Motif ID: NR3C1.p2

Z-value: 0.713


Transcription factors associated with NR3C1.p2:

Gene SymbolEntrez IDGene Name
NR3C1 2908 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NR3C1chr5_-_142763393-0.495.3e-02Click!


Activity profile for motif NR3C1.p2.

activity profile for motif NR3C1.p2


Sorted Z-values histogram for motif NR3C1.p2

Sorted Z-values for motif NR3C1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR3C1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_-_20098929 1.030 NM_001001673
NM_001110356
NM_001110357
NM_001110358
NM_001110359
NM_001110360
NM_001110361
RNASE9






ribonuclease, RNase A family, 9 (non-active)






chr7_-_122126422 0.910 NM_139175
RNF133
ring finger protein 133
chr6_-_32299757 0.696 NM_004557
NOTCH4
notch 4
chr22_+_39404940 0.629 NM_005297
MCHR1
melanin-concentrating hormone receptor 1
chr20_-_44612619 0.625 NM_080721
C20orf123
chromosome 20 open reading frame 123
chr9_-_70780574 0.621


chr3_+_2117246 0.607 NM_175607
CNTN4
contactin 4
chr11_+_110631916 0.578 NM_198498
C11orf53
chromosome 11 open reading frame 53
chr1_+_103961476 0.575 NM_000699
AMY2A
amylase, alpha 2A (pancreatic)
chr8_-_31010772 0.575 NM_001015508
PURG
purine-rich element binding protein G
chr6_+_134251940 0.535 NM_198392
NM_003206
TCF21

transcription factor 21

chr6_+_134251957 0.532 TCF21
transcription factor 21
chr11_+_4799126 0.514 NM_001004753
OR51F2
olfactory receptor, family 51, subfamily F, member 2
chr22_+_21042091 0.512 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr20_+_42776888 0.504 WISP2
WNT1 inducible signaling pathway protein 2
chr4_+_71713324 0.503 NM_031889
ENAM
enamelin
chr11_+_73036241 0.501 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr17_+_42641426 0.489 NM_001002841
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr4_+_91035025 0.480 NM_007351
MMRN1
multimerin 1
chr2_+_107969410 0.470 NM_021815
SLC5A7
solute carrier family 5 (choline transporter), member 7
chr18_-_22696532 0.470 NM_004028
AQP4
aquaporin 4
chr3_-_19950675 0.466 NM_144715
EFHB
EF-hand domain family, member B
chr7_+_94377145 0.458 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory (inhibitor) subunit 9A


chr1_-_156800017 0.458 NM_001160325
OR6P1
olfactory receptor, family 6, subfamily P, member 1
chr3_+_173043832 0.436 NM_001164436
TMEM212
transmembrane protein 212
chr12_-_9804682 0.428 NM_001781
CD69
CD69 molecule
chr20_+_30061905 0.421 NM_080625
C20orf160
chromosome 20 open reading frame 160
chr2_-_233586145 0.414 NGEF
neuronal guanine nucleotide exchange factor
chr1_-_117554999 0.414 NM_024626
VTCN1
V-set domain containing T cell activation inhibitor 1
chr1_+_43539239 0.413 NM_005424
TIE1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr19_+_14913298 0.381 NM_012377
OR7C2
olfactory receptor, family 7, subfamily C, member 2
chr6_+_29187565 0.378 NM_001005216
OR2J3
olfactory receptor, family 2, subfamily J, member 3
chr19_+_54707347 0.377 NM_001136019
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr5_+_169749068 0.374


chr6_+_150731720 0.373 NM_001164694
NM_001164695
NM_203395
IYD


iodotyrosine deiodinase


chr2_-_104834344 0.372 LOC100506421
hypothetical LOC100506421
chr11_+_59804634 0.358 NM_148975
MS4A4A
membrane-spanning 4-domains, subfamily A, member 4
chr17_+_35078032 0.346 NM_002686
PNMT
phenylethanolamine N-methyltransferase
chrX_+_18618965 0.340 NM_006240
NM_152224
NM_152226
PPEF1


protein phosphatase, EF-hand calcium binding domain 1


chr22_-_15453440 0.334 NM_014406
CCT8L2
chaperonin containing TCP1, subunit 8 (theta)-like 2
chr5_+_94752803 0.331 NM_152548
FAM81B
family with sequence similarity 81, member B
chr15_-_43280664 0.329 NM_138356
SHF
Src homology 2 domain containing F
chr14_+_99309688 0.326 EML1
echinoderm microtubule associated protein like 1
chr4_+_147779492 0.326 NM_004575
POU4F2
POU class 4 homeobox 2
chr7_-_122627235 0.325 NM_022444
SLC13A1
solute carrier family 13 (sodium/sulfate symporters), member 1
chr1_-_60164912 0.324 NM_000775
CYP2J2
cytochrome P450, family 2, subfamily J, polypeptide 2
chr3_+_150065732 0.313 NM_001870
CPA3
carboxypeptidase A3 (mast cell)
chr11_-_66367279 0.312


chr7_-_16811131 0.311 NM_006408
AGR2
anterior gradient homolog 2 (Xenopus laevis)
chr1_-_158759606 0.310 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr17_+_58915909 0.310 NM_001178057
NM_152830
ACE

angiotensin I converting enzyme (peptidyl-dipeptidase A) 1

chr5_+_180399830 0.309 NM_152547
BTNL9
butyrophilin-like 9
chr22_+_21053972 0.308


chr2_-_236837726 0.307 NM_212556
ASB18
ankyrin repeat and SOCS box containing 18
chr7_-_88262966 0.303 NM_152706
C7orf62
chromosome 7 open reading frame 62
chr11_+_55362802 0.298 NM_001005496
OR5D16
olfactory receptor, family 5, subfamily D, member 16
chr6_-_89984214 0.298 NM_002042
GABRR1
gamma-aminobutyric acid (GABA) receptor, rho 1
chr6_+_49575629 0.297 NM_001010904
GLYATL3
glycine-N-acyltransferase-like 3
chr22_+_36008465 0.297 CYTH4
cytohesin 4
chr2_+_143603368 0.287 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr7_-_98643024 0.287 NM_001145715
KPNA7
karyopherin alpha 7 (importin alpha 8)
chr6_+_26264531 0.287 HIST1H1E
histone cluster 1, H1e
chr2_-_233586164 0.284 NM_019850
NGEF
neuronal guanine nucleotide exchange factor
chr10_-_92671005 0.282 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr11_-_33678861 0.282 NM_001166692
C11orf91
chromosome 11 open reading frame 91
chr3_-_197422653 0.280 NM_001039617
ZDHHC19
zinc finger, DHHC-type containing 19
chr7_-_96492064 0.280 NM_005221
DLX5
distal-less homeobox 5
chr6_-_52776558 0.274 NM_145740
GSTA1
glutathione S-transferase alpha 1
chr19_+_11327173 0.274 LPPR2
lipid phosphate phosphatase-related protein type 2
chr17_-_2913650 0.272 NM_014566
OR1D4
OR1D5
olfactory receptor, family 1, subfamily D, member 4 (gene/pseudogene)
olfactory receptor, family 1, subfamily D, member 5
chr11_-_36576352 0.272 NM_000536
RAG2
recombination activating gene 2
chr22_+_36008511 0.268 CYTH4
cytohesin 4
chr2_-_56266408 0.267 LOC100129434
hypothetical LOC100129434
chr17_-_68100537 0.266 LOC100499467
hypothetical LOC100499467
chr10_-_69125932 0.263 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr8_+_103633023 0.262 NM_024410
ODF1
outer dense fiber of sperm tails 1
chr20_+_62164900 0.262 TCEA2
transcription elongation factor A (SII), 2
chr16_+_30293598 0.259 NM_013292
MYLPF
myosin light chain, phosphorylatable, fast skeletal muscle
chr16_+_8722068 0.259 NM_001127448
ABAT
4-aminobutyrate aminotransferase
chr16_-_21130368 0.258 NM_003460
ZP2
zona pellucida glycoprotein 2 (sperm receptor)
chr4_-_95482994 0.258 NM_014485
HPGDS
hematopoietic prostaglandin D synthase
chr6_+_26264537 0.257 NM_005321
HIST1H1E
histone cluster 1, H1e
chr19_+_11327061 0.255 NM_001170635
NM_022737
LPPR2

lipid phosphate phosphatase-related protein type 2

chr5_-_149649380 0.253 CAMK2A
calcium/calmodulin-dependent protein kinase II alpha
chr3_-_117647011 0.252 LSAMP
limbic system-associated membrane protein
chr13_+_112825113 0.251 NM_000504
F10
coagulation factor X
chr8_-_53484753 0.244 NM_014682
ST18
suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)
chr15_+_57696016 0.242 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr10_-_92670764 0.241 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr15_+_72892205 0.241 NM_021819
LMAN1L
lectin, mannose-binding, 1 like
chr7_-_48035169 0.237 NM_001030019
NM_152782
SUN3

Sad1 and UNC84 domain containing 3

chr14_-_64416307 0.237 SPTB
spectrin, beta, erythrocytic
chr9_+_76302071 0.235 NM_006914
RORB
RAR-related orphan receptor B
chr16_+_2145810 0.234 TRAF7
TNF receptor-associated factor 7
chr6_-_132952517 0.232 NM_003967
TAAR5
trace amine associated receptor 5
chr7_-_143587653 0.230 NM_001005328
OR2A7
OR2A4
olfactory receptor, family 2, subfamily A, member 7
olfactory receptor, family 2, subfamily A, member 4
chr3_-_147696411 0.229 NM_020359
PLSCR2
phospholipid scramblase 2
chr21_+_43024936 0.228 PDE9A
phosphodiesterase 9A
chr18_+_30652223 0.225 NM_001198942
NM_001198944
NM_032980
NM_032981
DTNA



dystrobrevin, alpha



chr17_-_4783943 0.225 NM_001165417
NM_001165418
NM_003562
SLC25A11


solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11


chr12_-_69837831 0.225 TSPAN8
tetraspanin 8
chr14_-_23686269 0.224 PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr16_-_70591377 0.222 NM_181536
PKD1L3
polycystic kidney disease 1-like 3
chr5_+_180399871 0.220 BTNL9
butyrophilin-like 9
chr13_-_46368968 0.218 NM_000621
NM_001165947
HTR2A

5-hydroxytryptamine (serotonin) receptor 2A

chr1_-_151788341 0.218 NM_002960
S100A3
S100 calcium binding protein A3
chr6_-_133008834 0.217 NM_138327
TAAR1
trace amine associated receptor 1
chr7_-_104354325 0.216 LOC723809
hypothetical LOC723809
chr1_+_84646621 0.215 NM_058248
DNASE2B
deoxyribonuclease II beta
chr9_+_101628829 0.215 NM_173200
NR4A3
nuclear receptor subfamily 4, group A, member 3
chr12_+_68028397 0.213 NM_000239
LYZ
lysozyme
chrX_-_70243362 0.213 NM_001025265
CXorf65
chromosome X open reading frame 65
chr11_+_18390421 0.212 NM_002301
NM_017448
LDHC

lactate dehydrogenase C

chr17_+_53587492 0.206 NM_012374
OR4D1
olfactory receptor, family 4, subfamily D, member 1
chr3_+_168936125 0.201 NM_001122752
NM_005025
SERPINI1

serpin peptidase inhibitor, clade I (neuroserpin), member 1

chr20_-_3635774 0.199 NM_023068
SIGLEC1
sialic acid binding Ig-like lectin 1, sialoadhesin
chr11_+_44742551 0.199 NM_130783
TSPAN18
tetraspanin 18
chr6_+_123359076 0.197 CLVS2
clavesin 2
chr11_-_64906683 0.195 NM_001077241
NM_182556
SLC25A45

solute carrier family 25, member 45

chr14_+_67238355 0.192 NM_152443
RDH12
retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
chr17_+_42641712 0.191 NM_002476
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr14_+_23905984 0.191 NM_001136022
NM_001198967
NFATC4

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4

chr2_-_208763017 0.189 NM_001099334
C2orf80
chromosome 2 open reading frame 80
chr14_+_62740878 0.189 NM_020663
RHOJ
ras homolog gene family, member J
chr6_-_31756119 0.188 NM_025262
LY6G5C
lymphocyte antigen 6 complex, locus G5C
chr3_+_99350859 0.187 NM_001005514
OR5H14
olfactory receptor, family 5, subfamily H, member 14
chr4_+_86918870 0.187 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr11_+_124294355 0.187 NM_001037558
HEPN1
hepatocellular carcinoma, down-regulated 1
chr5_+_137231458 0.185 MYOT
myotilin
chr15_+_64787983 0.185 NM_001142861
SMAD6
SMAD family member 6
chr3_-_152659186 0.185 NM_178822
IGSF10
immunoglobulin superfamily, member 10
chr6_+_53991672 0.185 NM_138569
C6orf142
chromosome 6 open reading frame 142
chr20_-_24987615 0.184 NM_032501
ACSS1
acyl-CoA synthetase short-chain family member 1
chr2_-_31293882 0.183 NM_001145122
CAPN14
calpain 14
chr14_-_76612286 0.182


chr5_+_55098469 0.181 NM_001166534
DDX4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chr4_-_2390050 0.181 NM_001172656
NM_001172657
NM_001172658
NM_020972
ZFYVE28



zinc finger, FYVE domain containing 28



chr6_+_35544174 0.180 RPL10A
ribosomal protein L10a
chr16_+_65938753 0.180 NM_001161575
LRRC36
leucine rich repeat containing 36
chr16_-_4792857 0.178 ROGDI
rogdi homolog (Drosophila)
chr6_-_26358811 0.177 NM_021018
HIST1H3F
histone cluster 1, H3f
chr6_+_35544155 0.177 NM_007104
RPL10A
ribosomal protein L10a
chr19_+_15644885 0.176 NM_023944
CYP4F12
cytochrome P450, family 4, subfamily F, polypeptide 12
chr10_-_90601655 0.176 NM_144590
ANKRD22
ankyrin repeat domain 22
chr15_-_72288362 0.175 NM_001142617
NM_001142619
NM_001142620
STRA6


stimulated by retinoic acid gene 6 homolog (mouse)


chr11_+_123398929 0.174 NM_001001953
OR10G9
olfactory receptor, family 10, subfamily G, member 9
chr2_-_238164042 0.173 RAB17
RAB17, member RAS oncogene family
chr9_-_41944687 0.172 MGC21881
hypothetical locus MGC21881
chr16_-_20610078 0.171 NM_052956
ACSM1
acyl-CoA synthetase medium-chain family member 1
chr20_+_31083111 0.169 NM_174897
BPIL3
bactericidal/permeability-increasing protein-like 3
chr7_-_107558021 0.169 NM_007356
LAMB4
laminin, beta 4
chr1_+_190394214 0.168 NM_130782
RGS18
regulator of G-protein signaling 18
chr8_+_11877238 0.168 NM_001033017
DEFB135
defensin, beta 135
chr6_-_6265874 0.168 F13A1
coagulation factor XIII, A1 polypeptide
chr17_-_31441390 0.166 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr14_-_20128228 0.166 NM_145250
RNASE11
ribonuclease, RNase A family, 11 (non-active)
chr1_-_232962369 0.164 PP2672
hypothetical LOC100130249
chr6_-_6265896 0.164 NM_000129
F13A1
coagulation factor XIII, A1 polypeptide
chr6_-_52736231 0.164 NM_000846
GSTA2
glutathione S-transferase alpha 2
chrX_+_22200950 0.164 NM_152577
ZNF645
zinc finger protein 645
chr12_-_89976261 0.163 NM_007035
KERA
keratocan
chr9_-_89939719 0.162 NM_001166137
FAM75C2
family with sequence similarity 75, member C2
chr17_+_7900926 0.161


chr5_+_137231443 0.161 NM_001135940
NM_006790
MYOT

myotilin

chr20_+_30831298 0.156 NM_175850
DNMT3B
DNA (cytosine-5-)-methyltransferase 3 beta
chr16_+_28211123 0.154 NM_001024401
SBK1
SH3-binding domain kinase 1
chr11_-_67163600 0.154 NM_005995
TBX10
T-box 10
chr6_+_38798529 0.154 NM_001371
DNAH8
dynein, axonemal, heavy chain 8
chr15_-_31999815 0.152


chr3_-_167037946 0.151 NM_000055
BCHE
butyrylcholinesterase
chr1_+_22852268 0.150 NM_000491
C1QB
complement component 1, q subcomponent, B chain
chr6_-_132064233 0.150 NM_030908
OR2A4
olfactory receptor, family 2, subfamily A, member 4
chr11_+_66927976 0.149 NM_198517
TBC1D10C
TBC1 domain family, member 10C
chr11_-_4924905 0.149 NM_001005329
OR51A4
olfactory receptor, family 51, subfamily A, member 4
chr19_+_59927763 0.147 NM_153443
KIR3DL3
KIR2DL3
KIR3DP1
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
killer cell immunoglobulin-like receptor, three domains, pseudogene 1
chr14_+_19365447 0.147 NM_001004723
OR4N2
olfactory receptor, family 4, subfamily N, member 2
chr17_-_36570508 0.144 NM_032524
KRTAP4-4
keratin associated protein 4-4
chr16_-_66075216 0.144 NM_001138
AGRP
agouti related protein homolog (mouse)
chr11_-_5178505 0.143 NM_001004760
OR51V1
olfactory receptor, family 51, subfamily V, member 1
chr20_+_61838389 0.142 NM_017806
LIME1
Lck interacting transmembrane adaptor 1
chr11_-_123414917 0.142 NM_001004463
OR10G7
olfactory receptor, family 10, subfamily G, member 7
chr2_-_73373956 0.141 NM_001965
EGR4
early growth response 4
chr12_+_68028407 0.139 LYZ
lysozyme
chr11_-_5964790 0.139 NM_001005173
OR52L1
olfactory receptor, family 52, subfamily L, member 1
chr8_-_95289945 0.137 NM_004063
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr4_-_10295412 0.137 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chr7_+_20621769 0.136 NM_001163941
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr19_-_14853166 0.136 NM_030901
OR7A17
olfactory receptor, family 7, subfamily A, member 17
chr18_+_30427279 0.133 NM_001128175
NM_001198938
NM_001198939
NM_001198940
DTNA



dystrobrevin, alpha



chr8_-_145206010 0.133


chr6_-_49942147 0.132 NM_001131
NM_170609
CRISP1

cysteine-rich secretory protein 1

chr17_+_20423628 0.132 NM_001190790
CDRT15L2
CMT1A duplicated region transcript 15-like 2
chr9_-_14900992 0.132 NM_144966
FREM1
FRAS1 related extracellular matrix 1
chr20_+_43283423 0.132 NM_003008
SEMG2
semenogelin II
chr10_+_95316387 0.130 NM_001195755
NM_181745
GPR120

G protein-coupled receptor 120

chr2_-_26717713 0.129 NM_001029881
CIB4
calcium and integrin binding family member 4
chr2_-_27215781 0.128 NM_178553
C2orf53
chromosome 2 open reading frame 53
chr8_+_36760999 0.128 NM_001031836
KCNU1
potassium channel, subfamily U, member 1
chr11_-_102331643 0.128 NM_002427
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr10_+_77212524 0.128 NM_032024
C10orf11
chromosome 10 open reading frame 11

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.37 1.90e-10 GO:0007608 sensory perception of smell
3.01 1.15e-08 GO:0007606 sensory perception of chemical stimulus
2.35 1.53e-07 GO:0007600 sensory perception
1.88 1.27e-05 GO:0050877 neurological system process
1.31 6.89e-05 GO:0050896 response to stimulus
1.72 8.98e-05 GO:0003008 system process
1.30 2.45e-03 GO:0032501 multicellular organismal process
1.66 3.51e-02 GO:0002376 immune system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.63 4.20e-14 GO:0005886 plasma membrane
1.61 1.16e-13 GO:0071944 cell periphery
1.42 1.43e-09 GO:0031224 intrinsic to membrane
1.35 1.67e-08 GO:0044425 membrane part
1.40 2.63e-08 GO:0016021 integral to membrane
1.29 4.70e-08 GO:0016020 membrane
1.65 6.60e-06 GO:0005576 extracellular region
1.89 1.76e-03 GO:0005615 extracellular space
1.69 1.17e-02 GO:0044421 extracellular region part

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.58 1.73e-11 GO:0004930 G-protein coupled receptor activity
2.02 1.96e-11 GO:0004872 receptor activity
3.46 3.51e-11 GO:0004984 olfactory receptor activity
1.81 3.10e-09 GO:0004871 signal transducer activity
1.81 3.10e-09 GO:0060089 molecular transducer activity
2.05 1.90e-08 GO:0004888 transmembrane receptor activity
10.55 2.41e-02 GO:0004522 pancreatic ribonuclease activity
7.83 2.93e-02 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters
5.48 3.06e-02 GO:0003823 antigen binding