Motif ID: PITX1..3.p2

Z-value: 2.907


Transcription factors associated with PITX1..3.p2:

Gene SymbolEntrez IDGene Name
PITX1 5307 paired-like homeodomain 1
PITX2 5308 paired-like homeodomain 2
PITX3 5309 paired-like homeodomain 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PITX1chr5_-_1343977400.504.9e-02Click!
PITX2chr4_-_111777584,
chr4_-_111777956
-0.486.0e-02Click!
PITX3chr10_-_103991219-0.048.7e-01Click!


Activity profile for motif PITX1..3.p2.

activity profile for motif PITX1..3.p2


Sorted Z-values histogram for motif PITX1..3.p2

Sorted Z-values for motif PITX1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PITX1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_154536051 5.603 NM_001004319
VHLL
von Hippel-Lindau tumor suppressor-like
chr17_-_59818033 3.877 PECAM1
platelet/endothelial cell adhesion molecule
chr1_-_92144146 3.609 NM_001195684
TGFBR3
transforming growth factor, beta receptor III
chr20_+_60946920 3.483 NM_080750
DPH3P1
DPH3, KTI11 homolog (S. cerevisiae) pseudogene 1
chrX_-_2892288 3.228 NM_000047
ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr1_-_100003936 2.790 NM_001013660
FRRS1
ferric-chelate reductase 1
chr12_+_122510338 2.632 NM_180699
SNRNP35
small nuclear ribonucleoprotein 35kDa (U11/U12)
chr16_-_21762256 2.614 LOC100132247
NPIPL3
LOC613037
nuclear pore complex interacting protein related gene
nuclear pore complex interacting protein-like 3
nuclear pore complex interacting protein pseudogene
chr1_-_149611768 2.499 NM_003944
SELENBP1
selenium binding protein 1
chr12_-_116021473 2.481 NM_001168325
NM_017899
TESC

tescalcin

chr1_+_16203317 2.446 NM_178840
C1orf64
chromosome 1 open reading frame 64
chr16_+_70654625 2.352 NM_020995
HPR
haptoglobin-related protein
chr16_+_29378694 2.294 NM_001017390
NM_177552
SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr16_+_30118036 2.281 NM_001017390
NM_177552
SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr19_-_56564068 2.260 NM_152353
CLDND2
claudin domain containing 2
chr17_+_4621924 2.181 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr7_-_143587653 2.107 NM_001005328
OR2A7
OR2A4
olfactory receptor, family 2, subfamily A, member 7
olfactory receptor, family 2, subfamily A, member 4
chr16_+_29597829 2.106 NM_014298
QPRT
quinolinate phosphoribosyltransferase
chr11_+_61861458 2.105 ASRGL1
asparaginase like 1
chr19_+_16115454 2.097 HSH2D
hematopoietic SH2 domain containing
chr12_+_108149558 2.097 ACACB
acetyl-CoA carboxylase beta
chr16_+_86561124 2.026 NM_001173543
BANP
BTG3 associated nuclear protein
chr3_-_110517929 2.007 NM_138815
DPPA2
developmental pluripotency associated 2
chrX_+_9391314 1.978 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr19_-_50834483 1.952 EML2
echinoderm microtubule associated protein like 2
chr19_+_4134350 1.942 NM_133475
ANKRD24
ankyrin repeat domain 24
chr17_-_44400952 1.940 NM_004123
GIP
gastric inhibitory polypeptide
chr22_-_20314274 1.911 NM_001017964
YDJC
YdjC homolog (bacterial)
chr19_+_17198012 1.889 NM_024578
OCEL1
occludin/ELL domain containing 1
chr4_+_2596956 1.884 NM_003704
FAM193A
family with sequence similarity 193, member A
chr9_-_115178161 1.875 NM_031219
HDHD3
haloacid dehalogenase-like hydrolase domain containing 3
chr1_-_159474503 1.869 NM_001077469
NM_001077470
NM_001077471
NM_001077472
NM_001077473
NM_001077474
NM_001077475
NM_001077476
NM_001077477
NM_001077478
NM_001077479
NM_001077480
NM_001077481
NM_001077482
NM_005122
NR1I3














nuclear receptor subfamily 1, group I, member 3














chr20_+_2851852 1.862 NM_080841
PTPRA
protein tyrosine phosphatase, receptor type, A
chr16_-_15741438 1.858 MYH11
myosin, heavy chain 11, smooth muscle
chr22_-_20314366 1.851 YDJC
YdjC homolog (bacterial)
chr12_-_55042793 1.814 NM_001638
APOF
apolipoprotein F
chr17_+_37957509 1.775 NM_000413
HSD17B1
hydroxysteroid (17-beta) dehydrogenase 1
chr6_-_3390197 1.773 NM_021945
SLC22A23
solute carrier family 22, member 23
chr11_-_46569489 1.758 NM_017749
AMBRA1
autophagy/beclin-1 regulator 1
chr16_-_18705578 1.727


chr19_-_5790702 1.704 NM_000150
NM_001040701
FUT6

fucosyltransferase 6 (alpha (1,3) fucosyltransferase)

chr16_-_23371952 1.695 NM_153603
COG7
component of oligomeric golgi complex 7
chr9_+_134884627 1.695 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr1_+_40631603 1.693 NM_001198979
SMAP2
small ArfGAP2
chr17_-_10500189 1.670 NM_002470
MYH3
myosin, heavy chain 3, skeletal muscle, embryonic
chr19_+_4439690 1.667 HDGFRP2
hepatoma-derived growth factor-related protein 2
chr9_+_130257254 1.666 NM_153436
ODF2
outer dense fiber of sperm tails 2
chr14_-_34078532 1.665 NM_018453
EAPP
E2F-associated phosphoprotein
chr20_-_43440290 1.644 NM_014477
TP53TG5
TP53 target 5
chr19_-_8473473 1.641 NM_032152
PRAM1
PML-RARA regulated adaptor molecule 1
chr2_+_201755865 1.637 NM_001230
NM_032974
NM_032977
CASP10


caspase 10, apoptosis-related cysteine peptidase


chr17_+_38412267 1.625 NM_005533
IFI35
interferon-induced protein 35
chr3_+_188222337 1.620 NM_003032
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr2_+_218992053 1.609 NM_007127
VIL1
villin 1
chr1_+_13232405 1.600 NM_001013407
NM_001010889
PRAMEF5
PRAMEF6
PRAME family member 5
PRAME family member 6
chr19_-_1352474 1.587 NM_000156
NM_138924
GAMT

guanidinoacetate N-methyltransferase

chr20_-_32728749 1.585 NM_080476
PIGU
phosphatidylinositol glycan anchor biosynthesis, class U
chr12_-_7935010 1.583 SLC2A14
solute carrier family 2 (facilitated glucose transporter), member 14
chr12_+_120132233 1.557 P2RX4
purinergic receptor P2X, ligand-gated ion channel, 4
chr9_+_131291144 1.553


chr3_-_10337837 1.549 NM_183352
SEC13
SEC13 homolog (S. cerevisiae)
chr20_-_41788975 1.518 NM_001008901
NM_176791
GTSF1L

gametocyte specific factor 1-like

chr16_-_30301634 1.512 NM_052838
SEPT1
septin 1
chr3_-_10337724 1.512 NM_001136232
SEC13
SEC13 homolog (S. cerevisiae)
chr6_-_132064233 1.510 NM_030908
OR2A4
olfactory receptor, family 2, subfamily A, member 4
chr1_+_28528099 1.508 NM_001127350
NM_017638
MED18

mediator complex subunit 18

chr15_-_70838703 1.503


chr2_-_96314148 1.491 SNRNP200
small nuclear ribonucleoprotein 200kDa (U5)
chr20_-_4938913 1.489 NM_203327
SLC23A2
solute carrier family 23 (nucleobase transporters), member 2
chr19_-_2036227 1.489 MOBKL2A
MOB1, Mps One Binder kinase activator-like 2A (yeast)
chr19_-_12706458 1.478 C19orf43
chromosome 19 open reading frame 43
chr19_+_49894260 1.475 NM_001039213
CEACAM16
carcinoembryonic antigen-related cell adhesion molecule 16
chr4_-_88463031 1.461 NM_001136230
NM_178135
HSD17B13

hydroxysteroid (17-beta) dehydrogenase 13

chr5_+_81636921 1.456 NM_001017971
ATP6AP1L
ATPase, H+ transporting, lysosomal accessory protein 1-like
chr15_-_20638283 1.454 NM_001142275
NIPA1
non imprinted in Prader-Willi/Angelman syndrome 1
chr20_+_51235228 1.452 NM_001193421
TSHZ2
teashirt zinc finger homeobox 2
chr12_+_7809078 1.440 NM_001145465
NANOGNB
NANOG neighbor homeobox
chrX_-_119898692 1.438 NM_173571
NM_001080137
NM_001080138
NM_001080139
NM_001080141
NM_001080142
NM_001080143
NM_001080144
NM_001080145
NM_001080146
CT47A11
CT47A10
CT47A9
CT47A8
CT47A6
CT47A5
CT47A4
CT47A3
CT47A2
CT47A1
cancer/testis antigen family 47, member A11
cancer/testis antigen family 47, member A10
cancer/testis antigen family 47, member A9
cancer/testis antigen family 47, member A8
cancer/testis antigen family 47, member A6
cancer/testis antigen family 47, member A5
cancer/testis antigen family 47, member A4
cancer/testis antigen family 47, member A3
cancer/testis antigen family 47, member A2
cancer/testis antigen family 47, member A1
chr19_-_12706480 1.420 C19orf43
chromosome 19 open reading frame 43
chr7_+_821719 1.416 NM_001171946
SUN1
Sad1 and UNC84 domain containing 1
chr17_+_1612031 1.389 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr17_+_46176105 1.367 LUC7L3
LUC7-like 3 (S. cerevisiae)
chr17_-_78599695 1.367 B3GNTL1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
chr6_+_42126242 1.360 TAF8
TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
chr2_+_38746555 1.359 NM_138801
GALM
galactose mutarotase (aldose 1-epimerase)
chr22_-_29231597 1.358 NM_001161368
NM_174977
SEC14L4

SEC14-like 4 (S. cerevisiae)

chr19_+_6323443 1.344 NM_032306
ALKBH7
alkB, alkylation repair homolog 7 (E. coli)
chr17_+_1612056 1.341 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr17_+_70997280 1.335 KIAA0195
KIAA0195
chr12_+_31691360 1.329 NM_001135864
METTL20
methyltransferase like 20
chr19_-_54857003 1.323 IRF3
interferon regulatory factor 3
chr7_+_73262188 1.322 LAT2
linker for activation of T cells family, member 2
chr19_-_44497815 1.319 NM_020862
LRFN1
leucine rich repeat and fibronectin type III domain containing 1
chr15_-_20666684 1.317 LOC283683
hypothetical LOC283683
chr16_-_86527608 1.314 NM_001739
CA5A
carbonic anhydrase VA, mitochondrial
chr1_-_149245503 1.310 NM_001163259
NM_001163260
NM_001040217
FAM63A


family with sequence similarity 63, member A


chr4_+_74499651 1.303 ALB
albumin
chr19_-_59383944 1.297 MBOAT7
membrane bound O-acyltransferase domain containing 7
chr9_+_131605270 1.294 TOR1B
torsin family 1, member B (torsin B)
chr19_+_52532210 1.291 NM_018485
GPR77
G protein-coupled receptor 77
chr22_-_22714230 1.285 NM_000853
GSTT1
glutathione S-transferase theta 1
chr6_-_150001376 1.284 NM_007044
KATNA1
katanin p60 (ATPase containing) subunit A 1
chr9_+_131605215 1.280 NM_014506
TOR1B
torsin family 1, member B (torsin B)
chr12_-_131882616 1.264


chr5_-_10361167 1.261 NM_138809
CMBL
carboxymethylenebutenolidase homolog (Pseudomonas)
chr20_-_32354736 1.260 NM_000687
AHCY
adenosylhomocysteinase
chr8_-_141537859 1.259 NM_031466
TRAPPC9
trafficking protein particle complex 9
chr7_-_100645032 1.246 PLOD3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr19_+_12064077 1.239 ZNF788
zinc finger family member 788
chrX_-_70243362 1.236 NM_001025265
CXorf65
chromosome X open reading frame 65
chr15_-_39623750 1.234 NM_015540
RPAP1
RNA polymerase II associated protein 1
chr20_-_47307554 1.231 ZNFX1
zinc finger, NFX1-type containing 1
chr22_+_20350272 1.223 NM_014337
NM_148175
NM_148176
PPIL2


peptidylprolyl isomerase (cyclophilin)-like 2


chr16_-_88623809 1.222 NM_001214
C16orf3
chromosome 16 open reading frame 3
chr17_+_73694992 1.222 NM_001010982
NM_001145526
AFMID

arylformamidase

chr20_+_43952189 1.218 CTSA
cathepsin A
chr11_-_64520964 1.215 NM_138456
BATF2
basic leucine zipper transcription factor, ATF-like 2
chr19_+_51059357 1.215 NM_004497
FOXA3
forkhead box A3
chr20_+_35240936 1.213 RPN2
ribophorin II
chr22_+_19248733 1.211 MED15
mediator complex subunit 15
chr16_+_70599987 1.201 NM_001361
DHODH
dihydroorotate dehydrogenase
chr22_-_36570287 1.199 NM_138797
ANKRD54
ankyrin repeat domain 54
chr16_-_2254318 1.196 RNPS1
RNA binding protein S1, serine-rich domain
chr9_-_116196505 1.193 NM_030767
AKNA
AT-hook transcription factor
chr17_+_29707583 1.182 NM_005408
CCL13
chemokine (C-C motif) ligand 13
chr1_+_10432362 1.181 NM_001302
CORT
cortistatin
chr4_+_56731117 1.158 NM_020722
KIAA1211
KIAA1211
chr7_-_2561853 1.152 NM_152743
BAAT1
BRCA1-associated ATM activator 1
chr6_-_31871530 1.151 NM_006295
VARS
valyl-tRNA synthetase
chr16_-_24934151 1.140 NM_001006634
NM_018054
ARHGAP17

Rho GTPase activating protein 17

chr17_+_1611983 1.138 NM_002615
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr3_+_52296893 1.138 GLYCTK
glycerate kinase
chr18_-_3001944 1.132 NM_014646
LPIN2
lipin 2
chr19_-_56825400 1.128 NM_003830
SIGLEC5
sialic acid binding Ig-like lectin 5
chr16_-_31013626 1.122 NM_024006
NM_206824
VKORC1

vitamin K epoxide reductase complex, subunit 1

chr16_-_27187559 1.120 NM_145080
NSMCE1
non-SMC element 1 homolog (S. cerevisiae)
chr9_+_130504591 1.119 NM_013355
PKN3
protein kinase N3
chr7_+_44007012 1.111 NM_175064
SPDYE1
speedy homolog E1 (Xenopus laevis)
chr19_+_60168463 1.104 NM_001174081
NLRP2
NLR family, pyrin domain containing 2
chr2_+_201756048 1.083 CASP10
caspase 10, apoptosis-related cysteine peptidase
chr6_+_31706345 1.083 PRRC2A
proline-rich coiled-coil 2A
chr11_+_22652894 1.074 NM_005256
GAS2
growth arrest-specific 2
chr16_-_73798539 1.072 NM_001025200
CTRB1
CTRB2
chymotrypsinogen B1
chymotrypsinogen B2
chr9_+_6710862 1.070 NM_001146696
KDM4C
lysine (K)-specific demethylase 4C
chr19_+_53656317 1.069 NM_170720
KCNJ14
potassium inwardly-rectifying channel, subfamily J, member 14
chr20_+_309272 1.067 NM_021158
TRIB3
tribbles homolog 3 (Drosophila)
chr22_+_40372957 1.054 XRCC6
X-ray repair complementing defective repair in Chinese hamster cells 6
chr17_+_59244363 1.047 DDX42
DEAD (Asp-Glu-Ala-Asp) box polypeptide 42
chr1_+_24713396 1.046 RCAN3
RCAN family member 3
chr22_+_17012841 1.039 USP18
ubiquitin specific peptidase 18
chr1_-_17253073 1.033 NM_003000
SDHB
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
chr12_+_120132319 1.033 P2RX4
purinergic receptor P2X, ligand-gated ion channel, 4
chr3_+_4510160 1.028 ITPR1
inositol 1,4,5-triphosphate receptor, type 1
chr17_-_38427957 1.026 NM_006373
VAT1
vesicle amine transport protein 1 homolog (T. californica)
chr19_+_50100843 1.021 NM_000041
APOE
apolipoprotein E
chr7_+_65217239 1.017 NM_001040647
NM_001040648
NM_001142414
NM_014478
CRCP



CGRP receptor component



chr7_-_129478430 1.006 NM_016478
ZC3HC1
zinc finger, C3HC-type containing 1
chr19_-_16111695 1.006


chr16_+_65558878 1.006 NM_001185176
CES3
carboxylesterase 3
chr12_-_52975777 1.004 NM_006163
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr17_+_68740952 1.002 C17orf80
chromosome 17 open reading frame 80
chr20_+_35351473 1.001 MANBAL
mannosidase, beta A, lysosomal-like
chr19_-_59542197 0.997 NM_012276
LILRA4
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4
chr1_+_28029909 0.988 PPP1R8
protein phosphatase 1, regulatory (inhibitor) subunit 8
chr12_-_52975823 0.988 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr19_-_38052481 0.988 NM_001126335
NM_014270
SLC7A9

solute carrier family 7 (cationic amino acid transporter, y+ system), member 9

chr22_+_34109095 0.983 HMOX1
heme oxygenase (decycling) 1
chr17_+_17320989 0.982 NM_018019
MED9
mediator complex subunit 9
chr11_+_22652957 0.981 GAS2
growth arrest-specific 2
chrX_-_53646332 0.980 HUWE1
HECT, UBA and WWE domain containing 1
chr19_+_50234135 0.979 NM_007056
CLASRP
CLK4-associating serine/arginine rich protein
chr20_+_32598352 0.976 NM_181509
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr20_+_35351428 0.976 NM_001003897
NM_022077
MANBAL

mannosidase, beta A, lysosomal-like

chr20_+_43423990 0.971 NM_001197129
SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr17_-_59451662 0.970 NM_001099786
NM_001099787
NM_001099788
NM_001099789
ICAM2



intercellular adhesion molecule 2



chr11_+_69872033 0.963 PPFIA1
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
chr19_+_17906904 0.962 NM_138442
CCDC124
coiled-coil domain containing 124
chr6_-_35588613 0.962 NM_003322
TULP1
tubby like protein 1
chr1_-_152847105 0.953 ADAR
adenosine deaminase, RNA-specific
chr16_+_29597965 0.948 QPRT
quinolinate phosphoribosyltransferase
chr1_+_28029922 0.948 PPP1R8
protein phosphatase 1, regulatory (inhibitor) subunit 8
chr5_-_134291882 0.945


chr2_+_38746742 0.945 GALM
galactose mutarotase (aldose 1-epimerase)
chr1_-_153379344 0.945 NM_018973
NM_153741
DPM3

dolichyl-phosphate mannosyltransferase polypeptide 3

chr16_+_43009 0.943 SNRNP25
small nuclear ribonucleoprotein 25kDa (U11/U12)
chr4_-_23500706 0.942 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr6_+_42126228 0.939 NM_138572
TAF8
TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
chr16_+_65552600 0.936 NM_001185177
NM_024922
CES3

carboxylesterase 3

chr1_+_154605626 0.935 NM_020407
RHBG
Rh family, B glycoprotein (gene/pseudogene)
chr11_-_65244718 0.934 NM_032193
RNASEH2C
ribonuclease H2, subunit C
chr19_-_12858956 0.922 NM_006563
KLF1
Kruppel-like factor 1 (erythroid)
chr16_-_73576508 0.920 NM_030581
WDR59
WD repeat domain 59
chr16_-_57309625 0.918 GOT2
glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)
chr19_-_44518465 0.918 GMFG
glia maturation factor, gamma
chr9_+_131428225 0.917 NM_014064
METTL11A
methyltransferase like 11A
chr19_-_60528480 0.912 NM_001085488
TMEM150B
transmembrane protein 150B
chr19_+_55383249 0.912 MYH14
myosin, heavy chain 14, non-muscle
chr1_-_152847256 0.909 ADAR
adenosine deaminase, RNA-specific
chr22_+_19458378 0.908 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chrX_+_96025562 0.906 NM_013347
RPA4
replication protein A4, 30kDa

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.27 5.70e-03 GO:0044428 nuclear part
1.14 1.04e-02 GO:0044422 organelle part
1.25 1.19e-02 GO:0043233 organelle lumen
1.24 1.59e-02 GO:0031974 membrane-enclosed lumen
1.09 1.66e-02 GO:0043227 membrane-bounded organelle
1.13 1.83e-02 GO:0044444 cytoplasmic part
1.14 2.09e-02 GO:0044446 intracellular organelle part
1.18 2.35e-02 GO:0032991 macromolecular complex
1.09 2.57e-02 GO:0043231 intracellular membrane-bounded organelle
1.24 3.23e-02 GO:0070013 intracellular organelle lumen
1.06 3.48e-02 GO:0005622 intracellular
1.27 3.90e-02 GO:0031981 nuclear lumen
1.32 4.17e-02 GO:0005654 nucleoplasm

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.43 3.75e-02 GO:0003723 RNA binding