Motif ID: REST.p3

Z-value: 0.337


Transcription factors associated with REST.p3:

Gene SymbolEntrez IDGene Name
REST 5978 RE1-silencing transcription factor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RESTchr4_+_57469884-0.439.5e-02Click!


Activity profile for motif REST.p3.

activity profile for motif REST.p3


Sorted Z-values histogram for motif REST.p3

Sorted Z-values for motif REST.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of REST.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_+_30019465 6.366 NM_001011718
XKR7
XK, Kell blood group complex subunit-related family, member 7
chr3_+_9720509 5.457 NM_153635
CPNE9
copine family member IX
chr8_-_145530639 3.918 NM_031309
SCRT1
scratch homolog 1, zinc finger protein (Drosophila)
chr12_+_46133 3.840 NM_001170738
IQSEC3
IQ motif and Sec7 domain 3
chr19_-_60383280 3.535 NM_003180
SYT5
synaptotagmin V
chr9_+_134447795 3.389 NM_020064
BARHL1
BarH-like homeobox 1
chr1_-_173979292 3.114 NM_003285
TNR
tenascin R (restrictin, janusin)
chr20_-_60228665 3.111 NM_007232
HRH3
histamine receptor H3
chr10_+_99599984 2.982 NM_001010917
GOLGA7B
golgin A7 family, member B
chrX_-_48943582 2.922 NM_003179
SYP
synaptophysin
chr9_+_139153409 2.539 NM_000832
NM_001185090
NM_001185091
NM_007327
NM_021569
GRIN1




glutamate receptor, ionotropic, N-methyl D-aspartate 1




chr10_+_26545241 2.459 NM_000818
NM_001134366
GAD2

glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)

chr15_+_65904994 2.443 NM_001031807
SKOR1
SKI family transcriptional corepressor 1
chr1_+_33124658 2.385 NM_002143
HPCA
hippocalcin
chr17_+_39741306 2.338 NM_001144825
NM_001144826
NM_006695
RUNDC3A


RUN domain containing 3A


chrX_-_47364173 2.329 NM_006950
NM_133499
SYN1

synapsin I

chr3_-_133236447 2.196 NM_130808
CPNE4
copine IV
chr12_+_117903682 2.146 NM_194286
SRRM4
serine/arginine repetitive matrix 4
chr18_-_5187240 2.143 NM_001145194
LOC642597
hypothetical protein LOC642597
chr12_+_111713931 2.135 NM_001143854
NM_014954
RPH3A

rabphilin 3A homolog (mouse)

chr12_-_3472245 2.063 LOC100129223
hypothetical LOC100129223
chr1_-_239587090 2.026 NM_002924
RGS7
regulator of G-protein signaling 7
chr7_-_100595552 1.960 NM_003378
VGF
VGF nerve growth factor inducible
chr5_-_135729062 1.939 NM_001167576
NM_001167577
NM_020389
TRPC7


transient receptor potential cation channel, subfamily C, member 7


chr10_+_26545599 1.897 GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr1_-_207892420 1.897 NM_000228
LAMB3
laminin, beta 3
chr10_-_50640327 1.892 NM_001143996
NM_001143997
NM_018245
OGDHL


oxoglutarate dehydrogenase-like


chr1_+_152806924 1.886 CHRNB2
cholinergic receptor, nicotinic, beta 2 (neuronal)
chr15_-_81175542 1.873 NM_004644
AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr20_+_5839973 1.806 NM_001819
CHGB
chromogranin B (secretogranin 1)
chr8_+_57520915 1.786


chr17_-_3283884 1.756 NM_003554
OR1E2
olfactory receptor, family 1, subfamily E, member 2
chr5_+_33972247 1.742 NM_016568
RXFP3
relaxin/insulin-like family peptide receptor 3
chr6_+_154402135 1.695 NM_000914
NM_001008503
NM_001008504
NM_001008505
NM_001145282
NM_001145283
NM_001145285
NM_001145286
NM_001145284
OPRM1








opioid receptor, mu 1








chr8_-_145723209 1.623 NM_001024678
LRRC24
leucine rich repeat containing 24
chr14_+_92459197 1.604 NM_001275
CHGA
chromogranin A (parathyroid secretory protein 1)
chr14_-_50631794 1.591 TRIM9
tripartite motif containing 9
chr4_+_158361185 1.539 NM_000826
NM_001083619
NM_001083620
GRIA2


glutamate receptor, ionotropic, AMPA 2


chr14_-_50631407 1.506 TRIM9
tripartite motif containing 9
chr14_-_73962557 1.441 NM_001105579
TMEM90A
transmembrane protein 90A
chr7_+_154943466 1.430 NM_001427
EN2
engrailed homeobox 2
chrX_-_47364039 1.381


chr1_+_208178198 1.367 SYT14
synaptotagmin XIV
chr19_+_45728270 1.349 SPTBN4
spectrin, beta, non-erythrocytic 4
chr19_+_38867273 1.322 NM_022467
CHST8
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr14_+_92459244 1.313 CHGA
chromogranin A (parathyroid secretory protein 1)
chr19_-_45416112 1.300 NM_152479
TTC9B
tetratricopeptide repeat domain 9B
chr11_-_74818858 1.296 KLHL35
kelch-like 35 (Drosophila)
chr4_+_8633116 1.274 NM_080819
GPR78
G protein-coupled receptor 78
chr12_+_111714096 1.266 RPH3A
rabphilin 3A homolog (mouse)
chr15_-_29950188 1.258 OTUD7A
OTU domain containing 7A
chr6_+_153113624 1.248 NM_003381
NM_194435
VIP

vasoactive intestinal peptide

chr10_-_102780840 1.225 PDZD7
PDZ domain containing 7
chr11_+_22316242 1.196 NM_020346
SLC17A6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr1_+_208178160 1.186 NM_001146261
NM_001146262
NM_001146264
NM_153262
SYT14



synaptotagmin XIV



chr4_-_175986952 1.164 NM_001042543
NM_006529
GLRA3

glycine receptor, alpha 3

chr19_-_45416043 1.137 TTC9B
tetratricopeptide repeat domain 9B
chr1_-_102235377 1.127 NM_058170
OLFM3
olfactomedin 3
chr11_-_74818685 1.074 KLHL35
kelch-like 35 (Drosophila)
chr2_+_114916368 1.038 NM_020868
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr16_+_4948318 0.999 NM_014692
SEC14L5
SEC14-like 5 (S. cerevisiae)
chr6_+_110406890 0.991 NM_005284
GPR6
G protein-coupled receptor 6
chr16_+_24174975 0.933 CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr5_-_151284515 0.915 NM_000171
NM_001146040
GLRA1

glycine receptor, alpha 1

chr17_+_70178911 0.908 RAB37
RAB37, member RAS oncogene family
chr19_-_3922089 0.907 DAPK3
death-associated protein kinase 3
chr15_-_29950070 0.894 OTUD7A
OTU domain containing 7A
chr11_+_627268 0.864 NM_000797
DRD4
dopamine receptor D4
chr19_-_3922032 0.850 DAPK3
death-associated protein kinase 3
chr17_-_3248453 0.839 NM_003553
OR1E1
olfactory receptor, family 1, subfamily E, member 1
chr11_-_74819165 0.828 NM_001039548
KLHL35
kelch-like 35 (Drosophila)
chr20_+_61798446 0.801 NM_003823
TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr1_-_239587007 0.800 RGS7
regulator of G-protein signaling 7
chr11_-_123030091 0.780 SCN3B
sodium channel, voltage-gated, type III, beta
chr17_-_24357014 0.779 NM_001098635
NM_178860
SEZ6

seizure related 6 homolog (mouse)

chr16_+_24175173 0.765 CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr2_-_27384617 0.760 NM_003353
UCN
urocortin
chr20_-_10148137 0.735 LOC100131208
similar to hCG2045825
chr3_+_62279707 0.734 C3orf14
chromosome 3 open reading frame 14
chr8_-_57521065 0.727 NM_006211
PENK
proenkephalin
chr1_+_152806874 0.727 NM_000748
CHRNB2
cholinergic receptor, nicotinic, beta 2 (neuronal)
chr7_+_8439762 0.707 NXPH1
neurexophilin 1
chr3_+_62280435 0.686 NM_020685
C3orf14
chromosome 3 open reading frame 14
chr14_-_104142125 0.681 NM_207379
TMEM179
transmembrane protein 179
chr17_+_70178850 0.677 NM_175738
RAB37
RAB37, member RAS oncogene family
chr17_+_27838041 0.673 NM_003885
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr7_+_8440109 0.666 NM_152745
NXPH1
neurexophilin 1
chr20_+_61798512 0.598 TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr15_-_70399551 0.592 NM_052840
CELF6
CUGBP, Elav-like family member 6
chr1_-_23393808 0.590 NM_000864
HTR1D
5-hydroxytryptamine (serotonin) receptor 1D
chr5_-_175969697 0.585 NM_052899
GPRIN1
G protein regulated inducer of neurite outgrowth 1
chr17_-_7159094 0.584 NM_004489
GPS2
G protein pathway suppressor 2
chr16_+_2959362 0.566 PAQR4
progestin and adipoQ receptor family member IV
chr5_+_175231098 0.553 NM_001008220
CPLX2
complexin 2
chr18_-_39111243 0.539 NM_020783
SYT4
synaptotagmin IV
chr10_-_102780867 0.534 NM_001195263
NM_024895
PDZD7

PDZ domain containing 7

chr16_+_2959342 0.523 NM_152341
PAQR4
progestin and adipoQ receptor family member IV
chr11_+_62136788 0.508 NM_000327
ROM1
retinal outer segment membrane protein 1
chr7_+_145444385 0.498 NM_014141
CNTNAP2
contactin associated protein-like 2
chr10_+_73225533 0.456 NM_001171933
NM_001171934
CDH23

cadherin-related 23

chr16_+_2450081 0.451 NM_025108
C16orf59
chromosome 16 open reading frame 59
chr15_+_67009892 0.424 NM_145658
NM_001184780
SPESP1
NOX5
sperm equatorial segment protein 1
NADPH oxidase, EF-hand calcium binding domain 5
chr11_+_45863774 0.398 NM_005456
MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr20_+_44091219 0.397 NM_020708
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr11_-_6633427 0.397 NM_003737
DCHS1
dachsous 1 (Drosophila)
chr15_-_70399523 0.390 CELF6
CUGBP, Elav-like family member 6
chr12_+_50981915 0.388 NM_002284
KRT86
keratin 86
chr3_-_188870799 0.378 NM_001048
SST
somatostatin
chr9_-_73251639 0.360 TRPM3
transient receptor potential cation channel, subfamily M, member 3
chr17_+_1120607 0.322 NM_001164405
BHLHA9
basic helix-loop-helix family, member a9
chr2_+_207215386 0.322 NM_001102659
LOC200726
hCG1657980
chr19_-_11500912 0.317 NM_001142464
NM_001142465
NM_016581
ECSIT


ECSIT homolog (Drosophila)


chr2_-_51113040 0.307 NM_001135659
NM_004801
NRXN1

neurexin 1

chr19_-_50618921 0.305 ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr2_-_51112743 0.293 NRXN1
neurexin 1
chr19_-_50429306 0.285 NM_138568
EXOC3L2
exocyst complex component 3-like 2
chr2_+_131230252 0.281 NM_001105194
NM_001105195
FAM123C

family with sequence similarity 123C

chr19_-_50618982 0.279 ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr10_+_89409332 0.278 NM_001015880
NM_004670
PAPSS2

3'-phosphoadenosine 5'-phosphosulfate synthase 2

chr19_+_45728207 0.270 NM_025213
SPTBN4
spectrin, beta, non-erythrocytic 4
chr8_+_69027143 0.251 NM_024870
NM_025170
PREX2

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2

chr16_-_2125825 0.238 NM_000296
NM_001009944
PKD1

polycystic kidney disease 1 (autosomal dominant)

chr3_-_48675321 0.237 NM_001407
CELSR3
cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
chr7_+_8440541 0.223 NXPH1
neurexophilin 1
chr19_+_9064854 0.221 NM_001004456
OR1M1
olfactory receptor, family 1, subfamily M, member 1
chr1_+_1836125 0.221 NM_138705
CALML6
calmodulin-like 6
chr9_-_138236775 0.221 NM_178138
LHX3
LIM homeobox 3
chr11_-_1725924 0.203 NM_001170820
LOC402778
CD225 family protein FLJ76511
chr5_+_175231210 0.190 CPLX2
complexin 2
chr15_-_70399301 0.186 NM_001172684
CELF6
CUGBP, Elav-like family member 6
chr1_-_151390050 0.184 NM_001014291
SPRR2G
small proline-rich protein 2G
chr8_+_69026895 0.172 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr15_+_73074882 0.160 NM_001178111
NM_001178112
NM_138967
SCAMP5


secretory carrier membrane protein 5


chr17_+_77925441 0.157 NM_018949
UTS2R
urotensin 2 receptor
chr9_-_103397023 0.150 NM_147180
PPP3R2
protein phosphatase 3, regulatory subunit B, beta
chr8_+_69027277 0.144 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr9_-_130078017 0.140 NM_004486
GOLGA2
golgin A2
chr11_-_122357545 0.137 NM_001098169
BSX
brain-specific homeobox
chr19_-_44427446 0.135 NM_172139
IL28B
interleukin 28B (interferon, lambda 3)
chr10_-_44200458 0.135 NM_000609
NM_001033886
NM_001178134
NM_199168
CXCL12



chemokine (C-X-C motif) ligand 12



chr12_+_112280757 0.128 PLBD2
phospholipase B domain containing 2
chr14_-_93829347 0.124 NM_001100607
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr20_+_44091265 0.121 SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr3_+_195336631 0.119 HES1
hairy and enhancer of split 1, (Drosophila)
chr6_-_32121784 0.117 NM_032470
TNXB
tenascin XB
chr17_-_37022465 0.108 NM_005557
KRT16
keratin 16
chr1_+_100777044 0.106 GPR88
G protein-coupled receptor 88
chr11_-_27677755 0.100 NM_170734
BDNF
brain-derived neurotrophic factor
chr15_-_70399181 0.091 CELF6
CUGBP, Elav-like family member 6
chr2_-_96174865 0.074 NM_004418
DUSP2
dual specificity phosphatase 2
chr19_+_15058790 0.066 NM_001004713
OR1I1
olfactory receptor, family 1, subfamily I, member 1
chr5_+_175231170 0.064


chr5_+_141283550 0.060 NM_001142603
NM_014773
KIAA0141

KIAA0141

chr21_-_34749908 0.057 NM_001127670
KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chr7_-_19778928 0.051 NM_152774
TMEM196
transmembrane protein 196
chr2_-_96174502 0.050 DUSP2
dual specificity phosphatase 2
chr8_+_80685859 0.050 STMN2
stathmin-like 2
chr11_+_64565118 0.038 SAC3D1
SAC3 domain containing 1
chr22_+_18388656 0.034 C22orf25
chromosome 22 open reading frame 25
chr1_+_210672817 0.030 NM_013349
NENF
neuron derived neurotrophic factor
chr6_+_43257883 0.029 NM_015089
CUL9
cullin 9
chr20_+_56861430 0.024 NM_001077490
NM_080425
GNAS

GNAS complex locus

chr5_+_175231144 0.016 CPLX2
complexin 2
chr3_+_52787478 0.014 NM_001166434
ITIH1
inter-alpha (globulin) inhibitor H1
chr17_-_3546236 0.001 NM_002561
NM_175080
NM_175081
P2RX5-TAX1BP3
P2RX5


P2RX5-TAX1BP3 read-through transcript
purinergic receptor P2X, ligand-gated ion channel, 5


chr14_+_20226762 0.001 NM_001097577
NM_194431
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
6.58 1.21e-08 GO:0019226 transmission of nerve impulse
6.58 1.21e-08 GO:0035637 multicellular organismal signaling
7.02 1.34e-08 GO:0007268 synaptic transmission
3.80 1.41e-08 GO:0050877 neurological system process
3.33 5.00e-08 GO:0003008 system process
1.93 2.53e-06 GO:0032501 multicellular organismal process
5.28 4.40e-06 GO:0007186 G-protein coupled receptor protein signaling pathway
4.28 2.09e-05 GO:0007267 cell-cell signaling
3.54 1.10e-04 GO:0007154 cell communication
2.02 3.12e-04 GO:0023052 signaling
4.84 1.65e-03 GO:0006873 cellular ion homeostasis
4.67 2.42e-03 GO:0055082 cellular chemical homeostasis
5.58 2.64e-03 GO:0007610 behavior
4.47 3.96e-03 GO:0050801 ion homeostasis
4.38 1.11e-02 GO:0046903 secretion
24.47 1.12e-02 GO:0060078 regulation of postsynaptic membrane potential
3.68 1.51e-02 GO:0048878 chemical homeostasis
10.13 1.61e-02 GO:0001505 regulation of neurotransmitter levels
3.86 1.88e-02 GO:0019725 cellular homeostasis
6.32 2.31e-02 GO:0055074 calcium ion homeostasis
7.51 2.40e-02 GO:0031644 regulation of neurological system process
6.09 3.00e-02 GO:0072507 divalent inorganic cation homeostasis
11.84 3.65e-02 GO:0007269 neurotransmitter secretion
8.73 3.75e-02 GO:0006836 neurotransmitter transport
8.32 4.91e-02 GO:0003001 generation of a signal involved in cell-cell signaling
8.32 4.91e-02 GO:0023061 signal release

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
17.07 4.02e-08 GO:0008021 synaptic vesicle
26.10 7.70e-08 GO:0030672 synaptic vesicle membrane
6.51 1.13e-07 GO:0043005 neuron projection
15.55 7.46e-07 GO:0030665 clathrin coated vesicle membrane
6.08 9.76e-07 GO:0045202 synapse
7.17 1.14e-06 GO:0044456 synapse part
10.10 1.45e-06 GO:0030136 clathrin-coated vesicle
11.49 1.08e-05 GO:0030662 coated vesicle membrane
8.25 1.18e-05 GO:0030135 coated vesicle
6.81 2.43e-05 GO:0030659 cytoplasmic vesicle membrane
8.59 3.16e-05 GO:0043025 neuronal cell body
6.58 3.51e-05 GO:0012506 vesicle membrane
8.35 4.13e-05 GO:0044297 cell body
3.86 1.04e-04 GO:0016023 cytoplasmic membrane-bounded vesicle
3.79 1.36e-04 GO:0031988 membrane-bounded vesicle
5.65 1.76e-04 GO:0044433 cytoplasmic vesicle part
3.63 2.48e-04 GO:0031410 cytoplasmic vesicle
3.41 3.24e-04 GO:0042995 cell projection
3.52 3.91e-04 GO:0031982 vesicle
3.88 8.84e-04 GO:0030054 cell junction
6.22 5.52e-03 GO:0030425 dendrite
25.91 2.39e-02 GO:0032589 neuron projection membrane
2.02 2.41e-02 GO:0044459 plasma membrane part
73.39 3.35e-02 GO:0032590 dendrite membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
18.74 1.08e-04 GO:0005231 excitatory extracellular ligand-gated ion channel activity
12.24 1.37e-03 GO:0005230 extracellular ligand-gated ion channel activity
27.96 1.62e-03 GO:0005184 neuropeptide hormone activity
4.25 8.42e-03 GO:0005216 ion channel activity
8.90 8.50e-03 GO:0005179 hormone activity
4.18 9.68e-03 GO:0022838 substrate-specific channel activity
2.59 1.15e-02 GO:0005215 transporter activity
33.88 1.22e-02 GO:0016594 glycine binding
4.05 1.27e-02 GO:0015267 channel activity
4.04 1.30e-02 GO:0022803 passive transmembrane transporter activity
7.17 2.82e-02 GO:0043176 amine binding
7.05 3.08e-02 GO:0015276 ligand-gated ion channel activity
7.05 3.08e-02 GO:0022834 ligand-gated channel activity
4.40 3.14e-02 GO:0022836 gated channel activity
73.39 3.98e-02 GO:0016933 extracellular-glycine-gated ion channel activity
73.39 3.98e-02 GO:0016934 extracellular-glycine-gated chloride channel activity
3.05 4.92e-02 GO:0005509 calcium ion binding