Motif ID: PDX1.p2

Z-value: 0.502


Transcription factors associated with PDX1.p2:

Gene SymbolEntrez IDGene Name
PDX1 3651 pancreatic and duodenal homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PDX1chr13_+_273921360.302.7e-01Click!


Activity profile for motif PDX1.p2.

activity profile for motif PDX1.p2


Sorted Z-values histogram for motif PDX1.p2

Sorted Z-values for motif PDX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PDX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_17624304 0.386 NM_001166393
MTUS1
microtubule associated tumor suppressor 1
chr8_-_17624009 0.308 NM_001001931
MTUS1
microtubule associated tumor suppressor 1
chr11_+_55899675 0.269 NM_001005204
NM_001013356
OR8U1
OR8U8
olfactory receptor, family 8, subfamily U, member 1
olfactory receptor, family 8, subfamily U, member 8
chr11_-_123182266 0.269 NM_001005325
OR6M1
olfactory receptor, family 6, subfamily M, member 1
chr2_+_113452066 0.269 NM_019618
IL1F9
interleukin 1 family, member 9
chr5_+_147628567 0.242 NM_001040129
SPINK13
serine peptidase inhibitor, Kazal type 13 (putative)
chr6_-_133076873 0.241 NM_004666
VNN1
vanin 1
chr8_-_17599438 0.225 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr8_+_76614757 0.223 NM_004133
HNF4G
hepatocyte nuclear factor 4, gamma
chr1_+_62835759 0.219 NM_014495
ANGPTL3
angiopoietin-like 3
chr18_-_45630154 0.209 MYO5B
myosin VB
chr10_+_118177371 0.204 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chr3_+_101720753 0.189 TMEM45A
transmembrane protein 45A
chr4_-_69116839 0.166 NM_001077
UGT2B17
UDP glucuronosyltransferase 2 family, polypeptide B17
chr3_-_168674502 0.163 NM_006217
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr3_+_116824840 0.159 NM_001130064
NM_002045
GAP43

growth associated protein 43

chr9_-_8723893 0.151 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr4_+_187424336 0.151 F11
coagulation factor XI
chr6_-_55848346 0.146 BMP5
bone morphogenetic protein 5
chr3_+_46594079 0.133 NM_003212
TDGF1
teratocarcinoma-derived growth factor 1
chr16_+_18986417 0.133 NM_016138
COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr16_+_18986459 0.127 COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr1_+_157441133 0.126 NM_002036
DARC
Duffy blood group, chemokine receptor
chr18_+_54039730 0.121 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr11_+_22652894 0.118 NM_005256
GAS2
growth arrest-specific 2
chr4_+_88939725 0.114 NM_004967
IBSP
integrin-binding sialoprotein
chr16_+_69115227 0.113 SF3B3
splicing factor 3b, subunit 3, 130kDa
chr8_+_32698892 0.111 NM_001159996
NRG1
neuregulin 1
chr6_+_130381408 0.107 NM_001007102
NM_032438
L3MBTL3

l(3)mbt-like 3 (Drosophila)

chr3_-_121883647 0.106 HGD
homogentisate 1,2-dioxygenase
chr11_+_22652957 0.104 GAS2
growth arrest-specific 2
chr8_+_26569709 0.104 DPYSL2
dihydropyrimidinase-like 2
chr21_-_30781537 0.100 NM_181608
KRTAP19-2
keratin associated protein 19-2
chr17_-_7023378 0.099 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chr18_+_54039779 0.096 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr6_+_167624792 0.095 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr6_-_55848317 0.086 NM_021073
BMP5
bone morphogenetic protein 5
chr12_-_52305900 0.086 ATF7
activating transcription factor 7
chr1_-_20122638 0.084 NM_014589
PLA2G2E
phospholipase A2, group IIE
chr9_+_137553104 0.082 NM_002297
LCN1
lipocalin 1 (tear prealbumin)
chr12_-_10853940 0.079 NM_023917
TAS2R9
taste receptor, type 2, member 9
chr16_+_18986721 0.075 NM_001190983
COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chrX_+_110252960 0.074 NM_001128168
NM_001128172
NM_001128173
PAK3


p21 protein (Cdc42/Rac)-activated kinase 3


chr2_+_169629544 0.073 NM_005771
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr11_-_5130174 0.070 NM_012375
OR52A1
olfactory receptor, family 52, subfamily A, member 1
chr12_-_101835510 0.068 NM_000277
PAH
phenylalanine hydroxylase
chr17_-_36418869 0.068 NM_031958
KRTAP3-1
keratin associated protein 3-1
chr6_-_123999640 0.066 NM_006073
TRDN
triadin
chr17_-_36890877 0.066 NM_002280
KRT35
keratin 35
chr2_-_188127294 0.064 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr16_-_21078262 0.064 NM_017539
DNAH3
dynein, axonemal, heavy chain 3
chr14_+_20580224 0.063 NM_032572
RNASE7
ribonuclease, RNase A family, 7
chr15_-_42756377 0.063 NM_001145112
PATL2
protein associated with topoisomerase II homolog 2 (yeast)
chr2_-_218516950 0.061 NM_022648
TNS1
tensin 1
chr2_+_204440753 0.060 NM_001037631
NM_005214
CTLA4

cytotoxic T-lymphocyte-associated protein 4

chr14_+_38653177 0.059 NM_001009182
NM_001009183
NM_003616
SIP1


survival of motor neuron protein interacting protein 1


chr2_-_188127430 0.059 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr2_-_165768798 0.058 NM_001081676
NM_001081677
NM_006922
SCN3A


sodium channel, voltage-gated, type III, alpha subunit


chr6_-_134540666 0.057 NM_001143677
SGK1
serum/glucocorticoid regulated kinase 1
chr16_+_69115189 0.057 NM_012426
SF3B3
splicing factor 3b, subunit 3, 130kDa
chr4_-_155753249 0.054 FGG
fibrinogen gamma chain
chr3_+_185253528 0.053 NM_130770
HTR3C
5-hydroxytryptamine (serotonin) receptor 3, family member C
chr17_-_39499527 0.052 LSM12
LSM12 homolog (S. cerevisiae)
chrX_+_99786044 0.049 SRPX2
sushi-repeat containing protein, X-linked 2
chr12_-_4358968 0.049 NM_020638
FGF23
fibroblast growth factor 23
chr7_+_116182676 0.048


chr14_-_80934523 0.047 NM_033104
STON2
stonin 2
chr18_+_54039818 0.047 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr2_-_27215781 0.047 NM_178553
C2orf53
chromosome 2 open reading frame 53
chr1_+_100776280 0.046 NM_022049
GPR88
G protein-coupled receptor 88
chr4_+_89115825 0.043 NM_000582
NM_001040058
NM_001040060
SPP1


secreted phosphoprotein 1


chr18_+_59374372 0.043 NM_080474
SERPINB12
serpin peptidase inhibitor, clade B (ovalbumin), member 12
chr4_-_176970372 0.043 GPM6A
glycoprotein M6A
chr5_+_34720368 0.042 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr17_-_36409632 0.042 NM_031959
KRTAP3-2
keratin associated protein 3-2
chr1_-_202402043 0.041 NM_000537
REN
renin
chr12_-_102968044 0.040 NM_031302
GLT8D2
glycosyltransferase 8 domain containing 2
chr4_-_176970895 0.039 GPM6A
glycoprotein M6A
chr11_-_55661769 0.039 NM_001004064
OR8J3
olfactory receptor, family 8, subfamily J, member 3
chr19_-_56229808 0.038 NM_019598
NM_145894
NM_145895
KLK12


kallikrein-related peptidase 12


chr6_-_131333173 0.038 EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr2_-_183095308 0.037 NM_005019
NM_001003683
PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr17_-_9635325 0.037 NM_001105571
DHRS7C
dehydrogenase/reductase (SDR family) member 7C
chr6_+_144654565 0.036 NM_007124
UTRN
utrophin
chr1_+_12900031 0.036 NM_001012277
PRAMEF7
PRAME family member 7
chr5_+_140207540 0.036 NM_014005
NM_031857
PCDHA9

protocadherin alpha 9

chr1_+_43508251 0.035 NM_144626
TMEM125
transmembrane protein 125
chr10_+_70650064 0.034 NM_025130
HKDC1
hexokinase domain containing 1
chr12_-_54150188 0.033 NM_001005499
OR6C70
olfactory receptor, family 6, subfamily C, member 70
chr4_+_187424111 0.032 NM_000128
F11
coagulation factor XI
chr8_-_27171852 0.032 STMN4
stathmin-like 4
chr3_-_69120188 0.032 C3orf64
chromosome 3 open reading frame 64
chr4_+_95595419 0.031 PDLIM5
PDZ and LIM domain 5
chr20_+_43423990 0.031 NM_001197129
SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr1_-_230717850 0.031 NM_020808
SIPA1L2
signal-induced proliferation-associated 1 like 2
chrX_+_99785818 0.031 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr10_+_63478974 0.031 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr3_+_110024234 0.030 NM_016388
TRAT1
T cell receptor associated transmembrane adaptor 1
chr9_+_33614214 0.029 ANXA2P2
annexin A2 pseudogene 2
chr11_+_89458765 0.028 NM_001143975
UBTFL1
upstream binding transcription factor, RNA polymerase I-like 1
chr7_-_11643113 0.028 THSD7A
thrombospondin, type I, domain containing 7A
chr14_-_46882144 0.028 NM_182830
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr4_+_74825138 0.028 NM_000584
IL8
interleukin 8
chr8_+_11877238 0.027 NM_001033017
DEFB135
defensin, beta 135
chr16_+_69115225 0.027 SF3B3
splicing factor 3b, subunit 3, 130kDa
chr6_+_72979234 0.027 NM_001168407
NM_001168408
RIMS1

regulating synaptic membrane exocytosis 1

chr6_-_138581319 0.027 NM_021635
PBOV1
prostate and breast cancer overexpressed 1
chr1_-_150328153 0.027 NM_001008536
TCHHL1
trichohyalin-like 1
chrX_+_48572226 0.027 NM_181532
ERAS
ES cell expressed Ras
chr11_+_6823458 0.026 NM_178168
OR10A5
olfactory receptor, family 10, subfamily A, member 5
chr12_+_108061584 0.026 NM_001093
ACACB
acetyl-CoA carboxylase beta
chr21_-_30631882 0.025 NM_001077711
KRTAP27-1
keratin associated protein 27-1
chr1_+_57093030 0.025 NM_000562
C8A
complement component 8, alpha polypeptide
chr6_-_29563657 0.025 NM_052967
MAS1L
MAS1 oncogene-like
chr11_+_111294810 0.025 NM_080659
C11orf52
chromosome 11 open reading frame 52
chr10_+_116687904 0.024 NM_139169
TRUB1
TruB pseudouridine (psi) synthase homolog 1 (E. coli)
chr1_-_161379606 0.024 RGS5
regulator of G-protein signaling 5
chr4_+_86615275 0.024 NM_001025616
ARHGAP24
Rho GTPase activating protein 24
chr12_+_118100977 0.024 NM_014365
HSPB8
heat shock 22kDa protein 8
chrX_-_131375217 0.023 NM_001170701
NM_001170702
NM_001170703
MBNL3


muscleblind-like 3 (Drosophila)


chr11_+_61732715 0.023 NM_002407
SCGB2A1
secretoglobin, family 2A, member 1
chr12_-_14740694 0.022 NM_004963
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr3_-_152517204 0.022 NM_023915
GPR87
G protein-coupled receptor 87
chr2_-_99412694 0.022 REV1
REV1 homolog (S. cerevisiae)
chr16_+_56286212 0.022 NM_032269
CCDC135
coiled-coil domain containing 135
chr6_-_31215089 0.021 NM_014069
PSORS1C2
psoriasis susceptibility 1 candidate 2
chr3_+_11153778 0.021 NM_001098213
HRH1
histamine receptor H1
chr6_+_158653679 0.020 NM_001007466
NM_020245
TULP4

tubby like protein 4

chr2_+_17861266 0.020 NM_001105569
MSGN1
mesogenin 1
chr9_-_139084833 0.020 NM_178448
C9orf140
chromosome 9 open reading frame 140
chr17_+_18566060 0.020 NM_001037330
TRIM16L
tripartite motif containing 16-like
chr7_-_128330615 0.019 KCP
kielin/chordin-like protein
chr4_+_74500748 0.019 ALB
albumin
chr6_-_46933901 0.018 GPR116
G protein-coupled receptor 116
chr17_+_7900926 0.018


chr21_-_30666417 0.018 NM_181621
KRTAP13-2
keratin associated protein 13-2
chr9_+_140226457 0.018 NM_001145249
FAM157B
family with sequence similarity 157, member B
chrX_-_131923092 0.016 NM_001077188
NM_147175
HS6ST2

heparan sulfate 6-O-sulfotransferase 2

chr12_-_52306348 0.015 NM_001130060
NM_006856
ATF7

activating transcription factor 7

chr17_+_35372751 0.015 NM_178171
GSDMA
gasdermin A
chr12_+_4700012 0.015 NM_017417
GALNT8
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)
chr5_+_140181405 0.015 NM_018908
NM_031501
PCDHA5

protocadherin alpha 5

chr17_+_7423528 0.015 NM_001251
NM_001040059
CD68

CD68 molecule

chr12_+_4569504 0.014 NM_003845
DYRK4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr10_+_86174665 0.013 FAM190B
family with sequence similarity 190, member B
chr10_+_94584449 0.013 NM_001013848
EXOC6
exocyst complex component 6
chr18_+_606671 0.013 NM_199167
CLUL1
clusterin-like 1 (retinal)
chr1_+_84382575 0.013 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr17_-_39499463 0.012 LSM12
LSM12 homolog (S. cerevisiae)
chr1_+_28637247 0.012 NM_023923
PHACTR4
phosphatase and actin regulator 4
chr2_+_169634330 0.012 DHRS9
dehydrogenase/reductase (SDR family) member 9
chr11_-_116168316 0.012 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr2_+_227900471 0.011 NM_020194
MFF
mitochondrial fission factor
chr1_-_245942679 0.011 NM_001005286
OR6F1
olfactory receptor, family 6, subfamily F, member 1
chr3_+_141879555 0.010 NM_152616
TRIM42
tripartite motif containing 42
chr1_+_84540921 0.010 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr17_+_7423685 0.010 CD68
CD68 molecule
chr3_+_49522871 0.009 DAG1
dystroglycan 1 (dystrophin-associated glycoprotein 1)
chr17_+_7423662 0.009 CD68
CD68 molecule
chr10_-_56230953 0.009 NM_001142763
NM_001142764
NM_001142765
NM_001142766
NM_001142767
NM_001142768
NM_001142769
NM_001142770
NM_001142771
NM_001142772
NM_001142773
NM_033056
PCDH15











protocadherin-related 15











chr21_-_30460841 0.009 NM_012131
CLDN17
claudin 17
chr12_+_10074542 0.008 NM_207345
CLEC9A
C-type lectin domain family 9, member A
chr17_-_39500512 0.008 NM_152344
LSM12
LSM12 homolog (S. cerevisiae)
chr17_+_7423704 0.008 CD68
CD68 molecule
chr10_+_126620681 0.008 NM_017580
ZRANB1
zinc finger, RAN-binding domain containing 1
chr9_+_33016482 0.007 DNAJA1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr11_-_55684368 0.007 NM_001004058
OR8K5
olfactory receptor, family 8, subfamily K, member 5
chr2_+_38746742 0.006 GALM
galactose mutarotase (aldose 1-epimerase)
chr10_+_80942362 0.006 NM_001099692
EIF5AL1
eukaryotic translation initiation factor 5A-like 1
chr2_-_121964373 0.006 CLASP1
cytoplasmic linker associated protein 1
chr5_+_179934143 0.005 CNOT6
CCR4-NOT transcription complex, subunit 6
chr4_+_71492581 0.005 NM_016519
AMBN
ameloblastin (enamel matrix protein)
chr2_-_46988449 0.005 MCFD2
multiple coagulation factor deficiency 2
chr21_-_45173061 0.005 NM_001127491
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr16_-_70339666 0.005 AP1G1
adaptor-related protein complex 1, gamma 1 subunit
chr1_-_159786441 0.005 NM_000569
NM_001127592
FCGR3A

Fc fragment of IgG, low affinity IIIa, receptor (CD16a)

chrX_-_48655978 0.005 PIM2
pim-2 oncogene
chr5_+_140698537 0.005 NM_018915
NM_032009
PCDHGA2

protocadherin gamma subfamily A, 2

chr3_+_35658852 0.004 NM_016300
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr2_+_203763649 0.004 RPL12
ribosomal protein L12
chr22_-_23665312 0.003 NM_001001663
TMEM211
transmembrane protein 211
chr3_-_124822113 0.003 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr3_-_47909001 0.003 MAP4
microtubule-associated protein 4
chr12_-_48902692 0.003 NM_001113547
LIMA1
LIM domain and actin binding 1
chr1_+_161305558 0.003 NM_001113381
RGS4
regulator of G-protein signaling 4
chr21_-_44824907 0.003 NM_198694
KRTAP10-5
keratin associated protein 10-5
chr6_-_52060327 0.002 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr2_+_105799354 0.002 NCK2
NCK adaptor protein 2
chr8_-_27906287 0.001 NM_173833
SCARA5
scavenger receptor class A, member 5 (putative)
chr12_-_119938667 0.001 NM_022895
C12orf43
chromosome 12 open reading frame 43
chr17_-_1195096 0.000 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr4_+_53975597 0.000 FIP1L1
FIP1 like 1 (S. cerevisiae)
chr16_-_69114931 0.000 NM_001195139
NM_015386
COG4

component of oligomeric golgi complex 4

chr9_-_21218132 0.000 NM_021268
IFNA17
interferon, alpha 17
chr3_+_52786642 0.000 NM_002215
ITIH1
inter-alpha (globulin) inhibitor H1
chr4_-_176970407 0.000 GPM6A
glycoprotein M6A
chr1_+_184532027 0.000 NM_001127708
NM_001127709
NM_001127710
NM_005807
PRG4



proteoglycan 4




Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.04 2.17e-03 GO:0005576 extracellular region
1.59 1.04e-02 GO:0071944 cell periphery

Nothing significant found in function category.