Motif ID: PBX1.p2

Z-value: 0.894


Transcription factors associated with PBX1.p2:

Gene SymbolEntrez IDGene Name
PBX1 5087 pre-B-cell leukemia homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PBX1chr1_+_1627953280.485.8e-02Click!


Activity profile for motif PBX1.p2.

activity profile for motif PBX1.p2


Sorted Z-values histogram for motif PBX1.p2

Sorted Z-values for motif PBX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PBX1.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_189752575 0.969 NM_000393
COL5A2
collagen, type V, alpha 2
chr17_+_70495318 0.966 NM_014603
CDR2L
cerebellar degeneration-related protein 2-like
chr6_-_166960690 0.805 NM_021135
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr22_-_28972683 0.786 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr2_+_20510312 0.758 NM_004040
RHOB
ras homolog gene family, member B
chr10_+_124310170 0.634 NM_004406
NM_007329
NM_017579
DMBT1


deleted in malignant brain tumors 1


chr3_+_112934016 0.630 NM_001134437
PHLDB2
pleckstrin homology-like domain, family B, member 2
chr13_-_109236897 0.556 NM_003749
IRS2
insulin receptor substrate 2
chr12_+_77782719 0.525 SYT1
synaptotagmin I
chr5_-_171814026 0.523 NM_001017995
SH3PXD2B
SH3 and PX domains 2B
chr6_-_166960649 0.516 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr5_-_149515613 0.495 NM_002609
PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr4_+_86968069 0.459 ARHGAP24
Rho GTPase activating protein 24
chr5_+_54434230 0.444 NM_006144
GZMA
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
chr5_+_15553288 0.432 NM_012304
FBXL7
F-box and leucine-rich repeat protein 7
chrX_-_10605726 0.423 NM_001098624
MID1
midline 1 (Opitz/BBB syndrome)
chr14_+_54104383 0.421 NM_001161576
NM_015589
SAMD4A

sterile alpha motif domain containing 4A

chrX_-_92815222 0.419 NM_004538
NAP1L3
nucleosome assembly protein 1-like 3
chr9_+_112470871 0.408 NM_001166280
NM_001166281
NM_005592
MUSK


muscle, skeletal, receptor tyrosine kinase


chr3_+_161040343 0.406 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr10_+_69539255 0.397 NM_032578
MYPN
myopalladin
chr9_-_83494198 0.385 TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr14_+_51025604 0.372 NM_001042481
FRMD6
FERM domain containing 6
chr3_+_185762233 0.369 NM_004443
EPHB3
EPH receptor B3
chr6_-_166960496 0.367 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr18_+_45342398 0.363 NM_006033
LIPG
lipase, endothelial
chr1_+_162795328 0.363 NM_002585
PBX1
pre-B-cell leukemia homeobox 1
chr1_-_35143570 0.360 NM_001080418
DLGAP3
discs, large (Drosophila) homolog-associated protein 3
chr6_+_151603264 0.355


chr11_+_113671744 0.348 NM_006169
NNMT
nicotinamide N-methyltransferase
chr6_+_151603201 0.340 AKAP12
A kinase (PRKA) anchor protein 12
chr9_-_128910132 0.337 ANGPTL2
angiopoietin-like 2
chr5_-_171813960 0.332 SH3PXD2B
SH3 and PX domains 2B
chr8_+_69027143 0.331 NM_024870
NM_025170
PREX2

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2

chr2_-_192767844 0.330 NM_016192
TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr5_+_150008030 0.328 SYNPO
synaptopodin
chr14_+_93455010 0.325 NM_138344
FAM181A
family with sequence similarity 181, member A
chr14_-_75196911 0.325 C14orf1
chromosome 14 open reading frame 1
chr2_-_218843109 0.314 NM_001087
AAMP
angio-associated, migratory cell protein
chr19_+_13767207 0.312 NM_023072
ZSWIM4
zinc finger, SWIM-type containing 4
chr1_-_171442937 0.311 NM_003326
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr4_-_177950658 0.304 NM_005429
VEGFC
vascular endothelial growth factor C
chr2_-_218843088 0.298 AAMP
angio-associated, migratory cell protein
chr15_+_39032927 0.296 NM_001142776
NM_024111
CHAC1

ChaC, cation transport regulator homolog 1 (E. coli)

chr13_-_32757835 0.294 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr10_+_103976132 0.293 NM_152310
ELOVL3
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3
chr16_+_2145810 0.292 TRAF7
TNF receptor-associated factor 7
chr1_+_170656450 0.289 NM_139240
C1orf105
chromosome 1 open reading frame 105
chr5_-_149515502 0.286 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr3_+_161040439 0.286 SCHIP1
schwannomin interacting protein 1
chr11_-_7804094 0.278 NM_153445
OR5P3
olfactory receptor, family 5, subfamily P, member 3
chr16_+_2145765 0.277 NM_032271
TRAF7
TNF receptor-associated factor 7
chr10_-_44794146 0.269 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr19_+_12941431 0.263 NM_152654
DAND5
DAN domain family, member 5
chr4_+_8935987 0.260 NM_001105662
USP17L2
USP17L6P
USP17
ubiquitin specific peptidase 17-like 2
ubiquitin specific peptidase 17-like 6 (pseudogene)
ubiquitin specific peptidase 17
chr1_-_226712140 0.251 NM_033445
HIST3H2A
histone cluster 3, H2a
chr8_+_69026895 0.250 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr22_+_27468018 0.248 NM_172002
HSCB
HscB iron-sulfur cluster co-chaperone homolog (E. coli)
chr13_+_56619622 0.248 NM_198441
NM_001130404
NM_001130405
NM_001130406
NM_001130407
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
proline rich 20A
proline rich 20B
proline rich 20C
proline rich 20D
proline rich 20E
chr7_-_77163475 0.243


chr6_+_151603346 0.239 AKAP12
A kinase (PRKA) anchor protein 12
chr19_-_44573343 0.238 PAF1
Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
chr3_-_113495763 0.238 NM_183061
SLC9A10
solute carrier family 9, member 10
chr5_-_149515331 0.237 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr4_-_111777956 0.237 NM_153426
NM_153427
PITX2

paired-like homeodomain 2

chr7_+_128136347 0.237 FAM71F1
family with sequence similarity 71, member F1
chr17_-_71023221 0.236 NM_020753
CASKIN2
CASK interacting protein 2
chr2_-_192767494 0.233 TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr7_-_7646573 0.230 RPA3
replication protein A3, 14kDa
chr1_-_147665783 0.225 HIST2H2BF
histone cluster 2, H2bf
chr13_+_94052022 0.224 NM_180989
GPR180
G protein-coupled receptor 180
chr10_-_102880892 0.218 NM_001085398
TLX1NB
TLX1 neighbor
chr19_+_46462113 0.218 HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr11_+_69176391 0.218 CCND1
cyclin D1
chr2_+_28469850 0.216 FOSL2
FOS-like antigen 2
chr8_-_49996353 0.215 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr12_-_112143209 0.215 NM_138451
IQCD
IQ motif containing D
chr19_+_14501406 0.214 TECR
trans-2,3-enoyl-CoA reductase
chr8_-_25371858 0.212 NM_017634
KCTD9
potassium channel tetramerisation domain containing 9
chr17_-_1566223 0.209 C17orf91
chromosome 17 open reading frame 91
chr12_+_21570457 0.209 NM_030572
C12orf39
chromosome 12 open reading frame 39
chr5_-_58607673 0.208 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr16_+_15503623 0.205 NM_001142469
C16orf45
chromosome 16 open reading frame 45
chr4_+_77575276 0.199 NM_020859
SHROOM3
shroom family member 3
chr7_-_137182125 0.198 NM_004717
DGKI
diacylglycerol kinase, iota
chr19_+_14501403 0.197 TECR
trans-2,3-enoyl-CoA reductase
chr3_+_171621721 0.196 NM_001185056
CLDN11
claudin 11
chr3_+_138132006 0.195 NM_001190796
NCK1
NCK adaptor protein 1
chr13_+_96726415 0.194 MBNL2
muscleblind-like 2 (Drosophila)
chr12_+_77782648 0.189 SYT1
synaptotagmin I
chr11_-_85074848 0.189 NM_152723
CCDC89
coiled-coil domain containing 89
chr15_+_41597097 0.189 NM_002373
MAP1A
microtubule-associated protein 1A
chr19_+_46461897 0.184 NM_007040
HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr10_+_102881050 0.184 NM_001195517
NM_005521
TLX1

T-cell leukemia homeobox 1

chr14_-_103251497 0.182 NM_001100118
NM_001100119
NM_005432
XRCC3


X-ray repair complementing defective repair in Chinese hamster cells 3


chr19_-_14501048 0.181 DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr5_-_16795336 0.175 MYO10
myosin X
chr7_-_121571472 0.174 NM_005763
AASS
aminoadipate-semialdehyde synthase
chr11_-_27679175 0.174 NM_001143808
NM_001143809
NM_001143810
NM_001143811
BDNF



brain-derived neurotrophic factor



chr1_+_201729893 0.174 NM_014359
OPTC
opticin
chr17_-_43977273 0.169 NM_002145
HOXB2
homeobox B2
chr12_-_54409710 0.169 CD63
CD63 molecule
chr17_-_71023048 0.168 CASKIN2
CASK interacting protein 2
chr4_-_140696740 0.168 NM_030648
SETD7
SET domain containing (lysine methyltransferase) 7
chr19_+_14501363 0.161 NM_138501
TECR
trans-2,3-enoyl-CoA reductase
chr9_+_36180927 0.161 CLTA
clathrin, light chain A
chr17_-_36436979 0.161 NM_031957
KRTAP1-5
keratin associated protein 1-5
chr2_+_216695062 0.160 XRCC5
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
chr19_-_44573468 0.160 NM_019088
PAF1
Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
chr17_-_36456949 0.159 NM_001123387
KRTAP2-1
keratin associated protein 2-1
chr11_+_113436438 0.159 NM_001018011
ZBTB16
zinc finger and BTB domain containing 16
chr17_+_54763689 0.158 NM_001005404
YPEL2
yippee-like 2 (Drosophila)
chr15_-_84139021 0.158 KLHL25
kelch-like 25 (Drosophila)
chr16_+_1772929 0.158 NM_012225
NUBP2
nucleotide binding protein 2 (MinD homolog, E. coli)
chr19_-_59355246 0.157 NM_024316
LENG1
leukocyte receptor cluster (LRC) member 1
chr9_-_72926333 0.157 NM_001007471
TRPM3
transient receptor potential cation channel, subfamily M, member 3
chr1_-_120285753 0.154 NOTCH2
notch 2
chr4_+_176076083 0.152 NM_001130703
NM_001130704
NM_001130705
NM_014269
ADAM29



ADAM metallopeptidase domain 29



chr3_+_138063697 0.151 NM_006153
NCK1
NCK adaptor protein 1
chr10_+_17310263 0.151 NM_003380
VIM
vimentin
chr11_-_102174102 0.151 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chrX_+_46581418 0.148 RP2
retinitis pigmentosa 2 (X-linked recessive)
chr5_+_15553539 0.141 FBXL7
F-box and leucine-rich repeat protein 7
chr3_+_131175803 0.140 NM_007117
TRH
thyrotropin-releasing hormone
chr2_+_71534260 0.139 NM_001130976
NM_001130977
NM_001130978
NM_001130979
NM_001130980
NM_001130981
NM_003494
DYSF






dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)






chr16_+_1773004 0.136 NUBP2
nucleotide binding protein 2 (MinD homolog, E. coli)
chr1_+_16220952 0.135 NM_001042704
NM_004070
CLCNKA

CLCNKB
chloride channel Ka

chloride channel Kb
chr7_-_526005 0.135 NM_002607
NM_033023
PDGFA

platelet-derived growth factor alpha polypeptide

chr12_+_47945132 0.135 TUBA1C
tubulin, alpha 1c
chr9_+_36180936 0.134 CLTA
clathrin, light chain A
chr14_+_64041257 0.132 ZBTB1
zinc finger and BTB domain containing 1
chr7_-_27108826 0.131 NM_006735
HOXA2
homeobox A2
chr22_+_34025872 0.130 TOM1
target of myb1 (chicken)
chr10_-_79067296 0.130 KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chrX_-_145703940 0.130 NM_001144064
CXorf51
chromosome X open reading frame 51
chr10_+_99390459 0.129 PI4K2A
phosphatidylinositol 4-kinase type 2 alpha
chr4_+_154083584 0.129 NM_033393
FHDC1
FH2 domain containing 1
chr16_+_67778441 0.126 NM_006750
SNTB2
syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
chr2_+_12774264 0.126 NM_021643
TRIB2
tribbles homolog 2 (Drosophila)
chr9_+_36180885 0.126 CLTA
clathrin, light chain A
chr16_+_81218142 0.125 CDH13
cadherin 13, H-cadherin (heart)
chr10_+_114699953 0.124 NM_001146274
NM_001146283
NM_001146284
NM_001146285
NM_001146286
NM_001198525
NM_001198526
NM_001198527
NM_001198528
NM_001198529
NM_001198530
NM_001198531
NM_030756
TCF7L2












transcription factor 7-like 2 (T-cell specific, HMG-box)












chr8_+_69027166 0.124 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr11_-_102174032 0.124 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr3_-_50340598 0.124 TUSC2
tumor suppressor candidate 2
chr16_+_3433606 0.124 NM_001083601
NAT15
N-acetyltransferase 15 (GCN5-related, putative)
chr4_-_70115037 0.123 NM_001073
UGT2B11
UDP glucuronosyltransferase 2 family, polypeptide B11
chr14_-_91642703 0.123 NM_001127696
NM_001127697
NM_001164774
NM_001164776
NM_001164777
NM_001164778
NM_001164779
NM_001164780
NM_001164781
NM_001164782
NM_004993
NM_030660
ATXN3











ataxin 3











chr11_-_129803515 0.122 ADAMTS8
ADAM metallopeptidase with thrombospondin type 1 motif, 8
chr12_+_27568311 0.121 NM_001198915
NM_001198916
NM_003622
NM_177444
PPFIBP1



PTPRF interacting protein, binding protein 1 (liprin beta 1)



chr12_+_47009029 0.120 NM_181788
H1FNT
H1 histone family, member N, testis-specific
chr9_-_98421894 0.120 NM_003671
NM_033331
CDC14B

CDC14 cell division cycle 14 homolog B (S. cerevisiae)

chrX_-_10548458 0.120 NM_000381
NM_033289
MID1

midline 1 (Opitz/BBB syndrome)

chr17_-_7471832 0.120 NM_133491
SAT2
spermidine/spermine N1-acetyltransferase family member 2
chr3_-_71196696 0.119 FOXP1
forkhead box P1
chr9_-_14303509 0.119 NFIB
nuclear factor I/B
chr9_+_36180956 0.117 CLTA
clathrin, light chain A
chr19_-_54646837 0.116 NM_017916
PIH1D1
PIH1 domain containing 1
chr21_-_46473143 0.116 NM_001001438
NM_001145436
NM_001145437
NM_002340
LSS



lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)



chr21_-_35174742 0.116 RUNX1
runt-related transcription factor 1
chr13_+_97856148 0.116


chr9_-_106407728 0.115 NM_001004481
OR13C2
olfactory receptor, family 13, subfamily C, member 2
chr3_-_161766055 0.115 NM_002268
KPNA4
karyopherin alpha 4 (importin alpha 3)
chr19_-_63301386 0.115 ZSCAN18
zinc finger and SCAN domain containing 18
chr3_-_150993299 0.114 NM_001144960
C3orf16
chromosome 3 open reading frame 16
chr6_+_26212082 0.113 NM_003542
HIST1H4C
histone cluster 1, H4c
chr1_+_216585298 0.112 NM_001135599
NM_003238
TGFB2

transforming growth factor, beta 2

chr3_-_161766005 0.112 KPNA4
karyopherin alpha 4 (importin alpha 3)
chr19_-_3928840 0.111 EEF2
eukaryotic translation elongation factor 2
chr17_-_77411803 0.111 NM_000918
P4HB
prolyl 4-hydroxylase, beta polypeptide
chr13_+_96726197 0.110 MBNL2
muscleblind-like 2 (Drosophila)
chr5_+_90711887 0.110 LOC100129716
hypothetical LOC100129716
chr2_-_162808123 0.109 NM_004460
FAP
fibroblast activation protein, alpha
chr7_-_141320041 0.109 NM_176817
TAS2R38
taste receptor, type 2, member 38
chr3_+_130641779 0.108 IFT122
intraflagellar transport 122 homolog (Chlamydomonas)
chr9_+_129604962 0.108 NM_004957
FPGS
folylpolyglutamate synthase
chr13_+_26029799 0.107 NM_006646
WASF3
WAS protein family, member 3
chr19_+_46462169 0.107 HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr3_+_162697289 0.106 NM_001080440
OTOL1
otolin 1 homolog (zebrafish)
chr11_+_19328846 0.105 NM_001111018
NAV2
neuron navigator 2
chr3_+_52786642 0.105 NM_002215
ITIH1
inter-alpha (globulin) inhibitor H1
chr18_-_45272840 0.104 NM_000985
NM_001035006
RPL17

ribosomal protein L17

chr8_-_23768242 0.104 NM_003155
STC1
stanniocalcin 1
chr3_-_158704056 0.103 NM_001167915
NM_001167916
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chr13_-_95094920 0.103 NM_014934
NM_198968
DZIP1

DAZ interacting protein 1

chr4_-_118226119 0.103 NM_152402
TRAM1L1
translocation associated membrane protein 1-like 1
chr3_-_21767819 0.103 NM_024697
ZNF385D
zinc finger protein 385D
chr4_+_81325447 0.103 NM_020226
PRDM8
PR domain containing 8
chr6_-_63053811 0.102 NM_152688
KHDRBS2
KH domain containing, RNA binding, signal transduction associated 2
chr16_+_81218074 0.102 NM_001257
CDH13
cadherin 13, H-cadherin (heart)
chr18_-_45272820 0.102 RPL17
ribosomal protein L17
chr3_+_130641828 0.101 IFT122
intraflagellar transport 122 homolog (Chlamydomonas)
chr22_-_41741100 0.100 NM_001184970
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr7_-_143230096 0.100 NM_014719
FAM115A
family with sequence similarity 115, member A
chr22_+_34025792 0.099 NM_001135730
NM_001135732
NM_005488
TOM1


target of myb1 (chicken)


chr18_+_58005519 0.098 KIAA1468
KIAA1468
chr14_-_23653965 0.098 NRL
neural retina leucine zipper
chr12_+_47945086 0.098 NM_032704
TUBA1C
tubulin, alpha 1c
chr12_-_90097384 0.097 NM_133503
DCN
decorin
chr4_-_83771386 0.097 SCD5
stearoyl-CoA desaturase 5

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
5.22 1.24e-05 GO:0065004 protein-DNA complex assembly
4.94 3.01e-05 GO:0071824 protein-DNA complex subunit organization
5.34 6.06e-05 GO:0006334 nucleosome assembly
5.06 1.30e-04 GO:0031497 chromatin assembly
4.82 2.66e-04 GO:0034728 nucleosome organization
2.82 2.96e-04 GO:0034622 cellular macromolecular complex assembly
2.14 9.97e-04 GO:0071844 cellular component assembly at cellular level
4.12 1.11e-03 GO:0006323 DNA packaging
2.40 2.35e-03 GO:0034621 cellular macromolecular complex subunit organization
3.85 2.90e-03 GO:0006333 chromatin assembly or disassembly
3.54 9.26e-03 GO:0071103 DNA conformation change
1.99 2.95e-02 GO:0065003 macromolecular complex assembly
1.88 4.28e-02 GO:0043933 macromolecular complex subunit organization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
6.50 1.63e-05 GO:0000786 nucleosome
5.12 1.81e-05 GO:0032993 protein-DNA complex
1.14 2.98e-02 GO:0043229 intracellular organelle
1.13 3.54e-02 GO:0043226 organelle
2.53 4.84e-02 GO:0000785 chromatin

Nothing significant found in function category.