Motif ID: RREB1.p2

Z-value: 0.683


Transcription factors associated with RREB1.p2:

Gene SymbolEntrez IDGene Name
RREB1 6239 ras responsive element binding protein 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RREB1chr6_+_70531830.591.6e-02Click!


Activity profile for motif RREB1.p2.

activity profile for motif RREB1.p2


Sorted Z-values histogram for motif RREB1.p2

Sorted Z-values for motif RREB1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RREB1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_187917791 4.472 NM_000893
NM_001102416
NM_001166451
KNG1


kininogen 1


chr11_-_133786935 4.109 NM_018644
NM_054025
B3GAT1

beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)

chr4_+_191245840 4.106 NM_033178
NM_012147
NM_001177376
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L4
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr4_-_809879 3.687 NM_006651
CPLX1
complexin 1
chr4_+_191232653 3.681 NM_033178
NM_012147
NM_001177376
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L4
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr4_+_191239247 2.710 NM_033178
NM_012147
NM_001177376
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L4
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr10_+_135343649 2.695 NM_012147
DUX2
double homeobox 2
chr4_+_191226073 2.644 NM_012147
NM_001177376
NM_001127388
NM_001127389
NM_001164467
DUX2
DUX4L4
DUX4L6
DUX4L5
DUX4L3
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
chr10_+_135330357 2.245 NM_033178
NM_012147
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr10_+_135333667 2.166 NM_033178
NM_012147
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr22_+_49459935 2.157 NM_001080420
SHANK3
SH3 and multiple ankyrin repeat domains 3
chr7_+_100792841 2.155 NM_133457
EMID2
EMI domain containing 2
chr4_+_191242540 2.120 NM_033178
NM_012147
NM_001177376
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L4
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr19_+_3317575 2.059 NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chr2_+_174907914 2.054 NM_001145250
SP9
Sp9 transcription factor homolog (mouse)
chr21_+_42946719 1.962 NM_001001567
NM_001001568
NM_001001569
NM_001001570
NM_001001571
NM_001001572
NM_001001573
NM_001001574
NM_001001575
NM_001001576
NM_001001577
NM_001001578
NM_001001579
NM_001001580
NM_001001581
NM_001001582
NM_001001583
NM_001001584
NM_001001585
NM_002606
PDE9A



















phosphodiesterase 9A



















chr20_-_22512893 1.953 FOXA2
forkhead box A2
chr7_+_100111689 1.949 GNB2
guanine nucleotide binding protein (G protein), beta polypeptide 2
chr17_-_44047299 1.934 NM_024016
HOXB8
homeobox B8
chr4_+_191229360 1.917 NM_033178
NM_012147
NM_001177376
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L4
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chrX_-_119133802 1.883 NM_139282
RHOXF1
Rhox homeobox family, member 1
chr20_+_48032918 1.866 NM_005985
SNAI1
snail homolog 1 (Drosophila)
chr2_+_26768894 1.861 NM_002246
KCNK3
potassium channel, subfamily K, member 3
chr14_+_104244998 1.848 INF2
inverted formin, FH2 and WH2 domain containing
chr22_+_49333327 1.841 NM_138433
KLHDC7B
kelch domain containing 7B
chr7_-_100331417 1.832 NM_000665
NM_015831
ACHE

acetylcholinesterase

chr20_-_61574259 1.805 NM_004518
NM_172106
NM_172107
NM_172108
NM_172109
KCNQ2




potassium voltage-gated channel, KQT-like subfamily, member 2




chr19_+_40213431 1.790 NM_001037
NM_199037
SCN1B

sodium channel, voltage-gated, type I, beta

chr19_+_3317589 1.762 NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chr14_+_28305922 1.730 NM_005249
FOXG1
forkhead box G1
chr8_-_145725289 1.706 C8orf82
chromosome 8 open reading frame 82
chr21_-_46428788 1.692 NM_001142854
NM_032261
C21orf56

chromosome 21 open reading frame 56

chrX_+_151975421 1.681 NM_013364
PNMA3
paraneoplastic antigen MA3
chr11_-_76058542 1.677 NM_005512
LRRC32
leucine rich repeat containing 32
chr4_+_191235959 1.650 NM_001177376
DUX4L4
double homeobox 4 like 4
chr14_-_36121536 1.649 NM_014360
NKX2-8
NK2 homeobox 8
chr19_-_51168396 1.643 NM_002516
NOVA2
neuro-oncological ventral antigen 2
chr10_-_133995323 1.623 STK32C
serine/threonine kinase 32C
chr8_+_37672427 1.610 NM_025069
ZNF703
zinc finger protein 703
chr9_-_43570725 1.591 NM_001145196
FAM75A6
family with sequence similarity 75, member A6
chrX_+_151975518 1.590 PNMA3
paraneoplastic antigen MA3
chr1_-_40903897 1.590 NM_014747
RIMS3
regulating synaptic membrane exocytosis 3
chr2_+_219453487 1.588 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr1_-_34404029 1.575 NM_052896
CSMD2
CUB and Sushi multiple domains 2
chr20_-_26137755 1.558 LOC284801
hypothetical protein LOC284801
chr8_-_145136125 1.533 PARP10
poly (ADP-ribose) polymerase family, member 10
chr7_-_150411345 1.531 NM_031434
TMUB1
transmembrane and ubiquitin-like domain containing 1
chr2_+_72998111 1.529 NM_004097
EMX1
empty spiracles homeobox 1
chr1_+_1940605 1.515 NM_000815
GABRD
gamma-aminobutyric acid (GABA) A receptor, delta
chr17_+_62391216 1.501 NM_014405
CACNG4
calcium channel, voltage-dependent, gamma subunit 4
chr16_+_1143738 1.491 CACNA1H
calcium channel, voltage-dependent, T type, alpha 1H subunit
chr21_-_44506526 1.466 NM_013369
NM_175867
DNMT3L

DNA (cytosine-5-)-methyltransferase 3-like

chr1_+_945331 1.453 NM_198576
AGRN
agrin
chr8_-_41624030 1.447 NM_152568
NKX6-3
NK6 homeobox 3
chr19_+_13924318 1.433 NM_138353
DCAF15
DDB1 and CUL4 associated factor 15
chr19_-_52667056 1.418 NM_015063
SLC8A2
solute carrier family 8 (sodium/calcium exchanger), member 2
chrX_-_151057615 1.414 NM_001011543
NM_021048
MAGEA10

melanoma antigen family A, 10

chr19_+_60691671 1.411 NM_001144950
NM_001195267
SSC5D

scavenger receptor cysteine rich domain containing (5 domains)

chr8_-_111056099 1.411 NM_014379
KCNV1
potassium channel, subfamily V, member 1
chr19_-_360138 1.394 NM_001136263
C2CD4C
C2 calcium-dependent domain containing 4C
chr1_+_144183811 1.388 ANKRD34A
ankyrin repeat domain 34A
chr17_+_39741306 1.364 NM_001144825
NM_001144826
NM_006695
RUNDC3A


RUN domain containing 3A


chr20_+_13924014 1.357 NM_080676
MACROD2
MACRO domain containing 2
chr7_+_44110470 1.344 NM_001129
AEBP1
AE binding protein 1
chr7_+_44110527 1.320 AEBP1
AE binding protein 1
chr8_-_145725197 1.318 NM_001001795
C8orf82
chromosome 8 open reading frame 82
chrX_-_151653756 1.316 NM_001166386
NM_001166387
NM_005367
MAGEA12


melanoma antigen family A, 12


chr19_+_13924287 1.315 DCAF15
DDB1 and CUL4 associated factor 15
chr1_-_226670928 1.312 TRIM17
tripartite motif containing 17
chr4_+_54660954 1.309 NM_133267
GSX2
GS homeobox 2
chr11_-_6633427 1.306 NM_003737
DCHS1
dachsous 1 (Drosophila)
chr18_+_42168180 1.303 NM_152470
C18orf23
RNF165
chromosome 18 open reading frame 23
ring finger protein 165
chr20_-_62151216 1.291 NM_018419
SOX18
SRY (sex determining region Y)-box 18
chr7_-_143731718 1.287 NM_001080413
NOBOX
NOBOX oogenesis homeobox
chr8_+_144706699 1.282 NM_001166237
GSDMD
gasdermin D
chr7_-_150411504 1.277 NM_001136044
TMUB1
transmembrane and ubiquitin-like domain containing 1
chr21_-_46473143 1.267 NM_001001438
NM_001145436
NM_001145437
NM_002340
LSS



lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)



chr2_+_200031333 1.266


chrX_+_152643516 1.264 NM_000033
ABCD1
ATP-binding cassette, sub-family D (ALD), member 1
chr19_+_540849 1.261 NM_001194
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr19_-_13977875 1.258 RFX1
regulatory factor X, 1 (influences HLA class II expression)
chr7_-_75876830 1.252 NM_080744
SRCRB4D
scavenger receptor cysteine rich domain containing, group B (4 domains)
chr6_-_32184975 1.247 NM_019105
TNXB
tenascin XB
chr14_+_23907065 1.246 NM_001198965
NM_004554
NFATC4

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4

chr11_-_76059435 1.240 NM_001128922
LRRC32
leucine rich repeat containing 32
chr1_-_226671205 1.238 NM_001024940
NM_001134855
NM_016102
TRIM17


tripartite motif containing 17


chr19_+_61344341 1.229 NM_018337
ZNF444
zinc finger protein 444
chr17_+_76988134 1.228 NM_001080519
BAHCC1
BAH domain and coiled-coil containing 1
chr13_+_44813479 1.223 LOC100190939
hypothetical LOC100190939
chr19_-_55763091 1.222 NM_001080457
LRRC4B
leucine rich repeat containing 4B
chr17_-_73636362 1.218 TMC6
transmembrane channel-like 6
chr12_-_46439127 1.218 NM_001098531
RAPGEF3
Rap guanine nucleotide exchange factor (GEF) 3
chr14_+_23937766 1.209 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr1_-_154484341 1.202 NM_198406
NM_024897
PAQR6

progestin and adipoQ receptor family member VI

chr19_-_295778 1.202 NM_017550
MIER2
mesoderm induction early response 1, family member 2
chr21_-_46473100 1.176 LSS
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
chr15_+_72209973 1.173 ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr10_-_98935652 1.170 NM_003061
SLIT1
slit homolog 1 (Drosophila)
chr7_+_100111712 1.167 GNB2
guanine nucleotide binding protein (G protein), beta polypeptide 2
chr16_+_1143241 1.163 NM_001005407
NM_021098
CACNA1H

calcium channel, voltage-dependent, T type, alpha 1H subunit

chr12_+_6800950 1.162 NM_014449
NM_019858
GPR162

G protein-coupled receptor 162

chr11_-_74740298 1.156 NM_004041
NM_020251
ARRB1

arrestin, beta 1

chr19_+_61344501 1.155 ZNF444
zinc finger protein 444
chr1_+_199259664 1.153


chr21_-_46473046 1.145 LSS
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
chr17_-_30724732 1.133 NM_001104587
NM_001104588
NM_001104589
NM_001104590
NM_152270
SLFN11




schlafen family member 11




chr19_-_34897802 1.127 NM_001031726
C19orf12
chromosome 19 open reading frame 12
chr19_+_14405100 1.122 NM_002741
PKN1
protein kinase N1
chr11_-_69228286 1.118 NM_005117
FGF19
fibroblast growth factor 19
chr1_+_945399 1.112


chr16_-_65516919 1.111 NM_001128850
NM_004165
RRAD

Ras-related associated with diabetes

chr5_+_2805261 1.102 NM_178569
C5orf38
chromosome 5 open reading frame 38
chr22_+_36286350 1.097 NM_152243
CDC42EP1
CDC42 effector protein (Rho GTPase binding) 1
chr3_-_10522267 1.096 NM_001001331
NM_001683
ATP2B2

ATPase, Ca++ transporting, plasma membrane 2

chr19_-_8581559 1.094 NM_030957
ADAMTS10
ADAM metallopeptidase with thrombospondin type 1 motif, 10
chr5_+_146594718 1.087 NM_001112724
NM_145001
STK32A

serine/threonine kinase 32A

chr22_-_29052863 1.072 NM_031937
TBC1D10A
TBC1 domain family, member 10A
chr11_-_17454995 1.071 NM_000352
ABCC8
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
chr10_+_120957084 1.070 NM_005308
GRK5
G protein-coupled receptor kinase 5
chr17_+_5914364 1.069 NM_015253
WSCD1
WSC domain containing 1
chr14_-_20636568 1.065 NM_016423
ZNF219
zinc finger protein 219
chr1_+_154318954 1.064 LMNA
lamin A/C
chr1_-_1525309 1.060 LOC643988
hypothetical LOC643988
chr7_+_75770801 1.057 HSPB1
heat shock 27kDa protein 1
chr15_+_72209795 1.055 NM_020851
ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr9_+_136358145 1.051 RXRA
retinoid X receptor, alpha
chr11_-_124137260 1.048 NM_138961
ESAM
endothelial cell adhesion molecule
chrX_-_48976714 1.043 NM_005183
CACNA1F
calcium channel, voltage-dependent, L type, alpha 1F subunit
chr12_+_6807831 1.041 NM_014262
LEPREL2
leprecan-like 2
chr9_+_35896188 1.041 NM_001039792
HRCT1
histidine rich carboxyl terminus 1
chr3_+_12304332 1.036 NM_005037
NM_138712
PPARG

peroxisome proliferator-activated receptor gamma

chr11_+_128266460 1.026 NM_000890
KCNJ5
potassium inwardly-rectifying channel, subfamily J, member 5
chr12_-_53268538 1.023 NM_006741
PPP1R1A
protein phosphatase 1, regulatory (inhibitor) subunit 1A
chr20_-_3610635 1.020 NM_025220
NM_153202
ADAM33

ADAM metallopeptidase domain 33

chr7_-_74705276 1.018 NM_001145064
GATSL2
GATS protein-like 2
chr17_+_7846636 1.017 NM_000180
GUCY2D
guanylate cyclase 2D, membrane (retina-specific)
chr17_-_36981830 1.012 NM_000226
KRT9
keratin 9
chr14_-_20636337 1.010 ZNF219
zinc finger protein 219
chr19_-_53706644 1.010


chr12_+_56435042 1.006 NM_138396
MARCH9
membrane-associated ring finger (C3HC4) 9
chr6_-_36915712 1.005 CPNE5
copine V
chr8_-_145530639 1.004 NM_031309
SCRT1
scratch homolog 1, zinc finger protein (Drosophila)
chr22_-_42589543 0.996 NM_014351
SULT4A1
sulfotransferase family 4A, member 1
chr5_+_128823904 0.995 NM_133638
ADAMTS19
ADAM metallopeptidase with thrombospondin type 1 motif, 19
chr5_-_2804768 0.993 NM_001134222
NM_033267
IRX2

iroquois homeobox 2

chr19_-_242335 0.990 NM_003712
NM_177526
PPAP2C

phosphatidic acid phosphatase type 2C

chr2_+_219532590 0.987 NM_003936
CDK5R2
cyclin-dependent kinase 5, regulatory subunit 2 (p39)
chr20_-_33489383 0.986 NM_000557
GDF5
growth differentiation factor 5
chr17_-_40866062 0.985 NM_174919
SH3D20
SH3 domain containing 20
chr8_-_145119627 0.984 NM_201378
PLEC
plectin
chr19_-_242168 0.982 NM_177543
PPAP2C
phosphatidic acid phosphatase type 2C
chr2_+_20729904 0.974 NM_182828
GDF7
growth differentiation factor 7
chr1_+_47654330 0.974 NM_012186
FOXE3
forkhead box E3
chr5_-_176833197 0.972 DBN1
drebrin 1
chr10_-_95350949 0.970 NM_006744
RBP4
retinol binding protein 4, plasma
chrX_+_51944658 0.964 NM_001098800
NM_030801
NM_177535
NM_177537
MAGED4
MAGED4B


melanoma antigen family D, 4
melanoma antigen family D, 4B


chr15_-_86600658 0.961 NM_001007156
NM_001012338
NM_002530
NTRK3


neurotrophic tyrosine kinase, receptor, type 3


chr19_+_3317536 0.959 NM_005597
NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chr1_+_945472 0.952 AGRN
agrin
chr22_-_28992787 0.952 NM_020530
OSM
oncostatin M
chr19_+_45996881 0.950 NM_080732
EGLN2
egl nine homolog 2 (C. elegans)
chrX_+_66680593 0.947 NM_000044
AR
androgen receptor
chrX_-_151672985 0.942 NM_005361
NM_175742
NM_175743
MAGEA2


melanoma antigen family A, 2


chr7_-_150129295 0.937 NM_014020
TMEM176B
transmembrane protein 176B
chr10_-_133995315 0.937 STK32C
serine/threonine kinase 32C
chr19_+_12995782 0.935 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr5_+_145698779 0.932 NM_002700
POU4F3
POU class 4 homeobox 3
chr17_-_28644118 0.931 NM_183377
ACCN1
amiloride-sensitive cation channel 1, neuronal
chr19_+_60691733 0.928 SSC5D
scavenger receptor cysteine rich domain containing (5 domains)
chr6_-_163754903 0.928 LOC100526820
hypothetical LOC100526820
chr9_+_136358134 0.926 NM_002957
RXRA
retinoid X receptor, alpha
chr8_+_120497732 0.925 NM_002514
NOV
nephroblastoma overexpressed gene
chr11_+_279113 0.921 NM_025092
ATHL1
ATH1, acid trehalase-like 1 (yeast)
chr2_+_176695658 0.920 NM_014213
HOXD9
homeobox D9
chr19_+_54786723 0.918 NM_020719
PRR12
proline rich 12
chr8_-_28299508 0.917 ZNF395
zinc finger protein 395
chr7_+_74017015 0.916 NM_001145063
GATSL1
GATSL2
GATS protein-like 1
GATS protein-like 2
chrX_-_70067650 0.912 NM_001048164
NM_032803
SLC7A3

solute carrier family 7 (cationic amino acid transporter, y+ system), member 3

chr16_-_69030421 0.911 NM_006927
ST3GAL2
ST3 beta-galactoside alpha-2,3-sialyltransferase 2
chr22_-_41913076 0.902 NM_015140
TTLL12
tubulin tyrosine ligase-like family, member 12
chr1_+_1066138 0.901


chr11_+_10283171 0.888 NM_001124
ADM
adrenomedullin
chrX_-_48578878 0.887 NM_013271
PCSK1N
proprotein convertase subtilisin/kexin type 1 inhibitor
chr16_-_1215254 0.883 NM_012467
TPSG1
tryptase gamma 1
chr1_-_16272523 0.881 NM_182623
FAM131C
family with sequence similarity 131, member C
chr14_-_62581656 0.881 NM_139318
NM_172375
KCNH5

potassium voltage-gated channel, subfamily H (eag-related), member 5

chr18_+_75261231 0.876 NM_172387
NM_172389
NFATC1

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

chr19_-_7845325 0.869 NM_001190467
FLJ22184
hypothetical protein FLJ22184
chr9_+_115958051 0.858 NM_032888
COL27A1
collagen, type XXVII, alpha 1
chr21_-_43368963 0.857 NM_000071
CBS
cystathionine-beta-synthase
chr16_+_28741873 0.855 ATXN2L
ataxin 2-like
chr19_-_52666886 0.854 SLC8A2
solute carrier family 8 (sodium/calcium exchanger), member 2
chr3_+_194441586 0.852 NM_020386
HRASLS
HRAS-like suppressor
chr12_+_56135353 0.851 NM_031479
INHBE
inhibin, beta E
chr2_-_128149112 0.848 NM_001136037
NM_001161403
LIMS2

LIM and senescent cell antigen-like domains 2

chr8_-_144694754 0.848 NM_015117
ZC3H3
zinc finger CCCH-type containing 3
chr15_+_72208751 0.847 NM_001130136
ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr21_-_46472835 0.845 LSS
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
chr9_-_116307531 0.842 NM_001173425
NM_015404
DFNB31

deafness, autosomal recessive 31

chr9_-_139235595 0.838 NM_031297
RNF208
ring finger protein 208

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.38 7.33e-28 GO:0007275 multicellular organismal development
1.43 1.24e-27 GO:0048731 system development
1.63 7.18e-27 GO:0007399 nervous system development
1.35 5.22e-26 GO:0032502 developmental process
1.39 1.18e-25 GO:0048856 anatomical structure development
1.76 4.29e-21 GO:0048699 generation of neurons
1.73 8.29e-21 GO:0022008 neurogenesis
1.46 1.51e-20 GO:0030154 cell differentiation
1.83 3.71e-20 GO:0030182 neuron differentiation
1.45 3.87e-20 GO:0048869 cellular developmental process
1.53 3.62e-19 GO:0009653 anatomical structure morphogenesis
1.46 1.02e-18 GO:0048513 organ development
1.65 1.17e-16 GO:0048468 cell development
1.52 3.58e-15 GO:0051239 regulation of multicellular organismal process
1.63 3.99e-15 GO:0050793 regulation of developmental process
1.22 4.40e-15 GO:0032501 multicellular organismal process
1.73 5.80e-15 GO:0045595 regulation of cell differentiation
1.33 2.85e-14 GO:0048518 positive regulation of biological process
1.82 2.46e-13 GO:0000904 cell morphogenesis involved in differentiation
1.76 3.30e-13 GO:0048666 neuron development
1.74 4.22e-13 GO:0009887 organ morphogenesis
2.02 6.05e-13 GO:0060284 regulation of cell development
1.79 9.10e-13 GO:0007417 central nervous system development
1.81 9.82e-13 GO:0031175 neuron projection development
1.85 1.13e-12 GO:0048812 neuron projection morphogenesis
1.86 1.14e-12 GO:0048667 cell morphogenesis involved in neuron differentiation
1.88 1.14e-12 GO:0007409 axonogenesis
1.64 1.30e-12 GO:2000026 regulation of multicellular organismal development
1.14 2.78e-12 GO:0065007 biological regulation
1.62 4.79e-12 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.66 5.44e-12 GO:0010628 positive regulation of gene expression
1.33 8.55e-12 GO:0048519 negative regulation of biological process
1.53 1.31e-11 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.32 1.55e-11 GO:0048522 positive regulation of cellular process
1.78 1.98e-11 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.60 2.64e-11 GO:0051173 positive regulation of nitrogen compound metabolic process
1.33 5.42e-11 GO:0048523 negative regulation of cellular process
1.66 6.99e-11 GO:0045893 positive regulation of transcription, DNA-dependent
1.93 7.33e-11 GO:0051093 negative regulation of developmental process
1.65 1.31e-10 GO:0032989 cellular component morphogenesis
1.67 1.32e-10 GO:0000902 cell morphogenesis
2.03 1.47e-10 GO:0045596 negative regulation of cell differentiation
1.62 2.62e-10 GO:0051254 positive regulation of RNA metabolic process
1.14 2.68e-10 GO:0050789 regulation of biological process
1.72 4.54e-10 GO:0048858 cell projection morphogenesis
1.84 9.59e-10 GO:0007420 brain development
1.70 1.05e-09 GO:0032990 cell part morphogenesis
1.14 1.15e-09 GO:0050794 regulation of cellular process
1.62 1.18e-09 GO:0030030 cell projection organization
1.94 3.53e-09 GO:0051960 regulation of nervous system development
1.56 3.55e-09 GO:0010557 positive regulation of macromolecule biosynthetic process
1.52 4.55e-09 GO:0031328 positive regulation of cellular biosynthetic process
1.51 5.40e-09 GO:0009891 positive regulation of biosynthetic process
1.41 5.81e-09 GO:0009893 positive regulation of metabolic process
1.42 1.38e-08 GO:0031325 positive regulation of cellular metabolic process
2.08 1.45e-08 GO:0045664 regulation of neuron differentiation
1.97 1.49e-08 GO:0050767 regulation of neurogenesis
1.33 1.55e-08 GO:0007166 cell surface receptor linked signaling pathway
1.42 2.89e-08 GO:0010604 positive regulation of macromolecule metabolic process
1.63 2.96e-08 GO:0051253 negative regulation of RNA metabolic process
1.74 3.76e-08 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.21 3.79e-08 GO:0023052 signaling
1.64 3.81e-08 GO:0045892 negative regulation of transcription, DNA-dependent
1.70 4.64e-08 GO:0007268 synaptic transmission
1.52 6.93e-08 GO:0007267 cell-cell signaling
1.48 8.51e-08 GO:0009888 tissue development
1.65 1.07e-07 GO:0019226 transmission of nerve impulse
1.65 1.07e-07 GO:0035637 multicellular organismal signaling
2.05 1.08e-07 GO:0032582 negative regulation of gene-specific transcription
1.57 2.74e-07 GO:0010629 negative regulation of gene expression
2.15 2.75e-07 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
1.52 3.18e-07 GO:0009790 embryo development
1.24 4.09e-07 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.76 5.39e-07 GO:0007411 axon guidance
1.72 6.52e-07 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.52 7.58e-07 GO:0031327 negative regulation of cellular biosynthetic process
1.51 9.00e-07 GO:0009890 negative regulation of biosynthetic process
2.24 1.06e-06 GO:0010769 regulation of cell morphogenesis involved in differentiation
2.22 1.56e-06 GO:0022604 regulation of cell morphogenesis
1.41 1.70e-06 GO:0007154 cell communication
1.64 2.22e-06 GO:0032583 regulation of gene-specific transcription
1.23 3.37e-06 GO:0051171 regulation of nitrogen compound metabolic process
1.52 4.69e-06 GO:0051172 negative regulation of nitrogen compound metabolic process
1.43 4.84e-06 GO:0040011 locomotion
1.52 5.36e-06 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.30 5.64e-06 GO:0023051 regulation of signaling
1.50 6.61e-06 GO:0010558 negative regulation of macromolecule biosynthetic process
1.40 7.03e-06 GO:0009605 response to external stimulus
1.18 7.98e-06 GO:0019222 regulation of metabolic process
1.25 1.01e-05 GO:0006355 regulation of transcription, DNA-dependent
1.25 1.08e-05 GO:0051252 regulation of RNA metabolic process
1.22 1.09e-05 GO:0031326 regulation of cellular biosynthetic process
1.70 1.09e-05 GO:0044057 regulation of system process
1.84 1.18e-05 GO:0048568 embryonic organ development
1.76 1.22e-05 GO:0007423 sensory organ development
1.19 1.50e-05 GO:0080090 regulation of primary metabolic process
2.47 1.74e-05 GO:0021953 central nervous system neuron differentiation
1.18 1.80e-05 GO:0031323 regulation of cellular metabolic process
1.22 2.05e-05 GO:0009889 regulation of biosynthetic process
1.27 2.34e-05 GO:0048583 regulation of response to stimulus
1.49 2.71e-05 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.71 2.77e-05 GO:0022603 regulation of anatomical structure morphogenesis
1.64 2.86e-05 GO:0048598 embryonic morphogenesis
1.72 2.98e-05 GO:0048729 tissue morphogenesis
1.24 4.22e-05 GO:0065008 regulation of biological quality
1.65 7.49e-05 GO:0007389 pattern specification process
2.16 1.12e-04 GO:0003001 generation of a signal involved in cell-cell signaling
2.16 1.12e-04 GO:0023061 signal release
1.21 1.96e-04 GO:0010468 regulation of gene expression
1.89 2.25e-04 GO:0030900 forebrain development
1.37 2.98e-04 GO:0031324 negative regulation of cellular metabolic process
1.35 3.52e-04 GO:0009892 negative regulation of metabolic process
1.22 3.92e-04 GO:0042221 response to chemical stimulus
2.40 4.11e-04 GO:0050770 regulation of axonogenesis
1.34 4.49e-04 GO:0010646 regulation of cell communication
1.21 4.67e-04 GO:2000112 regulation of cellular macromolecule biosynthetic process
2.03 4.69e-04 GO:0010975 regulation of neuron projection development
1.93 5.28e-04 GO:0031344 regulation of cell projection organization
1.68 5.53e-04 GO:0061061 muscle structure development
1.49 5.77e-04 GO:0006935 chemotaxis
1.49 5.77e-04 GO:0042330 taxis
1.17 5.98e-04 GO:0007165 signal transduction
1.89 7.17e-04 GO:0006813 potassium ion transport
1.92 7.87e-04 GO:0045165 cell fate commitment
1.76 7.93e-04 GO:0043193 positive regulation of gene-specific transcription
1.90 8.11e-04 GO:0048562 embryonic organ morphogenesis
1.81 8.97e-04 GO:0048732 gland development
1.17 9.69e-04 GO:0060255 regulation of macromolecule metabolic process
2.44 9.88e-04 GO:0007269 neurotransmitter secretion
2.34 9.89e-04 GO:0010721 negative regulation of cell development
1.35 1.33e-03 GO:0010605 negative regulation of macromolecule metabolic process
1.20 1.43e-03 GO:0010556 regulation of macromolecule biosynthetic process
2.08 1.75e-03 GO:0006836 neurotransmitter transport
1.27 2.23e-03 GO:0009966 regulation of signal transduction
2.01 2.73e-03 GO:0043583 ear development
1.49 3.48e-03 GO:0051094 positive regulation of developmental process
1.83 3.82e-03 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
1.34 4.50e-03 GO:0006351 transcription, DNA-dependent
1.49 4.59e-03 GO:0046903 secretion
2.09 4.89e-03 GO:0048839 inner ear development
1.67 5.27e-03 GO:0003002 regionalization
1.35 5.84e-03 GO:0051128 regulation of cellular component organization
1.55 7.67e-03 GO:0045597 positive regulation of cell differentiation
1.66 9.86e-03 GO:0002009 morphogenesis of an epithelium
2.15 1.04e-02 GO:0042471 ear morphogenesis
1.35 1.08e-02 GO:0007155 cell adhesion
1.35 1.08e-02 GO:0022610 biological adhesion
2.25 1.32e-02 GO:0042472 inner ear morphogenesis
2.55 1.34e-02 GO:0048663 neuron fate commitment
1.43 1.67e-02 GO:0048585 negative regulation of response to stimulus
1.30 1.88e-02 GO:0032879 regulation of localization
1.70 1.96e-02 GO:0007517 muscle organ development
1.86 2.08e-02 GO:0030799 regulation of cyclic nucleotide metabolic process
1.49 2.39e-02 GO:0060429 epithelium development
2.16 2.66e-02 GO:0048638 regulation of developmental growth
2.64 3.03e-02 GO:0046888 negative regulation of hormone secretion
1.49 3.16e-02 GO:0043009 chordate embryonic development
1.48 3.17e-02 GO:0009792 embryo development ending in birth or egg hatching
2.02 3.30e-02 GO:0001505 regulation of neurotransmitter levels
2.27 3.35e-02 GO:0048634 regulation of muscle organ development
1.36 3.38e-02 GO:0007167 enzyme linked receptor protein signaling pathway
1.70 3.47e-02 GO:0003012 muscle system process
1.67 3.59e-02 GO:0003013 circulatory system process
1.67 3.59e-02 GO:0008015 blood circulation
1.77 3.60e-02 GO:0060562 epithelial tube morphogenesis
1.53 3.88e-02 GO:0032940 secretion by cell
1.78 4.13e-02 GO:0001655 urogenital system development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.32 1.72e-11 GO:0044459 plasma membrane part
1.66 1.24e-07 GO:0045202 synapse
2.13 5.08e-07 GO:0034703 cation channel complex
1.17 5.30e-07 GO:0005886 plasma membrane
1.17 7.22e-07 GO:0071944 cell periphery
1.73 1.17e-06 GO:0044456 synapse part
1.48 5.46e-06 GO:0030054 cell junction
1.78 3.48e-05 GO:0034702 ion channel complex
2.24 4.72e-05 GO:0008076 voltage-gated potassium channel complex
2.24 4.72e-05 GO:0034705 potassium channel complex
1.30 7.53e-05 GO:0031226 intrinsic to plasma membrane
1.29 1.53e-04 GO:0005887 integral to plasma membrane
1.51 3.83e-04 GO:0043005 neuron projection
1.51 7.60e-04 GO:0031012 extracellular matrix
2.10 1.07e-03 GO:0008021 synaptic vesicle
1.32 2.55e-03 GO:0005624 membrane fraction
1.31 5.28e-03 GO:0005626 insoluble fraction
1.49 1.25e-02 GO:0005578 proteinaceous extracellular matrix
1.87 1.91e-02 GO:0019717 synaptosome
1.28 2.08e-02 GO:0042995 cell projection
1.25 2.52e-02 GO:0044421 extracellular region part
1.65 3.57e-02 GO:0030136 clathrin-coated vesicle
2.28 4.28e-02 GO:0030672 synaptic vesicle membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.92 3.67e-26 GO:0043565 sequence-specific DNA binding
1.60 6.52e-17 GO:0030528 transcription regulator activity
1.59 3.23e-16 GO:0001071 nucleic acid binding transcription factor activity
1.59 3.23e-16 GO:0003700 sequence-specific DNA binding transcription factor activity
1.92 1.34e-09 GO:0005261 cation channel activity
2.03 7.00e-09 GO:0000975 regulatory region DNA binding
2.03 7.00e-09 GO:0001067 regulatory region nucleic acid binding
2.03 7.00e-09 GO:0044212 transcription regulatory region DNA binding
2.04 1.29e-08 GO:0010843 promoter binding
2.16 1.19e-07 GO:0022843 voltage-gated cation channel activity
1.96 6.88e-07 GO:0005244 voltage-gated ion channel activity
1.96 6.88e-07 GO:0022832 voltage-gated channel activity
2.13 3.66e-06 GO:0005267 potassium channel activity
1.61 3.86e-06 GO:0022838 substrate-specific channel activity
1.70 4.08e-06 GO:0022836 gated channel activity
1.61 5.16e-06 GO:0005216 ion channel activity
1.10 9.81e-06 GO:0005515 protein binding
1.56 3.02e-05 GO:0015267 channel activity
1.56 3.56e-05 GO:0022803 passive transmembrane transporter activity
1.61 2.52e-04 GO:0016564 transcription repressor activity
2.09 4.67e-04 GO:0005249 voltage-gated potassium channel activity
1.39 7.33e-04 GO:0046983 protein dimerization activity
1.48 1.13e-03 GO:0019904 protein domain specific binding
1.56 1.38e-03 GO:0016563 transcription activator activity
1.19 2.43e-03 GO:0003677 DNA binding
1.99 6.50e-03 GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
2.03 8.93e-03 GO:0003705 sequence-specific enhancer binding RNA polymerase II transcription factor activity
1.37 1.44e-02 GO:0008324 cation transmembrane transporter activity
1.95 1.98e-02 GO:0003704 specific RNA polymerase II transcription factor activity
1.55 2.35e-02 GO:0003702 RNA polymerase II transcription factor activity
1.04 2.44e-02 GO:0005488 binding
1.30 3.54e-02 GO:0015075 ion transmembrane transporter activity
1.27 4.41e-02 GO:0022891 substrate-specific transmembrane transporter activity