.443 NM_012131
CLDN17
claudin 17
chr2_+_119416214 0.442 NM_006770
MARCO
macrophage receptor with collagenous structure
chr3_+_171183203 0.440 SEC62
SEC62 homolog (S. cerevisiae)
chr3_+_162697289 0.439 NM_001080440
OTOL1
otolin 1 homolog (zebrafish)
chr3_-_147696411 0.436 NM_020359
PLSCR2
phospholipid scramblase 2
chr6_-_48186868 0.432 C6orf138
chromosome 6 open reading frame 138
chr2_-_233349469 0.432 NM_001172416
NM_001172417
NM_002242
KCNJ13


potassium inwardly-rectifying channel, subfamily J, member 13


chr2_-_127817143 0.429 NM_006609
MAP3K2
mitogen-activated protein kinase kinase kinase 2
chr6_+_26473376 0.428 NM_001197247
NM_001197249
NM_007047
NM_001197248
BTN3A2



butyrophilin, subfamily 3, member A2



chr6_-_33016561 0.426 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr4_+_74491272 0.426 ALB
albumin
chr6_-_25982418 0.425 NM_001098486
NM_006632
SLC17A3

solute carrier family 17 (sodium phosphate), member 3

chr6_-_138862273 0.425


chr4_+_74493918 0.423 ALB
albumin
chr1_+_246195157 0.423 NM_001004491
OR2AK2
olfactory receptor, family 2, subfamily AK, member 2
chr11_+_56512922 0.420 NM_001005323
OR5AK2
olfactory receptor, family 5, subfamily AK, member 2
chr4_-_84254873 0.419 PLAC8
placenta-specific 8
chr11_-_13474101 0.418 NM_000315
PTH
parathyroid hormone
chr11_-_55987452 0.415 NM_001004743
OR5M9
olfactory receptor, family 5, subfamily M, member 9
chrX_-_130251068 0.413 NM_001170961
NM_001170962
NM_001555
NM_205833
IGSF1



immunoglobulin superfamily, member 1



chr6_-_138862271 0.413 NM_001144060
NHSL1
NHS-like 1
chr11_+_55343658 0.410 NM_001001952
OR5D18
olfactory receptor, family 5, subfamily D, member 18
chr10_-_116434364 0.409 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr4_+_71418886 0.408 NM_212557
AMTN
amelotin
chr8_-_86441115 0.406 NM_001164830
CA1
carbonic anhydrase I
chr1_+_81544432 0.406 LPHN2
latrophilin 2
chr2_+_36777406 0.406 VIT
vitrin
chr2_+_234624084 0.405 NM_006944
SPP2
secreted phosphoprotein 2, 24kDa
chr2_-_27215781 0.404 NM_178553
C2orf53
chromosome 2 open reading frame 53
chr6_+_126282078 0.400 NCOA7
nuclear receptor coactivator 7
chr7_-_87180499 0.399 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr12_+_83954229 0.399 NM_001079910
NM_032165
LRRIQ1

leucine-rich repeats and IQ motif containing 1

chr6_+_32003180 0.397 NM_000063
NM_001145903
C2

complement component 2

chr8_-_110689396 0.393 SYBU
syntabulin (syntaxin-interacting)
chr3_-_195553297 0.391 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr6_+_16251260 0.389 MYLIP
myosin regulatory light chain interacting protein
chr4_-_69852090 0.388 NM_024743
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr1_+_246682699 0.385 NM_001004136
OR2T2
olfactory receptor, family 2, subfamily T, member 2
chr4_-_68511738 0.384 NM_001114387
NM_182606
TMPRSS11A

transmembrane protease, serine 11A

chr20_+_62266217 0.382 MYT1
myelin transcription factor 1
chr3_+_153074118 0.380 NM_033050
SUCNR1
succinate receptor 1
chr1_+_103898844 0.380 NM_020978
AMY2B
amylase, alpha 2B (pancreatic)
chr13_-_97916768 0.376 STK24
serine/threonine kinase 24
chr16_+_80626402 0.375 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr7_+_94953148 0.372 NM_016116
NM_145872
ASB4

ankyrin repeat and SOCS box containing 4

chr16_+_80626456 0.372 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr2_-_131073329 0.366 NM_032545
NM_001079530
CFC1
CFC1B
cripto, FRL-1, cryptic family 1
cripto, FRL-1, cryptic family 1B
chr5_+_121523769 0.361 NM_001195535
LOC728460
hypothetical LOC728460
chr16_-_70763524 0.359 NM_031293
PMFBP1
polyamine modulated factor 1 binding protein 1
chrX_-_32340291 0.353 NM_004011
NM_004012
DMD

dystrophin

chr1_+_205329206 0.353 NM_000716
NM_001017364
NM_001017367
C4BPB


complement component 4 binding protein, beta


chr7_-_93027057 0.353 NM_001164738
CALCR
calcitonin receptor
chr17_+_71975224 0.351 NM_001088
AANAT
aralkylamine N-acetyltransferase
chr10_+_116687904 0.349 NM_139169
TRUB1
TruB pseudouridine (psi) synthase homolog 1 (E. coli)
chr1_+_74473672 0.347 NM_015978
TNNI3K
TNNI3 interacting kinase
chr17_+_46176105 0.346 LUC7L3
LUC7-like 3 (S. cerevisiae)
chr17_+_9670105 0.342 NM_004246
GLP2R
glucagon-like peptide 2 receptor
chr5_+_147672181 0.342 NM_032566
SPINK7
serine peptidase inhibitor, Kazal type 7 (putative)
chrX_-_100920493 0.341 GK
glycerol kinase
chr1_-_68688219 0.336 NM_000329
RPE65
retinal pigment epithelium-specific protein 65kDa
chr2_+_42649105 0.328 NM_020744
MTA3
metastasis associated 1 family, member 3
chr20_+_56919233 0.325 GNAS
GNAS complex locus
chr20_+_29565974 0.324 HM13
histocompatibility (minor) 13
chr10_+_101078784 0.324 NM_020348
CNNM1
cyclin M1
chr20_-_34707971 0.322 NM_032214
NM_175077
SLA2

Src-like-adaptor 2

chr2_+_207512522 0.319 NM_173077
CPO
carboxypeptidase O
chr6_+_49575629 0.318 NM_001010904
GLYATL3
glycine-N-acyltransferase-like 3
chr20_+_43764068 0.317 NM_172005
WFDC13
WAP four-disulfide core domain 13
chr4_+_74498042 0.317 ALB
albumin
chr4_+_74497998 0.314 ALB
albumin
chrX_+_118913827 0.312 NM_001008534
NM_001008535
NM_178813
AKAP14


A kinase (PRKA) anchor protein 14


chr12_-_80676562 0.311 PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr6_+_27400518 0.308 NM_032030
FKSG83
FKSG83
chr17_-_39500512 0.308 NM_152344
LSM12
LSM12 homolog (S. cerevisiae)
chr15_+_22832198 0.305 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr20_-_33580861 0.304 NM_001145350
C20orf173
chromosome 20 open reading frame 173
chr15_-_74963246 0.304 NM_020843
SCAPER
S-phase cyclin A-associated protein in the ER
chr10_+_7785360 0.303 ITIH2
inter-alpha (globulin) inhibitor H2
chr15_-_64108718 0.301


chr17_-_36113502 0.297 NM_019016
KRT24
keratin 24
chr14_+_20429382 0.296 NM_002935
RNASE2
RNASE3
ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
ribonuclease, RNase A family, 3
chr14_-_24148658 0.296 NM_033423
GZMH
granzyme H (cathepsin G-like 2, protein h-CCPX)
chr11_-_128399218 0.296 NM_014715
ARHGAP32
Rho GTPase activating protein 32
chr8_-_16094518 0.296 MSR1
macrophage scavenger receptor 1
chr2_-_215953818 0.293 FN1
fibronectin 1
chr11_+_55096179 0.293 NM_001004701
OR4C16
olfactory receptor, family 4, subfamily C, member 16
chr1_+_50348052 0.293 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr14_+_23844269 0.290


chr6_+_53043729 0.289 NM_012347
FBXO9
F-box protein 9
chr19_+_55383249 0.288 MYH14
myosin, heavy chain 14, non-muscle
chr4_+_166519392 0.288 NM_001873
CPE
carboxypeptidase E
chrX_-_23765377 0.287 RPL9
ribosomal protein L9
chr7_-_111216180 0.287 DOCK4
dedicator of cytokinesis 4
chr17_+_50697355 0.286 HLF
hepatic leukemia factor
chr1_-_35143570 0.286 NM_001080418
DLGAP3
discs, large (Drosophila) homolog-associated protein 3
chr14_-_88948486 0.285 FOXN3
forkhead box N3
chr6_+_158654464 0.284 TULP4
tubby like protein 4
chr6_-_28294642 0.281 LOC222699
transducer of ERBB2, 2 pseudogene
chr3_+_188397967 0.281 NM_153708
RTP1
receptor (chemosensory) transporter protein 1
chrX_+_90977115 0.281 NM_001168360
NM_001168361
NM_001168362
NM_001168363
PCDH11X



protocadherin 11 X-linked



chr19_-_14853166 0.280 NM_030901
OR7A17
olfactory receptor, family 7, subfamily A, member 17

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.79 6.66e-10 GO:0007606 sensory perception of chemical stimulus
2.81 7.42e-09 GO:0007608 sensory perception of smell
1.27 5.38e-05 GO:0050896 response to stimulus
1.87 5.56e-04 GO:0007600 sensory perception

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.51 5.25e-05 GO:0005576 extracellular region
1.30 5.16e-04 GO:0005886 plasma membrane
1.30 5.29e-04 GO:0071944 cell periphery

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.24 4.29e-10 GO:0004930 G-protein coupled receptor activity
2.84 2.99e-09 GO:0004984 olfactory receptor activity
1.85 1.10e-07 GO:0004888 transmembrane receptor activity
1.61 1.52e-05 GO:0004872 receptor activity
1.46 8.16e-04 GO:0004871 signal transducer activity
1.46 8.16e-04 GO:0060089 molecular transducer activity
9.22 9.65e-03 GO:0004522 pancreatic ribonuclease activity
7.49 3.95e-02 GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters