Motif ID: NKX6-1,2.p2

Z-value: 0.996


Transcription factors associated with NKX6-1,2.p2:

Gene SymbolEntrez IDGene Name
NKX6-1 4825 NK6 homeobox 1
NKX6-2 84504 NK6 homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX6-2chr10_-_134449467-0.302.7e-01Click!
NKX6-1chr4_-_85638410-0.273.2e-01Click!


Activity profile for motif NKX6-1,2.p2.

activity profile for motif NKX6-1,2.p2


Sorted Z-values histogram for motif NKX6-1,2.p2

Sorted Z-values for motif NKX6-1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX6-1,2.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_169654742 2.057 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr2_-_160764819 1.917 NM_000888
ITGB6
integrin, beta 6
chr2_-_160765008 1.384 ITGB6
integrin, beta 6
chr5_+_166644420 1.267 NM_001122679
ODZ2
odz, odd Oz/ten-m homolog 2 (Drosophila)
chr3_-_64186151 1.233 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr2_-_151052391 1.153 NM_005168
RND3
Rho family GTPase 3
chr7_-_41709191 1.147 NM_002192
INHBA
inhibin, beta A
chr4_-_90978469 1.047 NM_001146055
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chrX_-_10495476 1.033 NM_001193278
NM_001193279
NM_001193280
NM_001193281
MID1



midline 1 (Opitz/BBB syndrome)



chr2_-_237987579 0.907 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr12_+_32546243 0.899 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr17_+_58440629 0.860 NM_025185
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr2_-_237987554 0.853 COL6A3
collagen, type VI, alpha 3
chr20_+_19863716 0.831 RIN2
Ras and Rab interactor 2
chr8_-_122722674 0.827 NM_005328
HAS2
hyaluronan synthase 2
chr5_-_58331515 0.778 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chr4_-_177427252 0.712 NM_080874
ASB5
ankyrin repeat and SOCS box containing 5
chr2_-_237987545 0.710 COL6A3
collagen, type VI, alpha 3
chr17_+_58625086 0.700 TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr7_+_28692122 0.693 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr9_+_81376666 0.680 NM_007005
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chrX_-_10504852 0.640 NM_001193277
MID1
midline 1 (Opitz/BBB syndrome)
chr12_-_28016182 0.621 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr14_+_100365390 0.612 MEG3
maternally expressed 3 (non-protein coding)
chr1_+_199884152 0.600 NAV1
neuron navigator 1
chr9_-_21375258 0.600 NM_000605
IFNA2
interferon, alpha 2
chr5_+_149977398 0.597 NM_001166209
SYNPO
synaptopodin
chr5_-_64813459 0.586 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr7_-_107667728 0.586 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr4_+_54790190 0.573 PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr7_+_28305464 0.571 NM_182899
CREB5
cAMP responsive element binding protein 5
chr8_+_133060353 0.569 EFR3A
EFR3 homolog A (S. cerevisiae)
chrX_+_102727068 0.546 NM_001006935
NM_001006937
NM_024863
TCEAL4


transcription elongation factor A (SII)-like 4


chr14_+_100365162 0.546 MEG3
maternally expressed 3 (non-protein coding)
chr4_+_75393053 0.537 NM_001013442
EPGN
epithelial mitogen homolog (mouse)
chr15_+_47502666 0.536 NM_002009
FGF7
fibroblast growth factor 7
chr1_+_208568218 0.517 NM_001122834
NM_001170564
HHAT

hedgehog acyltransferase

chr1_-_89261021 0.512 NM_018284
GBP3
guanylate binding protein 3
chr10_-_14412813 0.508 NM_018027
FRMD4A
FERM domain containing 4A
chr7_+_93862137 0.507 COL1A2
PLAG1
collagen, type I, alpha 2
pleiomorphic adenoma gene 1
chr3_-_74652952 0.505 NM_020872
CNTN3
contactin 3 (plasmacytoma associated)
chr8_-_23768242 0.502 NM_003155
STC1
stanniocalcin 1
chr2_-_237987553 0.496 COL6A3
collagen, type VI, alpha 3
chr17_-_39191658 0.494 NM_025237
SOST
sclerostin
chr21_-_35343448 0.481 RUNX1
runt-related transcription factor 1
chr8_-_82769761 0.477 NM_001010893
SLC10A5
solute carrier family 10 (sodium/bile acid cotransporter family), member 5
chr21_-_35343456 0.467 NM_001754
RUNX1
runt-related transcription factor 1
chr5_+_145296313 0.463 NM_152550
SH3RF2
SH3 domain containing ring finger 2
chr6_+_118976134 0.459 NM_002667
PLN
phospholamban
chr7_+_5609416 0.456 FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr13_-_32658215 0.455 NM_178007
STARD13
StAR-related lipid transfer (START) domain containing 13
chr12_+_56406296 0.448 LOC100130776
hypothetical LOC100130776
chr21_-_35343500 0.443 RUNX1
runt-related transcription factor 1
chr12_+_54611212 0.440 NM_001345
DGKA
diacylglycerol kinase, alpha 80kDa
chr3_-_79899748 0.434 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr13_-_37070862 0.434 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr1_-_109957195 0.431 NM_005272
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr2_-_227952249 0.429 NM_024795
TM4SF20
transmembrane 4 L six family member 20
chr12_+_74071116 0.428 GLIPR1L2
GLI pathogenesis-related 1 like 2
chr1_-_109201228 0.427 NM_152763
AKNAD1
AKNA domain containing 1
chr1_+_78888064 0.423 NM_006417
IFI44
interferon-induced protein 44
chr5_-_43075904 0.420 NM_001014279
C5orf39
chromosome 5 open reading frame 39
chr8_+_104900591 0.417 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chr5_+_49997489 0.417 NM_001178055
PARP8
poly (ADP-ribose) polymerase family, member 8
chr1_+_156229686 0.411 NM_018240
KIRREL
kin of IRRE like (Drosophila)
chr3_-_113495763 0.407 NM_183061
SLC9A10
solute carrier family 9, member 10
chr6_+_116956868 0.406 NM_153036
FAM26D
family with sequence similarity 26, member D
chr14_+_62740878 0.405 NM_020663
RHOJ
ras homolog gene family, member J
chr2_-_217268492 0.405 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr5_-_13997588 0.405 NM_001369
DNAH5
dynein, axonemal, heavy chain 5
chr5_+_35892747 0.397 NM_002185
IL7R
interleukin 7 receptor
chr12_-_90029328 0.389 LUM
lumican
chr1_+_194887630 0.389 NM_000186
NM_001014975
CFH

complement factor H

chr2_-_225519974 0.388 DOCK10
dedicator of cytokinesis 10
chr5_+_140780797 0.364 PCDHGA11
protocadherin gamma subfamily A, 11
chr2_-_217267742 0.364 IGFBP5
insulin-like growth factor binding protein 5
chrX_+_47326746 0.363 TIMP1
TIMP metallopeptidase inhibitor 1
chr13_-_35327798 0.361 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr1_-_205161821 0.354 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr21_-_34806373 0.349 KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chr11_+_6898780 0.342 NM_001004684
OR2D3
olfactory receptor, family 2, subfamily D, member 3
chr2_+_68815416 0.341 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr5_+_155686333 0.341 NM_000337
NM_001128209
NM_172244
SGCD


sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)


chr13_-_35686665 0.341 NM_017826
SOHLH2
spermatogenesis and oogenesis specific basic helix-loop-helix 2
chr13_+_31211678 0.340 NM_001166058
NM_130806
RXFP2

relaxin/insulin-like family peptide receptor 2

chr2_+_220017617 0.336 SPEG
SPEG complex locus
chr7_+_45899080 0.336 IGFBP1
insulin-like growth factor binding protein 1
chr4_-_170314382 0.335 SH3RF1
SH3 domain containing ring finger 1
chr3_-_170348215 0.335 NM_001164000
MECOM
MDS1 and EVI1 complex locus
chr4_+_3285671 0.333 NM_002926
NM_198229
RGS12

regulator of G-protein signaling 12

chr5_+_140719773 0.332 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr11_-_57728228 0.331 NM_001004459
OR1S2
olfactory receptor, family 1, subfamily S, member 2
chr1_-_53972464 0.330 NM_147193
GLIS1
GLIS family zinc finger 1
chr5_+_140762551 0.329 NM_018921
NM_032089
PCDHGA9

protocadherin gamma subfamily A, 9

chr8_+_24354387 0.329 NM_003817
ADAM7
ADAM metallopeptidase domain 7
chr4_+_187227302 0.324 NM_003265
TLR3
toll-like receptor 3
chr2_+_234490781 0.323 NM_024080
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr4_+_54790020 0.322 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr2_+_210152609 0.318 NM_002374
NM_031845
NM_031847
MAP2


microtubule-associated protein 2


chr1_-_184696839 0.317 NM_002597
PDC
phosducin
chr12_-_10464308 0.315 NM_002261
NM_007333
KLRC3

killer cell lectin-like receptor subfamily C, member 3

chr12_-_90029672 0.315 NM_002345
LUM
lumican
chr9_+_27099138 0.314 NM_000459
TEK
TEK tyrosine kinase, endothelial
chrX_+_47326594 0.313 NM_003254
TIMP1
TIMP metallopeptidase inhibitor 1
chr3_+_150065732 0.311 NM_001870
CPA3
carboxypeptidase A3 (mast cell)
chr7_+_128099581 0.309 NM_001012454
NM_001128926
FAM71F2

family with sequence similarity 71, member F2

chr10_-_90601655 0.304 NM_144590
ANKRD22
ankyrin repeat domain 22
chr18_+_59705918 0.301 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr10_+_64894943 0.301 LOC84989
hypothetical LOC84989
chr21_+_29439768 0.299 C21orf7
chromosome 21 open reading frame 7
chr6_+_125346208 0.295 NM_152553
RNF217
ring finger protein 217
chr4_-_87593306 0.288 NM_002753
MAPK10
mitogen-activated protein kinase 10
chr6_+_88026338 0.287 ZNF292
zinc finger protein 292
chr17_-_10217046 0.286 NM_003802
MYH13
myosin, heavy chain 13, skeletal muscle
chr12_-_16652202 0.286 NM_001001395
LMO3
LIM domain only 3 (rhombotin-like 2)
chr17_-_36559579 0.282 NM_033188
KRTAP4-5
keratin associated protein 4-5
chr11_+_122258600 0.276 NM_024806
NM_199124
C11orf63

chromosome 11 open reading frame 63

chr13_-_109600709 0.275 COL4A1
collagen, type IV, alpha 1
chr8_+_79591074 0.275 PKIA
protein kinase (cAMP-dependent, catalytic) inhibitor alpha
chr5_+_140546839 0.275 NM_019119
PCDHB9
protocadherin beta 9
chr13_+_99027366 0.273


chr5_+_140848905 0.273 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr19_-_47623340 0.270 NM_005357
LIPE
lipase, hormone-sensitive
chr8_+_11225904 0.268 NM_054028
AMAC1L2
acyl-malonyl condensing enzyme 1-like 2
chr1_-_67366807 0.267 NM_001013674
C1orf141
chromosome 1 open reading frame 141
chr6_-_31242593 0.266 NM_001173531
NM_203289
POU5F1

POU class 5 homeobox 1

chr15_+_78520634 0.265 ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr18_-_49944986 0.263 MBD2
methyl-CpG binding domain protein 2
chr1_+_203179976 0.261 NM_001160331
NFASC
neurofascin
chr3_-_148607096 0.260 NM_032153
ZIC4
Zic family member 4
chr11_-_128399218 0.260 NM_014715
ARHGAP32
Rho GTPase activating protein 32
chr11_-_27637771 0.259 NM_001143816
NM_170735
BDNF

brain-derived neurotrophic factor

chr1_-_120413798 0.258 NM_024408
NOTCH2
notch 2
chr5_+_140780720 0.257 NM_018914
NM_032091
NM_032092
PCDHGA11


protocadherin gamma subfamily A, 11


chr4_-_77147625 0.256 NM_002416
CXCL9
chemokine (C-X-C motif) ligand 9
chr4_+_120167721 0.255 SYNPO2
synaptopodin 2
chr7_+_120752656 0.255 NM_016087
WNT16
wingless-type MMTV integration site family, member 16
chr3_+_85858321 0.255 NM_153184
CADM2
cell adhesion molecule 2
chr1_+_207668787 0.252 NM_001104548
LOC642587
NPC-A-5
chr1_+_170656450 0.252 NM_139240
C1orf105
chromosome 1 open reading frame 105
chr9_+_81377289 0.251 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr2_+_135312655 0.251 NM_138326
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chrX_-_114158388 0.251 NM_000640
IL13RA2
interleukin 13 receptor, alpha 2
chr3_-_121445831 0.248 NM_001168271
NM_153002
GPR156

G protein-coupled receptor 156

chr4_-_138673078 0.246 NM_019035
PCDH18
protocadherin 18
chr1_-_219982081 0.244 NM_007207
NM_144729
DUSP10

dual specificity phosphatase 10

chr1_-_21249974 0.243 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr13_-_46368968 0.243 NM_000621
NM_001165947
HTR2A

5-hydroxytryptamine (serotonin) receptor 2A

chr1_-_219982016 0.242 DUSP10
dual specificity phosphatase 10
chr11_+_55629094 0.242 NM_001005200
OR8H2
olfactory receptor, family 8, subfamily H, member 2
chr8_+_67507271 0.241 NM_144650
ADHFE1
alcohol dehydrogenase, iron containing, 1
chr17_-_36376663 0.240 NM_213656
KRT39
keratin 39
chr3_+_133518900 0.239 NM_001099
NM_001134194
ACPP

acid phosphatase, prostate

chr2_-_162808123 0.237 NM_004460
FAP
fibroblast activation protein, alpha
chr8_+_42671718 0.237 NM_000749
CHRNB3
cholinergic receptor, nicotinic, beta 3
chr10_-_96819064 0.237 NM_000770
NM_001198853
NM_001198854
NM_001198855
CYP2C8



cytochrome P450, family 2, subfamily C, polypeptide 8



chrX_+_135058402 0.236 NM_001159700
FHL1
four and a half LIM domains 1
chr8_-_131483395 0.236 NM_018482
ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr20_+_9146036 0.235 NM_182797
PLCB4
phospholipase C, beta 4
chr5_+_140790310 0.231 NM_003735
NM_032094
PCDHGA12

protocadherin gamma subfamily A, 12

chr8_+_79590890 0.231 NM_006823
NM_181839
PKIA

protein kinase (cAMP-dependent, catalytic) inhibitor alpha

chr8_-_72431274 0.229 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr15_-_74091817 0.228 NM_138573
NRG4
neuregulin 4
chr6_-_37773609 0.227 NM_153487
MDGA1
MAM domain containing glycosylphosphatidylinositol anchor 1
chrX_-_119550402 0.227 CUL4B
cullin 4B
chr3_-_21767819 0.226 NM_024697
ZNF385D
zinc finger protein 385D
chr1_+_78858675 0.225 NM_006820
IFI44L
interferon-induced protein 44-like
chr11_-_7941617 0.223 NM_176821
NLRP10
NLR family, pyrin domain containing 10
chr6_-_152744143 0.223 SYNE1
spectrin repeat containing, nuclear envelope 1
chr1_+_180685878 0.222 NM_001137669
RGSL1
regulator of G-protein signaling like 1
chr17_-_7248137 0.222 NM_152766
C17orf61-PLSCR3
C17orf61
C17orf61-PLSCR3 read-through transcript
chromosome 17 open reading frame 61
chr2_+_61243132 0.220 NM_001143959
C2orf74
chromosome 2 open reading frame 74
chr6_+_114285209 0.220 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chrX_-_19898302 0.219 NM_198279
CXorf23
chromosome X open reading frame 23
chr10_-_69422391 0.218 HERC4
hect domain and RLD 4
chr4_-_70760381 0.214 NM_005420
SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
chr6_+_12398514 0.213 NM_001168319
NM_001955
EDN1

endothelin 1

chr2_+_17861266 0.213 NM_001105569
MSGN1
mesogenin 1
chr14_-_70071484 0.212 NM_003814
ADAM20
ADAM metallopeptidase domain 20
chr3_+_190990142 0.212 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr7_-_22828922 0.210 NM_019059
TOMM7
translocase of outer mitochondrial membrane 7 homolog (yeast)
chr7_-_7541974 0.210 NM_001037763
COL28A1
collagen, type XXVIII, alpha 1
chr4_-_159312973 0.206 FAM198B
family with sequence similarity 198, member B
chr4_-_189263395 0.206 NM_173553
TRIML2
tripartite motif family-like 2
chr4_-_100492854 0.206 NM_000669
ADH1C
alcohol dehydrogenase 1C (class I), gamma polypeptide
chr18_-_45272820 0.205 RPL17
ribosomal protein L17
chrX_-_10605726 0.204 NM_001098624
MID1
midline 1 (Opitz/BBB syndrome)
chr19_+_24061717 0.203 NM_203282
ZNF254
zinc finger protein 254
chr2_-_202271598 0.203 NM_033066
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr11_-_101906640 0.202 NM_002423
MMP7
matrix metallopeptidase 7 (matrilysin, uterine)
chr1_+_205068844 0.202 NM_013371
IL19
interleukin 19
chr1_-_32054164 0.202 NM_144569
SPOCD1
SPOC domain containing 1
chrX_+_80343958 0.202 NM_003022
SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr3_-_116272911 0.200 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr9_-_111253484 0.200 NM_001145369
NM_001145370
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr1_+_33319287 0.199 NM_052998
ADC
arginine decarboxylase
chr12_+_27288344 0.196 NM_015000
STK38L
serine/threonine kinase 38 like
chr5_+_76418214 0.196 LOC728723
hypothetical LOC728723
chr3_+_149930656 0.194 NM_032049
AGTR1
angiotensin II receptor, type 1
chr4_-_77097582 0.192 SDAD1
SDA1 domain containing 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.48 4.43e-03 GO:0048583 regulation of response to stimulus
1.24 1.47e-02 GO:0032501 multicellular organismal process
6.12 1.88e-02 GO:0050886 endocrine process
1.33 4.57e-02 GO:0048731 system development
1.45 4.69e-02 GO:0003008 system process
1.68 4.97e-02 GO:0048584 positive regulation of response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.66 7.52e-04 GO:0044421 extracellular region part
1.27 3.38e-03 GO:0005886 plasma membrane
1.26 3.77e-03 GO:0071944 cell periphery
2.76 4.62e-02 GO:0044420 extracellular matrix part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.70 3.07e-02 GO:0005509 calcium ion binding