Motif ID: PRDM1.p3

Z-value: 1.729


Transcription factors associated with PRDM1.p3:

Gene SymbolEntrez IDGene Name
PRDM1 639 PR domain containing 1, with ZNF domain

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PRDM1chr6_+_106640881-0.263.3e-01Click!


Activity profile for motif PRDM1.p3.

activity profile for motif PRDM1.p3


Sorted Z-values histogram for motif PRDM1.p3

Sorted Z-values for motif PRDM1.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of PRDM1.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_16717887 2.332 BNC2
basonuclin 2
chr4_+_142777172 1.621 NM_000585
NM_172174
IL15

interleukin 15

chr17_+_6600080 1.549 XAF1
XIAP associated factor 1
chr3_-_115825742 1.367 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr3_+_8518508 1.247 NM_014583
LMCD1
LIM and cysteine-rich domains 1
chr12_+_6431437 1.204 NM_018009
TAPBPL
TAP binding protein-like
chr1_+_110254755 1.182 NM_000757
NM_172210
NM_172211
NM_172212
CSF1



colony stimulating factor 1 (macrophage)



chr1_+_110254979 1.124 CSF1
colony stimulating factor 1 (macrophage)
chr4_-_186814852 1.082 SORBS2
sorbin and SH3 domain containing 2
chr12_+_25096472 1.070 NM_006152
LRMP
lymphoid-restricted membrane protein
chr8_-_29176490 1.063 NM_015254
KIF13B
kinesin family member 13B
chr22_-_28972683 1.020 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr6_-_112682401 1.002 LAMA4
laminin, alpha 4
chr11_-_40272239 0.988 NM_020929
LRRC4C
leucine rich repeat containing 4C
chr4_-_186815116 0.973 NM_001145674
NM_001145675
SORBS2

sorbin and SH3 domain containing 2

chr3_+_8518539 0.973 LMCD1
LIM and cysteine-rich domains 1
chr2_+_205118801 0.969 PARD3B
par-3 partitioning defective 3 homolog B (C. elegans)
chr16_+_55580910 0.936 NM_032206
NLRC5
NLR family, CARD domain containing 5
chrX_-_100920493 0.923 GK
glycerol kinase
chrX_+_10084984 0.921 NM_001830
CLCN4
chloride channel 4
chr5_-_37220702 0.907 C5orf42
chromosome 5 open reading frame 42
chr10_-_131652007 0.896 NM_001005463
EBF3
early B-cell factor 3
chr6_-_112682038 0.893 LAMA4
laminin, alpha 4
chr8_-_145132582 0.880 NM_032789
PARP10
poly (ADP-ribose) polymerase family, member 10
chr17_+_6599879 0.853 NM_017523
NM_199139
XAF1

XIAP associated factor 1

chr2_+_230989150 0.847 SP100
SP100 nuclear antigen
chr5_+_131774478 0.843 NM_001013717
C5orf56
chromosome 5 open reading frame 56
chr12_+_25096755 0.831 LRMP
lymphoid-restricted membrane protein
chr6_-_112682573 0.829 LAMA4
laminin, alpha 4
chr11_+_32069183 0.801 RCN1
reticulocalbin 1, EF-hand calcium binding domain
chr16_+_49333513 0.799 NM_001042412
CYLD
cylindromatosis (turban tumor syndrome)
chr8_-_145132551 0.795 PARP10
poly (ADP-ribose) polymerase family, member 10
chr6_-_112682459 0.791 NM_001105206
NM_001105207
NM_001105208
NM_001105209
NM_002290
LAMA4




laminin, alpha 4




chr1_+_160868932 0.787 DDR2
discoidin domain receptor tyrosine kinase 2
chr4_+_37569093 0.778 NM_015173
TBC1D1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr11_-_104344473 0.748 NM_001225
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr15_+_82945223 0.747 NM_001007072
NM_017894
NM_181877
ZSCAN2


zinc finger and SCAN domain containing 2


chr2_-_21106291 0.702 APOB
apolipoprotein B (including Ag(x) antigen)
chr1_-_219982049 0.698 DUSP10
dual specificity phosphatase 10
chr2_+_205118961 0.691 PARD3B
par-3 partitioning defective 3 homolog B (C. elegans)
chr10_+_63478974 0.683 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr3_+_120495906 0.678 NM_020754
ARHGAP31
Rho GTPase activating protein 31
chr10_+_114125955 0.655 ACSL5
acyl-CoA synthetase long-chain family member 5
chr14_+_23675233 0.653 PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr8_-_79880095 0.646 NM_000880
IL7
interleukin 7
chr16_-_71650034 0.635 NM_001164766
ZFHX3
zinc finger homeobox 3
chr10_+_114125927 0.635 NM_016234
ACSL5
acyl-CoA synthetase long-chain family member 5
chr3_+_186529376 0.614 MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr16_+_49333461 0.604 NM_001042355
NM_015247
CYLD

cylindromatosis (turban tumor syndrome)

chr2_+_230900121 0.599 NM_138402
SP140L
SP140 nuclear body protein-like
chr11_-_85107569 0.597 NM_206929
SYTL2
synaptotagmin-like 2
chr6_-_32919751 0.593 NM_148919
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr20_+_56904042 0.592 GNAS
GNAS complex locus
chr8_+_97575071 0.585 SDC2
syndecan 2
chr5_+_73145098 0.572 RGNEF
190 kDa guanine nucleotide exchange factor
chr8_-_38324809 0.565 WHSC1L1
Wolf-Hirschhorn syndrome candidate 1-like 1
chr8_+_97575052 0.556 NM_002998
SDC2
syndecan 2
chrX_-_118711183 0.556 SEPT6
septin 6
chr11_+_63060848 0.538 NM_004585
RARRES3
retinoic acid receptor responder (tazarotene induced) 3
chr22_-_34886727 0.534 NM_145640
APOL3
apolipoprotein L, 3
chr11_-_40271086 0.511 LRRC4C
leucine rich repeat containing 4C
chr18_+_18989786 0.511 NM_138375
CABLES1
Cdk5 and Abl enzyme substrate 1
chr2_+_230989177 0.491 SP100
SP100 nuclear antigen
chr10_+_114126004 0.488 ACSL5
acyl-CoA synthetase long-chain family member 5
chr2_-_19421852 0.487 NM_145260
OSR1
odd-skipped related 1 (Drosophila)
chr1_+_158063278 0.485 SLAMF8
SLAM family member 8
chr5_-_142795269 0.479 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr8_+_144711619 0.479 NM_024736
GSDMD
gasdermin D
chr9_+_136673464 0.477 NM_000093
COL5A1
collagen, type V, alpha 1
chr14_-_23771401 0.474 NM_006156
NEDD8
neural precursor cell expressed, developmentally down-regulated 8
chr1_+_160868822 0.473 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr2_-_230792844 0.473 NM_004509
NM_004510
NM_080424
SP110


SP110 nuclear body protein


chr8_+_97575196 0.465 SDC2
syndecan 2
chr4_+_146623405 0.455 NM_001003688
SMAD1
SMAD family member 1
chr10_+_91082218 0.451 NM_001031683
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr16_-_70763524 0.447 NM_031293
PMFBP1
polyamine modulated factor 1 binding protein 1
chr10_-_44200458 0.432 NM_000609
NM_001033886
NM_001178134
NM_199168
CXCL12



chemokine (C-X-C motif) ligand 12



chr2_-_189752575 0.430 NM_000393
COL5A2
collagen, type V, alpha 2
chr5_+_96237923 0.422 ERAP2
endoplasmic reticulum aminopeptidase 2
chr2_+_230989114 0.417 NM_001080391
NM_003113
SP100

SP100 nuclear antigen

chrX_-_118711350 0.408 NM_015129
NM_145799
NM_145800
NM_145802
SEPT6



septin 6



chr12_+_11694172 0.386 ETV6
ets variant 6
chr11_-_4371463 0.385 NM_003141
TRIM21
tripartite motif containing 21
chr1_-_8406288 0.383 NM_001042682
RERE
arginine-glutamic acid dipeptide (RE) repeats
chr6_+_167445284 0.382 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr21_-_34820916 0.379 NM_203418
RCAN1
regulator of calcineurin 1
chr9_+_96806235 0.376 C9orf3
chromosome 9 open reading frame 3
chr17_-_45626364 0.372


chr20_-_5048443 0.369 NM_182649
PCNA
proliferating cell nuclear antigen
chr1_-_219982016 0.365 DUSP10
dual specificity phosphatase 10
chr11_+_71387572 0.364 NM_001039659
NM_001039660
NM_173042
IL18BP


interleukin 18 binding protein


chr16_-_28425632 0.363 NM_145659
IL27
interleukin 27
chr1_-_219982081 0.360 NM_007207
NM_144729
DUSP10

dual specificity phosphatase 10

chr11_-_77730573 0.355 NM_012296
GAB2
GRB2-associated binding protein 2
chr9_-_116608113 0.349 NM_005118
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr8_+_97575244 0.347 SDC2
syndecan 2
chr16_-_70763849 0.347 NM_001160213
PMFBP1
polyamine modulated factor 1 binding protein 1
chr14_+_23675206 0.344 NM_006263
NM_176783
PSME1

proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)

chr1_-_7998265 0.339 ERRFI1
ERBB receptor feedback inhibitor 1
chr14_-_23771399 0.334 NEDD8
neural precursor cell expressed, developmentally down-regulated 8
chr11_+_64079665 0.333 NM_018484
SLC22A11
solute carrier family 22 (organic anion/urate transporter), member 11
chr19_+_40931285 0.326 NM_019104
LIN37
lin-37 homolog (C. elegans)
chr20_+_337346 0.324 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr2_+_205118710 0.321 NM_057177
NM_152526
NM_205863
PARD3B


par-3 partitioning defective 3 homolog B (C. elegans)


chr3_+_51952326 0.320 PARP3
poly (ADP-ribose) polymerase family, member 3
chr9_-_14858974 0.318 FREM1
FRAS1 related extracellular matrix 1
chr3_-_49826221 0.318 UBA7
ubiquitin-like modifier activating enzyme 7
chr1_-_2486313 0.314 NM_003820
TNFRSF14
tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
chr11_+_71388619 0.314 NM_001145055
IL18BP
interleukin 18 binding protein
chr3_-_49826360 0.307 NM_003335
UBA7
ubiquitin-like modifier activating enzyme 7
chr13_+_30207690 0.298 ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr20_+_56903595 0.297 GNAS
GNAS complex locus
chr21_+_25856311 0.297 MIR155HG
MIR155 host gene (non-protein coding)
chr10_+_91051685 0.285 NM_001547
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr19_+_56958452 0.280 NM_001462
FPR2
formyl peptide receptor 2
chr15_+_67393795 0.276 NM_001104554
PAQR5
progestin and adipoQ receptor family member V
chr11_+_71388310 0.275 NM_001145057
IL18BP
interleukin 18 binding protein
chr14_+_72594985 0.273 RBM25
RNA binding motif protein 25
chr1_-_166171838 0.272 NM_015415
BRP44
brain protein 44
chr19_-_18058632 0.270 NM_005535
NM_153701
IL12RB1

interleukin 12 receptor, beta 1

chr7_+_5220342 0.268 NM_001033520
WIPI2
WD repeat domain, phosphoinositide interacting 2
chr1_-_242073094 0.265 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chr6_+_32929902 0.265 NM_002800
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
chr10_+_92970302 0.264 NM_032373
PCGF5
polycomb group ring finger 5
chr10_+_91077581 0.263 NM_001549
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr20_+_336693 0.256 NM_006462
NM_031229
RBCK1

RanBP-type and C3HC4-type zinc finger containing 1

chr12_+_100795480 0.256 DRAM1
DNA-damage regulated autophagy modulator 1
chr4_-_185632610 0.255 NM_002199
IRF2
interferon regulatory factor 2
chr9_+_18464138 0.255 ADAMTSL1
ADAMTS-like 1
chrX_-_118711088 0.252 SEPT6
septin 6
chr19_-_53239030 0.251 NM_019855
CABP5
calcium binding protein 5
chr11_-_85108030 0.251 NM_001162952
NM_206930
SYTL2

synaptotagmin-like 2

chr14_-_23771312 0.249 NEDD8
neural precursor cell expressed, developmentally down-regulated 8
chr2_+_174968701 0.248 NM_001193528
NM_024583
SCRN3

secernin 3

chr10_+_123744131 0.248 TACC2
transforming, acidic coiled-coil containing protein 2
chr2_-_174968595 0.247 NM_004882
CIR1
corepressor interacting with RBPJ, 1
chr5_-_34078991 0.246 NM_030945
NM_181435
C1QTNF3

C1q and tumor necrosis factor related protein 3

chr11_+_130745580 0.243 NM_001048209
NTM
neurotrimin
chr14_-_68329407 0.243 NM_004926
ZFP36L1
zinc finger protein 36, C3H type-like 1
chr7_-_96471544 0.239 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chr16_-_10696285 0.235 NM_144674
TEKT5
tektin 5
chr1_-_152847256 0.235 ADAR
adenosine deaminase, RNA-specific
chr11_+_5602782 0.232 NM_021616
TRIM34
tripartite motif containing 34
chr13_+_30207668 0.228 NM_001629
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr22_-_34965498 0.226 APOL2
apolipoprotein L, 2
chr11_+_28088406 0.226 METTL15
methyltransferase like 15
chr20_+_336963 0.224 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr6_-_101018271 0.224 NM_005068
SIM1
single-minded homolog 1 (Drosophila)
chr17_+_3326045 0.224 NM_000049
ASPA
aspartoacylase
chr12_+_100795213 0.221 NM_018370
DRAM1
DNA-damage regulated autophagy modulator 1
chr22_-_34965945 0.219 NM_145637
APOL2
apolipoprotein L, 2
chr1_-_146543016 0.217


chr14_+_72595020 0.217 RBM25
RNA binding motif protein 25
chr6_-_25044156 0.215 FAM65B
family with sequence similarity 65, member B
chr17_+_17339059 0.213


chr10_-_13789628 0.211 FRMD4A
FERM domain containing 4A
chr11_+_58668827 0.210 NM_022074
NM_198847
FAM111A

family with sequence similarity 111, member A

chr12_+_27511009 0.208 NM_001145010
C12orf70
chromosome 12 open reading frame 70
chr2_-_45648608 0.206 SRBD1
S1 RNA binding domain 1
chrX_-_118711144 0.204 SEPT6
septin 6
chr7_-_51351825 0.201 COBL
cordon-bleu homolog (mouse)
chr12_-_54995923 0.198 CNPY2
canopy 2 homolog (zebrafish)
chr3_-_44527083 0.197 ZNF852
zinc finger protein 852
chr11_+_63764988 0.195 NM_004470
FKBP2
FK506 binding protein 2, 13kDa
chr3_+_171112053 0.189 NM_182610
SAMD7
sterile alpha motif domain containing 7
chr2_+_230798687 0.184 NM_001005176
NM_007237
SP140

SP140 nuclear body protein

chr19_+_39402167 0.182 LSM14A
LSM14A, SCD6 homolog A (S. cerevisiae)
chr17_+_75851984 0.181


chr14_-_23685629 0.178 NM_002818
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr4_+_88075176 0.177 NM_001166693
AFF1
AF4/FMR2 family, member 1
chr12_+_109536214 0.174 NM_001082537
NM_001082538
NM_001173976
NM_024549
NM_001173975
TCTN1




tectonic family member 1




chr10_+_92970487 0.169 PCGF5
polycomb group ring finger 5
chr6_+_30018287 0.167 NM_002116
HLA-A
major histocompatibility complex, class I, A
chr3_-_161584137 0.166 NM_001190242
IFT80
intraflagellar transport 80 homolog (Chlamydomonas)
chr14_-_23981493 0.166 NM_020195
SDR39U1
short chain dehydrogenase/reductase family 39U, member 1
chr2_-_190893015 0.165 NM_014362
NM_198047
HIBCH

3-hydroxyisobutyryl-CoA hydrolase

chr11_+_59001421 0.163 NM_001004705
OR4D10
olfactory receptor, family 4, subfamily D, member 10
chr17_-_78000890 0.163 NM_001193655
C17orf62
chromosome 17 open reading frame 62
chr9_+_111582317 0.162 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr11_-_5662762 0.162 NM_033034
NM_033092
NM_033093
TRIM5


tripartite motif containing 5


chr15_-_40537002 0.161 NM_022473
ZFP106
zinc finger protein 106 homolog (mouse)
chr17_-_5078773 0.158 NM_207103
C17orf87
chromosome 17 open reading frame 87
chr1_-_152847301 0.157 NM_001111
NM_015840
NM_015841
ADAR


adenosine deaminase, RNA-specific


chr7_-_132371208 0.157 EEF1G
eukaryotic translation elongation factor 1 gamma
chr18_+_46659424 0.156 NM_001168335
NM_002396
ME2

malic enzyme 2, NAD(+)-dependent, mitochondrial

chr20_+_13924014 0.156 NM_080676
MACROD2
MACRO domain containing 2
chr7_+_128367961 0.155 NM_001098627
IRF5
interferon regulatory factor 5
chr1_-_146398501 0.153 LOC100286793
FLJ39739
hypothetical LOC100286793
hypothetical FLJ39739
chr3_-_44527122 0.150 ZNF852
zinc finger protein 852
chr9_+_101717278 0.150 STX17
syntaxin 17
chr2_+_43919606 0.150 NM_022437
ABCG8
ATP-binding cassette, sub-family G (WHITE), member 8
chr17_+_38412267 0.149 NM_005533
IFI35
interferon-induced protein 35
chr2_+_148495043 0.149 NM_018328
MBD5
methyl-CpG binding domain protein 5
chr20_+_336717 0.148 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr7_+_89681069 0.148 NM_001040666
STEAP2
six transmembrane epithelial antigen of the prostate 2
chr19_-_52427698 0.147 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr10_-_113923507 0.144 GPAM
glycerol-3-phosphate acyltransferase, mitochondrial
chr3_-_11598829 0.142 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr10_-_97311084 0.141 NM_015385
NM_024991
SORBS1

sorbin and SH3 domain containing 1

chr9_+_130306782 0.138 NM_001003722
NM_001499
GLE1

GLE1 RNA export mediator homolog (yeast)


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
12.25 2.30e-07 GO:0060337 type I interferon-mediated signaling pathway
12.25 2.30e-07 GO:0071357 cellular response to type I interferon
12.06 2.80e-07 GO:0034340 response to type I interferon
2.53 7.97e-06 GO:0002376 immune system process
5.28 3.01e-05 GO:0071345 cellular response to cytokine stimulus
5.51 4.30e-05 GO:0019221 cytokine-mediated signaling pathway
2.94 5.38e-05 GO:0006955 immune response
50.64 3.42e-04 GO:0002483 antigen processing and presentation of endogenous peptide antigen
50.64 3.42e-04 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
2.94 6.65e-04 GO:0071310 cellular response to organic substance
2.58 6.72e-04 GO:0051704 multi-organism process
5.35 1.17e-03 GO:0009615 response to virus
36.17 2.34e-03 GO:0019883 antigen processing and presentation of endogenous antigen
2.56 2.74e-03 GO:0006508 proteolysis
2.56 2.74e-03 GO:0006952 defense response
3.48 3.06e-03 GO:0045087 innate immune response
3.81 3.14e-03 GO:0034097 response to cytokine stimulus
2.70 3.29e-03 GO:0002682 regulation of immune system process
6.63 9.69e-03 GO:0030330 DNA damage response, signal transduction by p53 class mediator
3.00 4.13e-02 GO:0051707 response to other organism
19.48 4.43e-02 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
2.24 4.88e-02 GO:0010605 negative regulation of macromolecule metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
7.04 1.02e-02 GO:0000502 proteasome complex
7.17 3.14e-02 GO:0035770 RNA granule
12.66 4.20e-02 GO:0005839 proteasome core complex
63.29 4.32e-02 GO:0071797 LUBAC complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.11 9.36e-03 GO:0005126 cytokine receptor binding
2.46 3.40e-02 GO:0008233 peptidase activity
2.03 4.32e-02 GO:0001071 nucleic acid binding transcription factor activity
2.03 4.32e-02 GO:0003700 sequence-specific DNA binding transcription factor activity