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• Activity deltas table
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Motif ID: REST.p3

Z-value: 0.337

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr20_+_30019465	6.366	NM_001011718	XKR7	XK, Kell blood group complex subunit-related family, member 7
chr3_+_9720509	5.457	NM_153635	CPNE9	copine family member IX
chr8_-_145530639	3.918	NM_031309	SCRT1	scratch homolog 1, zinc finger protein (Drosophila)
chr12_+_46133	3.840	NM_001170738	IQSEC3	IQ motif and Sec7 domain 3
chr19_-_60383280	3.535	NM_003180	SYT5	synaptotagmin V
chr9_+_134447795	3.389	NM_020064	BARHL1	BarH-like homeobox 1
chr1_-_173979292	3.114	NM_003285	TNR	tenascin R (restrictin, janusin)
chr20_-_60228665	3.111	NM_007232	HRH3	histamine receptor H3
chr10_+_99599984	2.982	NM_001010917	GOLGA7B	golgin A7 family, member B
chrX_-_48943582	2.922	NM_003179	SYP	synaptophysin
chr9_+_139153409	2.539	NM_000832 NM_001185090 NM_001185091 NM_007327 NM_021569	GRIN1	glutamate receptor, ionotropic, N-methyl D-aspartate 1
chr10_+_26545241	2.459	NM_000818 NM_001134366	GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr15_+_65904994	2.443	NM_001031807	SKOR1	SKI family transcriptional corepressor 1
chr1_+_33124658	2.385	NM_002143	HPCA	hippocalcin
chr17_+_39741306	2.338	NM_001144825 NM_001144826 NM_006695	RUNDC3A	RUN domain containing 3A
chrX_-_47364173	2.329	NM_006950 NM_133499	SYN1	synapsin I
chr3_-_133236447	2.196	NM_130808	CPNE4	copine IV
chr12_+_117903682	2.146	NM_194286	SRRM4	serine/arginine repetitive matrix 4
chr18_-_5187240	2.143	NM_001145194	LOC642597	hypothetical protein LOC642597
chr12_+_111713931	2.135	NM_001143854 NM_014954	RPH3A	rabphilin 3A homolog (mouse)
chr12_-_3472245	2.063		LOC100129223	hypothetical LOC100129223
chr1_-_239587090	2.026	NM_002924	RGS7	regulator of G-protein signaling 7
chr7_-_100595552	1.960	NM_003378	VGF	VGF nerve growth factor inducible
chr5_-_135729062	1.939	NM_001167576 NM_001167577 NM_020389	TRPC7	transient receptor potential cation channel, subfamily C, member 7
chr10_+_26545599	1.897		GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr1_-_207892420	1.897	NM_000228	LAMB3	laminin, beta 3
chr10_-_50640327	1.892	NM_001143996 NM_001143997 NM_018245	OGDHL	oxoglutarate dehydrogenase-like
chr1_+_152806924	1.886		CHRNB2	cholinergic receptor, nicotinic, beta 2 (neuronal)
chr15_-_81175542	1.873	NM_004644	AP3B2	adaptor-related protein complex 3, beta 2 subunit
chr20_+_5839973	1.806	NM_001819	CHGB	chromogranin B (secretogranin 1)
chr8_+_57520915	1.786
chr17_-_3283884	1.756	NM_003554	OR1E2	olfactory receptor, family 1, subfamily E, member 2
chr5_+_33972247	1.742	NM_016568	RXFP3	relaxin/insulin-like family peptide receptor 3
chr6_+_154402135	1.695	NM_000914 NM_001008503 NM_001008504 NM_001008505 NM_001145282 NM_001145283 NM_001145285 NM_001145286 NM_001145284	OPRM1	opioid receptor, mu 1
chr8_-_145723209	1.623	NM_001024678	LRRC24	leucine rich repeat containing 24
chr14_+_92459197	1.604	NM_001275	CHGA	chromogranin A (parathyroid secretory protein 1)
chr14_-_50631794	1.591		TRIM9	tripartite motif containing 9
chr4_+_158361185	1.539	NM_000826 NM_001083619 NM_001083620	GRIA2	glutamate receptor, ionotropic, AMPA 2
chr14_-_50631407	1.506		TRIM9	tripartite motif containing 9
chr14_-_73962557	1.441	NM_001105579	TMEM90A	transmembrane protein 90A
chr7_+_154943466	1.430	NM_001427	EN2	engrailed homeobox 2
chrX_-_47364039	1.381
chr1_+_208178198	1.367		SYT14	synaptotagmin XIV
chr19_+_45728270	1.349		SPTBN4	spectrin, beta, non-erythrocytic 4
chr19_+_38867273	1.322	NM_022467	CHST8	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr14_+_92459244	1.313		CHGA	chromogranin A (parathyroid secretory protein 1)
chr19_-_45416112	1.300	NM_152479	TTC9B	tetratricopeptide repeat domain 9B
chr11_-_74818858	1.296		KLHL35	kelch-like 35 (Drosophila)
chr4_+_8633116	1.274	NM_080819	GPR78	G protein-coupled receptor 78
chr12_+_111714096	1.266		RPH3A	rabphilin 3A homolog (mouse)
chr15_-_29950188	1.258		OTUD7A	OTU domain containing 7A
chr6_+_153113624	1.248	NM_003381 NM_194435	VIP	vasoactive intestinal peptide
chr10_-_102780840	1.225		PDZD7	PDZ domain containing 7
chr11_+_22316242	1.196	NM_020346	SLC17A6	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr1_+_208178160	1.186	NM_001146261 NM_001146262 NM_001146264 NM_153262	SYT14	synaptotagmin XIV
chr4_-_175986952	1.164	NM_001042543 NM_006529	GLRA3	glycine receptor, alpha 3
chr19_-_45416043	1.137		TTC9B	tetratricopeptide repeat domain 9B
chr1_-_102235377	1.127	NM_058170	OLFM3	olfactomedin 3
chr11_-_74818685	1.074		KLHL35	kelch-like 35 (Drosophila)
chr2_+_114916368	1.038	NM_020868	DPP10	dipeptidyl-peptidase 10 (non-functional)
chr16_+_4948318	0.999	NM_014692	SEC14L5	SEC14-like 5 (S. cerevisiae)
chr6_+_110406890	0.991	NM_005284	GPR6	G protein-coupled receptor 6
chr16_+_24174975	0.933		CACNG3	calcium channel, voltage-dependent, gamma subunit 3
chr5_-_151284515	0.915	NM_000171 NM_001146040	GLRA1	glycine receptor, alpha 1
chr17_+_70178911	0.908		RAB37	RAB37, member RAS oncogene family
chr19_-_3922089	0.907		DAPK3	death-associated protein kinase 3
chr15_-_29950070	0.894		OTUD7A	OTU domain containing 7A
chr11_+_627268	0.864	NM_000797	DRD4	dopamine receptor D4
chr19_-_3922032	0.850		DAPK3	death-associated protein kinase 3
chr17_-_3248453	0.839	NM_003553	OR1E1	olfactory receptor, family 1, subfamily E, member 1
chr11_-_74819165	0.828	NM_001039548	KLHL35	kelch-like 35 (Drosophila)
chr20_+_61798446	0.801	NM_003823	TNFRSF6B	tumor necrosis factor receptor superfamily, member 6b, decoy
chr1_-_239587007	0.800		RGS7	regulator of G-protein signaling 7
chr11_-_123030091	0.780		SCN3B	sodium channel, voltage-gated, type III, beta
chr17_-_24357014	0.779	NM_001098635 NM_178860	SEZ6	seizure related 6 homolog (mouse)
chr16_+_24175173	0.765		CACNG3	calcium channel, voltage-dependent, gamma subunit 3
chr2_-_27384617	0.760	NM_003353	UCN	urocortin
chr20_-_10148137	0.735		LOC100131208	similar to hCG2045825
chr3_+_62279707	0.734		C3orf14	chromosome 3 open reading frame 14
chr8_-_57521065	0.727	NM_006211	PENK	proenkephalin
chr1_+_152806874	0.727	NM_000748	CHRNB2	cholinergic receptor, nicotinic, beta 2 (neuronal)
chr7_+_8439762	0.707		NXPH1	neurexophilin 1
chr3_+_62280435	0.686	NM_020685	C3orf14	chromosome 3 open reading frame 14
chr14_-_104142125	0.681	NM_207379	TMEM179	transmembrane protein 179
chr17_+_70178850	0.677	NM_175738	RAB37	RAB37, member RAS oncogene family
chr17_+_27838041	0.673	NM_003885	CDK5R1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr7_+_8440109	0.666	NM_152745	NXPH1	neurexophilin 1
chr20_+_61798512	0.598		TNFRSF6B	tumor necrosis factor receptor superfamily, member 6b, decoy
chr15_-_70399551	0.592	NM_052840	CELF6	CUGBP, Elav-like family member 6
chr1_-_23393808	0.590	NM_000864	HTR1D	5-hydroxytryptamine (serotonin) receptor 1D
chr5_-_175969697	0.585	NM_052899	GPRIN1	G protein regulated inducer of neurite outgrowth 1
chr17_-_7159094	0.584	NM_004489	GPS2	G protein pathway suppressor 2
chr16_+_2959362	0.566		PAQR4	progestin and adipoQ receptor family member IV
chr5_+_175231098	0.553	NM_001008220	CPLX2	complexin 2
chr18_-_39111243	0.539	NM_020783	SYT4	synaptotagmin IV
chr10_-_102780867	0.534	NM_001195263 NM_024895	PDZD7	PDZ domain containing 7
chr16_+_2959342	0.523	NM_152341	PAQR4	progestin and adipoQ receptor family member IV
chr11_+_62136788	0.508	NM_000327	ROM1	retinal outer segment membrane protein 1
chr7_+_145444385	0.498	NM_014141	CNTNAP2	contactin associated protein-like 2
chr10_+_73225533	0.456	NM_001171933 NM_001171934	CDH23	cadherin-related 23
chr16_+_2450081	0.451	NM_025108	C16orf59	chromosome 16 open reading frame 59
chr15_+_67009892	0.424	NM_145658 NM_001184780	SPESP1 NOX5	sperm equatorial segment protein 1 NADPH oxidase, EF-hand calcium binding domain 5
chr11_+_45863774	0.398	NM_005456	MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1
chr20_+_44091219	0.397	NM_020708	SLC12A5	solute carrier family 12 (potassium/chloride transporter), member 5
chr11_-_6633427	0.397	NM_003737	DCHS1	dachsous 1 (Drosophila)
chr15_-_70399523	0.390		CELF6	CUGBP, Elav-like family member 6
chr12_+_50981915	0.388	NM_002284	KRT86	keratin 86
chr3_-_188870799	0.378	NM_001048	SST	somatostatin
chr9_-_73251639	0.360		TRPM3	transient receptor potential cation channel, subfamily M, member 3
chr17_+_1120607	0.322	NM_001164405	BHLHA9	basic helix-loop-helix family, member a9
chr2_+_207215386	0.322	NM_001102659	LOC200726	hCG1657980
chr19_-_11500912	0.317	NM_001142464 NM_001142465 NM_016581	ECSIT	ECSIT homolog (Drosophila)
chr2_-_51113040	0.307	NM_001135659 NM_004801	NRXN1	neurexin 1
chr19_-_50618921	0.305		ERCC1	excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr2_-_51112743	0.293		NRXN1	neurexin 1
chr19_-_50429306	0.285	NM_138568	EXOC3L2	exocyst complex component 3-like 2
chr2_+_131230252	0.281	NM_001105194 NM_001105195	FAM123C	family with sequence similarity 123C
chr19_-_50618982	0.279		ERCC1	excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr10_+_89409332	0.278	NM_001015880 NM_004670	PAPSS2	3'-phosphoadenosine 5'-phosphosulfate synthase 2
chr19_+_45728207	0.270	NM_025213	SPTBN4	spectrin, beta, non-erythrocytic 4
chr8_+_69027143	0.251	NM_024870 NM_025170	PREX2	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr16_-_2125825	0.238	NM_000296 NM_001009944	PKD1	polycystic kidney disease 1 (autosomal dominant)
chr3_-_48675321	0.237	NM_001407	CELSR3	cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
chr7_+_8440541	0.223		NXPH1	neurexophilin 1
chr19_+_9064854	0.221	NM_001004456	OR1M1	olfactory receptor, family 1, subfamily M, member 1
chr1_+_1836125	0.221	NM_138705	CALML6	calmodulin-like 6
chr9_-_138236775	0.221	NM_178138	LHX3	LIM homeobox 3
chr11_-_1725924	0.203	NM_001170820	LOC402778	CD225 family protein FLJ76511
chr5_+_175231210	0.190		CPLX2	complexin 2
chr15_-_70399301	0.186	NM_001172684	CELF6	CUGBP, Elav-like family member 6
chr1_-_151390050	0.184	NM_001014291	SPRR2G	small proline-rich protein 2G
chr8_+_69026895	0.172		PREX2	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr15_+_73074882	0.160	NM_001178111 NM_001178112 NM_138967	SCAMP5	secretory carrier membrane protein 5
chr17_+_77925441	0.157	NM_018949	UTS2R	urotensin 2 receptor
chr9_-_103397023	0.150	NM_147180	PPP3R2	protein phosphatase 3, regulatory subunit B, beta
chr8_+_69027277	0.144		PREX2	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr9_-_130078017	0.140	NM_004486	GOLGA2	golgin A2
chr11_-_122357545	0.137	NM_001098169	BSX	brain-specific homeobox
chr19_-_44427446	0.135	NM_172139	IL28B	interleukin 28B (interferon, lambda 3)
chr10_-_44200458	0.135	NM_000609 NM_001033886 NM_001178134 NM_199168	CXCL12	chemokine (C-X-C motif) ligand 12
chr12_+_112280757	0.128		PLBD2	phospholipase B domain containing 2
chr14_-_93829347	0.124	NM_001100607	SERPINA10	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr20_+_44091265	0.121		SLC12A5	solute carrier family 12 (potassium/chloride transporter), member 5
chr3_+_195336631	0.119		HES1	hairy and enhancer of split 1, (Drosophila)
chr6_-_32121784	0.117	NM_032470	TNXB	tenascin XB
chr17_-_37022465	0.108	NM_005557	KRT16	keratin 16
chr1_+_100777044	0.106		GPR88	G protein-coupled receptor 88
chr11_-_27677755	0.100	NM_170734	BDNF	brain-derived neurotrophic factor
chr15_-_70399181	0.091		CELF6	CUGBP, Elav-like family member 6
chr2_-_96174865	0.074	NM_004418	DUSP2	dual specificity phosphatase 2
chr19_+_15058790	0.066	NM_001004713	OR1I1	olfactory receptor, family 1, subfamily I, member 1
chr5_+_175231170	0.064
chr5_+_141283550	0.060	NM_001142603 NM_014773	KIAA0141	KIAA0141
chr21_-_34749908	0.057	NM_001127670	KCNE1	potassium voltage-gated channel, Isk-related family, member 1
chr7_-_19778928	0.051	NM_152774	TMEM196	transmembrane protein 196
chr2_-_96174502	0.050		DUSP2	dual specificity phosphatase 2
chr8_+_80685859	0.050		STMN2	stathmin-like 2
chr11_+_64565118	0.038		SAC3D1	SAC3 domain containing 1
chr22_+_18388656	0.034		C22orf25	chromosome 22 open reading frame 25
chr1_+_210672817	0.030	NM_013349	NENF	neuron derived neurotrophic factor
chr6_+_43257883	0.029	NM_015089	CUL9	cullin 9
chr20_+_56861430	0.024	NM_001077490 NM_080425	GNAS	GNAS complex locus
chr5_+_175231144	0.016		CPLX2	complexin 2
chr3_+_52787478	0.014	NM_001166434	ITIH1	inter-alpha (globulin) inhibitor H1
chr17_-_3546236	0.001	NM_002561 NM_175080 NM_175081	P2RX5-TAX1BP3 P2RX5	P2RX5-TAX1BP3 read-through transcript purinergic receptor P2X, ligand-gated ion channel, 5
chr14_+_20226762	0.001	NM_001097577 NM_194431	ANG RNASE4	angiogenin, ribonuclease, RNase A family, 5 ribonuclease, RNase A family, 4

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
6.58	1.21e-08	GO:0019226	transmission of nerve impulse
6.58	1.21e-08	GO:0035637	multicellular organismal signaling
7.02	1.34e-08	GO:0007268	synaptic transmission
3.80	1.41e-08	GO:0050877	neurological system process
3.33	5.00e-08	GO:0003008	system process
1.93	2.53e-06	GO:0032501	multicellular organismal process
5.28	4.40e-06	GO:0007186	G-protein coupled receptor protein signaling pathway
4.28	2.09e-05	GO:0007267	cell-cell signaling
3.54	1.10e-04	GO:0007154	cell communication
2.02	3.12e-04	GO:0023052	signaling
4.84	1.65e-03	GO:0006873	cellular ion homeostasis
4.67	2.42e-03	GO:0055082	cellular chemical homeostasis
5.58	2.64e-03	GO:0007610	behavior
4.47	3.96e-03	GO:0050801	ion homeostasis
4.38	1.11e-02	GO:0046903	secretion
24.47	1.12e-02	GO:0060078	regulation of postsynaptic membrane potential
3.68	1.51e-02	GO:0048878	chemical homeostasis
10.13	1.61e-02	GO:0001505	regulation of neurotransmitter levels
3.86	1.88e-02	GO:0019725	cellular homeostasis
6.32	2.31e-02	GO:0055074	calcium ion homeostasis
7.51	2.40e-02	GO:0031644	regulation of neurological system process
6.09	3.00e-02	GO:0072507	divalent inorganic cation homeostasis
11.84	3.65e-02	GO:0007269	neurotransmitter secretion
8.73	3.75e-02	GO:0006836	neurotransmitter transport
8.32	4.91e-02	GO:0003001	generation of a signal involved in cell-cell signaling
8.32	4.91e-02	GO:0023061	signal release

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
17.07	4.02e-08	GO:0008021	synaptic vesicle
26.10	7.70e-08	GO:0030672	synaptic vesicle membrane
6.51	1.13e-07	GO:0043005	neuron projection
15.55	7.46e-07	GO:0030665	clathrin coated vesicle membrane
6.08	9.76e-07	GO:0045202	synapse
7.17	1.14e-06	GO:0044456	synapse part
10.10	1.45e-06	GO:0030136	clathrin-coated vesicle
11.49	1.08e-05	GO:0030662	coated vesicle membrane
8.25	1.18e-05	GO:0030135	coated vesicle
6.81	2.43e-05	GO:0030659	cytoplasmic vesicle membrane
8.59	3.16e-05	GO:0043025	neuronal cell body
6.58	3.51e-05	GO:0012506	vesicle membrane
8.35	4.13e-05	GO:0044297	cell body
3.86	1.04e-04	GO:0016023	cytoplasmic membrane-bounded vesicle
3.79	1.36e-04	GO:0031988	membrane-bounded vesicle
5.65	1.76e-04	GO:0044433	cytoplasmic vesicle part
3.63	2.48e-04	GO:0031410	cytoplasmic vesicle
3.41	3.24e-04	GO:0042995	cell projection
3.52	3.91e-04	GO:0031982	vesicle
3.88	8.84e-04	GO:0030054	cell junction
6.22	5.52e-03	GO:0030425	dendrite
25.91	2.39e-02	GO:0032589	neuron projection membrane
2.02	2.41e-02	GO:0044459	plasma membrane part
73.39	3.35e-02	GO:0032590	dendrite membrane

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
18.74	1.08e-04	GO:0005231	excitatory extracellular ligand-gated ion channel activity
12.24	1.37e-03	GO:0005230	extracellular ligand-gated ion channel activity
27.96	1.62e-03	GO:0005184	neuropeptide hormone activity
4.25	8.42e-03	GO:0005216	ion channel activity
8.90	8.50e-03	GO:0005179	hormone activity
4.18	9.68e-03	GO:0022838	substrate-specific channel activity
2.59	1.15e-02	GO:0005215	transporter activity
33.88	1.22e-02	GO:0016594	glycine binding
4.05	1.27e-02	GO:0015267	channel activity
4.04	1.30e-02	GO:0022803	passive transmembrane transporter activity
7.17	2.82e-02	GO:0043176	amine binding
7.05	3.08e-02	GO:0015276	ligand-gated ion channel activity
7.05	3.08e-02	GO:0022834	ligand-gated channel activity
4.40	3.14e-02	GO:0022836	gated channel activity
73.39	3.98e-02	GO:0016933	extracellular-glycine-gated ion channel activity
73.39	3.98e-02	GO:0016934	extracellular-glycine-gated chloride channel activity
3.05	4.92e-02	GO:0005509	calcium ion binding