Motif ID: NKX3-2.p2

Z-value: 1.595


Transcription factors associated with NKX3-2.p2:

Gene SymbolEntrez IDGene Name
NKX3-2 579 NK3 homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX3-2chr4_-_13155135-0.214.4e-01Click!


Activity profile for motif NKX3-2.p2.

activity profile for motif NKX3-2.p2


Sorted Z-values histogram for motif NKX3-2.p2

Sorted Z-values for motif NKX3-2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_72513311 1.468 NM_001146029
NM_003612
SEMA7A

semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)

chr2_-_70634129 1.150 NM_001099691
NM_003236
TGFA

transforming growth factor, alpha

chr10_+_24795446 0.864 KIAA1217
KIAA1217
chr18_+_40514772 0.848 NM_015559
SETBP1
SET binding protein 1
chr4_+_169654742 0.788 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chrX_-_107568211 0.782 NM_033641
COL4A6
collagen, type IV, alpha 6
chr10_+_24795465 0.764 KIAA1217
KIAA1217
chr12_+_4253143 0.740 NM_001759
CCND2
cyclin D2
chr11_-_119514058 0.719 NM_012101
TRIM29
tripartite motif containing 29
chr9_+_2612052 0.707 VLDLR
very low density lipoprotein receptor
chr11_-_119514011 0.677 TRIM29
tripartite motif containing 29
chr10_-_123343761 0.668 NM_001144916
FGFR2
fibroblast growth factor receptor 2
chr22_+_35586950 0.666 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr2_+_64540843 0.662 HSPC159
galectin-related protein
chr3_-_55490401 0.641 WNT5A
wingless-type MMTV integration site family, member 5A
chr2_+_61986287 0.633 NM_152516
COMMD1
copper metabolism (Murr1) domain containing 1
chr10_-_90702490 0.618 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr11_-_119513948 0.616 TRIM29
tripartite motif containing 29
chr5_+_52812236 0.602 NM_006350
NM_013409
FST

follistatin

chr3_+_106568243 0.601 ALCAM
activated leukocyte cell adhesion molecule

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 13 of 13 entries
enrichment   p-value GO term description
1.65 9.06e-03 GO:0030029 actin filament-based process
1.50 3.64e-05 GO:0012501 programmed cell death
1.49 1.55e-06 GO:0008219 cell death
1.49 2.49e-06 GO:0016265 death
1.48 9.86e-05 GO:0006915 apoptosis
1.23 1.32e-02 GO:0043412 macromolecule modification
1.23 2.94e-02 GO:0006464 protein modification process
1.21 3.65e-03 GO:0044267 cellular protein metabolic process
1.19 2.26e-02 GO:0048518 positive regulation of biological process
1.17 4.89e-05 GO:0044260 cellular macromolecule metabolic process
1.14 1.00e-03 GO:0043170 macromolecule metabolic process
1.10 3.23e-02 GO:0044237 cellular metabolic process
1.08 4.05e-07 GO:0009987 cellular process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 23 entries
enrichment   p-value GO term description
1.83 7.93e-04 GO:0031252 cell leading edge
1.62 1.78e-03 GO:0015629 actin cytoskeleton
1.43 2.32e-02 GO:0005768 endosome
1.39 1.52e-03 GO:0044451 nucleoplasm part
1.28 1.96e-03 GO:0005654 nucleoplasm
1.27 4.67e-02 GO:0005794 Golgi apparatus
1.22 8.93e-03 GO:0031981 nuclear lumen
1.20 4.11e-03 GO:0043233 organelle lumen
1.20 6.90e-03 GO:0070013 intracellular organelle lumen
1.19 6.42e-03 GO:0031974 membrane-enclosed lumen
1.19 2.37e-02 GO:0005829 cytosol
1.18 9.66e-04 GO:0043234 protein complex
1.15 4.46e-13 GO:0005737 cytoplasm
1.14 2.07e-06 GO:0044444 cytoplasmic part
1.13 1.08e-04 GO:0044446 intracellular organelle part
1.13 1.60e-04 GO:0044422 organelle part
1.10 2.44e-12 GO:0044424 intracellular part
1.10 1.55e-08 GO:0043229 intracellular organelle
1.10 2.53e-08 GO:0043226 organelle
1.10 6.79e-07 GO:0043231 intracellular membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 5 of 5 entries
enrichment   p-value GO term description
1.96 3.38e-02 GO:0031267 small GTPase binding
1.61 1.40e-03 GO:0003779 actin binding
1.44 4.28e-03 GO:0008092 cytoskeletal protein binding
1.18 5.41e-16 GO:0005515 protein binding
1.07 2.64e-07 GO:0005488 binding