Motif ID: PRRX1,2.p2

Z-value: 1.612


Transcription factors associated with PRRX1,2.p2:

Gene SymbolEntrez IDGene Name
PRRX1 5396 paired related homeobox 1
PRRX2 51450 paired related homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PRRX2chr9_+_131467740-0.504.6e-02Click!
PRRX1chr1_+_168898898-0.243.8e-01Click!


Activity profile for motif PRRX1,2.p2.

activity profile for motif PRRX1,2.p2


Sorted Z-values histogram for motif PRRX1,2.p2

Sorted Z-values for motif PRRX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PRRX1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_88155360 5.072 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr17_-_10362583 4.213 NM_005963
MYH1
myosin, heavy chain 1, skeletal muscle, adult
chr18_+_31488530 3.875 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr1_-_58920315 3.572


chrX_+_77889861 3.400 NM_005296
LPAR4
lysophosphatidic acid receptor 4
chr16_+_51690564 3.372 CHD9
chromodomain helicase DNA binding protein 9
chr1_-_114215768 3.299 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr17_-_10313600 3.224 NM_017533
MYH4
myosin, heavy chain 4, skeletal muscle
chr2_+_182558795 3.120 NM_001080545
PPP1R1C
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr12_+_28301399 3.074 NM_018318
CCDC91
coiled-coil domain containing 91
chr5_+_67622242 2.983 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chrX_+_7147471 2.919 NM_000351
STS
steroid sulfatase (microsomal), isozyme S
chr8_-_72431274 2.907 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr9_-_94226380 2.741 NM_005014
OMD
osteomodulin
chr10_+_69539255 2.689 NM_032578
MYPN
myopalladin
chr5_-_88235624 2.688 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr1_-_39119845 2.682 NM_030772
GJA9-MYCBP
GJA9
GJA9-MYCBP read-through transcript
gap junction protein, alpha 9, 59kDa
chr11_-_30558495 2.659 NM_001584
MPPED2
metallophosphoesterase domain containing 2
chr7_+_106897737 2.629 NM_005295
GPR22
G protein-coupled receptor 22
chr7_-_92615593 2.624 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr11_+_86710076 2.604 TMEM135
transmembrane protein 135
chr6_+_118976134 2.590 NM_002667
PLN
phospholamban
chr18_-_35634247 2.565 LOC647946
hypothetical LOC647946
chr8_-_87311624 2.496 NM_138817
SLC7A13
solute carrier family 7, (cationic amino acid transporter, y+ system) member 13
chr10_-_98280299 2.454 TM9SF3
transmembrane 9 superfamily member 3
chr2_-_144994038 2.437 ZEB2
zinc finger E-box binding homeobox 2
chr3_+_179759181 2.424 NM_005832
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr20_+_5935897 2.393 NM_001127458
CRLS1
cardiolipin synthase 1
chr5_+_60969392 2.319 NM_173667
FLJ37543
hypothetical protein FLJ37543
chr5_-_88215034 2.318 NM_001193350
NM_002397
MEF2C

myocyte enhancer factor 2C

chr7_-_107667728 2.247 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr1_+_198263352 2.246 NM_003822
NM_205860
NR5A2

nuclear receptor subfamily 5, group A, member 2

chr7_-_122627235 2.231 NM_022444
SLC13A1
solute carrier family 13 (sodium/sulfate symporters), member 1
chr16_+_7322751 2.224 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr13_-_35327798 2.208 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr6_-_87861492 2.185 NM_000735
CGA
glycoprotein hormones, alpha polypeptide
chr9_-_14076901 2.179 NFIB
nuclear factor I/B
chr5_+_155686333 2.175 NM_000337
NM_001128209
NM_172244
SGCD


sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)


chr12_-_101036407 2.105 NM_024057
NUP37
nucleoporin 37kDa
chr12_+_91654395 2.103 NM_001004330
PLEKHG7
pleckstrin homology domain containing, family G (with RhoGef domain) member 7
chr5_+_59819761 2.103 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr3_-_25658829 2.087 TOP2B
topoisomerase (DNA) II beta 180kDa
chr4_+_74825138 2.009 NM_000584
IL8
interleukin 8
chr2_-_144991556 1.987 ZEB2
zinc finger E-box binding homeobox 2
chr6_-_33268177 1.984 NM_001163771
NM_080679
NM_080680
NM_080681
COL11A2



collagen, type XI, alpha 2



chr1_+_100089118 1.978 NM_000646
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr2_-_160765008 1.961 ITGB6
integrin, beta 6
chr5_+_56545657 1.945 NM_001127236
GPBP1
GC-rich promoter binding protein 1
chr11_-_85103438 1.931 NM_032379
SYTL2
synaptotagmin-like 2
chr3_+_28406990 1.929 NM_001040432
ZCWPW2
zinc finger, CW type with PWWP domain 2
chr9_-_94206648 1.920 NM_014057
NM_033014
OGN

osteoglycin

chr13_+_47948586 1.899 RB1
retinoblastoma 1
chr1_+_194887630 1.897 NM_000186
NM_001014975
CFH

complement factor H

chr15_+_47502666 1.870 NM_002009
FGF7
fibroblast growth factor 7
chr13_+_51933228 1.858 CKAP2
cytoskeleton associated protein 2
chr6_+_88021644 1.822 ZNF292
zinc finger protein 292
chr1_+_67404756 1.820 NM_144701
IL23R
interleukin 23 receptor
chr2_-_188021117 1.802 NM_005795
CALCRL
calcitonin receptor-like
chr13_-_93929719 1.799 NM_001129889
NM_001922
DCT

dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)

chr7_-_25234582 1.796 NM_022150
NPVF
neuropeptide VF precursor
chr9_+_109131814 1.795 RAD23B
RAD23 homolog B (S. cerevisiae)
chr17_+_65582981 1.787 NM_018658
NM_170741
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr7_+_115650240 1.780 NM_152829
TES
testis derived transcript (3 LIM domains)
chr12_-_16652202 1.777 NM_001001395
LMO3
LIM domain only 3 (rhombotin-like 2)
chr1_+_62835759 1.766 NM_014495
ANGPTL3
angiopoietin-like 3
chr14_+_95915774 1.763 NM_016472
C14orf129
chromosome 14 open reading frame 129
chr4_+_159662349 1.761 NM_021634
RXFP1
relaxin/insulin-like family peptide receptor 1
chr2_-_206790871 1.761 NM_001098199
NM_005279
GPR1

G protein-coupled receptor 1

chr21_-_18697829 1.739 NM_002772
TMPRSS15
transmembrane protease, serine 15
chr1_-_214663360 1.735 NM_007123
NM_206933
USH2A

Usher syndrome 2A (autosomal recessive, mild)

chr2_-_175170674 1.734 WIPF1
WAS/WASL interacting protein family, member 1
chr6_-_76022565 1.717 TMEM30A
transmembrane protein 30A
chr12_-_15706340 1.707 EPS8
epidermal growth factor receptor pathway substrate 8
chr12_+_15590552 1.696 NM_030668
NM_030669
NM_030670
NM_030671
PTPRO



protein tyrosine phosphatase, receptor type, O



chr3_-_158704056 1.692 NM_001167915
NM_001167916
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chr9_-_124949033 1.683 STRBP
spermatid perinuclear RNA binding protein
chr12_-_103846186 1.682 NM_032148
SLC41A2
solute carrier family 41, member 2
chr13_-_46368968 1.675 NM_000621
NM_001165947
HTR2A

5-hydroxytryptamine (serotonin) receptor 2A

chr15_+_91244563 1.673 CHD2
chromodomain helicase DNA binding protein 2
chr4_-_38710376 1.666 NM_024943
TMEM156
transmembrane protein 156
chr6_-_117853710 1.658 NM_002944
ROS1
c-ros oncogene 1 , receptor tyrosine kinase
chr6_-_76027286 1.656 TMEM30A
transmembrane protein 30A
chr1_+_84402962 1.640 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr5_+_127012611 1.637 NM_001048252
CTXN3
cortexin 3
chr8_+_9990471 1.620 NM_001135671
MSRA
methionine sulfoxide reductase A
chr7_-_7724762 1.615 NM_002947
RPA3
replication protein A3, 14kDa
chr9_+_124072947 1.612 NM_199177
MRRF
mitochondrial ribosome recycling factor
chr2_-_225086564 1.611 CUL3
cullin 3
chr6_-_130072971 1.607 NM_033515
ARHGAP18
Rho GTPase activating protein 18
chr3_+_153468518 1.594 NM_021038
NM_207292
MBNL1

muscleblind-like (Drosophila)

chr1_-_171441234 1.590 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr2_-_210726539 1.570 C2orf67
chromosome 2 open reading frame 67
chr6_-_139654807 1.559 NM_153235
TXLNB
taxilin beta
chr2_-_98646367 1.557 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr2_+_204509698 1.550 NM_012092
ICOS
inducible T-cell co-stimulator
chr6_-_138581319 1.548 NM_021635
PBOV1
prostate and breast cancer overexpressed 1
chr7_-_91632525 1.533 NM_001161528
LOC401387
leucine-rich repeat and death domain-containing protein
chr3_-_69212192 1.533 NM_003968
NM_198195
UBA3

ubiquitin-like modifier activating enzyme 3

chr7_+_17349425 1.530 AHR
aryl hydrocarbon receptor
chr4_+_169250281 1.528 NM_007193
ANXA10
annexin A10
chr1_+_196874759 1.519 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr3_+_174598937 1.512 NM_014932
NLGN1
neuroligin 1
chr5_-_59819642 1.504 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr17_-_10265991 1.501 NM_002472
MYH8
myosin, heavy chain 8, skeletal muscle, perinatal
chr7_-_26198673 1.500 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr4_-_176970895 1.500 GPM6A
glycoprotein M6A
chr21_-_14840506 1.491 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr6_+_12825818 1.487 NM_030948
PHACTR1
phosphatase and actin regulator 1
chr8_-_82557956 1.486 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr1_+_196874839 1.485 PTPRC
protein tyrosine phosphatase, receptor type, C
chr5_-_39400319 1.478 NM_001737
C9
complement component 9
chr12_-_16321885 1.469 NM_001170798
SLC15A5
solute carrier family 15, member 5
chr2_+_187162969 1.463 NM_001145000
NM_002210
ITGAV

integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)

chr18_+_6824431 1.449 NM_001010000
ARHGAP28
Rho GTPase activating protein 28
chr6_+_12825022 1.439 PHACTR1
phosphatase and actin regulator 1
chr1_+_149299504 1.433 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr14_+_69307914 1.431 SRSF5
serine/arginine-rich splicing factor 5
chr2_-_20375497 1.424 PUM2
pumilio homolog 2 (Drosophila)
chrX_-_76824726 1.420 ATRX
alpha thalassemia/mental retardation syndrome X-linked
chr10_-_96819064 1.411 NM_000770
NM_001198853
NM_001198854
NM_001198855
CYP2C8



cytochrome P450, family 2, subfamily C, polypeptide 8



chr1_+_165564904 1.405 NM_001198783
POU2F1
POU class 2 homeobox 1
chr7_+_113842284 1.399 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chr9_-_3213007 1.396


chr1_+_149299490 1.389 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr3_-_115960807 1.389 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr7_-_28186867 1.388 NM_175061
JAZF1
JAZF zinc finger 1
chr8_-_42742729 1.381 NM_004198
CHRNA6
cholinergic receptor, nicotinic, alpha 6
chr5_-_94442941 1.379 MCTP1
multiple C2 domains, transmembrane 1
chrX_+_70682204 1.379 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr10_-_69422391 1.377 HERC4
hect domain and RLD 4
chr7_+_90176647 1.373 NM_012395
CDK14
cyclin-dependent kinase 14
chr10_+_44726635 1.371 NM_001123376
TMEM72
transmembrane protein 72
chr3_+_149930656 1.371 NM_032049
AGTR1
angiotensin II receptor, type 1
chr21_-_38955487 1.365 NM_001136154
NM_004449
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chrX_+_100111352 1.352 NM_001012990
NM_001162490
NM_001162491
ARL13A


ADP-ribosylation factor-like 13A


chr1_+_149299307 1.351 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr12_+_49155798 1.349 LARP4
La ribonucleoprotein domain family, member 4
chr15_+_22832198 1.345 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr12_-_88573949 1.342 NM_001001323
NM_001682
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chr6_-_114490701 1.337 NM_153612
HS3ST5
heparan sulfate (glucosamine) 3-O-sulfotransferase 5
chr1_+_149299530 1.333 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chrX_-_80344096 1.330 NM_030763
HMGN5
high-mobility group nucleosome binding domain 5
chr12_-_10464308 1.328 NM_002261
NM_007333
KLRC3

killer cell lectin-like receptor subfamily C, member 3

chr6_+_88026338 1.326 ZNF292
zinc finger protein 292
chr10_-_98326435 1.324 TM9SF3
transmembrane 9 superfamily member 3
chr12_+_49922592 1.308 DAZAP2
DAZ associated protein 2
chr8_+_107807415 1.306 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr3_+_99350859 1.306 NM_001005514
OR5H14
olfactory receptor, family 5, subfamily H, member 14
chr7_-_135263737 1.295 MTPN
LUZP6
myotrophin
leucine zipper protein 6
chr21_+_29322100 1.294 USP16
ubiquitin specific peptidase 16
chr3_+_150028130 1.284 NM_001871
CPB1
carboxypeptidase B1 (tissue)
chr3_-_71860958 1.273 NM_001134650
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr4_-_139382672 1.263 NM_014331
SLC7A11
solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
chr2_-_162808123 1.263 NM_004460
FAP
fibroblast activation protein, alpha
chr10_+_126620681 1.262 NM_017580
ZRANB1
zinc finger, RAN-binding domain containing 1
chr8_-_99906944 1.262 NM_006281
STK3
serine/threonine kinase 3
chr10_-_25344871 1.258 NM_145010
ENKUR
enkurin, TRPC channel interacting protein
chr5_+_139856688 1.253 ANKHD1
ankyrin repeat and KH domain containing 1
chr3_-_56673113 1.252 NM_015224
C3orf63
chromosome 3 open reading frame 63
chr12_+_103677388 1.252 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr10_+_90414125 1.249 NM_001198828
NM_001198829
NM_001198830
NM_004190
LIPF



lipase, gastric



chr2_+_28892366 1.249 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr12_-_9651748 1.249 NM_002258
KLRB1
killer cell lectin-like receptor subfamily B, member 1
chr18_+_17607633 1.248 MIB1
mindbomb homolog 1 (Drosophila)
chrX_+_99726445 1.245 NM_022144
TNMD
tenomodulin
chr12_-_15757114 1.237 EPS8
epidermal growth factor receptor pathway substrate 8
chr2_-_160764819 1.237 NM_000888
ITGB6
integrin, beta 6
chr17_+_51585834 1.236 NM_153228
ANKFN1
ankyrin-repeat and fibronectin type III domain containing 1
chr2_+_86998248 1.235 NM_001024457
RGPD1
RANBP2-like and GRIP domain containing 1
chr12_-_54150188 1.225 NM_001005499
OR6C70
olfactory receptor, family 6, subfamily C, member 70
chr6_+_64289585 1.220 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr10_-_92671005 1.215 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr21_+_29439768 1.213 C21orf7
chromosome 21 open reading frame 7
chr2_-_20390601 1.210 NM_015317
PUM2
pumilio homolog 2 (Drosophila)
chr1_+_190552744 1.207 NM_001039152
RGS21
regulator of G-protein signaling 21
chr4_+_91035025 1.206 NM_007351
MMRN1
multimerin 1
chr5_+_65408500 1.204 ERBB2IP
erbb2 interacting protein
chr4_-_83566045 1.197


chr22_+_42726423 1.195 NM_001003828
PARVB
parvin, beta
chr1_-_198644111 1.194 ZNF281
zinc finger protein 281
chr2_-_88066423 1.192 NM_001024457
RGPD1
RANBP2-like and GRIP domain containing 1
chr2_+_169465995 1.190 NM_001081686
NM_021176
G6PC2

glucose-6-phosphatase, catalytic, 2

chr9_-_74757735 1.185 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr9_-_74735669 1.183 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr4_-_20914626 1.177 NM_147183
KCNIP4
Kv channel interacting protein 4
chr5_+_147562531 1.174 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr1_-_242073094 1.172 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chr8_-_108579270 1.171 NM_001146
ANGPT1
angiopoietin 1
chr5_+_102493155 1.161 NM_015216
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr10_+_32896656 1.161 NM_024688
C10orf68
chromosome 10 open reading frame 68
chr6_-_86407875 1.151 NM_001159675
NM_001159676
SYNCRIP

synaptotagmin binding, cytoplasmic RNA interacting protein

chr1_+_195010552 1.149 NM_001166624
NM_021023
CFHR3

complement factor H-related 3

chr19_-_49076080 1.142 NM_001033719
ZNF404
zinc finger protein 404
chr13_-_102209422 1.139 NM_001146197
C13orf40
chromosome 13 open reading frame 40
chrX_-_74292800 1.137 NM_004299
ABCB7
ATP-binding cassette, sub-family B (MDR/TAP), member 7
chr10_-_64698831 1.135 NM_004241
JMJD1C
jumonji domain containing 1C
chr5_-_160044844 1.125 ATP10B
ATPase, class V, type 10B
chr2_+_183316574 1.120 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr1_-_23758871 1.109 NM_002167
ID3
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr12_+_8167494 1.107 NM_016184
NM_194447
NM_194448
NM_194450
CLEC4A



C-type lectin domain family 4, member A




Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.