Motif ID: REST.p3

Z-value: 0.337


Transcription factors associated with REST.p3:

Gene SymbolEntrez IDGene Name
REST 5978 RE1-silencing transcription factor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RESTchr4_+_57469884-0.439.5e-02Click!


Activity profile for motif REST.p3.

activity profile for motif REST.p3


Sorted Z-values histogram for motif REST.p3

Sorted Z-values for motif REST.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of REST.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 166 entries
PromoterScoreRefseqGene SymbolGene Name
chr20_+_30019465 6.366 NM_001011718
 XKR7
XK, Kell blood group complex subunit-related family, member 7
chr3_+_9720509 5.457 NM_153635
 CPNE9
copine family member IX
chr8_-_145530639 3.918 NM_031309
 SCRT1
scratch homolog 1, zinc finger protein (Drosophila)
chr12_+_46133 3.840 NM_001170738
 IQSEC3
IQ motif and Sec7 domain 3
chr19_-_60383280 3.535 NM_003180
 SYT5
synaptotagmin V
chr9_+_134447795 3.389 NM_020064
 BARHL1
BarH-like homeobox 1
chr1_-_173979292 3.114 NM_003285
 TNR
tenascin R (restrictin, janusin)
chr20_-_60228665 3.111 NM_007232
 HRH3
histamine receptor H3
chr10_+_99599984 2.982 NM_001010917
 GOLGA7B
golgin A7 family, member B
chrX_-_48943582 2.922 NM_003179
 SYP
synaptophysin
chr9_+_139153409 2.539 NM_000832
NM_001185090
NM_001185091
NM_007327
NM_021569
 GRIN1




glutamate receptor, ionotropic, N-methyl D-aspartate 1




chr10_+_26545241 2.459 NM_000818
NM_001134366
 GAD2

glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)

chr15_+_65904994 2.443 NM_001031807
 SKOR1
SKI family transcriptional corepressor 1
chr1_+_33124658 2.385 NM_002143
 HPCA
hippocalcin
chr17_+_39741306 2.338 NM_001144825
NM_001144826
NM_006695
 RUNDC3A


RUN domain containing 3A


chrX_-_47364173 2.329 NM_006950
NM_133499
 SYN1

synapsin I

chr3_-_133236447 2.196 NM_130808
 CPNE4
copine IV
chr12_+_117903682 2.146 NM_194286
 SRRM4
serine/arginine repetitive matrix 4
chr18_-_5187240 2.143 NM_001145194
 LOC642597
hypothetical protein LOC642597
chr12_+_111713931 2.135 NM_001143854
NM_014954
 RPH3A

rabphilin 3A homolog (mouse)


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 26 entries
enrichment   p-value GO term description
24.47 1.12e-02 GO:0060078 regulation of postsynaptic membrane potential
11.84 3.65e-02 GO:0007269 neurotransmitter secretion
10.13 1.61e-02 GO:0001505 regulation of neurotransmitter levels
8.73 3.75e-02 GO:0006836 neurotransmitter transport
8.32 4.91e-02 GO:0003001 generation of a signal involved in cell-cell signaling
8.32 4.91e-02 GO:0023061 signal release
7.51 2.40e-02 GO:0031644 regulation of neurological system process
7.02 1.34e-08 GO:0007268 synaptic transmission
6.58 1.21e-08 GO:0019226 transmission of nerve impulse
6.58 1.21e-08 GO:0035637 multicellular organismal signaling
6.32 2.31e-02 GO:0055074 calcium ion homeostasis
6.09 3.00e-02 GO:0072507 divalent inorganic cation homeostasis
5.58 2.64e-03 GO:0007610 behavior
5.28 4.40e-06 GO:0007186 G-protein coupled receptor protein signaling pathway
4.84 1.65e-03 GO:0006873 cellular ion homeostasis
4.67 2.42e-03 GO:0055082 cellular chemical homeostasis
4.47 3.96e-03 GO:0050801 ion homeostasis
4.38 1.11e-02 GO:0046903 secretion
4.28 2.09e-05 GO:0007267 cell-cell signaling
3.86 1.88e-02 GO:0019725 cellular homeostasis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 24 entries
enrichment   p-value GO term description
73.39 3.35e-02 GO:0032590 dendrite membrane
26.10 7.70e-08 GO:0030672 synaptic vesicle membrane
25.91 2.39e-02 GO:0032589 neuron projection membrane
17.07 4.02e-08 GO:0008021 synaptic vesicle
15.55 7.46e-07 GO:0030665 clathrin coated vesicle membrane
11.49 1.08e-05 GO:0030662 coated vesicle membrane
10.10 1.45e-06 GO:0030136 clathrin-coated vesicle
8.59 3.16e-05 GO:0043025 neuronal cell body
8.35 4.13e-05 GO:0044297 cell body
8.25 1.18e-05 GO:0030135 coated vesicle
7.17 1.14e-06 GO:0044456 synapse part
6.81 2.43e-05 GO:0030659 cytoplasmic vesicle membrane
6.58 3.51e-05 GO:0012506 vesicle membrane
6.51 1.13e-07 GO:0043005 neuron projection
6.22 5.52e-03 GO:0030425 dendrite
6.08 9.76e-07 GO:0045202 synapse
5.65 1.76e-04 GO:0044433 cytoplasmic vesicle part
3.88 8.84e-04 GO:0030054 cell junction
3.86 1.04e-04 GO:0016023 cytoplasmic membrane-bounded vesicle
3.79 1.36e-04 GO:0031988 membrane-bounded vesicle

Gene overrepresentation in function category:

Showing 1 to 17 of 17 entries
enrichment   p-value GO term description
73.39 3.98e-02 GO:0016933 extracellular-glycine-gated ion channel activity
73.39 3.98e-02 GO:0016934 extracellular-glycine-gated chloride channel activity
33.88 1.22e-02 GO:0016594 glycine binding
27.96 1.62e-03 GO:0005184 neuropeptide hormone activity
18.74 1.08e-04 GO:0005231 excitatory extracellular ligand-gated ion channel activity
12.24 1.37e-03 GO:0005230 extracellular ligand-gated ion channel activity
8.90 8.50e-03 GO:0005179 hormone activity
7.17 2.82e-02 GO:0043176 amine binding
7.05 3.08e-02 GO:0015276 ligand-gated ion channel activity
7.05 3.08e-02 GO:0022834 ligand-gated channel activity
4.40 3.14e-02 GO:0022836 gated channel activity
4.25 8.42e-03 GO:0005216 ion channel activity
4.18 9.68e-03 GO:0022838 substrate-specific channel activity
4.05 1.27e-02 GO:0015267 channel activity
4.04 1.30e-02 GO:0022803 passive transmembrane transporter activity
3.05 4.92e-02 GO:0005509 calcium ion binding
2.59 1.15e-02 GO:0005215 transporter activity