Motif ID: NR6A1.p2

Z-value: 0.674


Transcription factors associated with NR6A1.p2:

Gene SymbolEntrez IDGene Name
NR6A1 2649 nuclear receptor subfamily 6, group A, member 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NR6A1chr9_-_126573349-0.194.8e-01Click!


Activity profile for motif NR6A1.p2.

activity profile for motif NR6A1.p2


Sorted Z-values histogram for motif NR6A1.p2

Sorted Z-values for motif NR6A1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR6A1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_82540172 0.761 NM_013370
NM_182980
OSGIN1

oxidative stress induced growth inhibitor 1

chr6_+_146906520 0.658 NM_006834
RAB32
RAB32, member RAS oncogene family
chr9_-_14303943 0.654 NFIB
nuclear factor I/B
chr14_+_92188546 0.504 RIN3
Ras and Rab interactor 3
chr9_-_14303899 0.497 NFIB
nuclear factor I/B
chr9_+_123083540 0.452 GSN
gelsolin
chr17_+_71586857 0.429 NM_180990
ZACN
zinc activated ligand-gated ion channel
chr3_-_127719283 0.404 NM_001165974
NM_144639
UROC1

urocanase domain containing 1

chr9_-_38059207 0.398 NM_003028
SHB
Src homology 2 domain containing adaptor protein B
chr14_-_106038122 0.395 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr17_-_45619038 0.391 COL1A1
collagen, type I, alpha 1
chr9_-_14303509 0.385 NFIB
nuclear factor I/B
chr9_-_14304036 0.382 NM_001190737
NM_005596
NFIB

nuclear factor I/B

chr9_-_21218132 0.365 NM_021268
IFNA17
interferon, alpha 17
chr10_+_89409332 0.364 NM_001015880
NM_004670
PAPSS2

3'-phosphoadenosine 5'-phosphosulfate synthase 2

chr7_+_100037817 0.352 NM_002593
PCOLCE
procollagen C-endopeptidase enhancer
chr14_+_92188329 0.347 RIN3
Ras and Rab interactor 3
chr16_+_55199978 0.341 NM_005953
MT2A
metallothionein 2A
chr14_-_106038573 0.333 IGHA1
IGHA2
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr14_-_105524207 0.318 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr6_+_129245978 0.303 NM_000426
NM_001079823
LAMA2

laminin, alpha 2

chr3_+_187866464 0.268 NM_000412
HRG
histidine-rich glycoprotein
chr2_-_128792515 0.258 NM_004807
HS6ST1
heparan sulfate 6-O-sulfotransferase 1
chr6_-_33655811 0.255 BAK1
BCL2-antagonist/killer 1
chr12_+_107797985 0.250 NM_001917
DAO
D-amino-acid oxidase
chr9_-_21207303 0.248 NM_002173
IFNA16
interferon, alpha 16
chr19_+_46390916 0.221 NM_030622
CYP2S1
cytochrome P450, family 2, subfamily S, polypeptide 1
chr9_-_38059082 0.218 SHB
Src homology 2 domain containing adaptor protein B
chr4_-_90977149 0.213 NM_001146054
NM_007308
NM_000345
SNCA


synuclein, alpha (non A4 component of amyloid precursor)


chr10_+_123744131 0.212 TACC2
transforming, acidic coiled-coil containing protein 2
chr6_+_32114060 0.208 NM_000500
NM_001128590
CYP21A2

cytochrome P450, family 21, subfamily A, polypeptide 2

chr6_+_43136159 0.199 NM_201522
KLC4
kinesin light chain 4
chr9_+_35782405 0.199 NM_003995
NPR2
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
chr10_-_126097483 0.199 NM_000274
NM_001171814
OAT

ornithine aminotransferase

chr7_+_28497272 0.198 CREB5
cAMP responsive element binding protein 5
chr17_-_45280377 0.198 NM_001077503
NM_001077504
NM_001077505
NM_001077506
NM_170685
TAC4




tachykinin 4 (hemokinin)




chr11_-_5980953 0.197 NM_001005179
OR56A4
olfactory receptor, family 56, subfamily A, member 4
chr6_-_33655995 0.187 NM_001188
BAK1
BCL2-antagonist/killer 1
chr2_-_224611568 0.185 NM_001136530
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr19_+_10057972 0.184 C19orf66
chromosome 19 open reading frame 66
chr9_-_21156609 0.182 NM_002175
IFNA21
interferon, alpha 21
chr16_-_360509 0.177 NM_006428
MRPL28
mitochondrial ribosomal protein L28
chr12_+_7039453 0.173


chr19_-_48382398 0.164 NM_001130014
NM_002781
PSG5

pregnancy specific beta-1-glycoprotein 5

chr16_-_68317945 0.158 NM_000903
NM_001025433
NM_001025434
NQO1


NAD(P)H dehydrogenase, quinone 1


chr2_-_31214868 0.156


chr4_+_1923629 0.145 WHSC1
Wolf-Hirschhorn syndrome candidate 1
chr1_-_10964680 0.144 NM_001170754
C1orf127
chromosome 1 open reading frame 127
chr11_+_65140207 0.142 NM_032223
PCNXL3
pecanex-like 3 (Drosophila)
chr2_-_162638875 0.142 DPP4
dipeptidyl-peptidase 4
chr5_-_14064846 0.140 DNAH5
dynein, axonemal, heavy chain 5
chr7_+_73506172 0.129 GTF2IRD1
GTF2I repeat domain containing 1
chrX_+_48803459 0.125 NM_001163322
NM_033626
NM_001163321
NM_001163323
CCDC120



coiled-coil domain containing 120



chr1_-_159435440 0.124 NM_005099
ADAMTS4
ADAM metallopeptidase with thrombospondin type 1 motif, 4
chr11_+_111294868 0.121 C11orf52
chromosome 11 open reading frame 52
chr14_-_72523404 0.119 NM_178441
ZFYVE1
zinc finger, FYVE domain containing 1
chr19_+_10058023 0.119 C19orf66
chromosome 19 open reading frame 66
chr1_+_224064365 0.115 NM_001136018
EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr1_+_9222489 0.115 H6PD
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
chr11_+_36274300 0.114 NM_001160167
PRR5L
proline rich 5 like
chr9_-_129719031 0.112 NM_175039
NM_175040
ST6GALNAC4

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4

chr6_-_132952517 0.112 NM_003967
TAAR5
trace amine associated receptor 5
chr9_-_113401921 0.107 NM_001146108
NM_001146109
PTGR1

prostaglandin reductase 1

chr16_+_716936 0.099 NM_207112
NM_032304
HAGHL

hydroxyacylglutathione hydrolase-like

chr6_-_56515640 0.099


chr9_-_21197141 0.096 NM_002171
IFNA10
interferon, alpha 10
chr7_+_73506047 0.096 NM_016328
GTF2IRD1
GTF2I repeat domain containing 1
chr6_+_155453114 0.094 NM_012454
TIAM2
T-cell lymphoma invasion and metastasis 2
chr10_-_126097444 0.093 OAT
ornithine aminotransferase
chr17_-_40339919 0.093 GFAP
glial fibrillary acidic protein
chr2_-_130646415 0.092 SMPD4
sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
chr13_+_23723831 0.090 SPATA13
spermatogenesis associated 13
chr15_+_75074793 0.090 PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr22_+_30340152 0.089 SFI1
Sfi1 homolog, spindle assembly associated (yeast)
chr8_-_37576515 0.087 LOC157860
hypothetical protein LOC157860
chr12_+_50592379 0.084 NM_001077401
ACVRL1
activin A receptor type II-like 1
chr1_-_6684426 0.084 DNAJC11
DnaJ (Hsp40) homolog, subfamily C, member 11
chr11_+_125163215 0.084 NM_001129883
PATE3
prostate and testis expressed 3
chr1_-_20707196 0.084 NM_024544
MUL1
mitochondrial E3 ubiquitin protein ligase 1
chr2_-_162638746 0.081 DPP4
dipeptidyl-peptidase 4
chr10_-_105228986 0.078 NM_001129742
CALHM3
calcium homeostasis modulator 3
chr14_-_105712630 0.076 IGHV4-31
IGHA1
IGHA2
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
chr7_-_65084641 0.074 GUSB
glucuronidase, beta
chr7_+_1543644 0.072 MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr10_+_80777265 0.071 PPIF
peptidylprolyl isomerase F
chr16_-_2254318 0.070 RNPS1
RNA binding protein S1, serine-rich domain
chr4_-_70661018 0.068 NM_014465
SULT1B1
sulfotransferase family, cytosolic, 1B, member 1
chr3_+_46594079 0.068 NM_003212
TDGF1
teratocarcinoma-derived growth factor 1
chr7_+_45899080 0.067 IGFBP1
insulin-like growth factor binding protein 1
chr14_-_105610144 0.066 IGHA1
IGHG1
IGHG3
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr19_-_48401532 0.066 NM_002780
NM_213633
PSG4

pregnancy specific beta-1-glycoprotein 4

chr6_-_43592670 0.066 YIPF3
Yip1 domain family, member 3
chrX_+_102727068 0.066 NM_001006935
NM_001006937
NM_024863
TCEAL4


transcription elongation factor A (SII)-like 4


chr10_+_124020810 0.065 NM_144587
BTBD16
BTB (POZ) domain containing 16
chr11_+_118259684 0.064 NM_001716
CXCR5
chemokine (C-X-C motif) receptor 5
chr2_+_96672200 0.064 NM_001113382
FER1L5
fer-1-like 5 (C. elegans)
chr1_-_120413698 0.063 NOTCH2
notch 2
chr8_-_93177057 0.062 NM_001198625
NM_001198626
NM_001198627
NM_001198631
NM_001198634
NM_001198679
RUNX1T1





runt-related transcription factor 1; translocated to, 1 (cyclin D-related)





chr11_+_65945050 0.062 NM_178864
NPAS4
neuronal PAS domain protein 4
chrX_+_54483565 0.061 NM_058163
TSR2
TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
chr3_+_186529376 0.059 MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr1_-_20707103 0.058 MUL1
mitochondrial E3 ubiquitin protein ligase 1
chr1_+_113038202 0.058 MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr14_+_104462199 0.057 PLD4
phospholipase D family, member 4
chr10_-_71562520 0.057 AIFM2
apoptosis-inducing factor, mitochondrion-associated, 2
chr22_+_49388427 0.056 NM_016431
MAPK8IP2
mitogen-activated protein kinase 8 interacting protein 2
chr1_+_224064427 0.056 EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr17_+_72958330 0.056 SEPT9
septin 9
chr11_+_111294810 0.055 NM_080659
C11orf52
chromosome 11 open reading frame 52
chr19_-_5797465 0.055 FUT3
fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
chr1_+_45046740 0.052 NM_001136537
BTBD19
BTB (POZ) domain containing 19
chr12_+_2792047 0.052 NM_018463
ITFG2
integrin alpha FG-GAP repeat containing 2
chr19_-_6671585 0.051 NM_000064
C3
complement component 3
chr1_+_78284176 0.050 NM_017655
GIPC2
GIPC PDZ domain containing family, member 2
chr13_-_23369124 0.050 NM_001007537
C1QTNF9B
C1q and tumor necrosis factor related protein 9B
chr19_+_44838373 0.046 NM_001190441
LGALS16
beta-galactoside-binding lectin
chr1_+_33003847 0.044 KIAA1522
KIAA1522
chr16_-_28130201 0.044 XPO6
exportin 6
chr2_-_97775300 0.043 TMEM131
transmembrane protein 131
chr19_-_47261761 0.043 NM_002088
GRIK5
glutamate receptor, ionotropic, kainate 5
chr14_-_106240998 0.043 IGHV1-69
IGHG1
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant gamma 1 (G1m marker)
chrX_-_8099307 0.042 NM_016378
VCX2
variable charge, X-linked 2
chr11_+_64946820 0.041 NEAT1
nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr11_-_786175 0.040 NM_024698
SLC25A22
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
chr1_-_158091296 0.040 C1orf204
chromosome 1 open reading frame 204
chr14_+_104462210 0.038 NM_138790
PLD4
phospholipase D family, member 4
chr19_+_8814268 0.037 NM_145208
MBD3L1
methyl-CpG binding domain protein 3-like 1
chr11_-_64520964 0.037 NM_138456
BATF2
basic leucine zipper transcription factor, ATF-like 2
chr14_-_105542441 0.036 IGLJ3
IGHA1
IGHG1
IGHM
immunoglobulin lambda joining 3
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr5_+_175241449 0.035 CPLX2
complexin 2
chr17_-_24426752 0.034 NM_004740
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr10_+_91488704 0.034 KIF20B
kinesin family member 20B
chr19_-_48133089 0.034 NM_002783
PSG7
pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)
chr14_-_75517844 0.033 NM_003239
TGFB3
transforming growth factor, beta 3
chr1_+_93072947 0.033 RPL5
ribosomal protein L5
chr1_-_145712107 0.032 NM_005266
GJA5
gap junction protein, alpha 5, 40kDa
chr11_+_66381077 0.031 LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr14_+_104462195 0.030 PLD4
phospholipase D family, member 4
chr19_+_47079089 0.030 NM_004706
NM_198977
ARHGEF1

Rho guanine nucleotide exchange factor (GEF) 1

chr5_+_134237325 0.030 NM_024715
TXNDC15
thioredoxin domain containing 15
chr14_-_105279582 0.029


chr14_+_105278855 0.029 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr2_-_162638174 0.029 DPP4
dipeptidyl-peptidase 4
chr11_+_71387572 0.028 NM_001039659
NM_001039660
NM_173042
IL18BP


interleukin 18 binding protein


chr3_+_134947573 0.027 NM_001063
TF
transferrin
chr12_-_6354650 0.027 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr1_+_151035850 0.026 NM_178352
LCE1D
late cornified envelope 1D
chr16_+_31274030 0.026 ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr1_+_210805319 0.025 NM_001030287
ATF3
activating transcription factor 3
chr6_+_117910472 0.024 NM_173674
DCBLD1
discoidin, CUB and LCCL domain containing 1
chr1_-_925332 0.024 NM_001142467
NM_021170
HES4

hairy and enhancer of split 4 (Drosophila)

chr10_+_47414028 0.022 NM_018232
FAM21B
family with sequence similarity 21, member B
chr6_-_43592481 0.022 YIPF3
Yip1 domain family, member 3
chr1_+_46151845 0.022 MAST2
microtubule associated serine/threonine kinase 2
chr12_-_46439127 0.021 NM_001098531
RAPGEF3
Rap guanine nucleotide exchange factor (GEF) 3
chrX_+_8392870 0.021 NM_001001888
VCX3B
VCX3A
variable charge, X-linked 3B
variable charge, X-linked 3A
chr22_-_22389502 0.021 LOC91316
glucuronidase, beta/immunoglobulin lambda-like polypeptide 1 pseudogene
chr9_+_139101235 0.019 NM_016219
MAN1B1
mannosidase, alpha, class 1B, member 1
chr10_-_71562602 0.018 NM_001198696
NM_032797
AIFM2

apoptosis-inducing factor, mitochondrion-associated, 2

chr2_-_25418249 0.017 NM_022552
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr1_+_33003814 0.017 NM_001198972
NM_001198973
KIAA1522

KIAA1522

chr1_+_143920424 0.016 NM_203458
NOTCH2NL
notch 2 N-terminal like
chr7_-_65084597 0.016 GUSB
glucuronidase, beta
chr1_-_40009513 0.016 NM_022120
OXCT2
3-oxoacid CoA transferase 2
chr16_-_3246587 0.015 NM_000243
NM_001198536
MEFV

Mediterranean fever

chr4_-_160175782 0.015 NM_152543
C4orf45
chromosome 4 open reading frame 45
chr22_-_22389524 0.014 LOC91316
glucuronidase, beta/immunoglobulin lambda-like polypeptide 1 pseudogene
chr4_-_154900466 0.014


chr1_-_46541517 0.014 LRRC41
leucine rich repeat containing 41
chr3_+_134947788 0.014 TF
transferrin
chr21_-_36836767 0.014 NM_001146078
CLDN14
claudin 14
chr21_+_44902276 0.013 NM_198697
KRTAP12-3
keratin associated protein 12-3
chr15_+_61122957 0.012 TPM1
tropomyosin 1 (alpha)
chr10_+_51507891 0.012 NM_018232
FAM21B
family with sequence similarity 21, member B
chr6_+_107456457 0.012 C6orf203
chromosome 6 open reading frame 203
chr13_+_107720475 0.011 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr3_+_114948600 0.011 ATP6V1A
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr1_+_107484151 0.011 NM_001113226
NM_001113228
NM_014917
NTNG1


netrin G1


chr6_+_30964441 0.010 NM_013994
DDR1
discoidin domain receptor tyrosine kinase 1
chr12_-_108736983 0.010 NM_001177431
NM_001177428
NM_001177433
NM_147204
TRPV4



transient receptor potential cation channel, subfamily V, member 4



chr16_-_57309625 0.010 GOT2
glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)
chr17_+_77289704 0.010 SLC25A10
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chr1_-_159369041 0.009 DEDD
death effector domain containing
chr2_-_21084911 0.009 APOB
apolipoprotein B (including Ag(x) antigen)
chr16_-_65781499 0.008 NM_178516
EXOC3L1
exocyst complex component 3-like 1
chr3_-_52287297 0.008 WDR82
WD repeat domain 82
chr17_-_57023322 0.007 NM_199290
NACA2
nascent polypeptide-associated complex alpha subunit 2
chrX_+_17563333 0.007 NM_001136024
NHS
Nance-Horan syndrome (congenital cataracts and dental anomalies)
chr1_+_151873134 0.007 NM_015607
C1orf77
chromosome 1 open reading frame 77
chr14_-_105804211 0.007 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr16_+_3391155 0.007 NM_001032292
NM_003450
ZNF174

zinc finger protein 174

chr6_-_43592679 0.007 NM_015388
YIPF3
Yip1 domain family, member 3
chr6_+_167504070 0.006 NM_001145121
TCP10L2
TCP10
t-complex 10-like 2 (mouse)
t-complex 10 homolog (mouse)
chr17_+_12633504 0.006 NM_014859
ARHGAP44
Rho GTPase activating protein 44
chrX_-_104352005 0.006 NM_031274
TEX13A
testis expressed 13A
chr6_-_116706828 0.005 TSPYL1
TSPY-like 1
chr7_-_65084622 0.005 GUSB
glucuronidase, beta
chr1_-_151873191 0.005 NM_001024210
S100A13
S100 calcium binding protein A13
chr6_-_167717907 0.005 NM_004610
TCP10
t-complex 10 homolog (mouse)
chr20_-_42457717 0.004



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
5.84 2.09e-02 GO:0030155 regulation of cell adhesion

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.87 2.24e-03 GO:0005624 membrane fraction
2.78 3.61e-03 GO:0005626 insoluble fraction
2.32 2.35e-02 GO:0000267 cell fraction
1.85 4.88e-02 GO:0005576 extracellular region

Gene overrepresentation in function category:

enrichment   p-value GO term description
13.06 6.97e-03 GO:0003823 antigen binding