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Motif ID: NKX3-2.p2

Z-value: 1.595

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr15_-_72513311	1.468	NM_001146029 NM_003612	SEMA7A	semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
chr2_-_70634129	1.150	NM_001099691 NM_003236	TGFA	transforming growth factor, alpha
chr10_+_24795446	0.864		KIAA1217	KIAA1217
chr18_+_40514772	0.848	NM_015559	SETBP1	SET binding protein 1
chr4_+_169654742	0.788	NM_001166108 NM_016081	PALLD	palladin, cytoskeletal associated protein
chrX_-_107568211	0.782	NM_033641	COL4A6	collagen, type IV, alpha 6
chr10_+_24795465	0.764		KIAA1217	KIAA1217
chr12_+_4253143	0.740	NM_001759	CCND2	cyclin D2
chr11_-_119514058	0.719	NM_012101	TRIM29	tripartite motif containing 29
chr9_+_2612052	0.707		VLDLR	very low density lipoprotein receptor
chr11_-_119514011	0.677		TRIM29	tripartite motif containing 29
chr10_-_123343761	0.668	NM_001144916	FGFR2	fibroblast growth factor receptor 2
chr22_+_35586950	0.666	NM_000631 NM_013416	NCF4	neutrophil cytosolic factor 4, 40kDa
chr2_+_64540843	0.662		HSPC159	galectin-related protein
chr3_-_55490401	0.641		WNT5A	wingless-type MMTV integration site family, member 5A
chr2_+_61986287	0.633	NM_152516	COMMD1	copper metabolism (Murr1) domain containing 1
chr10_-_90702490	0.618	NM_001613	ACTA2	actin, alpha 2, smooth muscle, aorta
chr11_-_119513948	0.616		TRIM29	tripartite motif containing 29
chr5_+_52812236	0.602	NM_006350 NM_013409	FST	follistatin
chr3_+_106568243	0.601		ALCAM	activated leukocyte cell adhesion molecule
chr10_-_98021144	0.601	NM_001114094 NM_013314	BLNK	B-cell linker
chr14_-_23878871	0.600	NM_006871	RIPK3	receptor-interacting serine-threonine kinase 3
chr12_-_51200347	0.595	NM_000424	KRT5	keratin 5
chr11_-_119513429	0.593		TRIM29	tripartite motif containing 29
chr1_+_154386358	0.576	NM_001193301	SEMA4A	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr16_-_71650034	0.562	NM_001164766	ZFHX3	zinc finger homeobox 3
chr16_+_55963899	0.561	NM_002996	CX3CL1	chemokine (C-X3-C motif) ligand 1
chr15_-_72513053	0.542	NM_001146030	SEMA7A	semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
chr21_-_26345294	0.538
chr3_+_106568430	0.536		ALCAM	activated leukocyte cell adhesion molecule
chr3_+_123256902	0.524	NM_175862	CD86	CD86 molecule
chr8_+_123863075	0.522	NM_014943	ZHX2	zinc fingers and homeoboxes 2
chr1_+_35020425	0.517	NM_001005752	GJB3	gap junction protein, beta 3, 31kDa
chr5_+_52812165	0.513		FST	follistatin
chr8_+_123863169	0.509		ZHX2	zinc fingers and homeoboxes 2
chr1_+_199519202	0.504	NM_000299 NM_001005337	PKP1	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)
chr10_-_105604942	0.503	NM_014631	SH3PXD2A	SH3 and PX domains 2A
chr16_+_55963883	0.499		CX3CL1	chemokine (C-X3-C motif) ligand 1
chr3_+_106568334	0.494	NM_001627	ALCAM	activated leukocyte cell adhesion molecule
chr1_-_94779727	0.490	NM_001178096 NM_001993	F3	coagulation factor III (thromboplastin, tissue factor)
chr3_-_48607596	0.468	NM_000094	COL7A1	collagen, type VII, alpha 1
chr11_-_127962662	0.467	NM_001143820	ETS1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
chr5_-_1547872	0.460		LPCAT1	lysophosphatidylcholine acyltransferase 1
chr17_-_3447084	0.460	NM_018727	TRPV1	transient receptor potential cation channel, subfamily V, member 1
chr12_-_15757114	0.455		EPS8	epidermal growth factor receptor pathway substrate 8
chr2_+_228386800	0.450	NM_001130046 NM_004591	CCL20	chemokine (C-C motif) ligand 20
chr17_-_7996409	0.448	NM_002616	PER1	period homolog 1 (Drosophila)
chr2_-_238861830	0.448	NM_022817	PER2	period homolog 2 (Drosophila)
chr12_-_56447090	0.445	NM_000785	CYP27B1	cytochrome P450, family 27, subfamily B, polypeptide 1
chr6_-_32605898	0.441	NM_002125	HLA-DRB5	major histocompatibility complex, class II, DR beta 5
chr5_+_150138510	0.440		C5orf62	chromosome 5 open reading frame 62
chr19_-_44112920	0.439	NM_001145901 NM_017827	SARS2	seryl-tRNA synthetase 2, mitochondrial
chrX_-_19815370	0.438		SH3KBP1	SH3-domain kinase binding protein 1
chr3_-_79899748	0.435	NM_002941	ROBO1	roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr10_+_20145350	0.435	NM_032812	PLXDC2	plexin domain containing 2
chr6_+_54819527	0.430	NM_001010872	FAM83B	family with sequence similarity 83, member B
chr10_+_12431714	0.429		CAMK1D	calcium/calmodulin-dependent protein kinase ID
chr5_+_150138489	0.429		C5orf62	chromosome 5 open reading frame 62
chr2_+_17585287	0.426	NM_003385	VSNL1	visinin-like 1
chr1_-_158306570	0.423	NM_002241	KCNJ10	potassium inwardly-rectifying channel, subfamily J, member 10
chr4_+_114190233	0.423	NM_001148 NM_020977	ANK2	ankyrin 2, neuronal
chr13_+_75232797	0.420	NM_015842	LMO7	LIM domain 7
chr17_-_35975227	0.419	NM_001838	CCR7	chemokine (C-C motif) receptor 7
chr10_-_116154212	0.418		AFAP1L2	actin filament associated protein 1-like 2
chr9_+_2612134	0.418		VLDLR	very low density lipoprotein receptor
chr9_+_2612099	0.415		VLDLR	very low density lipoprotein receptor
chr15_+_75074793	0.414		PSTPIP1	proline-serine-threonine phosphatase interacting protein 1
chr11_+_35117408	0.412		CD44	CD44 molecule (Indian blood group)
chr1_+_63861474	0.411	NM_001172818	PGM1	phosphoglucomutase 1
chr2_+_17585462	0.406		VSNL1	visinin-like 1
chr3_+_185762233	0.405	NM_004443	EPHB3	EPH receptor B3
chr1_-_24112345	0.404	NM_001841	CNR2	cannabinoid receptor 2 (macrophage)
chr11_+_129823667	0.402	NM_139055	ADAMTS15	ADAM metallopeptidase with thrombospondin type 1 motif, 15
chr17_+_7289086	0.397	NM_000747	CHRNB1	cholinergic receptor, nicotinic, beta 1 (muscle)
chr2_-_109728958	0.392	NM_144710 NM_178584	SEPT10	septin 10
chr10_-_116276651	0.388	NM_006720	ABLIM1	actin binding LIM protein 1
chr5_+_68746694	0.388	NM_001038603	MARVELD2	MARVEL domain containing 2
chrX_-_131089552	0.386	NM_194277	FRMD7	FERM domain containing 7
chr8_+_102574012	0.381		GRHL2	grainyhead-like 2 (Drosophila)
chr3_+_180853473	0.381	NM_003940	USP13	ubiquitin specific peptidase 13 (isopeptidase T-3)
chr8_+_120289735	0.380	NM_052886	MAL2	mal, T-cell differentiation protein 2 (gene/pseudogene)
chr2_-_160764819	0.375	NM_000888	ITGB6	integrin, beta 6
chr4_+_169789327	0.375	NM_001166109	PALLD	palladin, cytoskeletal associated protein
chr4_+_78297356	0.373	NM_004354	CCNG2	cyclin G2
chr5_+_135392482	0.369	NM_000358	TGFBI	transforming growth factor, beta-induced, 68kDa
chr9_+_33230165	0.368	NM_014471	SPINK4	serine peptidase inhibitor, Kazal type 4
chr5_-_149772563	0.367		CD74	CD74 molecule, major histocompatibility complex, class II invariant chain
chr3_+_138159396	0.366	NM_144717	IL20RB	interleukin 20 receptor beta
chr10_+_42953886	0.363	NM_018590	CSGALNACT2	chondroitin sulfate N-acetylgalactosaminyltransferase 2
chr1_-_111544603	0.363
chr1_-_219982081	0.359	NM_007207 NM_144729	DUSP10	dual specificity phosphatase 10
chr1_-_219982016	0.359		DUSP10	dual specificity phosphatase 10
chr5_+_140848905	0.355	NM_018929 NM_032407	PCDHGC5	protocadherin gamma subfamily C, 5
chr14_-_104602784	0.350	NM_013345	GPR132	G protein-coupled receptor 132
chr13_+_59869427	0.347	NM_001146070	TDRD3	tudor domain containing 3
chr14_+_64948332	0.346		FUT8	fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
chr6_+_30018287	0.346	NM_002116	HLA-A	major histocompatibility complex, class I, A
chr11_+_34599227	0.345		EHF	ets homologous factor
chr13_+_25726755	0.342	NM_001260	CDK8	cyclin-dependent kinase 8
chr8_+_32905027	0.341
chr6_-_31432954	0.341	NM_005514	HLA-B	major histocompatibility complex, class I, B
chr9_+_2611740	0.341	NM_001018056 NM_003383	VLDLR	very low density lipoprotein receptor
chr20_-_10602139	0.340		JAG1	jagged 1
chr15_-_57452357	0.340		MYO1E	myosin IE
chr10_+_24537725	0.338	NM_001098501 NM_019590	KIAA1217	KIAA1217
chr7_+_97199206	0.337	NM_003182 NM_013996 NM_013997 NM_013998	TAC1	tachykinin, precursor 1
chr6_-_32665409	0.337	NM_002124	HLA-DRB1 HLA-DRB4 HLA-DRB5	major histocompatibility complex, class II, DR beta 1 major histocompatibility complex, class II, DR beta 4 major histocompatibility complex, class II, DR beta 5
chr14_+_51397134	0.336		GNG2	guanine nucleotide binding protein (G protein), gamma 2
chr16_-_80602546	0.335	NM_145168	SDR42E1	short chain dehydrogenase/reductase family 42E, member 1
chr15_-_57452345	0.334		MYO1E	myosin IE
chr11_-_119499188	0.333		TRIM29	tripartite motif containing 29
chr11_-_110755112	0.332		POU2AF1	POU class 2 associating factor 1
chr13_+_51056631	0.332		WDFY2	WD repeat and FYVE domain containing 2
chr17_+_4776371	0.331	NM_000173	GP1BA	glycoprotein Ib (platelet), alpha polypeptide
chr3_+_123279439	0.329	NM_006889	CD86	CD86 molecule
chr4_+_148621518	0.327	NM_001166055 NM_001957	EDNRA	endothelin receptor type A
chr19_-_16103996	0.327
chrX_-_19727828	0.326	NM_001024666	SH3KBP1	SH3-domain kinase binding protein 1
chr18_-_59185330	0.325	NM_002035	KDSR	3-ketodihydrosphingosine reductase
chr1_-_231498081	0.325	NM_014801	PCNXL2	pecanex-like 2 (Drosophila)
chr19_+_55164668	0.324		SIGLEC16	sialic acid binding Ig-like lectin 16 (gene/pseudogene)
chr5_-_156935317	0.324	NM_033274	ADAM19	ADAM metallopeptidase domain 19
chr5_+_156628929	0.323	NM_014376	CYFIP2	cytoplasmic FMR1 interacting protein 2
chr17_-_928960	0.322		ABR	active BCR-related gene
chr2_-_197499584	0.321	NM_024989	PGAP1	post-GPI attachment to proteins 1
chr2_-_220144427	0.320		OBSL1	obscurin-like 1
chr14_-_24148658	0.319	NM_033423	GZMH	granzyme H (cathepsin G-like 2, protein h-CCPX)
chrX_-_19815586	0.316	NM_031892	SH3KBP1	SH3-domain kinase binding protein 1
chr18_+_40513889	0.316	NM_001130110	SETBP1	SET binding protein 1
chr6_+_30018265	0.312		HLA-A	major histocompatibility complex, class I, A
chr11_+_66580861	0.311	NM_014578	RHOD	ras homolog gene family, member D
chr6_-_29824748	0.309		LOC285830	hypothetical LOC285830
chr10_-_116154504	0.308	NM_001001936 NM_032550	AFAP1L2	actin filament associated protein 1-like 2
chr17_-_68600409	0.308		SLC39A11	solute carrier family 39 (metal ion transporter), member 11
chr5_-_156935283	0.307
chr10_+_96295511	0.307	NM_018063	HELLS	helicase, lymphoid-specific
chr16_-_11588525	0.306		LITAF	lipopolysaccharide-induced TNF factor
chr2_-_37727472	0.306		CDC42EP3	CDC42 effector protein (Rho GTPase binding) 3
chr1_-_219982049	0.306		DUSP10	dual specificity phosphatase 10
chr17_-_68600426	0.305		SLC39A11	solute carrier family 39 (metal ion transporter), member 11
chr1_+_43508251	0.305	NM_144626	TMEM125	transmembrane protein 125
chr1_-_24342158	0.304	NM_021258	IL22RA1	interleukin 22 receptor, alpha 1
chrX_+_41191630	0.303	NM_022567	NYX	nyctalopin
chr19_+_42517337	0.303	NM_181786	HKR1	HKR1, GLI-Kruppel zinc finger family member
chr8_-_42515774	0.302		SLC20A2	solute carrier family 20 (phosphate transporter), member 2
chr18_-_28304392	0.302	NM_022751	FAM59A	family with sequence similarity 59, member A
chr3_-_46693902	0.299	NM_182775	ALS2CL	ALS2 C-terminal like
chr16_+_49139694	0.298	NM_033119	NKD1	naked cuticle homolog 1 (Drosophila)
chr11_+_35117391	0.298		CD44	CD44 molecule (Indian blood group)
chr13_-_95503566	0.297	NM_020121	UGGT2	UDP-glucose glycoprotein glucosyltransferase 2
chr22_-_36907638	0.297	NM_001004426 NM_003560	PLA2G6	phospholipase A2, group VI (cytosolic, calcium-independent)
chr4_-_84474919	0.297		HPSE	heparanase
chr2_-_74460933	0.296	NM_001135040 NM_001190837 NM_004082	DCTN1	dynactin 1
chr14_+_30098079	0.295	NM_017769	G2E3	G2/M-phase specific E3 ubiquitin protein ligase
chr7_+_29200636	0.295	NM_004067	CHN2	chimerin (chimaerin) 2
chrX_+_128741562	0.294	NM_018990	SASH3	SAM and SH3 domain containing 3
chr16_-_28130201	0.294		XPO6	exportin 6
chr15_+_38296920	0.292	NM_001128628 NM_001128629	PAK6	p21 protein (Cdc42/Rac)-activated kinase 6
chr9_-_34448477	0.292	NM_001184940 NM_001184941 NM_001184942 NM_001184943 NM_001184944 NM_001184945 NM_147202	C9orf25	chromosome 9 open reading frame 25
chr10_-_123343320	0.292	NM_001144913 NM_001144914	FGFR2	fibroblast growth factor receptor 2
chr4_-_102487506	0.291		PPP3CA	protein phosphatase 3, catalytic subunit, alpha isozyme
chr2_+_220170804	0.289	NM_052902	STK11IP	serine/threonine kinase 11 interacting protein
chr11_+_59001421	0.288	NM_001004705	OR4D10	olfactory receptor, family 4, subfamily D, member 10
chr3_+_113061296	0.288		PHLDB2	pleckstrin homology-like domain, family B, member 2
chr21_+_38550739	0.287	NM_170736	KCNJ15	potassium inwardly-rectifying channel, subfamily J, member 15
chr17_-_68600415	0.287		SLC39A11	solute carrier family 39 (metal ion transporter), member 11
chr14_+_66043877	0.287	NM_001024218 NM_020806	GPHN	gephyrin
chr2_+_148495043	0.286	NM_018328	MBD5	methyl-CpG binding domain protein 5
chr3_+_123036719	0.286	NM_018456	EAF2	ELL associated factor 2
chr4_-_102487356	0.285		PPP3CA	protein phosphatase 3, catalytic subunit, alpha isozyme
chr12_+_52618815	0.285	NM_017410	HOXC13	homeobox C13
chr14_-_101841222	0.285	NM_014226	RAGE	renal tumor antigen
chr2_+_219141761	0.284	NM_005444	RQCD1	RCD1 required for cell differentiation1 homolog (S. pombe)
chr5_+_174084137	0.283	NM_002449	MSX2	msh homeobox 2
chr4_-_102487649	0.283	NM_000944 NM_001130691 NM_001130692	PPP3CA	protein phosphatase 3, catalytic subunit, alpha isozyme
chr15_+_60726801	0.282	NM_015059	TLN2	talin 2
chr6_-_31432934	0.282		HLA-B	major histocompatibility complex, class I, B
chr9_+_123369219	0.281	NM_032552	DAB2IP	DAB2 interacting protein
chr10_-_134940315	0.281	NM_001109 NM_001164489 NM_001164490	ADAM8	ADAM metallopeptidase domain 8
chr12_+_3470685	0.280	NM_019854	PRMT8	protein arginine methyltransferase 8
chr8_+_123863224	0.280		ZHX2	zinc fingers and homeoboxes 2
chr4_+_110991934	0.278	NM_198506	LRIT3	leucine-rich repeat, immunoglobulin-like and transmembrane domains 3
chr2_+_218790109	0.278	NM_152862	ARPC2	actin related protein 2/3 complex, subunit 2, 34kDa
chr10_+_86174665	0.276		FAM190B	family with sequence similarity 190, member B
chr10_+_91077581	0.276	NM_001549	IFIT3	interferon-induced protein with tetratricopeptide repeats 3
chr7_+_28497272	0.276		CREB5	cAMP responsive element binding protein 5
chr1_+_86662356	0.275	NM_006536	CLCA2	chloride channel accessory 2
chr4_-_84475023	0.275		HPSE	heparanase
chr2_+_68445936	0.274		PLEK	pleckstrin
chr10_+_104144218	0.273	NM_001077493 NM_001077494	NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr9_+_115970599	0.273		COL27A1	collagen, type XXVII, alpha 1
chr11_+_34599163	0.273	NM_012153	EHF	ets homologous factor
chr16_-_28528780	0.271	NM_001055 NM_177529	SULT1A1	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr3_+_187813405	0.270		AHSG	alpha-2-HS-glycoprotein
chr13_+_28131140	0.270	NM_015932	POMP	proteasome maturation protein
chr17_-_40843530	0.269		ARHGAP27	Rho GTPase activating protein 27
chr1_+_26728846	0.267		RPS6KA1	ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr21_-_42060334	0.266		RIPK4	receptor-interacting serine-threonine kinase 4
chr10_+_12431734	0.265		CAMK1D	calcium/calmodulin-dependent protein kinase ID
chr20_-_16501911	0.265	NM_024704	KIF16B	kinesin family member 16B

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.08	4.05e-07	GO:0009987	cellular process
1.49	1.55e-06	GO:0008219	cell death
1.49	2.49e-06	GO:0016265	death
1.50	3.64e-05	GO:0012501	programmed cell death
1.17	4.89e-05	GO:0044260	cellular macromolecule metabolic process
1.48	9.86e-05	GO:0006915	apoptosis
1.14	1.00e-03	GO:0043170	macromolecule metabolic process
1.21	3.65e-03	GO:0044267	cellular protein metabolic process
1.65	9.06e-03	GO:0030029	actin filament-based process
1.23	1.32e-02	GO:0043412	macromolecule modification
1.19	2.26e-02	GO:0048518	positive regulation of biological process
1.23	2.94e-02	GO:0006464	protein modification process
1.10	3.23e-02	GO:0044237	cellular metabolic process

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.15	4.46e-13	GO:0005737	cytoplasm
1.09	1.96e-12	GO:0005622	intracellular
1.10	2.44e-12	GO:0044424	intracellular part
1.10	1.55e-08	GO:0043229	intracellular organelle
1.10	2.53e-08	GO:0043226	organelle
1.10	6.79e-07	GO:0043231	intracellular membrane-bounded organelle
1.10	7.86e-07	GO:0043227	membrane-bounded organelle
1.14	2.07e-06	GO:0044444	cytoplasmic part
1.13	1.08e-04	GO:0044446	intracellular organelle part
1.13	1.60e-04	GO:0044422	organelle part
1.83	7.93e-04	GO:0031252	cell leading edge
1.18	9.66e-04	GO:0043234	protein complex
1.39	1.52e-03	GO:0044451	nucleoplasm part
1.62	1.78e-03	GO:0015629	actin cytoskeleton
1.28	1.96e-03	GO:0005654	nucleoplasm
1.20	4.11e-03	GO:0043233	organelle lumen
1.19	6.42e-03	GO:0031974	membrane-enclosed lumen
1.20	6.90e-03	GO:0070013	intracellular organelle lumen
1.22	8.93e-03	GO:0031981	nuclear lumen
1.10	2.09e-02	GO:0005634	nucleus
1.43	2.32e-02	GO:0005768	endosome
1.19	2.37e-02	GO:0005829	cytosol
1.27	4.67e-02	GO:0005794	Golgi apparatus

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.18	5.41e-16	GO:0005515	protein binding
1.07	2.64e-07	GO:0005488	binding
1.61	1.40e-03	GO:0003779	actin binding
1.44	4.28e-03	GO:0008092	cytoskeletal protein binding
1.96	3.38e-02	GO:0031267	small GTPase binding