Motif ID: NR5A1,2.p2

Z-value: 1.750


Transcription factors associated with NR5A1,2.p2:

Gene SymbolEntrez IDGene Name
NR5A1 2516 nuclear receptor subfamily 5, group A, member 1
NR5A2 2494 nuclear receptor subfamily 5, group A, member 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NR5A1chr9_-_1263095100.467.6e-02Click!
NR5A2chr1_+_198263352-0.332.1e-01Click!


Activity profile for motif NR5A1,2.p2.

activity profile for motif NR5A1,2.p2


Sorted Z-values histogram for motif NR5A1,2.p2

Sorted Z-values for motif NR5A1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR5A1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_145725197 1.764 NM_001001795
C8orf82
chromosome 8 open reading frame 82
chr3_+_50281582 1.526 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr5_+_176449156 1.476 NM_022963
FGFR4
fibroblast growth factor receptor 4
chr12_-_119038941 1.470 RAB35
RAB35, member RAS oncogene family
chr16_-_65510230 1.357 NM_004062
CDH16
cadherin 16, KSP-cadherin
chr12_-_9123126 1.339 A2M
alpha-2-macroglobulin
chr10_-_21826211 1.280 NM_001010911
C10orf114
chromosome 10 open reading frame 114
chr10_-_21826192 1.241 C10orf114
chromosome 10 open reading frame 114
chr16_-_65781499 1.236 NM_178516
EXOC3L1
exocyst complex component 3-like 1
chr19_+_540849 1.224 NM_001194
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr17_-_35774467 1.215 NM_152219
GJD3
gap junction protein, delta 3, 31.9kDa
chr22_+_40195058 1.192 NM_001098
ACO2
aconitase 2, mitochondrial
chr3_+_50281309 1.183 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr19_+_2279679 1.179 SPPL2B
signal peptide peptidase-like 2B
chr15_+_60838053 1.153 TLN2
talin 2
chr5_+_94981735 1.118 NM_199243
GPR150
G protein-coupled receptor 150
chr18_-_28606839 1.118 NM_020805
KLHL14
kelch-like 14 (Drosophila)
chr8_-_145725289 1.111 C8orf82
chromosome 8 open reading frame 82
chr12_+_6768966 1.104 CD4
CD4 molecule
chr1_+_17817397 1.075 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr20_-_42249146 1.070 JPH2
junctophilin 2
chr2_-_238164042 1.065 RAB17
RAB17, member RAS oncogene family
chr8_-_145090045 1.053 NM_201382
PLEC
plectin
chr2_+_219354948 1.052 CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr8_-_20156971 1.039 NM_021020
LZTS1
leucine zipper, putative tumor suppressor 1
chr19_-_47261761 1.037 NM_002088
GRIK5
glutamate receptor, ionotropic, kainate 5
chr17_+_72047709 1.035 NM_001077620
PRCD
progressive rod-cone degeneration
chr1_+_199108705 1.015 NM_005298
GPR25
G protein-coupled receptor 25
chr19_+_2279685 1.009 SPPL2B
signal peptide peptidase-like 2B
chr20_+_48241334 0.996 CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr17_-_45427565 0.989 NM_005220
DLX3
distal-less homeobox 3
chr1_-_116184846 0.988 NM_001111061
NHLH2
nescient helix loop helix 2
chr17_+_56832492 0.975 TBX2
T-box 2
chr5_-_149515331 0.974 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr3_+_52788976 0.968 NM_001166435
NM_001166436
ITIH1

inter-alpha (globulin) inhibitor H1

chr17_-_7023378 0.967 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chr8_-_37576515 0.958 LOC157860
hypothetical protein LOC157860
chr5_-_149515502 0.954 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr5_-_149515613 0.948 NM_002609
PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr20_-_44713466 0.938 NM_001193339
NM_001193342
NM_022829
SLC13A3


solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3


chr20_+_30019465 0.934 NM_001011718
XKR7
XK, Kell blood group complex subunit-related family, member 7
chr1_+_204390905 0.917 NM_000707
AVPR1B
arginine vasopressin receptor 1B
chr11_-_46364681 0.916 NM_000741
CHRM4
cholinergic receptor, muscarinic 4
chr14_-_102045849 0.910 NM_152326
ANKRD9
ankyrin repeat domain 9
chr2_+_63131466 0.909 NM_014562
OTX1
orthodenticle homeobox 1
chr19_-_54250808 0.906 NM_033142
CGB7
chorionic gonadotropin, beta polypeptide 7
chr14_-_102045749 0.899 ANKRD9
ankyrin repeat domain 9
chr8_+_145221973 0.899 CYC1
cytochrome c-1
chr6_-_27890496 0.894 NM_021066
HIST1H2AJ
histone cluster 1, H2aj
chr16_+_20328355 0.894 NM_017888
ACSM5
acyl-CoA synthetase medium-chain family member 5
chr9_-_139214962 0.888 NM_001128228
TPRN
taperin
chr3_-_50580066 0.886 NM_001171740
NM_001171743
NM_016210
C3orf18


chromosome 3 open reading frame 18


chr12_+_6768866 0.885 NM_000616
CD4
CD4 molecule
chr17_-_6557375 0.885 NM_001143838
NM_177550
SLC13A5

solute carrier family 13 (sodium-dependent citrate transporter), member 5

chrX_-_65752570 0.857 NM_021783
EDA2R
ectodysplasin A2 receptor
chr19_+_60543032 0.855 NM_032701
SUV420H2
suppressor of variegation 4-20 homolog 2 (Drosophila)
chr17_-_71017509 0.854 NM_001142643
CASKIN2
CASK interacting protein 2
chr15_+_92700167 0.854 NM_001159644
MCTP2
multiple C2 domains, transmembrane 2
chr1_-_27113018 0.853 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr9_-_130912728 0.847 NM_000755
CRAT
carnitine O-acetyltransferase
chr16_-_66007650 0.844 NM_013304
ZDHHC1
zinc finger, DHHC-type containing 1
chr11_-_118740069 0.839 NM_171997
USP2
ubiquitin specific peptidase 2
chr17_-_34015631 0.836 NM_025248
SRCIN1
SRC kinase signaling inhibitor 1
chr12_+_108061584 0.832 NM_001093
ACACB
acetyl-CoA carboxylase beta
chr1_+_17738863 0.831 NM_018125
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr19_+_2279628 0.830 NM_001077238
NM_152988
SPPL2B

signal peptide peptidase-like 2B

chr16_+_82540172 0.829 NM_013370
NM_182980
OSGIN1

oxidative stress induced growth inhibitor 1

chr3_+_52787478 0.828 NM_001166434
ITIH1
inter-alpha (globulin) inhibitor H1
chr7_-_100262971 0.825 NM_004444
EPHB4
EPH receptor B4
chr2_-_88208650 0.821 NM_001443
FABP1
fatty acid binding protein 1, liver
chr6_+_26381122 0.817 NM_003525
HIST1H2BI
histone cluster 1, H2bi
chr4_+_658250 0.816 MYL5
myosin, light chain 5, regulatory
chr12_-_9159780 0.814 A2M
alpha-2-macroglobulin
chr12_-_9159789 0.811 NM_000014
A2M
alpha-2-macroglobulin
chr12_-_9159707 0.806 A2M
alpha-2-macroglobulin
chr3_+_52803823 0.804 NM_002217
ITIH3
inter-alpha (globulin) inhibitor H3
chr12_-_9159742 0.804 A2M
alpha-2-macroglobulin
chr22_-_42589543 0.802 NM_014351
SULT4A1
sulfotransferase family 4A, member 1
chr2_+_174907914 0.797 NM_001145250
SP9
Sp9 transcription factor homolog (mouse)
chr3_-_49701085 0.786 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr3_+_187866464 0.783 NM_000412
HRG
histidine-rich glycoprotein
chr5_+_176807931 0.771 NM_001174102
PRR7
proline rich 7 (synaptic)
chr12_-_54392328 0.769 NM_001144997
ITGA7
integrin, alpha 7
chr18_-_42590989 0.768 NM_013305
ST8SIA5
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
chr11_+_65945050 0.765 NM_178864
NPAS4
neuronal PAS domain protein 4
chr6_+_43136159 0.762 NM_201522
KLC4
kinesin light chain 4
chr12_-_119038836 0.761 RAB35
RAB35, member RAS oncogene family
chr16_+_10745174 0.757 NM_002484
NUBP1
nucleotide binding protein 1 (MinD homolog, E. coli)
chr2_+_241023703 0.756 NM_002081
GPC1
glypican 1
chr1_+_160306093 0.752 NM_001164757
NM_014697
NOS1AP

nitric oxide synthase 1 (neuronal) adaptor protein

chr15_+_72005839 0.748 NM_005576
LOXL1
lysyl oxidase-like 1
chr12_-_23993830 0.743 NM_006940
SOX5
SRY (sex determining region Y)-box 5
chr11_+_120478584 0.741 NM_005422
TECTA
tectorin alpha
chr17_-_36996611 0.737 NM_000526
KRT14
keratin 14
chr17_+_56832255 0.735 TBX2
T-box 2
chr20_-_2031521 0.733


chr11_+_73339011 0.727 NM_153614
DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr15_+_72005847 0.727 LOXL1
lysyl oxidase-like 1
chr1_-_35143570 0.725 NM_001080418
DLGAP3
discs, large (Drosophila) homolog-associated protein 3
chr14_-_36058648 0.725 NM_003317
NKX2-1
NK2 homeobox 1
chr16_+_2528022 0.723 PDPK1
3-phosphoinositide dependent protein kinase-1
chr16_-_16224791 0.709 NM_001079528
NM_001171
ABCC6

ATP-binding cassette, sub-family C (CFTR/MRP), member 6

chr12_+_131577229 0.708 NM_001142641
FBRSL1
fibrosin-like 1
chr2_-_218551786 0.707 TNS1
tensin 1
chr2_+_12775814 0.707


chr17_+_77280801 0.706 NM_002949
MRPL12
mitochondrial ribosomal protein L12
chr11_-_70535889 0.703 SHANK2
SH3 and multiple ankyrin repeat domains 2
chr2_-_26635069 0.700 NM_194248
OTOF
otoferlin
chr20_-_34921689 0.698 NM_199181
KIAA0889
KIAA0889
chr11_+_67534364 0.695 NM_000694
NM_001030010
ALDH3B1

aldehyde dehydrogenase 3 family, member B1

chr20_-_42249631 0.693 NM_020433
NM_175913
JPH2

junctophilin 2

chr20_+_31541441 0.691 CBFA2T2
core-binding factor, runt domain, alpha subunit 2; translocated to, 2
chr6_+_31976754 0.689 NM_001178063
C2
complement component 2
chr16_-_31390926 0.689


chr7_+_27248688 0.687 NM_001989
EVX1
even-skipped homeobox 1
chr19_-_7874426 0.687


chr1_-_169888373 0.686 NM_000261
MYOC
myocilin, trabecular meshwork inducible glucocorticoid response
chr5_+_175902117 0.684 NM_001171976
CDHR2
cadherin-related family member 2
chrX_-_1470862 0.683 NM_001636
SLC25A6
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
chr3_+_50279993 0.682 NM_001005914
NM_004636
SEMA3B

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B

chr16_+_28782578 0.677 NM_001145795
NM_001145796
NM_001145797
SH2B1


SH2B adaptor protein 1


chr1_+_1250152 0.675


chr22_-_36836620 0.674 NM_025045
BAIAP2L2
BAI1-associated protein 2-like 2
chr14_-_60185659 0.669 NM_005982
SIX1
SIX homeobox 1
chr12_+_6768934 0.664 NM_001195014
NM_001195015
NM_001195016
NM_001195017
CD4



CD4 molecule



chr4_+_187424336 0.664 F11
coagulation factor XI
chr20_-_60360789 0.663 LAMA5
laminin, alpha 5
chr13_+_112681626 0.662 NM_024979
MCF2L
MCF.2 cell line derived transforming sequence-like
chr19_+_11510578 0.662 NM_001299
CNN1
calponin 1, basic, smooth muscle
chr9_-_14900992 0.661 NM_144966
FREM1
FRAS1 related extracellular matrix 1
chr15_+_72005864 0.661 LOXL1
lysyl oxidase-like 1
chr15_+_72005875 0.655 LOXL1
lysyl oxidase-like 1
chr11_-_8788765 0.654 NM_213618
ST5
suppression of tumorigenicity 5
chr11_-_118739838 0.651 USP2
ubiquitin specific peptidase 2
chr12_+_6517600 0.647


chr12_-_122032148 0.646 ABCB9
ATP-binding cassette, sub-family B (MDR/TAP), member 9
chr2_-_238164452 0.644 NM_022449
RAB17
RAB17, member RAS oncogene family
chr13_-_27460773 0.643 NM_001105577
PRHOXNB
parahox cluster neighbor
chr12_+_52708460 0.642 NM_004503
HOXC6
homeobox C6
chr1_-_27604656 0.642 WASF2
WAS protein family, member 2
chr1_-_31485320 0.641 NM_024522
NKAIN1
Na+/K+ transporting ATPase interacting 1
chr1_+_1250005 0.640 NM_001029885
GLTPD1
glycolipid transfer protein domain containing 1
chr16_-_30445353 0.638 NM_024671
ZNF768
zinc finger protein 768
chr19_+_53640841 0.637 NM_031485
GRWD1
glutamate-rich WD repeat containing 1
chr17_-_74361620 0.634 TIMP2
TIMP metallopeptidase inhibitor 2
chr17_-_35510074 0.633 NR1D1
nuclear receptor subfamily 1, group D, member 1
chr10_-_50640327 0.632 NM_001143996
NM_001143997
NM_018245
OGDHL


oxoglutarate dehydrogenase-like


chr11_+_63060848 0.631 NM_004585
RARRES3
retinoic acid receptor responder (tazarotene induced) 3
chr20_-_3696344 0.629 NM_001039140
C20orf27
chromosome 20 open reading frame 27
chr6_+_39124534 0.625 NM_002062
GLP1R
glucagon-like peptide 1 receptor
chr5_+_119827903 0.624 NM_016644
PRR16
proline rich 16
chr5_+_119827797 0.621 PRR16
proline rich 16
chr6_-_35588613 0.617 NM_003322
TULP1
tubby like protein 1
chr1_+_1250115 0.616 GLTPD1
glycolipid transfer protein domain containing 1
chr22_-_28041650 0.616 NM_001007279
NM_006477
RASL10A

RAS-like, family 10, member A

chr22_-_30671298 0.614 NM_015372
C22orf24
chromosome 22 open reading frame 24
chr12_-_119249938 0.613 NM_000928
PLA2G1B
phospholipase A2, group IB (pancreas)
chr8_-_59575249 0.609 NM_000780
CYP7A1
cytochrome P450, family 7, subfamily A, polypeptide 1
chr19_+_12995782 0.606 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr2_+_233029076 0.604 NM_001631
ALPI
alkaline phosphatase, intestinal
chr16_+_2528052 0.604 PDPK1
3-phosphoinositide dependent protein kinase-1
chr6_-_43135092 0.603 NM_015950
MRPL2
mitochondrial ribosomal protein L2
chr1_+_160618143 0.603 NM_001085375
C1orf226
chromosome 1 open reading frame 226
chr10_+_119292699 0.602


chr8_-_145723209 0.601 NM_001024678
LRRC24
leucine rich repeat containing 24
chr5_-_11956964 0.601 NM_001332
CTNND2
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
chr17_-_33982580 0.599 SRCIN1
SRC kinase signaling inhibitor 1
chr13_+_113546841 0.597 NM_000820
GAS6
growth arrest-specific 6
chr12_+_2032964 0.597 CACNA1C
calcium channel, voltage-dependent, L type, alpha 1C subunit
chr3_-_188936941 0.596 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr16_+_85101605 0.595 NM_001451
FOXF1
forkhead box F1
chr5_-_148014282 0.595 HTR4
5-hydroxytryptamine (serotonin) receptor 4
chr14_+_76298693 0.594 VASH1
vasohibin 1
chr12_-_52975777 0.592 NM_006163
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr11_-_59237893 0.591 NM_001005324
OR10V1
olfactory receptor, family 10, subfamily V, member 1
chr11_+_73037382 0.590 NM_001130036
PLEKHB1
pleckstrin homology domain containing, family B (evectins) member 1
chr17_-_71385651 0.589 TRIM47
tripartite motif containing 47
chr2_-_110665188 0.588 NM_033514
LIMS3-LOC440895
LIMS3
LIMS3-LOC440895 read-through
LIM and senescent cell antigen-like domains 3
chr12_-_120781002 0.586 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr7_-_75876830 0.585 NM_080744
SRCRB4D
scavenger receptor cysteine rich domain containing, group B (4 domains)
chr20_-_3097070 0.584 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr10_-_76488277 0.584 NM_001003892
DUPD1
dual specificity phosphatase and pro isomerase domain containing 1
chr17_-_24972471 0.582 NM_032854
CORO6
coronin 6
chr8_-_144862266 0.579 NM_001162914
LOC100130274
coiled-coil domain containing 121-like
chr17_+_1595012 0.578 SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr4_+_119732338 0.575 LOC729218
hypothetical LOC729218
chr11_-_5227611 0.574 NM_000559
HBG1
HBG2
hemoglobin, gamma A
hemoglobin, gamma G
chr13_-_113151453 0.571 NM_199162
ADPRHL1
ADP-ribosylhydrolase like 1
chr17_+_35471971 0.570 NM_001190919
THRA
thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
chr3_+_134947940 0.564 TF
transferrin
chr16_+_30903963 0.564 NM_001142777
NM_001142778
NM_025193
HSD3B7


hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7


chr20_+_29656744 0.561 NM_002165
NM_181353
ID1

inhibitor of DNA binding 1, dominant negative helix-loop-helix protein

chr19_+_53641029 0.561 GRWD1
glutamate-rich WD repeat containing 1
chr11_-_7941617 0.556 NM_176821
NLRP10
NLR family, pyrin domain containing 10
chr12_-_10853940 0.554 NM_023917
TAS2R9
taste receptor, type 2, member 9
chr9_-_14769530 0.551 NM_001177704
FREM1
FRAS1 related extracellular matrix 1
chr12_+_56230073 0.551 KIF5A
kinesin family member 5A
chr3_+_9720509 0.550 NM_153635
CPNE9
copine family member IX
chr11_+_119586879 0.550 NM_178507
OAF
OAF homolog (Drosophila)
chr19_+_53801811 0.550 NM_133498
SPACA4
sperm acrosome associated 4

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.23 1.97e-09 GO:0032501 multicellular organismal process
1.26 1.23e-06 GO:0007275 multicellular organismal development
1.29 2.97e-06 GO:0048731 system development
1.26 1.13e-05 GO:0048856 anatomical structure development
1.23 1.41e-05 GO:0032502 developmental process
1.08 6.67e-05 GO:0009987 cellular process
1.21 2.10e-04 GO:0023052 signaling
1.30 2.41e-04 GO:0065008 regulation of biological quality
1.30 3.37e-04 GO:0030154 cell differentiation
1.29 6.33e-04 GO:0048869 cellular developmental process
1.35 6.65e-04 GO:0009653 anatomical structure morphogenesis
1.74 1.38e-03 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.49 3.21e-03 GO:0010557 positive regulation of macromolecule biosynthetic process
1.62 3.58e-03 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.13 3.99e-03 GO:0050896 response to stimulus
1.33 4.32e-03 GO:0007399 nervous system development
1.64 4.56e-03 GO:0032583 regulation of gene-specific transcription
1.52 5.78e-03 GO:0045893 positive regulation of transcription, DNA-dependent
1.45 1.01e-02 GO:0051173 positive regulation of nitrogen compound metabolic process
1.39 1.31e-02 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.42 1.70e-02 GO:0031328 positive regulation of cellular biosynthetic process
1.44 2.26e-02 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.34 2.38e-02 GO:0031325 positive regulation of cellular metabolic process
1.10 2.41e-02 GO:0065007 biological regulation
1.18 2.47e-02 GO:0007165 signal transduction
1.39 2.70e-02 GO:0022008 neurogenesis
1.41 2.73e-02 GO:0009891 positive regulation of biosynthetic process
1.46 3.75e-02 GO:0010628 positive regulation of gene expression
1.21 3.82e-02 GO:0048518 positive regulation of biological process
1.46 3.82e-02 GO:0051254 positive regulation of RNA metabolic process
4.84 4.52e-02 GO:0048041 focal adhesion assembly

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.28 1.70e-04 GO:0005576 extracellular region
1.87 6.32e-04 GO:0016323 basolateral plasma membrane
1.44 1.12e-03 GO:0005615 extracellular space
1.37 1.67e-03 GO:0044421 extracellular region part
5.02 1.37e-02 GO:0005833 hemoglobin complex
1.43 2.82e-02 GO:0030054 cell junction
2.13 2.84e-02 GO:0005925 focal adhesion

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.10 2.97e-03 GO:0005515 protein binding
1.49 3.72e-03 GO:0005198 structural molecule activity
1.67 6.66e-03 GO:0016563 transcription activator activity
1.35 1.22e-02 GO:0030528 transcription regulator activity