Motif ID: POU3F1..4.p2

Z-value: 1.367


Transcription factors associated with POU3F1..4.p2:

Gene SymbolEntrez IDGene Name
POU3F1 5453 POU class 3 homeobox 1
POU3F2 5454 POU class 3 homeobox 2
POU3F3 5455 POU class 3 homeobox 3
POU3F4 5456 POU class 3 homeobox 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
POU3F2chr6_+_993893180.611.1e-02Click!
POU3F1chr1_-_382850330.194.8e-01Click!
POU3F3chr2_+_104838177-0.126.7e-01Click!
POU3F4chrX_+_826499240.087.7e-01Click!


Activity profile for motif POU3F1..4.p2.

activity profile for motif POU3F1..4.p2


Sorted Z-values histogram for motif POU3F1..4.p2

Sorted Z-values for motif POU3F1..4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU3F1..4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_170348215 1.333 NM_001164000
MECOM
MDS1 and EVI1 complex locus
chr17_-_44037332 1.329 NM_018952
HOXB6
homeobox B6
chr10_+_15125900 1.233 NM_001039702
NM_018324
OLAH

oleoyl-ACP hydrolase

chr13_+_42253685 1.191 NM_182508
C13orf30
chromosome 13 open reading frame 30
chr11_-_85146691 1.141 NM_001162951
NM_001162953
SYTL2

synaptotagmin-like 2

chr12_+_50342814 1.086 NM_001177984
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr1_+_239882202 1.084 NM_144625
WDR64
WD repeat domain 64
chrX_-_123925343 1.046 NM_001163278
NM_001163279
NM_014253
ODZ1


odz, odd Oz/ten-m homolog 1(Drosophila)


chr1_-_171286634 1.021 NM_005092
TNFSF18
tumor necrosis factor (ligand) superfamily, member 18
chr7_+_20621769 1.009 NM_001163941
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chrX_+_65300803 1.007 NM_001130860
NM_014799
HEPH

hephaestin

chr2_-_162808123 0.968 NM_004460
FAP
fibroblast activation protein, alpha
chr3_+_28406990 0.940 NM_001040432
ZCWPW2
zinc finger, CW type with PWWP domain 2
chr8_+_1980564 0.939 NM_003970
MYOM2
myomesin (M-protein) 2, 165kDa
chr12_-_90029328 0.917 LUM
lumican
chr15_+_76171981 0.884 NM_001101404
SH2D7
SH2 domain containing 7
chr1_-_143786993 0.881 NM_022359
PDE4DIP
phosphodiesterase 4D interacting protein
chr5_+_149320480 0.829 NM_000112
SLC26A2
solute carrier family 26 (sulfate transporter), member 2
chr7_-_122627235 0.825 NM_022444
SLC13A1
solute carrier family 13 (sodium/sulfate symporters), member 1
chr7_-_83116414 0.796 NM_012431
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr2_-_162717159 0.792 NM_002054
GCG
glucagon
chr3_+_25444837 0.758 NM_000965
RARB
retinoic acid receptor, beta
chrX_+_102471769 0.756 NM_152278
TCEAL7
transcription elongation factor A (SII)-like 7
chrX_+_134482212 0.752 NM_182540
DDX26B
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
chrX_-_15530112 0.747 NM_021804
ACE2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr2_+_189547358 0.746 COL3A1
collagen, type III, alpha 1
chr5_+_40945374 0.740 C7
complement component 7
chr1_+_195503956 0.732 NM_001193640
NM_201253
CRB1

crumbs homolog 1 (Drosophila)

chr12_+_79127363 0.722 NM_173591
OTOGL
otogelin-like
chr1_-_171441234 0.710 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr13_-_77390907 0.691 NM_001122659
NM_003991
EDNRB

endothelin receptor type B

chr6_-_46997579 0.689 NM_001098518
GPR116
G protein-coupled receptor 116
chr2_+_151922350 0.674 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr17_+_65582981 0.649 NM_018658
NM_170741
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr12_+_10015274 0.630 NM_138337
NM_201623
CLEC12A

C-type lectin domain family 12, member A

chr13_+_78068246 0.630 LOC780529
hypothetical LOC780529
chr1_+_66570683 0.629 PDE4B
phosphodiesterase 4B, cAMP-specific
chr12_-_69317441 0.628 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr9_+_74956494 0.620 NM_000700
ANXA1
annexin A1
chr5_+_40945315 0.618 NM_000587
C7
complement component 7
chr3_+_25444753 0.610 NM_016152
RARB
retinoic acid receptor, beta
chr2_-_197383120 0.580 NM_213608
C2orf66
chromosome 2 open reading frame 66
chr1_-_242073094 0.580 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chr19_+_16691786 0.576 NM_001007525
NWD1
NACHT and WD repeat domain containing 1
chr6_-_139654807 0.561 NM_153235
TXLNB
taxilin beta
chr3_+_44667504 0.551 ZNF35
zinc finger protein 35
chr4_-_77176163 0.537 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr11_+_113280727 0.533 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr13_+_100902942 0.524 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr16_+_6763810 0.519 NM_001142334
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr11_+_104986009 0.518 NM_000829
NM_001077243
NM_001077244
GRIA4


glutamate receptor, ionotrophic, AMPA 4


chr10_+_64894943 0.518 LOC84989
hypothetical LOC84989
chr2_+_166137091 0.516 NM_024969
CSRNP3
cysteine-serine-rich nuclear protein 3
chr12_-_29828958 0.513 NM_175861
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr12_+_49522967 0.505 NM_182559
TMPRSS12
transmembrane (C-terminal) protease, serine 12
chr3_+_70068440 0.500 NM_000248
NM_001184968
NM_198158
NM_198178
MITF



microphthalmia-associated transcription factor



chr2_+_189547377 0.494 COL3A1
collagen, type III, alpha 1
chr20_+_9406460 0.488 PLCB4
phospholipase C, beta 4
chr4_+_187385618 0.488 NM_000892
KLKB1
kallikrein B, plasma (Fletcher factor) 1
chr18_-_3835295 0.487 NM_001003809
DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr7_+_129634935 0.486 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr9_-_106407728 0.486 NM_001004481
OR13C2
olfactory receptor, family 13, subfamily C, member 2
chr13_-_35327798 0.485 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr6_+_28032997 0.484 NM_012367
OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr4_-_26100986 0.476 NM_000730
CCKAR
cholecystokinin A receptor
chr3_-_152529999 0.473 NM_176894
P2RY13
purinergic receptor P2Y, G-protein coupled, 13
chr10_-_16604009 0.471 NM_001010908
C1QL3
complement component 1, q subcomponent-like 3
chr2_+_135312655 0.470 NM_138326
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr14_-_80477783 0.467 C14orf145
chromosome 14 open reading frame 145
chr9_+_74956601 0.461 ANXA1
annexin A1
chr1_-_89364273 0.461 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr1_-_167663278 0.452 NM_021179
C1orf114
chromosome 1 open reading frame 114
chrX_+_67830204 0.450 NM_001142504
STARD8
StAR-related lipid transfer (START) domain containing 8
chr8_-_124613557 0.447 NM_148177
FBXO32
F-box protein 32
chr6_-_114490701 0.445 NM_153612
HS3ST5
heparan sulfate (glucosamine) 3-O-sulfotransferase 5
chr9_-_94226380 0.438 NM_005014
OMD
osteomodulin
chr18_+_57308754 0.436 NM_031891
CDH20
cadherin 20, type 2
chr15_-_48626193 0.436 NM_203494
USP50
ubiquitin specific peptidase 50
chrX_+_100692071 0.436 NM_016608
ARMCX1
armadillo repeat containing, X-linked 1
chr7_-_79979177 0.430 NM_001102386
GNAT3
guanine nucleotide binding protein, alpha transducing 3
chr3_+_149930656 0.429 NM_032049
AGTR1
angiotensin II receptor, type 1
chr2_+_189547323 0.427 NM_000090
COL3A1
collagen, type III, alpha 1
chr20_-_9767406 0.420 NM_020341
NM_177990
PAK7

p21 protein (Cdc42/Rac)-activated kinase 7

chr3_+_171112053 0.413 NM_182610
SAMD7
sterile alpha motif domain containing 7
chr18_-_51219880 0.412 TCF4
transcription factor 4
chr1_-_143708467 0.407 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr12_-_10215942 0.407 NM_001172632
NM_001172633
NM_002543
OLR1


oxidized low density lipoprotein (lectin-like) receptor 1


chr4_-_81213333 0.406 NM_001145794
NM_058172
ANTXR2

anthrax toxin receptor 2

chr2_-_144994038 0.406 ZEB2
zinc finger E-box binding homeobox 2
chr9_+_74956614 0.406 ANXA1
annexin A1
chr1_-_172228673 0.399 NM_172071
RC3H1
ring finger and CCCH-type domains 1
chr11_-_5279750 0.399 NM_033179
OR51B4
olfactory receptor, family 51, subfamily B, member 4
chrX_+_47999740 0.399 NM_005635
SSX1
synovial sarcoma, X breakpoint 1
chr3_+_63613383 0.396 NM_001080537
SNTN
sentan, cilia apical structure protein
chr4_-_109307325 0.393 NM_001166119
LEF1
lymphoid enhancer-binding factor 1
chr12_-_90100733 0.392 NM_001920
DCN
decorin
chr7_+_7573074 0.391 NM_019005
MIOS
missing oocyte, meiosis regulator, homolog (Drosophila)
chr1_+_157246305 0.390 NM_005531
IFI16
interferon, gamma-inducible protein 16
chr7_-_11838260 0.390 NM_015204
THSD7A
thrombospondin, type I, domain containing 7A
chr1_-_89414310 0.386 NM_207398
GBP7
guanylate binding protein 7
chr13_-_24644304 0.376 FAM123A
family with sequence similarity 123A
chr8_+_75899326 0.376 NM_015886
PI15
peptidase inhibitor 15
chr6_+_49575629 0.370 NM_001010904
GLYATL3
glycine-N-acyltransferase-like 3
chr7_-_107230867 0.369 NM_000111
SLC26A3
solute carrier family 26, member 3
chr5_+_140723939 0.369 NM_018918
NM_032054
PCDHGA5

protocadherin gamma subfamily A, 5

chr7_+_39839337 0.366


chr1_+_69998445 0.364 NM_020794
LRRC7
leucine rich repeat containing 7
chr12_+_21417068 0.363 NM_000415
IAPP
islet amyloid polypeptide
chr1_+_32438788 0.363 NM_024296
CCDC28B
coiled-coil domain containing 28B
chr6_-_152744143 0.358 SYNE1
spectrin repeat containing, nuclear envelope 1
chr21_-_39737997 0.355 NM_152505
LCA5L
Leber congenital amaurosis 5-like
chr4_+_159662349 0.355 NM_021634
RXFP1
relaxin/insulin-like family peptide receptor 1
chr12_+_54172413 0.354 NM_001005519
OR6C68
olfactory receptor, family 6, subfamily C, member 68
chr1_+_231007260 0.353 NM_019090
KIAA1383
KIAA1383
chr11_+_65027721 0.351


chr7_+_7974941 0.351 NM_138426
GLCCI1
glucocorticoid induced transcript 1
chr10_-_81698840 0.350 NM_003019
SFTPD
surfactant protein D
chrX_+_65299157 0.348 NM_138737
HEPH
hephaestin
chr2_-_190635566 0.345 NM_005259
MSTN
myostatin
chr4_+_120029426 0.344 NM_001128933
NM_001128934
NM_133477
SYNPO2


synaptopodin 2


chr11_+_94439703 0.342 NM_032102
SRSF8
serine/arginine-rich splicing factor 8
chr7_-_83108682 0.340 NM_001178129
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr12_-_9913199 0.337 CLEC2B
C-type lectin domain family 2, member B
chr1_+_47037256 0.336 NM_000779
NM_001099772
CYP4B1

cytochrome P450, family 4, subfamily B, polypeptide 1

chr5_-_110090264 0.333 NM_001039763
TMEM232
transmembrane protein 232
chr4_-_77097582 0.332 SDAD1
SDA1 domain containing 1
chr6_+_70633168 0.332 NM_001858
COL19A1
collagen, type XIX, alpha 1
chr6_-_152744022 0.331 SYNE1
spectrin repeat containing, nuclear envelope 1
chr1_+_32443822 0.329 NM_001160042
NM_018134
IQCC

IQ motif containing C

chr7_+_123036312 0.327 NM_080928
ASB15
ankyrin repeat and SOCS box containing 15
chr15_-_76210611 0.327 NM_006383
CIB2
calcium and integrin binding family member 2
chr9_-_110815542 0.327 NM_003798
CTNNAL1
catenin (cadherin-associated protein), alpha-like 1
chr3_+_150065732 0.322 NM_001870
CPA3
carboxypeptidase A3 (mast cell)
chr12_-_94469357 0.321 NM_032147
USP44
ubiquitin specific peptidase 44
chr5_-_156935283 0.320


chr1_+_66772393 0.318 NM_032291
SGIP1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr7_-_55897938 0.317 NM_207366
SEPT14
septin 14
chr2_+_214984705 0.316 NM_001080500
VWC2L
von Willebrand factor C domain containing protein 2-like
chr5_+_34720368 0.313 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr18_-_22699650 0.312 NM_001650
AQP4
aquaporin 4
chr11_-_30558495 0.311 NM_001584
MPPED2
metallophosphoesterase domain containing 2
chr3_+_174598937 0.309 NM_014932
NLGN1
neuroligin 1
chr1_-_152445432 0.309 NM_001010979
C1orf189
chromosome 1 open reading frame 189
chr7_+_106292975 0.308 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr15_+_90738108 0.308 NM_006011
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr6_+_47732181 0.308 NM_153839
GPR111
G protein-coupled receptor 111
chr17_+_25292748 0.307 NM_198529
EFCAB5
EF-hand calcium binding domain 5
chr4_-_38534802 0.307 NM_006068
TLR6
toll-like receptor 6
chr8_-_142333339 0.306 SLC45A4
solute carrier family 45, member 4
chr17_-_10362583 0.304 NM_005963
MYH1
myosin, heavy chain 1, skeletal muscle, adult
chr10_-_50066386 0.303 NM_001010863
C10orf128
chromosome 10 open reading frame 128
chr4_-_145281237 0.303 NM_002099
GYPA
glycophorin A (MNS blood group)
chr3_-_126136261 0.302 NM_033049
MUC13
mucin 13, cell surface associated
chr21_-_33107813 0.298 NM_001162495
NM_001162496
NM_019596
C21orf62


chromosome 21 open reading frame 62


chr15_-_74091817 0.298 NM_138573
NRG4
neuregulin 4
chr11_-_74478405 0.297 NM_001005285
OR2AT4
olfactory receptor, family 2, subfamily AT, member 4
chr12_+_50568010 0.297 NM_001130015
NM_182608
ANKRD33

ankyrin repeat domain 33

chr2_-_178191923 0.296 NM_152275
TTC30A
tetratricopeptide repeat domain 30A
chr7_+_106292932 0.296 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr7_-_87774130 0.296 NM_024636
STEAP4
STEAP family member 4
chr15_+_68971835 0.295 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chrX_+_77052834 0.294 NM_000052
ATP7A
ATPase, Cu++ transporting, alpha polypeptide
chr8_-_124818754 0.293 NM_001003954
NM_004306
ANXA13

annexin A13

chrX_+_67830215 0.293 STARD8
StAR-related lipid transfer (START) domain containing 8
chr19_+_59618416 0.293 NM_001005367
NM_020659
TTYH1

tweety homolog 1 (Drosophila)

chr4_-_44348414 0.291 NM_182592
YIPF7
Yip1 domain family, member 7
chr17_+_7753428 0.290 CHD3
chromodomain helicase DNA binding protein 3
chr10_-_69095362 0.288 NM_001127384
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr5_-_150306298 0.287 ZNF300P1
zinc finger protein 300 pseudogene 1
chr2_+_108590032 0.286 NM_001193482
LIMS1
LIM and senescent cell antigen-like domains 1
chr7_-_92615593 0.286 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr21_+_29374743 0.284 NM_020152
C21orf7
chromosome 21 open reading frame 7
chr1_+_185064654 0.283 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr3_+_190372456 0.282 NM_198485
TPRG1
tumor protein p63 regulated 1
chr18_+_606671 0.282 NM_199167
CLUL1
clusterin-like 1 (retinal)
chr8_-_92151363 0.280


chr20_-_42249146 0.279 JPH2
junctophilin 2
chr3_-_158704056 0.279 NM_001167915
NM_001167916
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chr17_+_58440629 0.275 NM_025185
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr11_-_5212168 0.274 NM_000519
HBD
hemoglobin, delta
chr19_-_49076080 0.274 NM_001033719
ZNF404
zinc finger protein 404
chr11_+_5732498 0.273 NM_001005175
OR52N4
olfactory receptor, family 52, subfamily N, member 4
chr5_-_156935317 0.273 NM_033274
ADAM19
ADAM metallopeptidase domain 19
chr1_+_208568218 0.273 NM_001122834
NM_001170564
HHAT

hedgehog acyltransferase

chr5_-_145875868 0.272 NM_194251
GPR151
G protein-coupled receptor 151
chr6_+_27215039 0.271 NM_003495
HIST1H4I
histone cluster 1, H4i
chr5_+_147562531 0.268 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr7_-_87694218 0.266 NM_198901
SRI
sorcin
chr11_+_102485293 0.265 NM_001080463
NM_001377
DYNC2H1

dynein, cytoplasmic 2, heavy chain 1

chr1_+_231007734 0.263 KIAA1383
KIAA1383
chr6_+_116939500 0.262 NM_153711
FAM26E
family with sequence similarity 26, member E
chr5_-_146441184 0.261 NM_181677
NM_181678
PPP2R2B

protein phosphatase 2, regulatory subunit B, beta

chr1_-_166149867 0.261 NM_001167749
NM_018417
ADCY10

adenylate cyclase 10 (soluble)

chr1_-_147665783 0.260 HIST2H2BF
histone cluster 2, H2bf
chr11_-_130291584 0.260 NM_014758
SNX19
sorting nexin 19
chr1_+_190552744 0.257 NM_001039152
RGS21
regulator of G-protein signaling 21
chr2_+_178893216 0.256 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr11_-_58255944 0.255 NM_005838
NM_201648
GLYAT

glycine-N-acyltransferase

chr11_-_66961709 0.254 NM_005608
PTPRCAP
protein tyrosine phosphatase, receptor type, C-associated protein
chr2_+_190723216 0.251 NM_001042520
C2orf88
chromosome 2 open reading frame 88

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.25 5.21e-03 GO:0050896 response to stimulus
2.16 1.00e-02 GO:0007606 sensory perception of chemical stimulus
2.23 1.15e-02 GO:0007608 sensory perception of smell

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.45 5.30e-08 GO:0071944 cell periphery
1.45 6.50e-08 GO:0005886 plasma membrane
1.23 2.14e-03 GO:0044425 membrane part
1.24 8.08e-03 GO:0016021 integral to membrane
1.18 1.14e-02 GO:0016020 membrane
1.23 1.76e-02 GO:0031224 intrinsic to membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.63 5.51e-06 GO:0004871 signal transducer activity
1.63 5.51e-06 GO:0060089 molecular transducer activity
1.70 8.40e-06 GO:0004872 receptor activity
2.03 1.54e-05 GO:0004930 G-protein coupled receptor activity
1.77 5.94e-05 GO:0004888 transmembrane receptor activity
2.27 2.54e-03 GO:0004984 olfactory receptor activity