Motif ID: RREB1.p2

Z-value: 0.683


Transcription factors associated with RREB1.p2:

Gene SymbolEntrez IDGene Name
RREB1 6239 ras responsive element binding protein 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RREB1chr6_+_70531830.591.6e-02Click!


Activity profile for motif RREB1.p2.

activity profile for motif RREB1.p2


Sorted Z-values histogram for motif RREB1.p2

Sorted Z-values for motif RREB1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RREB1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_187917791 4.472 NM_000893
NM_001102416
NM_001166451
 KNG1


kininogen 1


chr11_-_133786935 4.109 NM_018644
NM_054025
 B3GAT1

beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)

chr4_+_191245840 4.106 NM_033178
NM_012147
NM_001177376
NM_001127388
NM_001127389
NM_001164467
NM_001127386
 DUX4
DUX2
DUX4L4
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr4_-_809879 3.687 NM_006651
 CPLX1
complexin 1
chr4_+_191232653 3.681 NM_033178
NM_012147
NM_001177376
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
 DUX4
DUX2
DUX4L4
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr4_+_191239247 2.710 NM_033178
NM_012147
NM_001177376
NM_001127388
NM_001127389
NM_001164467
NM_001127386
 DUX4
DUX2
DUX4L4
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr10_+_135343649 2.695 NM_012147
 DUX2
double homeobox 2
chr4_+_191226073 2.644 NM_012147
NM_001177376
NM_001127388
NM_001127389
NM_001164467
 DUX2
DUX4L4
DUX4L6
DUX4L5
DUX4L3
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
chr10_+_135330357 2.245 NM_033178
NM_012147
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
 DUX4
DUX2
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr10_+_135333667 2.166 NM_033178
NM_012147
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
 DUX4
DUX2
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr22_+_49459935 2.157 NM_001080420
 SHANK3
SH3 and multiple ankyrin repeat domains 3
chr7_+_100792841 2.155 NM_133457
 EMID2
EMI domain containing 2
chr4_+_191242540 2.120 NM_033178
NM_012147
NM_001177376
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
 DUX4
DUX2
DUX4L4
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr19_+_3317575 2.059 NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chr2_+_174907914 2.054 NM_001145250
 SP9
Sp9 transcription factor homolog (mouse)
chr21_+_42946719 1.962 NM_001001567
NM_001001568
NM_001001569
NM_001001570
NM_001001571
NM_001001572
NM_001001573
NM_001001574
NM_001001575
NM_001001576
NM_001001577
NM_001001578
NM_001001579
NM_001001580
NM_001001581
NM_001001582
NM_001001583
NM_001001584
NM_001001585
NM_002606
 PDE9A



















phosphodiesterase 9A



















chr20_-_22512893 1.953 FOXA2
forkhead box A2
chr7_+_100111689 1.949 GNB2
guanine nucleotide binding protein (G protein), beta polypeptide 2
chr17_-_44047299 1.934 NM_024016
 HOXB8
homeobox B8
chr4_+_191229360 1.917 NM_033178
NM_012147
NM_001177376
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
 DUX4
DUX2
DUX4L4
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 167 entries
enrichment   p-value GO term description
2.64 3.03e-02 GO:0046888 negative regulation of hormone secretion
2.55 1.34e-02 GO:0048663 neuron fate commitment
2.47 1.74e-05 GO:0021953 central nervous system neuron differentiation
2.44 9.88e-04 GO:0007269 neurotransmitter secretion
2.40 4.11e-04 GO:0050770 regulation of axonogenesis
2.34 9.89e-04 GO:0010721 negative regulation of cell development
2.27 3.35e-02 GO:0048634 regulation of muscle organ development
2.25 1.32e-02 GO:0042472 inner ear morphogenesis
2.24 1.06e-06 GO:0010769 regulation of cell morphogenesis involved in differentiation
2.22 1.56e-06 GO:0022604 regulation of cell morphogenesis
2.16 1.12e-04 GO:0003001 generation of a signal involved in cell-cell signaling
2.16 1.12e-04 GO:0023061 signal release
2.16 2.66e-02 GO:0048638 regulation of developmental growth
2.15 2.75e-07 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
2.15 1.04e-02 GO:0042471 ear morphogenesis
2.09 4.89e-03 GO:0048839 inner ear development
2.08 1.45e-08 GO:0045664 regulation of neuron differentiation
2.08 1.75e-03 GO:0006836 neurotransmitter transport
2.05 1.08e-07 GO:0032582 negative regulation of gene-specific transcription
2.03 1.47e-10 GO:0045596 negative regulation of cell differentiation

Gene overrepresentation in compartment category:

Showing 1 to 20 of 23 entries
enrichment   p-value GO term description
2.28 4.28e-02 GO:0030672 synaptic vesicle membrane
2.24 4.72e-05 GO:0008076 voltage-gated potassium channel complex
2.24 4.72e-05 GO:0034705 potassium channel complex
2.13 5.08e-07 GO:0034703 cation channel complex
2.10 1.07e-03 GO:0008021 synaptic vesicle
1.87 1.91e-02 GO:0019717 synaptosome
1.78 3.48e-05 GO:0034702 ion channel complex
1.73 1.17e-06 GO:0044456 synapse part
1.66 1.24e-07 GO:0045202 synapse
1.65 3.57e-02 GO:0030136 clathrin-coated vesicle
1.51 3.83e-04 GO:0043005 neuron projection
1.51 7.60e-04 GO:0031012 extracellular matrix
1.49 1.25e-02 GO:0005578 proteinaceous extracellular matrix
1.48 5.46e-06 GO:0030054 cell junction
1.32 1.72e-11 GO:0044459 plasma membrane part
1.32 2.55e-03 GO:0005624 membrane fraction
1.31 5.28e-03 GO:0005626 insoluble fraction
1.30 7.53e-05 GO:0031226 intrinsic to plasma membrane
1.29 1.53e-04 GO:0005887 integral to plasma membrane
1.28 2.08e-02 GO:0042995 cell projection

Gene overrepresentation in function category:

Showing 1 to 20 of 33 entries
enrichment   p-value GO term description
2.16 1.19e-07 GO:0022843 voltage-gated cation channel activity
2.13 3.66e-06 GO:0005267 potassium channel activity
2.09 4.67e-04 GO:0005249 voltage-gated potassium channel activity
2.04 1.29e-08 GO:0010843 promoter binding
2.03 7.00e-09 GO:0000975 regulatory region DNA binding
2.03 7.00e-09 GO:0001067 regulatory region nucleic acid binding
2.03 7.00e-09 GO:0044212 transcription regulatory region DNA binding
2.03 8.93e-03 GO:0003705 sequence-specific enhancer binding RNA polymerase II transcription factor activity
1.99 6.50e-03 GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
1.96 6.88e-07 GO:0005244 voltage-gated ion channel activity
1.96 6.88e-07 GO:0022832 voltage-gated channel activity
1.95 1.98e-02 GO:0003704 specific RNA polymerase II transcription factor activity
1.92 3.67e-26 GO:0043565 sequence-specific DNA binding
1.92 1.34e-09 GO:0005261 cation channel activity
1.70 4.08e-06 GO:0022836 gated channel activity
1.61 3.86e-06 GO:0022838 substrate-specific channel activity
1.61 5.16e-06 GO:0005216 ion channel activity
1.61 2.52e-04 GO:0016564 transcription repressor activity
1.60 6.52e-17 GO:0030528 transcription regulator activity
1.59 3.23e-16 GO:0001071 nucleic acid binding transcription factor activity