Motif ID: POU6F1.p2

Z-value: 1.220


Transcription factors associated with POU6F1.p2:

Gene SymbolEntrez IDGene Name
POU6F1 5463 POU class 6 homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
POU6F1chr12_-_498782160.381.4e-01Click!


Activity profile for motif POU6F1.p2.

activity profile for motif POU6F1.p2


Sorted Z-values histogram for motif POU6F1.p2

Sorted Z-values for motif POU6F1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU6F1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_5466490 1.798 NM_001005163
OR52D1
olfactory receptor, family 52, subfamily D, member 1
chr6_+_47857733 1.697 NM_181744
OPN5
opsin 5
chr3_+_129682434 1.408


chr11_+_48284350 1.296 NM_001004725
OR4S1
olfactory receptor, family 4, subfamily S, member 1
chr5_+_140509803 1.198 NM_018939
PCDHB6
protocadherin beta 6
chr6_+_105511615 1.165 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr4_-_44348414 1.148 NM_182592
YIPF7
Yip1 domain family, member 7
chrX_-_55074125 1.093 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chr7_+_128136347 0.990 FAM71F1
family with sequence similarity 71, member F1
chr14_+_19473606 0.956 NM_001004063
OR4K1
olfactory receptor, family 4, subfamily K, member 1
chr6_-_26216299 0.936 NM_005323
HIST1H1T
histone cluster 1, H1t
chr9_-_205892 0.884 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr5_-_137502975 0.846 NM_003551
NME5
non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)
chrX_+_65299157 0.834 NM_138737
HEPH
hephaestin
chr4_-_145281237 0.815 NM_002099
GYPA
glycophorin A (MNS blood group)
chr1_+_58899 0.785 NM_001005484
OR4F4
OR4F5
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 5
chr1_+_109057078 0.765 NM_001144937
FNDC7
fibronectin type III domain containing 7
chr11_-_16454493 0.735 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr15_-_100280784 0.731 NM_001004195
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr9_-_94206648 0.710 NM_014057
NM_033014
OGN

osteoglycin

chrX_+_67830204 0.695 NM_001142504
STARD8
StAR-related lipid transfer (START) domain containing 8
chr1_-_195302973 0.655 NM_001994
F13B
coagulation factor XIII, B polypeptide
chr7_-_92693716 0.654 NM_001039372
HEPACAM2
HEPACAM family member 2
chr1_-_116112921 0.606 NM_001232
CASQ2
calsequestrin 2 (cardiac muscle)
chr11_-_123758448 0.592 NM_001005468
OR8B2
olfactory receptor, family 8, subfamily B, member 2
chr6_-_155818728 0.574 NM_015718
NOX3
NADPH oxidase 3
chr10_-_30958631 0.570 NM_183058
LYZL2
lysozyme-like 2
chr1_-_76170563 0.553 NM_080868
ASB17
ankyrin repeat and SOCS box containing 17
chr2_+_166034402 0.539 NM_001172173
CSRNP3
cysteine-serine-rich nuclear protein 3
chr2_-_27215781 0.534 NM_178553
C2orf53
chromosome 2 open reading frame 53
chr5_+_140583098 0.515 NM_018934
PCDHB14
protocadherin beta 14
chr1_-_116112853 0.499 CASQ2
calsequestrin 2 (cardiac muscle)
chr19_-_54350457 0.493 NM_002152
HRC
histidine rich calcium binding protein
chr6_-_123999640 0.489 NM_006073
TRDN
triadin
chr8_-_13018123 0.486 NM_001164271
DLC1
deleted in liver cancer 1
chr13_-_19008884 0.485 NM_001141968
NM_130785
NM_199254
TPTE2


transmembrane phosphoinositide 3-phosphatase and tensin homolog 2


chr8_-_125252884 0.485 C8orf78
chromosome 8 open reading frame 78
chr2_+_210152399 0.482 MAP2
microtubule-associated protein 2
chr10_+_4995597 0.481 AKR1C1
AKR1C3
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr11_+_55799604 0.480 NM_001004745
OR5T1
olfactory receptor, family 5, subfamily T, member 1
chr11_-_57173823 0.478 NM_145008
YPEL4
yippee-like 4 (Drosophila)
chr1_-_116112684 0.470 CASQ2
calsequestrin 2 (cardiac muscle)
chr4_+_90252990 0.466 NM_145715
TIGD2
tigger transposable element derived 2
chr10_+_4995453 0.442 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr3_-_153470022 0.437 LOC401093
hypothetical LOC401093
chr10_-_5035967 0.426 NM_001135241
AKR1C1
AKR1C2
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr18_+_59295123 0.416 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr14_-_56342097 0.410 NM_172337
OTX2
orthodenticle homeobox 2
chr6_+_127940011 0.409 NM_001010905
C6orf58
chromosome 6 open reading frame 58
chr16_-_69392568 0.399 VAC14
Vac14 homolog (S. cerevisiae)
chr3_-_110517929 0.396 NM_138815
DPPA2
developmental pluripotency associated 2
chr6_+_29187565 0.390 NM_001005216
OR2J3
olfactory receptor, family 2, subfamily J, member 3
chr10_+_29617995 0.388 NM_032517
LYZL1
lysozyme-like 1
chr17_+_46176105 0.383 LUC7L3
LUC7-like 3 (S. cerevisiae)
chr7_-_27125738 0.381 NM_030661
HOXA3
homeobox A3
chr7_-_100262971 0.371 NM_004444
EPHB4
EPH receptor B4
chr16_-_69392562 0.366 VAC14
Vac14 homolog (S. cerevisiae)
chr16_-_69392561 0.365 NM_018052
VAC14
Vac14 homolog (S. cerevisiae)
chr1_+_103961476 0.364 NM_000699
AMY2A
amylase, alpha 2A (pancreatic)
chrX_+_65299352 0.360 HEPH
hephaestin
chr4_-_45820686 0.360 NM_173536
GABRG1
gamma-aminobutyric acid (GABA) A receptor, gamma 1
chr17_-_36276987 0.359 NM_000223
KRT12
keratin 12
chr6_+_54281161 0.356 NM_014464
TINAG
tubulointerstitial nephritis antigen
chr3_-_191650291 0.351 NM_207316
TMEM207
transmembrane protein 207
chr19_-_60941551 0.346 NM_176820
NLRP9
NLR family, pyrin domain containing 9
chr1_-_161380562 0.345 RGS5
regulator of G-protein signaling 5
chr4_-_64957595 0.344 NM_001010874
TECRL
trans-2,3-enoyl-CoA reductase-like
chr6_-_29431950 0.343 NM_030876
OR5V1
olfactory receptor, family 5, subfamily V, member 1
chr19_+_61624 0.340 NM_001005240
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr4_-_122304925 0.338 NM_024873
TNIP3
TNFAIP3 interacting protein 3
chr10_+_96433240 0.336 NM_000772
NM_001128925
CYP2C18

cytochrome P450, family 2, subfamily C, polypeptide 18

chr4_-_68511738 0.335 NM_001114387
NM_182606
TMPRSS11A

transmembrane protease, serine 11A

chr7_+_99865189 0.329 NM_019606
MEPCE
methylphosphate capping enzyme
chr6_-_138231006 0.327


chr1_-_120189301 0.325 NM_001047980
NBPF7
neuroblastoma breakpoint family, member 7
chr1_+_185064654 0.323 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr10_+_4995685 0.321 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr7_+_38984133 0.321 NM_001166018
NM_007252
POU6F2

POU class 6 homeobox 2

chr12_-_28016182 0.321 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chrX_+_90977115 0.319 NM_001168360
NM_001168361
NM_001168362
NM_001168363
PCDH11X



protocadherin 11 X-linked



chr16_-_69392385 0.316 VAC14
Vac14 homolog (S. cerevisiae)
chr2_-_169596078 0.313 NM_003742
ABCB11
ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr18_+_27210737 0.311 NM_001134453
NM_177986
DSG4

desmoglein 4

chr6_+_72983183 0.309 NM_001168410
RIMS1
regulating synaptic membrane exocytosis 1
chr1_+_559618 0.308


chr8_-_114518194 0.304 NM_052900
NM_198123
CSMD3

CUB and Sushi multiple domains 3

chr5_-_95794416 0.302 NM_000439
PCSK1
proprotein convertase subtilisin/kexin type 1
chr17_-_64462976 0.302 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr5_-_145232723 0.301 NM_001080516
GRXCR2
glutaredoxin, cysteine rich 2
chr5_-_27074407 0.295 NM_016279
CDH9
cadherin 9, type 2 (T1-cadherin)
chr6_-_136888771 0.294 NM_001198608
NM_001198609
NM_001198611
MAP7


microtubule-associated protein 7


chr14_-_60022487 0.294 NM_174978
C14orf39
chromosome 14 open reading frame 39
chr1_+_61642287 0.292 NFIA
nuclear factor I/A
chr6_+_152053323 0.292 NM_001122742
ESR1
estrogen receptor 1
chr11_+_57714481 0.287 NM_001005283
OR9Q2
olfactory receptor, family 9, subfamily Q, member 2
chr15_+_72209973 0.283 ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr7_-_83662152 0.283 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr11_+_5329313 0.281 NM_001004750
OR51B6
olfactory receptor, family 51, subfamily B, member 6
chr16_-_69392545 0.275 VAC14
Vac14 homolog (S. cerevisiae)
chr7_+_120490054 0.273 C7orf58
chromosome 7 open reading frame 58
chr19_-_61876057 0.269 NM_001005850
ZNF835
zinc finger protein 835
chr16_+_79829794 0.267 NM_017429
BCMO1
beta-carotene 15,15'-monooxygenase 1
chr8_-_30826074 0.266 NM_031271
TEX15
testis expressed 15
chr3_-_18455207 0.266 NM_001131010
SATB1
SATB homeobox 1
chr22_+_21116283 0.265


chr17_-_36113502 0.265 NM_019016
KRT24
keratin 24
chr5_-_39238818 0.262 FYB
FYN binding protein
chr19_-_58486686 0.261 NM_033341
BIRC8
baculoviral IAP repeat containing 8
chr9_-_124981125 0.258 STRBP
spermatid perinuclear RNA binding protein
chr1_-_108588186 0.256 NM_001143989
NBPF4
NBPF6
neuroblastoma breakpoint family, member 4
neuroblastoma breakpoint family, member 6
chr6_+_134800533 0.256 LOC154092
hypothetical LOC154092
chr4_+_35962038 0.252 NM_001170700
DTHD1
death domain containing 1
chr7_+_134114912 0.252 CALD1
caldesmon 1
chr17_-_38087366 0.250 NM_016602
CCR10
chemokine (C-C motif) receptor 10
chr4_+_78651929 0.248 NM_006419
CXCL13
chemokine (C-X-C motif) ligand 13
chr7_+_138469029 0.245 NM_001144920
NM_001144923
NM_024926
TTC26


tetratricopeptide repeat domain 26


chr2_-_55090759 0.244 NM_007008
RTN4
reticulon 4
chr1_+_15145001 0.242 NM_001017999
KAZN
kazrin, periplakin interacting protein
chr11_+_71605466 0.241 NM_000803
NM_001113534
NM_001113535
NM_001113536
FOLR2



folate receptor 2 (fetal)



chr15_+_72209795 0.237 NM_020851
ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr16_+_33112480 0.236 NM_016212
TP53TG3
TP53 target 3
chr1_-_34404029 0.234 NM_052896
CSMD2
CUB and Sushi multiple domains 2
chr6_-_27988152 0.234 NM_033057
OR2B2
olfactory receptor, family 2, subfamily B, member 2
chr5_+_161207262 0.233 NM_001127643
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr2_-_1905508 0.232 MYT1L
myelin transcription factor 1-like
chr2_+_210152609 0.230 NM_002374
NM_031845
NM_031847
MAP2


microtubule-associated protein 2


chr13_-_102209422 0.230 NM_001146197
C13orf40
chromosome 13 open reading frame 40
chr4_-_145159889 0.228 NM_002100
GYPB
glycophorin B (MNS blood group)
chr1_-_158815895 0.221 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr13_+_107719977 0.218 NM_001145645
NM_006573
TNFSF13B

tumor necrosis factor (ligand) superfamily, member 13b

chr4_-_164614335 0.216 NM_032136
TKTL2
transketolase-like 2
chr4_+_88939725 0.216 NM_004967
IBSP
integrin-binding sialoprotein
chr3_+_153074118 0.214 NM_033050
SUCNR1
succinate receptor 1
chr2_-_142605739 0.214 NM_018557
LRP1B
low density lipoprotein receptor-related protein 1B
chr7_+_133862883 0.213 NM_020299
AKR1B10
aldo-keto reductase family 1, member B10 (aldose reductase)
chr7_+_93373755 0.210 NM_021955
GNGT1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr16_+_33169015 0.209 NM_016212
TP53TG3
TP53 target 3
chr11_-_4924905 0.203 NM_001005329
OR51A4
olfactory receptor, family 51, subfamily A, member 4
chr11_-_59390518 0.202 NM_001062
TCN1
transcobalamin I (vitamin B12 binding protein, R binder family)
chr6_-_49862858 0.197 NM_138733
PGK2
phosphoglycerate kinase 2
chr6_-_49942147 0.193 NM_001131
NM_170609
CRISP1

cysteine-rich secretory protein 1

chr7_+_99864348 0.192 NM_001194990
NM_001194991
NM_001194992
MEPCE


methylphosphate capping enzyme


chr1_+_556968 0.191


chr7_+_106897737 0.188 NM_005295
GPR22
G protein-coupled receptor 22
chr22_-_34566367 0.187 NM_001031695
NM_001082576
NM_001082577
NM_014309
RBFOX2



RNA binding protein, fox-1 homolog (C. elegans) 2



chr11_-_57927457 0.186 NM_001005469
OR5B3
olfactory receptor, family 5, subfamily B, member 3
chr10_+_94584449 0.185 NM_001013848
EXOC6
exocyst complex component 6
chr7_-_99604127 0.184 GAL3ST4
galactose-3-O-sulfotransferase 4
chr3_+_187813553 0.184 AHSG
alpha-2-HS-glycoprotein
chr6_-_76838944 0.181 NM_001563
IMPG1
interphotoreceptor matrix proteoglycan 1
chr17_-_64752550 0.181 NM_080282
ABCA10
ATP-binding cassette, sub-family A (ABC1), member 10
chr19_-_62348381 0.180 NM_052882
ZIM3
zinc finger, imprinted 3
chr10_+_90474280 0.176 NM_001080518
LIPK
lipase, family member K
chr17_+_7402315 0.176 NM_001198622
NM_001198623
NM_001198624
NM_003808
NM_172087
NM_172088
TNFSF13





tumor necrosis factor (ligand) superfamily, member 13





chr17_-_36294962 0.176 NM_019010
KRT20
keratin 20
chr11_-_123772456 0.174 NM_001005467
OR8B3
olfactory receptor, family 8, subfamily B, member 3
chr18_+_27281729 0.172 NM_001944
DSG3
desmoglein 3
chr3_-_197726587 0.171 NM_001077657
C3orf43
chromosome 3 open reading frame 43
chr14_-_57030227 0.170 NM_018168
C14orf105
chromosome 14 open reading frame 105
chr22_-_21193504 0.170 NM_080764
ZNF280B
zinc finger protein 280B
chr1_+_194887630 0.169 NM_000186
NM_001014975
CFH

complement factor H

chr3_+_143858428 0.169 NM_001172312
PLS1
plastin 1
chr4_-_145046109 0.167 NM_002102
NM_198682
GYPE

glycophorin E (MNS blood group)

chr20_+_71230 0.167 NM_030931
DEFB126
defensin, beta 126
chr13_+_77007809 0.166 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr18_-_55136673 0.166 NM_181654
CPLX4
complexin 4
chr3_+_162697289 0.166 NM_001080440
OTOL1
otolin 1 homolog (zebrafish)
chr9_-_94338072 0.166 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr16_-_32595553 0.163 NM_016212
TP53TG3
TP53 target 3
chr3_-_152641248 0.161 NM_001178145
NM_001178146
IGSF10

immunoglobulin superfamily, member 10

chr1_+_196874839 0.159 PTPRC
protein tyrosine phosphatase, receptor type, C
chr5_-_156525756 0.158 NM_130899
FAM71B
family with sequence similarity 71, member B
chr17_-_36232366 0.157 NM_000421
KRT10
keratin 10
chr1_-_104040594 0.157 NM_001008221
AMY1A
amylase, alpha 1A (salivary)
chr7_+_119700924 0.157 NM_012281
KCND2
potassium voltage-gated channel, Shal-related subfamily, member 2
chr8_-_93181091 0.157 NM_001198628
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr1_+_213245507 0.154 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chr22_-_38619739 0.153 NM_152512
ENTHD1
ENTH domain containing 1
chr6_+_12825818 0.152 NM_030948
PHACTR1
phosphatase and actin regulator 1
chr17_+_20712337 0.150


chr2_+_166137091 0.149 NM_024969
CSRNP3
cysteine-serine-rich nuclear protein 3
chr2_-_158439868 0.147 NM_001105
ACVR1
activin A receptor, type I
chr7_-_99604171 0.145 NM_024637
GAL3ST4
galactose-3-O-sulfotransferase 4
chr2_+_27652892 0.145 NM_032266
C2orf16
chromosome 2 open reading frame 16
chr11_+_60309396 0.145 NM_206893
MS4A10
membrane-spanning 4-domains, subfamily A, member 10
chr3_-_57209319 0.144 NM_003865
HESX1
HESX homeobox 1
chr2_+_176677479 0.143


chr14_-_20098929 0.143 NM_001001673
NM_001110356
NM_001110357
NM_001110358
NM_001110359
NM_001110360
NM_001110361
RNASE9






ribonuclease, RNase A family, 9 (non-active)






chr4_-_99283323 0.141 NM_174952
C4orf37
chromosome 4 open reading frame 37
chr5_-_134899537 0.138 NM_006161
NEUROG1
neurogenin 1
chr6_+_53991672 0.136 NM_138569
C6orf142
chromosome 6 open reading frame 142
chr4_+_41309482 0.136 LIMCH1
LIM and calponin homology domains 1
chr11_-_26550243 0.135 NM_001135091
NM_001135092
NM_145650
MUC15


mucin 15, cell surface associated


chr10_-_61819493 0.132 NM_020987
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr7_+_129771865 0.132 NM_001127441
NM_001127442
NM_080385
CPA5


carboxypeptidase A5


chr1_+_92190296 0.132 NM_001726
BRDT
bromodomain, testis-specific
chr6_+_132933153 0.130 NM_175067
TAAR6
trace amine associated receptor 6
chr8_+_1980564 0.129 NM_003970
MYOM2
myomesin (M-protein) 2, 165kDa
chrX_+_47871546 0.127 NM_205856
SPACA5
sperm acrosome associated 5
chr18_+_8707368 0.127 NM_015210
KIAA0802
KIAA0802

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.72 1.57e-09 GO:0007608 sensory perception of smell
3.41 1.22e-08 GO:0007606 sensory perception of chemical stimulus
1.46 1.57e-06 GO:0032501 multicellular organismal process
1.93 6.31e-06 GO:0003008 system process
2.02 2.51e-05 GO:0050877 neurological system process
2.36 3.07e-05 GO:0007600 sensory perception

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.87 7.78e-08 GO:0005576 extracellular region
1.52 2.94e-07 GO:0071944 cell periphery
1.52 6.54e-07 GO:0005886 plasma membrane
1.24 1.48e-02 GO:0044425 membrane part
12.42 4.28e-02 GO:0001518 voltage-gated sodium channel complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.14 3.80e-10 GO:0004872 receptor activity
3.80 4.25e-10 GO:0004984 olfactory receptor activity
2.61 1.78e-08 GO:0004930 G-protein coupled receptor activity
2.22 3.51e-08 GO:0004888 transmembrane receptor activity
1.87 1.47e-07 GO:0004871 signal transducer activity
1.87 1.47e-07 GO:0060089 molecular transducer activity
27.94 2.29e-02 GO:0047023 androsterone dehydrogenase activity
27.94 2.29e-02 GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity