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Motif ID: POU5F1.p2

Z-value: 0.731

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr17_+_64922420	4.787	NM_002758	MAP2K6	mitogen-activated protein kinase kinase 6
chr10_+_11246934	1.380	NM_001025076 NM_001083591	CELF2	CUGBP, Elav-like family member 2
chr1_-_153098811	1.359	NM_170782	KCNN3	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr7_-_36991189	1.333	NM_001039459	ELMO1	engulfment and cell motility 1
chr17_-_8756524	1.267	NM_014308	PIK3R5	phosphoinositide-3-kinase, regulatory subunit 5
chr1_+_190552744	1.160	NM_001039152	RGS21	regulator of G-protein signaling 21
chr21_-_31123797	1.022	NM_181606	KRTAP7-1	keratin associated protein 7-1 (gene/pseudogene)
chr20_-_7869068	0.930	NM_017545	HAO1	hydroxyacid oxidase (glycolate oxidase) 1
chr10_-_98021144	0.902	NM_001114094 NM_013314	BLNK	B-cell linker
chr3_-_152173475	0.898	NM_001195794 NM_174878	CLRN1	clarin 1
chr9_+_129066576	0.885	NM_032293	GARNL3	GTPase activating Rap/RanGAP domain-like 3
chr16_+_23754772	0.837	NM_002738 NM_212535	PRKCB	protein kinase C, beta
chr6_-_154692906	0.821	NM_001130699	IPCEF1	interaction protein for cytohesin exchange factors 1
chr8_+_92330691	0.811	NM_052832 NM_134266	SLC26A7	solute carrier family 26, member 7
chr5_-_147142249	0.800		JAKMIP2	janus kinase and microtubule interacting protein 2
chr22_+_21318779	0.777	NM_199127	GGTLC2	gamma-glutamyltransferase light chain 2
chr6_-_33016561	0.776	NM_002118	HLA-DMB	major histocompatibility complex, class II, DM beta
chr15_-_86600658	0.760	NM_001007156 NM_001012338 NM_002530	NTRK3	neurotrophic tyrosine kinase, receptor, type 3
chr1_+_66230977	0.748	NM_001037340	PDE4B	phosphodiesterase 4B, cAMP-specific
chr11_+_122901543	0.741		GRAMD1B	GRAM domain containing 1B
chr19_+_14554895	0.736	NM_207390	CLEC17A	C-type lectin domain family 17, member A
chr19_-_43800374	0.732	NM_001042600 NM_007181	MAP4K1	mitogen-activated protein kinase kinase kinase kinase 1
chr14_-_93512818	0.692		ASB2	ankyrin repeat and SOCS box containing 2
chr2_+_214984705	0.690	NM_001080500	VWC2L	von Willebrand factor C domain containing protein 2-like
chr10_+_11247059	0.688		CELF2	CUGBP, Elav-like family member 2
chr19_-_48815853	0.683	NM_182498	ZNF428	zinc finger protein 428
chr5_-_88155360	0.679	NM_001193348 NM_001193349	MEF2C	myocyte enhancer factor 2C
chr6_-_155818728	0.673	NM_015718	NOX3	NADPH oxidase 3
chr12_+_111829121	0.649	NM_001032409 NM_002534 NM_016816	OAS1	2',5'-oligoadenylate synthetase 1, 40/46kDa
chr12_+_91620749	0.645	NM_001037671 NM_001178097	C12orf74	chromosome 12 open reading frame 74
chr11_+_55362802	0.639	NM_001005496	OR5D16	olfactory receptor, family 5, subfamily D, member 16
chr16_+_12053555	0.638	NM_001080530	SNX29	sorting nexin 29
chr17_-_33179118	0.634	NM_000458 NM_001165923	HNF1B	HNF1 homeobox B
chr19_+_17719504	0.625	NM_001161357 NM_001161358	FCHO1	FCH domain only 1
chr11_+_122901689	0.609	NM_020716	GRAMD1B	GRAM domain containing 1B
chr1_+_33494745	0.606	NM_152493	ZNF362	zinc finger protein 362
chr11_+_128068982	0.587	NM_002017	FLI1	Friend leukemia virus integration 1
chr1_+_190811479	0.579	NM_002922	RGS1	regulator of G-protein signaling 1
chr17_-_16816113	0.575	NM_012452	TNFRSF13B	tumor necrosis factor receptor superfamily, member 13B
chr6_+_167456230	0.575	NM_031409	CCR6	chemokine (C-C motif) receptor 6
chr12_+_54231249	0.573	NM_001005494	OR6C4	olfactory receptor, family 6, subfamily C, member 4
chr1_+_162795328	0.569	NM_002585	PBX1	pre-B-cell leukemia homeobox 1
chr4_+_134289893	0.567	NM_020815 NM_032961	PCDH10	protocadherin 10
chr7_+_116447527	0.564		ST7	suppression of tumorigenicity 7
chr15_-_91078307	0.562		FAM174B	family with sequence similarity 174, member B
chr20_-_604822	0.562	NM_033129	SCRT2	scratch homolog 2, zinc finger protein (Drosophila)
chr6_-_149847809	0.561	NM_207360	ZC3H12D	zinc finger CCCH-type containing 12D
chr2_+_73973600	0.555	NM_001615	ACTG2	actin, gamma 2, smooth muscle, enteric
chr11_-_3620060	0.548	NM_053017 NM_001079536	ART5	ADP-ribosyltransferase 5
chr6_-_149847718	0.537		ZC3H12D	zinc finger CCCH-type containing 12D
chr7_-_31347032	0.531	NM_022728	NEUROD6	neurogenic differentiation 6
chr18_+_52965290	0.529		BOD1P	biorientation of chromosomes in cell division 1 pseudogene
chr17_-_59363352	0.526	NM_000626 NM_001039933 NM_021602	CD79B	CD79b molecule, immunoglobulin-associated beta
chr3_+_135996734	0.518	NM_004441	EPHB1	EPH receptor B1
chr17_-_33178987	0.516		HNF1B	HNF1 homeobox B
chr14_-_93512647	0.516		ASB2	ankyrin repeat and SOCS box containing 2
chr1_+_168381811	0.513	NM_001136107	METTL11B	methyltransferase like 11B
chr18_-_59137488	0.510	NM_000633 NM_000657	BCL2	B-cell CLL/lymphoma 2
chr19_+_40511909	0.504	NM_001185099 NM_001185100 NM_001185101 NM_001771	CD22	CD22 molecule
chr4_-_100575313	0.502	NM_001166504 NM_000673	ADH7	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr3_-_129023850	0.498	NM_007283	MGLL	monoglyceride lipase
chr1_+_162795538	0.498		PBX1	pre-B-cell leukemia homeobox 1
chr14_-_106084519	0.497		IGHA1 IGHG1	immunoglobulin heavy constant alpha 1 immunoglobulin heavy constant gamma 1 (G1m marker)
chr5_-_124108672	0.496	NM_020747	ZNF608	zinc finger protein 608
chr10_+_77212524	0.492	NM_032024	C10orf11	chromosome 10 open reading frame 11
chr1_+_179719338	0.482	NM_000721	CACNA1E	calcium channel, voltage-dependent, R type, alpha 1E subunit
chr6_+_10663934	0.482	NM_001491	GCNT2	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr3_-_52235218	0.475	NM_017442	TLR9	toll-like receptor 9
chr3_+_135996990	0.474		EPHB1	EPH receptor B1
chr8_-_102872354	0.469		NCALD	neurocalcin delta
chr22_+_21065134	0.465		LOC100290481	immunoglobulin lambda light chain-like
chr15_-_38387410	0.463	NM_004573	PLCB2	phospholipase C, beta 2
chr19_-_17377383	0.457	NM_004335	BST2	bone marrow stromal cell antigen 2
chr17_-_34635446	0.457	NM_198993	STAC2	SH3 and cysteine rich domain 2
chr12_+_25096755	0.455		LRMP	lymphoid-restricted membrane protein
chr2_+_68445821	0.455	NM_002664	PLEK	pleckstrin
chr2_+_5750229	0.454	NM_003108	SOX11	SRY (sex determining region Y)-box 11
chr3_+_174598937	0.453	NM_014932	NLGN1	neuroligin 1
chr16_+_23754860	0.450		PRKCB	protein kinase C, beta
chr12_-_49897743	0.447		POU6F1	POU class 6 homeobox 1
chr6_+_10693964	0.445	NM_145655	GCNT2	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr6_-_133120587	0.442	NM_004665	VNN2	vanin 2
chr6_-_168222645	0.442	NM_024919	FRMD1	FERM domain containing 1
chr13_-_69580459	0.437	NM_020866	KLHL1	kelch-like 1 (Drosophila)
chr12_-_10953427	0.436	NM_023920	TAS2R13	taste receptor, type 2, member 13
chr7_-_141320041	0.436	NM_176817	TAS2R38	taste receptor, type 2, member 38
chr1_+_173303616	0.435	NM_022093	TNN	tenascin N
chr1_-_205012348	0.433	NM_000572	IL10	interleukin 10
chr11_+_63829616	0.429	NM_004451	ESRRA	estrogen-related receptor alpha
chr5_-_158459006	0.427		EBF1	early B-cell factor 1
chr19_-_48815572	0.426		ZNF428	zinc finger protein 428
chr5_-_175897430	0.426		RNF44	ring finger protein 44
chr7_-_126670804	0.421	NM_000845	GRM8	glutamate receptor, metabotropic 8
chr5_-_111119846	0.421	NM_001142483	C5orf13	chromosome 5 open reading frame 13
chr14_-_56342097	0.420	NM_172337	OTX2	orthodenticle homeobox 2
chr13_-_27572646	0.418	NM_004119	FLT3	fms-related tyrosine kinase 3
chr2_+_17861266	0.417	NM_001105569	MSGN1	mesogenin 1
chr12_-_16321885	0.410	NM_001170798	SLC15A5	solute carrier family 15, member 5
chr17_-_39094787	0.410	NM_001040002	MEOX1	mesenchyme homeobox 1
chr16_+_23754822	0.409		PRKCB	protein kinase C, beta
chr20_+_17155680	0.408		PCSK2	proprotein convertase subtilisin/kexin type 2
chr17_-_38087366	0.408	NM_016602	CCR10	chemokine (C-C motif) receptor 10
chr16_+_31273969	0.407	NM_000887	ITGAX	integrin, alpha X (complement component 3 receptor 4 subunit)
chr3_+_51837608	0.403	NM_001085479	IQCF3	IQ motif containing F3
chr4_-_41579325	0.400
chrX_-_84521398	0.399	NM_024921	POF1B	premature ovarian failure, 1B
chr1_+_148125090	0.399	NM_003517	HIST2H2AC	histone cluster 2, H2ac
chr18_-_54447168	0.399	NM_052947	ALPK2	alpha-kinase 2
chr12_-_7136147	0.391	NM_001733	C1R	complement component 1, r subcomponent
chr16_+_31274030	0.390		ITGAX	integrin, alpha X (complement component 3 receptor 4 subunit)
chr20_+_17155669	0.390		PCSK2	proprotein convertase subtilisin/kexin type 2
chr1_+_5975345	0.388		KCNAB2	potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr15_-_78050515	0.388	NM_001114735 NM_004049	BCL2A1	BCL2-related protein A1
chr5_-_156322784	0.384	NM_001146726 NM_138379	TIMD4	T-cell immunoglobulin and mucin domain containing 4
chr6_-_32665409	0.383	NM_002124	HLA-DRB1 HLA-DRB4 HLA-DRB5	major histocompatibility complex, class II, DR beta 1 major histocompatibility complex, class II, DR beta 4 major histocompatibility complex, class II, DR beta 5
chr2_-_50428395	0.381	NM_138735	NRXN1	neurexin 1
chr10_+_124897627	0.381	NM_005519	HMX2	H6 family homeobox 2
chr3_+_99733432	0.380	NM_005290	GPR15	G protein-coupled receptor 15
chr10_+_68355797	0.379	NM_178011	LRRTM3	leucine rich repeat transmembrane neuronal 3
chr12_+_109956210	0.377	NM_015267	CUX2	cut-like homeobox 2
chrX_-_80344096	0.377	NM_030763	HMGN5	high-mobility group nucleosome binding domain 5
chr12_+_25096472	0.374	NM_006152	LRMP	lymphoid-restricted membrane protein
chr7_+_50318801	0.372		IKZF1	IKAROS family zinc finger 1 (Ikaros)
chr10_+_106103503	0.371	NM_001008723	CCDC147	coiled-coil domain containing 147
chr7_+_149842850	0.371	NM_153236	GIMAP7	GTPase, IMAP family member 7
chr8_-_72431274	0.366	NM_172058 NM_172059 NM_172060	EYA1	eyes absent homolog 1 (Drosophila)
chr5_-_160211623	0.366	NM_025153	ATP10B	ATPase, class V, type 10B
chr22_-_35938298	0.361	NM_001051	SSTR3	somatostatin receptor 3
chr2_+_189547358	0.361		COL3A1	collagen, type III, alpha 1
chr1_+_5975286	0.360		KCNAB2	potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr20_-_43693320	0.359	NM_147198	WFDC9	WAP four-disulfide core domain 9
chr7_-_100021658	0.358		LRCH4	leucine-rich repeats and calponin homology (CH) domain containing 4
chr1_+_154120170	0.358		SYT11	synaptotagmin XI
chr17_-_60988077	0.357	NM_004655	AXIN2	axin 2
chr7_+_73826244	0.355	NM_000265	NCF1 NCF1B NCF1C	neutrophil cytosolic factor 1 neutrophil cytosolic factor 1B pseudogene neutrophil cytosolic factor 1C pseudogene
chr3_-_57209319	0.354	NM_003865	HESX1	HESX homeobox 1
chr6_-_42527760	0.353	NM_033502	TRERF1	transcriptional regulating factor 1
chrX_+_16051344	0.352	NM_005314	GRPR	gastrin-releasing peptide receptor
chr11_+_128069183	0.351		FLI1	Friend leukemia virus integration 1
chr6_-_108252200	0.350	NM_198081	SCML4	sex comb on midleg-like 4 (Drosophila)
chr9_+_94766379	0.348		FGD3	FYVE, RhoGEF and PH domain containing 3
chr12_-_120502483	0.348	NM_001005366	KDM2B	lysine (K)-specific demethylase 2B
chr5_-_88215034	0.347	NM_001193350 NM_002397	MEF2C	myocyte enhancer factor 2C
chr7_+_116447499	0.346		ST7	suppression of tumorigenicity 7
chr2_-_157890400	0.345	NM_020711	ERMN	ermin, ERM-like protein
chr17_+_60563917	0.344	NM_001081955 NM_001165933 NM_003835	RGS9	regulator of G-protein signaling 9
chr12_+_111829191	0.343		OAS1	2',5'-oligoadenylate synthetase 1, 40/46kDa
chr6_+_26325124	0.343	NM_021052	HIST1H2AE	histone cluster 1, H2ae
chr16_+_23754997	0.342		PRKCB	protein kinase C, beta
chr22_+_30072739	0.338		FLJ20464	hypothetical protein FLJ20464
chr3_+_129124591	0.337	NM_207335	KBTBD12	kelch repeat and BTB (POZ) domain containing 12
chr3_+_141879555	0.336	NM_152616	TRIM42	tripartite motif containing 42
chr2_+_73973640	0.336		ACTG2	actin, gamma 2, smooth muscle, enteric
chr14_+_31868229	0.335	NM_004274	AKAP6	A kinase (PRKA) anchor protein 6
chr17_-_44249379	0.335	NM_001130918	TTLL6	tubulin tyrosine ligase-like family, member 6
chr17_+_60563963	0.335		RGS9	regulator of G-protein signaling 9
chr7_-_3049872	0.334	NM_032415	CARD11	caspase recruitment domain family, member 11
chr3_-_193928038	0.333	NM_004113	FGF12	fibroblast growth factor 12
chr12_-_103846186	0.333	NM_032148	SLC41A2	solute carrier family 41, member 2
chr8_-_72437020	0.333	NM_000503	EYA1	eyes absent homolog 1 (Drosophila)
chr7_-_27206249	0.332	NM_000522	HOXA13	homeobox A13
chr6_+_29187565	0.331	NM_001005216	OR2J3	olfactory receptor, family 2, subfamily J, member 3
chr14_+_78815406	0.330	NM_001105250 NM_138970	NRXN3	neurexin 3
chr8_+_144711619	0.329	NM_024736	GSDMD	gasdermin D
chr22_-_30072329	0.328		PATZ1	POZ (BTB) and AT hook containing zinc finger 1
chr5_-_66528330	0.327	NM_005582	CD180	CD180 molecule
chr12_-_7709734	0.326	NM_001644	APOBEC1	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
chr22_+_20715340	0.326
chr12_-_101398429	0.326		IGF1	insulin-like growth factor 1 (somatomedin C)
chr7_-_100021689	0.323	NM_002319	LRCH4	leucine-rich repeats and calponin homology (CH) domain containing 4
chr6_+_29902734	0.322	NM_002127	HLA-G	major histocompatibility complex, class I, G
chr10_+_120957084	0.322	NM_005308	GRK5	G protein-coupled receptor kinase 5
chr9_-_35069751	0.322	NM_004629	FANCG	Fanconi anemia, complementation group G
chr11_-_10630408	0.321	NM_001098579	MRVI1	murine retrovirus integration site 1 homolog
chr3_+_185300660	0.320	NM_182589	HTR3E	5-hydroxytryptamine (serotonin) receptor 3, family member E
chr14_+_99555471	0.320		EVL	Enah/Vasp-like
chr1_+_165564904	0.319	NM_001198783	POU2F1	POU class 2 homeobox 1
chr11_+_128069203	0.318		FLI1	Friend leukemia virus integration 1
chr12_-_51086330	0.318	NM_033033	KRT82	keratin 82
chr18_+_40513889	0.318	NM_001130110	SETBP1	SET binding protein 1
chr17_+_9670105	0.315	NM_004246	GLP2R	glucagon-like peptide 2 receptor
chr11_+_4522993	0.315	NM_001004137	OR52M1	olfactory receptor, family 52, subfamily M, member 1
chr1_-_158948176	0.314	NM_001778	CD48	CD48 molecule
chr22_-_30072217	0.313	NM_014323 NM_032050 NM_032051 NM_032052	PATZ1	POZ (BTB) and AT hook containing zinc finger 1
chr1_+_100957883	0.313	NM_001078 NM_080682	VCAM1	vascular cell adhesion molecule 1
chr12_-_101398470	0.313		IGF1	insulin-like growth factor 1 (somatomedin C)
chr17_-_70639382	0.310	NM_014595	NT5C	5', 3'-nucleotidase, cytosolic
chr14_-_105851580	0.310		IGHA1 IGHA2 IGHD IGHG1	immunoglobulin heavy constant alpha 1 immunoglobulin heavy constant alpha 2 (A2m marker) immunoglobulin heavy constant delta immunoglobulin heavy constant gamma 1 (G1m marker)
chrX_-_84521320	0.310		POF1B	premature ovarian failure, 1B
chr17_-_23151601	0.309	NM_000625	NOS2	nitric oxide synthase 2, inducible
chr14_-_88948486	0.309		FOXN3	forkhead box N3
chr8_+_11388918	0.308	NM_001715	BLK	B lymphoid tyrosine kinase
chr6_-_11340886	0.308		NEDD9	neural precursor cell expressed, developmentally down-regulated 9
chr6_+_135558744	0.303		MYB	v-myb myeloblastosis viral oncogene homolog (avian)
chr15_+_58083712	0.302	NM_012182	FOXB1	forkhead box B1
chr14_-_106184988	0.302		IGHA1 IGHG1	immunoglobulin heavy constant alpha 1 immunoglobulin heavy constant gamma 1 (G1m marker)
chr7_+_100021862	0.300	NM_033506	FBXO24	F-box protein 24
chr1_+_218930250	0.300	NM_024709	C1orf115	chromosome 1 open reading frame 115
chrX_+_28515479	0.298	NM_014271	IL1RAPL1	interleukin 1 receptor accessory protein-like 1
chr8_+_19840861	0.297	NM_000237	LPL	lipoprotein lipase

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.32	1.21e-12	GO:0032501	multicellular organismal process
1.24	5.87e-09	GO:0050896	response to stimulus
1.51	2.03e-07	GO:0003008	system process
1.56	1.52e-06	GO:0050877	neurological system process
1.18	3.27e-06	GO:0050789	regulation of biological process
1.32	6.60e-06	GO:0048856	anatomical structure development
1.18	6.81e-06	GO:0050794	regulation of cellular process
1.16	9.91e-06	GO:0065007	biological regulation
1.67	3.27e-05	GO:0007600	sensory perception
1.33	3.56e-05	GO:0048731	system development
1.60	8.53e-05	GO:0006357	regulation of transcription from RNA polymerase II promoter
1.26	1.13e-04	GO:0032502	developmental process
1.37	1.41e-04	GO:0006355	regulation of transcription, DNA-dependent
1.46	1.52e-04	GO:0007399	nervous system development
1.28	1.88e-04	GO:0007275	multicellular organismal development
1.35	2.28e-04	GO:0051252	regulation of RNA metabolic process
1.32	7.52e-04	GO:0010468	regulation of gene expression
1.62	1.02e-03	GO:0006955	immune response
1.80	1.06e-03	GO:0007606	sensory perception of chemical stimulus
1.47	1.36e-03	GO:0002376	immune system process
1.36	2.73e-03	GO:0048513	organ development
1.31	2.96e-03	GO:2000112	regulation of cellular macromolecule biosynthetic process
1.28	4.26e-03	GO:0048518	positive regulation of biological process
1.62	4.71e-03	GO:0010628	positive regulation of gene expression
1.23	4.85e-03	GO:0023052	signaling
1.28	5.55e-03	GO:0031326	regulation of cellular biosynthetic process
1.75	5.63e-03	GO:0045944	positive regulation of transcription from RNA polymerase II promoter
1.65	5.84e-03	GO:0045893	positive regulation of transcription, DNA-dependent
1.70	6.93e-03	GO:0045892	negative regulation of transcription, DNA-dependent
1.28	7.30e-03	GO:0009889	regulation of biosynthetic process
1.69	8.01e-03	GO:0051253	negative regulation of RNA metabolic process
1.29	8.86e-03	GO:0010556	regulation of macromolecule biosynthetic process
1.60	9.20e-03	GO:0030182	neuron differentiation
1.27	9.46e-03	GO:0051171	regulation of nitrogen compound metabolic process
1.71	1.08e-02	GO:0001775	cell activation
3.72	1.21e-02	GO:0050909	sensory perception of taste
1.27	1.52e-02	GO:0019219	regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.34	1.81e-02	GO:0007166	cell surface receptor linked signaling pathway
2.14	1.85e-02	GO:0007517	muscle organ development
1.55	1.89e-02	GO:0010557	positive regulation of macromolecule biosynthetic process
1.61	2.98e-02	GO:0010629	negative regulation of gene expression
1.66	3.27e-02	GO:0007417	central nervous system development
1.22	3.84e-02	GO:0007165	signal transduction
1.21	4.51e-02	GO:0080090	regulation of primary metabolic process

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.30	5.25e-09	GO:0005886	plasma membrane
1.30	7.12e-09	GO:0071944	cell periphery
1.27	1.36e-02	GO:0044459	plasma membrane part

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.50	4.11e-10	GO:0004871	signal transducer activity
1.50	4.11e-10	GO:0060089	molecular transducer activity
1.55	1.17e-09	GO:0004872	receptor activity
1.73	2.18e-09	GO:0030528	transcription regulator activity
1.91	3.10e-09	GO:0043565	sequence-specific DNA binding
1.72	7.40e-09	GO:0001071	nucleic acid binding transcription factor activity
1.72	7.40e-09	GO:0003700	sequence-specific DNA binding transcription factor activity
1.58	1.44e-07	GO:0004888	transmembrane receptor activity
1.65	9.65e-06	GO:0004930	G-protein coupled receptor activity
1.34	7.01e-05	GO:0003677	DNA binding
3.46	2.90e-02	GO:0003823	antigen binding