Motif ID: PAX2.p2

Z-value: 0.791


Transcription factors associated with PAX2.p2:

Gene SymbolEntrez IDGene Name
PAX2 5076 paired box 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PAX2chr10_+_102495327-0.766.4e-04Click!


Activity profile for motif PAX2.p2.

activity profile for motif PAX2.p2


Sorted Z-values histogram for motif PAX2.p2

Sorted Z-values for motif PAX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_85457469 1.520 PICALM
phosphatidylinositol binding clathrin assembly protein
chr5_+_133734768 1.474 NM_003337
 UBE2B
ubiquitin-conjugating enzyme E2B (RAD6 homolog)
chr6_+_160310118 1.316 NM_000876
 IGF2R
insulin-like growth factor 2 receptor
chr20_+_46971618 1.288 NM_006420
 ARFGEF2
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
chr11_+_7574992 1.284 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr11_-_85457753 1.281 NM_001008660
NM_007166
 PICALM

phosphatidylinositol binding clathrin assembly protein

chr11_-_85457736 1.243 PICALM
phosphatidylinositol binding clathrin assembly protein
chr12_-_56432385 1.210 NM_000075
 CDK4
cyclin-dependent kinase 4
chr2_+_46779553 1.195 NM_014011
 SOCS5
suppressor of cytokine signaling 5
chr14_+_23654161 1.149 DCAF11
DDB1 and CUL4 associated factor 11
chr15_-_63871492 1.143 DENND4A
DENN/MADD domain containing 4A
chr17_+_55051818 1.128 NM_004859
 CLTC
clathrin, heavy chain (Hc)
chr15_-_63871598 1.079 NM_001144823
NM_005848
 DENND4A

DENN/MADD domain containing 4A

chr2_+_46779827 1.077 NM_144949
 SOCS5
suppressor of cytokine signaling 5
chr18_+_9126742 1.066 NM_001083625
NM_015208
 ANKRD12

ankyrin repeat domain 12

chr3_+_19963534 1.051 NM_004162
 RAB5A
RAB5A, member RAS oncogene family
chr17_+_55052060 1.029 CLTC
clathrin, heavy chain (Hc)
chr17_+_55052046 1.012 CLTC
clathrin, heavy chain (Hc)
chr6_+_87921980 1.003 NM_015021
 ZNF292
zinc finger protein 292
chr14_+_23653848 0.984 DCAF11
DDB1 and CUL4 associated factor 11

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 62 entries
enrichment   p-value GO term description
2.10 8.73e-03 GO:0050657 nucleic acid transport
2.10 8.73e-03 GO:0050658 RNA transport
2.10 8.73e-03 GO:0051236 establishment of RNA localization
2.09 8.19e-03 GO:0006403 RNA localization
2.04 4.94e-03 GO:0015931 nucleobase, nucleoside, nucleotide and nucleic acid transport
1.97 4.43e-04 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
1.97 4.43e-04 GO:0000398 nuclear mRNA splicing, via spliceosome
1.95 4.96e-04 GO:0000375 RNA splicing, via transesterification reactions
1.78 4.38e-04 GO:0008380 RNA splicing
1.72 8.58e-05 GO:0006397 mRNA processing
1.66 9.39e-06 GO:0016071 mRNA metabolic process
1.65 1.62e-02 GO:0006511 ubiquitin-dependent protein catabolic process
1.63 6.22e-03 GO:0044419 interspecies interaction between organisms
1.63 6.27e-03 GO:0016568 chromatin modification
1.62 2.15e-08 GO:0046907 intracellular transport
1.62 2.78e-02 GO:0051603 proteolysis involved in cellular protein catabolic process
1.62 3.55e-02 GO:0019941 modification-dependent protein catabolic process
1.61 4.87e-06 GO:0006396 RNA processing
1.61 3.17e-02 GO:0044257 cellular protein catabolic process
1.61 4.58e-02 GO:0043632 modification-dependent macromolecule catabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 39 entries
enrichment   p-value GO term description
3.68 1.90e-02 GO:0031519 PcG protein complex
2.36 4.79e-04 GO:0000776 kinetochore
2.01 2.33e-03 GO:0005681 spliceosomal complex
1.90 8.75e-03 GO:0005769 early endosome
1.82 3.85e-02 GO:0000775 chromosome, centromeric region
1.65 4.16e-02 GO:0016604 nuclear body
1.55 1.50e-06 GO:0044451 nucleoplasm part
1.52 4.44e-12 GO:0005654 nucleoplasm
1.49 7.32e-03 GO:0044427 chromosomal part
1.49 9.50e-03 GO:0005768 endosome
1.47 7.39e-03 GO:0030529 ribonucleoprotein complex
1.44 5.65e-15 GO:0044428 nuclear part
1.43 1.34e-02 GO:0005694 chromosome
1.42 4.44e-11 GO:0031981 nuclear lumen
1.39 6.87e-13 GO:0043233 organelle lumen
1.39 1.30e-12 GO:0070013 intracellular organelle lumen
1.38 1.31e-12 GO:0031974 membrane-enclosed lumen
1.38 1.38e-02 GO:0031967 organelle envelope
1.35 3.43e-02 GO:0031975 envelope
1.34 4.09e-08 GO:0005829 cytosol

Gene overrepresentation in function category:

Showing 1 to 20 of 22 entries
enrichment   p-value GO term description
1.78 2.89e-03 GO:0003713 transcription coactivator activity
1.76 5.24e-03 GO:0004842 ubiquitin-protein ligase activity
1.71 8.94e-03 GO:0019787 small conjugating protein ligase activity
1.69 7.59e-05 GO:0003712 transcription cofactor activity
1.68 8.74e-05 GO:0000988 protein binding transcription factor activity
1.68 8.74e-05 GO:0000989 transcription factor binding transcription factor activity
1.60 2.33e-02 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.50 4.78e-06 GO:0003723 RNA binding
1.49 1.64e-02 GO:0016874 ligase activity
1.32 1.57e-08 GO:0000166 nucleotide binding
1.32 5.59e-05 GO:0030554 adenyl nucleotide binding
1.32 1.52e-04 GO:0005524 ATP binding
1.31 4.71e-06 GO:0017076 purine nucleotide binding
1.31 1.02e-05 GO:0035639 purine ribonucleoside triphosphate binding
1.31 1.48e-04 GO:0032559 adenyl ribonucleotide binding
1.30 1.57e-05 GO:0032553 ribonucleotide binding
1.30 1.57e-05 GO:0032555 purine ribonucleotide binding
1.25 1.63e-07 GO:0003676 nucleic acid binding
1.22 2.14e-20 GO:0005515 protein binding
1.20 2.48e-02 GO:0003677 DNA binding