Motif ID: POU1F1.p2

Z-value: 1.596


Transcription factors associated with POU1F1.p2:

Gene SymbolEntrez IDGene Name
POU1F1 5449 POU class 1 homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
POU1F1chr3_-_874083010.058.6e-01Click!


Activity profile for motif POU1F1.p2.

activity profile for motif POU1F1.p2


Sorted Z-values histogram for motif POU1F1.p2

Sorted Z-values for motif POU1F1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU1F1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_14740694 3.337 NM_004963
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr13_-_45654292 1.516 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr21_-_14840506 1.424 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr13_-_45654296 1.399 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr6_-_32742265 1.231 NM_002123
HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
chr6_-_33149244 1.228 NM_033554
HLA-DPA1
major histocompatibility complex, class II, DP alpha 1
chr13_-_45654327 1.179 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chrX_-_131089552 1.154 NM_194277
FRMD7
FERM domain containing 7
chr11_-_74478405 1.012 NM_001005285
OR2AT4
olfactory receptor, family 2, subfamily AT, member 4
chr6_+_167456230 1.003 NM_031409
CCR6
chemokine (C-C motif) receptor 6
chr9_-_70780574 0.972


chr2_+_143351536 0.948 NM_001032998
NM_003937
KYNU

kynureninase

chr12_+_111829191 0.936 OAS1
2',5'-oligoadenylate synthetase 1, 40/46kDa
chr4_-_47831002 0.923 NM_003328
TXK
TXK tyrosine kinase
chr6_+_132000134 0.912 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr6_+_32515596 0.900 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr12_-_54150188 0.875 NM_001005499
OR6C70
olfactory receptor, family 6, subfamily C, member 70
chr11_+_55319607 0.863 NM_001004735
OR5D14
olfactory receptor, family 5, subfamily D, member 14
chr7_-_44985084 0.834 MYO1G
myosin IG
chr4_-_77547481 0.833 NM_001042784
CCDC158
coiled-coil domain containing 158
chr3_-_122862447 0.827 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr3_+_123779122 0.825 NM_001113523
PARP15
poly (ADP-ribose) polymerase family, member 15
chr6_+_105511615 0.816 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr21_+_41663853 0.795 MX2
myxovirus (influenza virus) resistance 2 (mouse)
chrX_-_30505804 0.780 NM_025159
CXorf21
chromosome X open reading frame 21
chr1_+_145841569 0.761 NM_005267
GJA8
gap junction protein, alpha 8, 50kDa
chr1_-_246869181 0.758 NM_001001827
OR2T35
olfactory receptor, family 2, subfamily T, member 35
chr9_-_21067804 0.755 NM_002176
IFNB1
interferon, beta 1, fibroblast
chr3_+_99592199 0.745 NM_001005516
OR5K3
olfactory receptor, family 5, subfamily K, member 3
chr3_-_186752952 0.742 NM_139248
LIPH
lipase, member H
chr6_+_10663934 0.742 NM_001491
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr2_+_173940179 0.735 CDCA7
cell division cycle associated 7
chr7_-_122422989 0.734 NM_016945
TAS2R16
taste receptor, type 2, member 16
chr2_-_6924092 0.727 CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr6_+_31647854 0.690 NM_001159740
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr7_-_44985202 0.682 NM_033054
MYO1G
myosin IG
chr1_+_195179533 0.672 NM_005666
CFHR2
complement factor H-related 2
chr3_+_123256902 0.644 NM_175862
CD86
CD86 molecule
chr12_-_85756766 0.642 NM_013244
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr5_-_78318112 0.631 NM_000046
ARSB
arylsulfatase B
chrX_+_30171768 0.627 NM_002363
NM_177415
MAGEB1

melanoma antigen family B, 1

chr2_-_88208650 0.623 NM_001443
FABP1
fatty acid binding protein 1, liver
chr19_+_47073029 0.618 NM_001783
NM_021601
CD79A

CD79a molecule, immunoglobulin-associated alpha

chr12_+_111829121 0.603 NM_001032409
NM_002534
NM_016816
OAS1


2',5'-oligoadenylate synthetase 1, 40/46kDa


chr3_-_122862391 0.601 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr2_+_68445936 0.597 PLEK
pleckstrin
chr1_-_20318578 0.593 NM_012400
PLA2G2D
phospholipase A2, group IID
chr6_-_41276901 0.577 NM_024807
TREML2
triggering receptor expressed on myeloid cells-like 2
chr17_-_36232366 0.569 NM_000421
KRT10
keratin 10
chr2_+_68445821 0.558 NM_002664
PLEK
pleckstrin
chr7_+_37689903 0.553


chr16_+_65938753 0.551 NM_001161575
LRRC36
leucine rich repeat containing 36
chr3_-_139960874 0.549 NM_006219
PIK3CB
phosphoinositide-3-kinase, catalytic, beta polypeptide
chr18_-_62422195 0.546 NM_021153
CDH19
cadherin 19, type 2
chr12_+_53534565 0.538 NM_058173
MUCL1
mucin-like 1
chrX_-_49347279 0.536 NM_003785
PAGE1
P antigen family, member 1 (prostate associated)
chr6_+_27400518 0.536 NM_032030
FKSG83
FKSG83
chr3_-_172227152 0.535 SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr1_-_158815895 0.525 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr21_-_14501114 0.525 NM_198996
LIPI
lipase, member I
chr19_+_60019704 0.523 NM_013289
KIR3DL1
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
chr2_-_207291364 0.520 NM_001093730
DYTN
dystrotelin
chr2_-_27215781 0.517 NM_178553
C2orf53
chromosome 2 open reading frame 53
chr6_+_20642665 0.517 NM_017774
CDKAL1
CDK5 regulatory subunit associated protein 1-like 1
chr1_-_93172119 0.509


chr6_+_16251260 0.504 MYLIP
myosin regulatory light chain interacting protein
chr1_+_12046020 0.502 NM_001243
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr4_-_100492854 0.497 NM_000669
ADH1C
alcohol dehydrogenase 1C (class I), gamma polypeptide
chr6_-_26038817 0.495 NM_005835
SLC17A2
solute carrier family 17 (sodium phosphate), member 2
chr11_+_59564323 0.493 NM_173801
PLAC1L
placenta-specific 1-like
chr19_+_6981593 0.493 NM_001136507
MBD3L5
methyl-CpG-binding domain protein 3-like 5-like
chr11_+_18150959 0.491 NM_054032
MRGPRX4
MAS-related GPR, member X4
chr6_+_26359805 0.487 NM_003524
HIST1H2BH
histone cluster 1, H2bh
chr11_+_4976788 0.486 NM_001004755
OR51L1
olfactory receptor, family 51, subfamily L, member 1
chr17_-_36192311 0.482 NM_181537
KRT27
keratin 27
chr14_-_91268136 0.480 NM_024764
CATSPERB
cation channel, sperm-associated, beta
chr3_+_123817151 0.471 NM_152615
PARP15
poly (ADP-ribose) polymerase family, member 15
chr22_-_38619739 0.468 NM_152512
ENTHD1
ENTH domain containing 1
chr4_-_71751070 0.462 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr6_-_149847809 0.459 NM_207360
ZC3H12D
zinc finger CCCH-type containing 12D
chr1_+_559618 0.456


chr1_+_195010552 0.455 NM_001166624
NM_021023
CFHR3

complement factor H-related 3

chr2_+_102744921 0.454 NM_144632
TMEM182
transmembrane protein 182
chr11_+_59027624 0.454 NM_001004706
OR4D11
olfactory receptor, family 4, subfamily D, member 11
chr12_+_91341865 0.453 NM_001025233
CLLU1
chronic lymphocytic leukemia up-regulated 1
chr12_-_8656705 0.451 NM_020661
AICDA
activation-induced cytidine deaminase
chr2_+_79200995 0.451 NM_002909
REG1A
regenerating islet-derived 1 alpha
chr4_-_151990061 0.444 LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr8_-_42742729 0.444 NM_004198
CHRNA6
cholinergic receptor, nicotinic, alpha 6
chr6_+_32713160 0.442 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr6_-_149847718 0.439 ZC3H12D
zinc finger CCCH-type containing 12D
chr12_+_70618892 0.436 NM_173353
TPH2
tryptophan hydroxylase 2
chr7_-_87180499 0.435 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr9_-_5294579 0.432 NM_005059
NM_134441
RLN2

relaxin 2

chr11_-_40272239 0.427 NM_020929
LRRC4C
leucine rich repeat containing 4C
chr8_-_17797127 0.426 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr2_+_135312655 0.425 NM_138326
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr11_-_49960646 0.424 NM_001005270
OR4C12
olfactory receptor, family 4, subfamily C, member 12
chr14_-_19553191 0.422 NM_001004712
OR4K14
olfactory receptor, family 4, subfamily K, member 14
chr12_-_23628774 0.421 NM_178010
SOX5
SRY (sex determining region Y)-box 5
chr4_-_70547962 0.417 NM_006798
UGT2A1
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
chr5_-_75954807 0.416 NM_004101
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr1_+_246682699 0.414 NM_001004136
OR2T2
olfactory receptor, family 2, subfamily T, member 2
chr7_+_141265085 0.407 NM_001001656
OR9A4
olfactory receptor, family 9, subfamily A, member 4
chrX_+_125781427 0.397 NM_001122716
CXorf64
chromosome X open reading frame 64
chrX_-_2892288 0.395 NM_000047
ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr5_+_57823017 0.393 NM_152687
GAPT
GRB2-binding adaptor protein, transmembrane
chr9_+_101717278 0.392 STX17
syntaxin 17
chr1_-_157003095 0.391 NM_001005185
OR6N1
olfactory receptor, family 6, subfamily N, member 1
chr6_-_33028790 0.388 NM_006120
HLA-DMA
major histocompatibility complex, class II, DM alpha
chrX_-_130250880 0.388 IGSF1
immunoglobulin superfamily, member 1
chr7_+_37746520 0.386 NM_181791
GPR141
G protein-coupled receptor 141
chr4_+_74488910 0.385 ALB
albumin
chr6_-_22405708 0.385 NM_000948
PRL
prolactin
chr6_-_32665409 0.384 NM_002124
HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr21_-_30460841 0.383 NM_012131
CLDN17
claudin 17
chr3_+_99370233 0.383 NM_001005515
OR5H15
olfactory receptor, family 5, subfamily H, member 15
chr4_-_47678187 0.383 NM_001142564
CNGA1
cyclic nucleotide gated channel alpha 1
chr4_+_35959638 0.374 NM_001136536
DTHD1
death domain containing 1
chr7_+_137411717 0.373 NM_001190906
NM_001190907
NM_005989
AKR1D1


aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)


chr11_+_4799126 0.372 NM_001004753
OR51F2
olfactory receptor, family 51, subfamily F, member 2
chr12_-_101835026 0.372 PAH
phenylalanine hydroxylase
chr20_+_71230 0.369 NM_030931
DEFB126
defensin, beta 126
chr3_-_19950675 0.368 NM_144715
EFHB
EF-hand domain family, member B
chr5_+_147529488 0.366 NM_001001325
SPINK14
serine peptidase inhibitor, Kazal type 14 (putative)
chr4_-_110942783 0.366 NM_000204
CFI
complement factor I
chrX_+_69371229 0.365 NM_001013579
AWAT1
acyl-CoA wax alcohol acyltransferase 1
chr8_-_28403652 0.365 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chr7_-_88262966 0.364 NM_152706
C7orf62
chromosome 7 open reading frame 62
chr2_+_79201118 0.361 REG1A
regenerating islet-derived 1 alpha
chr15_-_53349775 0.357 NM_183234
NM_004580
RAB27A

RAB27A, member RAS oncogene family

chr5_-_78317444 0.357 NM_198709
ARSB
arylsulfatase B
chr6_+_135558572 0.356


chrX_-_23765377 0.352 RPL9
ribosomal protein L9
chr8_-_59575249 0.351 NM_000780
CYP7A1
cytochrome P450, family 7, subfamily A, polypeptide 1
chr1_-_151549790 0.350 NM_052891
PGLYRP3
peptidoglycan recognition protein 3
chr8_-_86441115 0.349 NM_001164830
CA1
carbonic anhydrase I
chr2_+_36777336 0.345 NM_001177969
NM_001177970
NM_001177971
NM_001177972
NM_053276
VIT




vitrin




chr13_+_110771015 0.342 NM_152324
C13orf16
chromosome 13 open reading frame 16
chr1_-_158815850 0.341 CD84
CD84 molecule
chr2_-_21079145 0.341 APOB
apolipoprotein B (including Ag(x) antigen)
chr3_+_153074118 0.340 NM_033050
SUCNR1
succinate receptor 1
chr14_-_105681377 0.340 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr1_+_190811479 0.340 NM_002922
RGS1
regulator of G-protein signaling 1
chr5_-_158690047 0.339 NM_002187
IL12B
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
chr11_+_55343658 0.338 NM_001001952
OR5D18
olfactory receptor, family 5, subfamily D, member 18
chr12_-_43593977 0.337 NM_001145110
NELL2
NEL-like 2 (chicken)
chr15_-_43457916 0.334 GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr19_+_48584602 0.332 NM_031451
TEX101
testis expressed 101
chr3_+_3056307 0.330 NM_175612
CNTN4
contactin 4
chr4_+_100704262 0.328 NM_000253
MTTP
microsomal triglyceride transfer protein
chr5_-_156705250 0.327 NM_001001343
FNDC9
fibronectin type III domain containing 9
chrX_+_105823723 0.327 NM_024539
RNF128
ring finger protein 128
chrX_+_18618965 0.326 NM_006240
NM_152224
NM_152226
PPEF1


protein phosphatase, EF-hand calcium binding domain 1


chr3_+_99350859 0.325 NM_001005514
OR5H14
olfactory receptor, family 5, subfamily H, member 14
chr12_+_58369392 0.321 NM_004731
SLC16A7
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
chr9_-_99746923 0.321 NM_018437
HEMGN
hemogen
chr12_-_101835183 0.321 PAH
phenylalanine hydroxylase
chr2_-_171631728 0.320 NM_001136555
TLK1
tousled-like kinase 1
chr10_+_88975184 0.319 NM_001099338
FAM22A
FAM22D
family with sequence similarity 22, member A
family with sequence similarity 22, member D
chr12_+_53178834 0.319 NM_001184976
NCKAP1L
NCK-associated protein 1-like
chrX_-_49851743 0.318 NM_139289
AKAP4
A kinase (PRKA) anchor protein 4
chr7_-_44985175 0.318 MYO1G
myosin IG
chr8_-_16094591 0.315 NM_002445
NM_138715
NM_138716
MSR1


macrophage scavenger receptor 1


chrX_-_49852397 0.314 NM_003886
AKAP4
A kinase (PRKA) anchor protein 4
chr11_-_64484184 0.314 NM_001037225
C11orf85
chromosome 11 open reading frame 85
chr4_+_71142893 0.313 NM_005212
CSN3
casein kappa
chr12_+_130004404 0.313 NM_198827
GPR133
G protein-coupled receptor 133
chrX_-_141120722 0.311 NM_016249
MAGEC2
melanoma antigen family C, 2
chr7_-_36991189 0.310 NM_001039459
ELMO1
engulfment and cell motility 1
chr10_+_11087259 0.310 NM_001025077
CELF2
CUGBP, Elav-like family member 2
chr12_-_47250069 0.309 NM_002289
LALBA
lactalbumin, alpha-
chr5_-_134290789 0.309


chrX_+_147608302 0.308 NM_001170628
AFF2
AF4/FMR2 family, member 2
chr11_+_30209138 0.307 NM_000510
NM_001018080
FSHB

follicle stimulating hormone, beta polypeptide

chr3_+_109504021 0.304 NM_007072
HHLA2
HERV-H LTR-associating 2
chr3_+_98641143 0.301 NM_173655
EPHA6
EPH receptor A6
chr8_-_82536312 0.297 NM_001080526
FABP9
fatty acid binding protein 9, testis
chr6_-_6632197 0.293


chr4_+_74488835 0.291 NM_000477
ALB
albumin
chr12_-_10953427 0.284 NM_023920
TAS2R13
taste receptor, type 2, member 13
chr12_-_10042956 0.283 NM_001099431
NM_016509
CLEC1B

C-type lectin domain family 1, member B

chr7_+_142629251 0.281 NM_176882
TAS2R40
taste receptor, type 2, member 40
chr9_-_122852356 0.280 NM_001735
C5
complement component 5
chr1_+_246195157 0.279 NM_001004491
OR2AK2
olfactory receptor, family 2, subfamily AK, member 2
chr6_-_123999640 0.278 NM_006073
TRDN
triadin
chr6_-_49942147 0.277 NM_001131
NM_170609
CRISP1

cysteine-rich secretory protein 1

chr14_-_106249999 0.276 IGHA1
immunoglobulin heavy constant alpha 1
chr1_+_150937463 0.274 NM_178428
LCE2A
late cornified envelope 2A
chr12_+_109956210 0.274 NM_015267
CUX2
cut-like homeobox 2
chr12_-_120591938 0.274 NM_173855
MORN3
MORN repeat containing 3
chr11_+_89507465 0.272 NM_005467
NAALAD2
N-acetylated alpha-linked acidic dipeptidase 2
chr1_-_100416358 0.271 NM_144620
LRRC39
leucine rich repeat containing 39
chr21_-_42659671 0.271 NM_003225
TFF1
trefoil factor 1
chr9_-_124370576 0.268 NM_001004454
OR1L8
olfactory receptor, family 1, subfamily L, member 8
chr1_+_179269183 0.267 NM_001194999
NM_001195000
NM_001195035
NM_001531
MR1



major histocompatibility complex, class I-related



chr15_+_43036194 0.267 NM_152448
C15orf43
chromosome 15 open reading frame 43
chr17_-_31281398 0.267 NM_001163122
NM_001163124
NM_001163125
NM_001163130
RDM1



RAD52 motif 1



chr7_-_141604323 0.267 NM_001001317
TRYX3
trypsin X3
chr13_+_45174446 0.267 NM_152719
SPERT
spermatid associated

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
4.21 1.82e-26 GO:0007606 sensory perception of chemical stimulus
4.42 3.39e-26 GO:0007608 sensory perception of smell
2.86 2.74e-18 GO:0007600 sensory perception
1.40 6.77e-12 GO:0050896 response to stimulus
2.02 5.19e-10 GO:0050877 neurological system process
1.82 2.46e-08 GO:0003008 system process
2.28 1.00e-07 GO:0006955 immune response
2.52 9.18e-06 GO:0050776 regulation of immune response
2.06 1.57e-05 GO:0006952 defense response
1.77 1.19e-04 GO:0002376 immune system process
2.50 2.42e-04 GO:0045087 innate immune response
10.42 4.90e-04 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
3.33 3.73e-03 GO:0006805 xenobiotic metabolic process
3.33 3.73e-03 GO:0071466 cellular response to xenobiotic stimulus
3.31 4.20e-03 GO:0009410 response to xenobiotic stimulus
4.64 5.44e-03 GO:0060333 interferon-gamma-mediated signaling pathway
1.26 6.46e-03 GO:0032501 multicellular organismal process
3.59 7.71e-03 GO:0002768 immune response-regulating cell surface receptor signaling pathway
4.83 8.38e-03 GO:0019882 antigen processing and presentation
2.45 9.65e-03 GO:0050778 positive regulation of immune response
4.23 1.60e-02 GO:0071346 cellular response to interferon-gamma
3.51 1.95e-02 GO:0002429 immune response-activating cell surface receptor signaling pathway
3.88 2.13e-02 GO:0034341 response to interferon-gamma
3.57 2.93e-02 GO:0050851 antigen receptor-mediated signaling pathway

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.54 2.83e-13 GO:0071944 cell periphery
1.53 1.08e-12 GO:0005886 plasma membrane
1.38 8.35e-10 GO:0031224 intrinsic to membrane
1.37 4.54e-09 GO:0016021 integral to membrane
1.30 1.22e-07 GO:0044425 membrane part
12.65 1.06e-05 GO:0042613 MHC class II protein complex
1.22 2.29e-05 GO:0016020 membrane
6.92 2.35e-04 GO:0042611 MHC protein complex
1.46 1.80e-03 GO:0005576 extracellular region

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.57 1.71e-27 GO:0004984 olfactory receptor activity
2.49 5.16e-21 GO:0004888 transmembrane receptor activity
2.87 6.58e-20 GO:0004930 G-protein coupled receptor activity
2.11 7.46e-17 GO:0004872 receptor activity
1.86 3.34e-13 GO:0004871 signal transducer activity
1.86 3.34e-13 GO:0060089 molecular transducer activity
4.98 2.38e-02 GO:0003823 antigen binding