Motif ID: RUNX1..3.p2

Z-value: 1.697


Transcription factors associated with RUNX1..3.p2:

Gene SymbolEntrez IDGene Name
RUNX1 861 runt-related transcription factor 1
RUNX2 860 runt-related transcription factor 2
RUNX3 864 runt-related transcription factor 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RUNX3chr1_-_251640610.775.5e-04Click!
RUNX1chr21_-_353434280.505.1e-02Click!
RUNX2chr6_+_45498354-0.146.0e-01Click!


Activity profile for motif RUNX1..3.p2.

activity profile for motif RUNX1..3.p2


Sorted Z-values histogram for motif RUNX1..3.p2

Sorted Z-values for motif RUNX1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RUNX1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_114215768 3.879 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr16_+_23754772 3.525 NM_002738
NM_212535
PRKCB

protein kinase C, beta

chr8_-_102872354 3.324 NCALD
neurocalcin delta
chr1_-_25164061 3.202 NM_001031680
RUNX3
runt-related transcription factor 3
chr2_-_158008763 2.987 NM_004288
CYTIP
cytohesin 1 interacting protein
chr16_+_29582069 2.907 NM_003123
SPN
sialophorin
chr17_-_31441390 2.456 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chrX_-_30505804 2.421 NM_025159
CXorf21
chromosome X open reading frame 21
chr16_+_29582065 2.329 SPN
sialophorin
chr8_-_21827057 2.254 NM_003974
DOK2
docking protein 2, 56kDa
chr22_+_21318779 2.234 NM_199127
GGTLC2
gamma-glutamyltransferase light chain 2
chr9_-_129580732 2.187 NM_170600
SH2D3C
SH2 domain containing 3C
chr8_-_102872614 2.058 NM_032041
NCALD
neurocalcin delta
chr16_+_23754822 2.053 PRKCB
protein kinase C, beta
chr22_+_38627031 1.905 NM_004810
GRAP2
GRB2-related adaptor protein 2
chrX_-_131089552 1.884 NM_194277
FRMD7
FERM domain containing 7
chr7_+_142850667 1.791 NM_177437
TAS2R60
taste receptor, type 2, member 60
chr6_-_41276901 1.762 NM_024807
TREML2
triggering receptor expressed on myeloid cells-like 2
chrX_+_78087484 1.715 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr1_+_32489426 1.667 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr15_+_19883745 1.657 NM_001005241
OR4N4
olfactory receptor, family 4, subfamily N, member 4
chr13_-_45654296 1.646 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr15_+_36776090 1.632 NM_207444
C15orf53
chromosome 15 open reading frame 53
chr1_+_246718487 1.630 NM_001004697
OR2T5
olfactory receptor, family 2, subfamily T, member 5
chr1_+_196874759 1.621 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr19_-_55560686 1.611 NM_004851
NAPSA
napsin A aspartic peptidase
chr6_+_160247962 1.607 NM_002377
MAS1
MAS1 oncogene
chr3_+_99733432 1.599 NM_005290
GPR15
G protein-coupled receptor 15
chr9_-_122728173 1.597 TRAF1
TNF receptor-associated factor 1
chr1_-_159306273 1.585 ARHGAP30
Rho GTPase activating protein 30
chr4_-_38482805 1.570 NM_003263
TLR1
toll-like receptor 1
chr1_+_20489998 1.520 NM_001039500
VWA5B1
von Willebrand factor A domain containing 5B1
chr8_-_102872372 1.517 NCALD
neurocalcin delta
chr6_+_28032997 1.517 NM_012367
OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr5_+_131424245 1.507 NM_000588
IL3
interleukin 3 (colony-stimulating factor, multiple)
chr1_+_196874867 1.490 PTPRC
protein tyrosine phosphatase, receptor type, C
chr4_-_1185144 1.488 LOC100130872
hypothetical LOC100130872
chr5_-_88155360 1.483 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr6_-_32271277 1.482 NM_022107
GPSM3
G-protein signaling modulator 3
chr6_-_34632061 1.481 NM_012391
SPDEF
SAM pointed domain containing ets transcription factor
chr4_-_113656762 1.481 NM_024019
NEUROG2
neurogenin 2
chr4_-_10295412 1.452 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chr22_+_38627129 1.449 GRAP2
GRB2-related adaptor protein 2
chr17_-_26665220 1.442 NM_006495
EVI2B
ecotropic viral integration site 2B
chr1_+_196874839 1.399 PTPRC
protein tyrosine phosphatase, receptor type, C
chr19_-_52667056 1.388 NM_015063
SLC8A2
solute carrier family 8 (sodium/calcium exchanger), member 2
chr11_-_2863536 1.383 NM_000076
NM_001122630
NM_001122631
CDKN1C


cyclin-dependent kinase inhibitor 1C (p57, Kip2)


chr13_-_45654292 1.370 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr1_+_190811479 1.358 NM_002922
RGS1
regulator of G-protein signaling 1
chr11_-_5302157 1.346 NM_033180
OR51B2
olfactory receptor, family 51, subfamily B, member 2
chr14_+_75058518 1.342 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chr16_+_65868913 1.336 NM_015432
PLEKHG4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr6_+_31651319 1.334 NM_000594
TNF
tumor necrosis factor
chr20_+_54420574 1.332 NM_001164116
NM_001164114
NM_001164115
NM_020356
CASS4



Cas scaffolding protein family member 4



chr5_-_39255335 1.330 NM_001465
NM_199335
FYB

FYN binding protein

chr17_-_26665144 1.329 EVI2B
ecotropic viral integration site 2B
chr16_+_23754860 1.283 PRKCB
protein kinase C, beta
chr1_-_182273114 1.280 GLT25D2
glycosyltransferase 25 domain containing 2
chr11_+_63864263 1.280 NM_032251
CCDC88B
coiled-coil domain containing 88B
chr3_+_114733907 1.264 NM_017699
SIDT1
SID1 transmembrane family, member 1
chr2_+_102401580 1.260 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr17_+_44643067 1.259 ABI3
ABI family, member 3
chr20_+_42776888 1.255 WISP2
WNT1 inducible signaling pathway protein 2
chr2_-_26554413 1.254 NM_004802
NM_194322
NM_194323
OTOF


otoferlin


chr10_-_105228986 1.253 NM_001129742
CALHM3
calcium homeostasis modulator 3
chr4_+_76700281 1.244 NM_178497
C4orf26
chromosome 4 open reading frame 26
chr19_-_47328399 1.239 NM_002698
POU2F2
POU class 2 homeobox 2
chr18_+_75354312 1.226 NFATC1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
chr16_+_31273969 1.219 NM_000887
ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr17_-_26665213 1.216 EVI2B
ecotropic viral integration site 2B
chrX_-_77801480 1.199 NM_152694
ZCCHC5
zinc finger, CCHC domain containing 5
chr16_+_23754997 1.195 PRKCB
protein kinase C, beta
chr4_-_38534802 1.180 NM_006068
TLR6
toll-like receptor 6
chr16_+_29581783 1.166 NM_001030288
SPN
sialophorin
chr5_+_176717449 1.150 NM_006480
RGS14
regulator of G-protein signaling 14
chr4_-_71751205 1.150 NM_144646
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr3_-_40325952 1.147 FLJ33065
hypothetical LOC440952
chr5_-_176258920 1.135 NM_002115
HK3
hexokinase 3 (white cell)
chr2_+_68445821 1.135 NM_002664
PLEK
pleckstrin
chr12_-_38300109 1.133 NM_005164
ABCD2
ATP-binding cassette, sub-family D (ALD), member 2
chr1_-_159306327 1.132 ARHGAP30
Rho GTPase activating protein 30
chr17_+_23818922 1.126


chr1_-_182273451 1.126 NM_015101
GLT25D2
glycosyltransferase 25 domain containing 2
chr5_-_137099602 1.125 NM_017415
KLHL3
kelch-like 3 (Drosophila)
chr1_+_202000906 1.124 NM_001136190
NM_017773
LAX1

lymphocyte transmembrane adaptor 1

chr14_+_60045621 1.116 NM_007374
SIX6
SIX homeobox 6
chr17_+_53587492 1.112 NM_012374
OR4D1
olfactory receptor, family 4, subfamily D, member 1
chr12_+_106692291 1.110 NM_203436
ASCL4
achaete-scute complex homolog 4 (Drosophila)
chr15_-_100280784 1.108 NM_001004195
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr17_-_26665194 1.103 EVI2B
ecotropic viral integration site 2B
chr14_-_93493519 1.101 NM_016150
ASB2
ankyrin repeat and SOCS box containing 2
chr12_+_25096755 1.100 LRMP
lymphoid-restricted membrane protein
chr17_+_45598363 1.098 NM_000023
NM_001135697
SGCA

sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)

chr16_+_30102426 1.084 CORO1A
coronin, actin binding protein, 1A
chr6_-_31954795 1.078 NM_001178044
NM_025257
SLC44A4

solute carrier family 44, member 4

chrX_+_48427103 1.075 NM_000377
WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr1_-_205161821 1.074 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr12_+_47658502 1.058 NM_005430
WNT1
wingless-type MMTV integration site family, member 1
chr1_-_159306369 1.051 NM_001025598
NM_181720
ARHGAP30

Rho GTPase activating protein 30

chr11_+_123398929 1.049 NM_001001953
OR10G9
olfactory receptor, family 10, subfamily G, member 9
chr5_-_137099361 1.037 KLHL3
kelch-like 3 (Drosophila)
chr1_-_159099090 1.035 NM_001166663
NM_001166664
NM_016382
CD244


CD244 molecule, natural killer cell receptor 2B4


chr17_+_43165608 1.034 NM_013351
TBX21
T-box 21
chr16_+_795443 1.031 NM_001013638
PRR25
proline rich 25
chr6_+_12825818 1.029 NM_030948
PHACTR1
phosphatase and actin regulator 1
chr16_+_28413421 1.024 NM_018690
APOBR
apolipoprotein B receptor
chr1_-_157313179 1.020 NM_004833
AIM2
absent in melanoma 2
chrX_+_48427137 1.019 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr15_-_63290839 1.017 NM_003613
CILP
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr11_+_123986661 1.017 NM_052959
PANX3
pannexin 3
chr1_+_156590109 1.010 NM_001042583
NM_001042584
NM_001042585
NM_001042586
NM_001042587
NM_001185107
NM_001185108
NM_001185110
NM_001185112
NM_001185113
NM_001185114
NM_001185115
NM_030893
CD1E












CD1e molecule












chr19_-_59452869 1.008 NM_001081442
NM_001081443
NM_006840
LILRB5


leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5


chr19_+_2240996 1.006


chr2_+_204279442 1.005 NM_006139
CD28
CD28 molecule
chr1_-_159306037 1.001 ARHGAP30
Rho GTPase activating protein 30
chr4_-_71751070 0.999 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr1_-_155788775 0.999 NM_001195388
NM_031281
FCRL5

Fc receptor-like 5

chr9_-_129557373 0.999 NM_001142534
NM_001142533
SH2D3C

SH2 domain containing 3C

chr2_+_69910424 0.991 GMCL1
germ cell-less homolog 1 (Drosophila)
chr8_+_1940282 0.987 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr11_-_56761250 0.987 NM_005161
APLNR
apelin receptor
chr11_+_4427100 0.980 NM_001005172
OR52K2
olfactory receptor, family 52, subfamily K, member 2
chrX_-_70755023 0.975 NM_001142797
NM_001504
CXCR3

chemokine (C-X-C motif) receptor 3

chr2_-_175170674 0.967 WIPF1
WAS/WASL interacting protein family, member 1
chr17_-_36376663 0.959 NM_213656
KRT39
keratin 39
chr6_+_30212488 0.958 NM_138700
TRIM40
tripartite motif containing 40
chr1_-_30969016 0.955 NM_002379
MATN1
matrilin 1, cartilage matrix protein
chr11_-_118799058 0.952 THY1
Thy-1 cell surface antigen
chr7_+_28415495 0.950 LOC401317
hypothetical LOC401317
chr19_-_48976852 0.950 KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr16_-_66590856 0.946 NM_022355
DPEP2
dipeptidase 2
chr19_+_59077241 0.943 NM_002739
PRKCG
protein kinase C, gamma
chr14_+_75058591 0.942 BATF
basic leucine zipper transcription factor, ATF-like
chr1_+_52871603 0.941 NM_001042693
FAM159A
family with sequence similarity 159, member A
chr7_+_116447527 0.938 ST7
suppression of tumorigenicity 7
chr20_+_16676997 0.931 NM_020157
OTOR
otoraplin
chr17_-_77512346 0.931 NM_178493
NOTUM
notum pectinacetylesterase homolog (Drosophila)
chr17_-_40401138 0.929 NM_006688
C1QL1
complement component 1, q subcomponent-like 1
chr6_-_36412562 0.929 NM_001010903
C6orf222
chromosome 6 open reading frame 222
chrX_-_135691168 0.921 NM_004840
ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr2_+_234490781 0.914 NM_024080
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr17_-_59363352 0.912 NM_000626
NM_001039933
NM_021602
CD79B


CD79b molecule, immunoglobulin-associated beta


chr20_-_48741481 0.903


chr10_+_70517863 0.903 SRGN
serglycin
chr3_-_181237210 0.898 NM_016559
PEX5L
peroxisomal biogenesis factor 5-like
chr3_+_190372456 0.892 NM_198485
TPRG1
tumor protein p63 regulated 1
chr12_-_66839589 0.887 NM_000619
IFNG
interferon, gamma
chr1_-_238842071 0.885 NM_022469
GREM2
gremlin 2
chr1_+_204797516 0.883 RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chrX_-_111809929 0.882 NM_178175
LHFPL1
lipoma HMGIC fusion partner-like 1
chr2_-_73723001 0.882 NM_003960
NAT8
N-acetyltransferase 8 (GCN5-related, putative)
chr17_-_64568641 0.873 NM_080283
ABCA9
ATP-binding cassette, sub-family A (ABC1), member 9
chr7_+_116447499 0.869 ST7
suppression of tumorigenicity 7
chr7_+_150376537 0.865 NM_004769
NM_020321
NM_020322
ACCN3


amiloride-sensitive cation channel 3


chr19_+_40474867 0.862 NM_002361
NM_080600
MAG

myelin associated glycoprotein

chr22_+_35586950 0.858 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr9_+_94749421 0.858 NM_001083536
FGD3
FYVE, RhoGEF and PH domain containing 3
chr19_+_61624 0.858 NM_001005240
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr1_-_159306210 0.857 ARHGAP30
Rho GTPase activating protein 30
chr6_-_32892705 0.854 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr6_-_149847809 0.851 NM_207360
ZC3H12D
zinc finger CCCH-type containing 12D
chr16_-_65510230 0.848 NM_004062
CDH16
cadherin 16, KSP-cadherin
chr6_+_167624792 0.843 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr19_-_18058632 0.838 NM_005535
NM_153701
IL12RB1

interleukin 12 receptor, beta 1

chr11_+_58967192 0.837 NM_001004728
OR5A1
olfactory receptor, family 5, subfamily A, member 1
chr1_-_34403443 0.835 CSMD2
CUB and Sushi multiple domains 2
chr10_+_11087280 0.831 CELF2
CUGBP, Elav-like family member 2
chr11_-_5232480 0.830 NM_000184
HBG1
HBG2
hemoglobin, gamma A
hemoglobin, gamma G
chr6_+_116956868 0.828 NM_153036
FAM26D
family with sequence similarity 26, member D
chr5_+_75734759 0.821 NM_006633
IQGAP2
IQ motif containing GTPase activating protein 2
chr17_-_31548167 0.815 NM_001001437
NM_021006
CCL3L3
CCL3
CCL3L1
chemokine (C-C motif) ligand 3-like 3
chemokine (C-C motif) ligand 3
chemokine (C-C motif) ligand 3-like 1
chr1_-_246789396 0.813 NM_001004694
OR2T29
OR2T5
olfactory receptor, family 2, subfamily T, member 29
olfactory receptor, family 2, subfamily T, member 5
chr1_-_238842011 0.812 GREM2
gremlin 2
chr19_-_52666886 0.811 SLC8A2
solute carrier family 8 (sodium/calcium exchanger), member 2
chr11_-_62213577 0.811 LRRN4CL
LRRN4 C-terminal like
chr8_-_134141586 0.806 NM_006748
SLA
Src-like-adaptor
chr16_-_70475381 0.797 ZNF821
zinc finger protein 821
chr22_+_17337970 0.785 DGCR5
DiGeorge syndrome critical region gene 5 (non-protein coding)
chr7_-_92686773 0.785 NM_198151
HEPACAM2
HEPACAM family member 2
chr6_+_135558572 0.782


chr1_-_74436415 0.777 NM_001105659
LRRIQ3
leucine-rich repeats and IQ motif containing 3
chr6_-_32121784 0.777 NM_032470
TNXB
tenascin XB
chr19_+_56420131 0.776 NM_001082618
NM_001177608
NM_001772
CD33


CD33 molecule


chr17_-_36807322 0.776 NM_002277
KRT31
keratin 31
chr20_+_24397834 0.774 NM_024893
TMEM90B
transmembrane protein 90B
chr17_-_71352090 0.771 UNC13D
unc-13 homolog D (C. elegans)
chr1_+_66772393 0.768 NM_032291
SGIP1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr14_-_104602784 0.762 NM_013345
GPR132
G protein-coupled receptor 132
chr8_-_7308438 0.761 NM_016512
NM_058200
NM_058201
NM_058202
NM_058203
SPAG11B




SPAG11A
sperm associated antigen 11B




sperm associated antigen 11A
chr1_+_204797214 0.759 RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chr11_-_66961709 0.757 NM_005608
PTPRCAP
protein tyrosine phosphatase, receptor type, C-associated protein
chr12_-_14740694 0.757 NM_004963
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr20_+_61394982 0.748 NM_020882
COL20A1
collagen, type XX, alpha 1
chr2_+_204440753 0.746 NM_001037631
NM_005214
CTLA4

cytotoxic T-lymphocyte-associated protein 4

chr12_-_113330574 0.746 NM_000192
NM_080717
TBX5

T-box 5

chr18_+_59726183 0.745 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr14_-_94012266 0.742 NM_001042518
NM_175739
SERPINA9

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9

chr13_-_36577800 0.738 NM_145203
CSNK1A1L
casein kinase 1, alpha 1-like
chrX_-_123925343 0.737 NM_001163278
NM_001163279
NM_014253
ODZ1


odz, odd Oz/ten-m homolog 1(Drosophila)


chr9_-_72926333 0.733 NM_001007471
TRPM3
transient receptor potential cation channel, subfamily M, member 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.62 7.97e-15 GO:0007608 sensory perception of smell
2.45 1.91e-13 GO:0007606 sensory perception of chemical stimulus
1.27 2.77e-11 GO:0050896 response to stimulus
1.91 6.92e-10 GO:0007600 sensory perception
1.60 8.08e-10 GO:0003008 system process
1.27 2.66e-08 GO:0032501 multicellular organismal process
1.62 7.29e-08 GO:0050877 neurological system process
1.63 2.60e-07 GO:0002376 immune system process
1.73 3.02e-05 GO:0006955 immune response
1.76 4.26e-03 GO:0001775 cell activation
1.36 6.76e-03 GO:0007166 cell surface receptor linked signaling pathway
2.23 7.51e-03 GO:0046649 lymphocyte activation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.42 1.42e-16 GO:0005886 plasma membrane
1.41 2.02e-16 GO:0071944 cell periphery
1.29 5.20e-12 GO:0031224 intrinsic to membrane
1.29 3.72e-11 GO:0016021 integral to membrane
1.25 8.12e-11 GO:0044425 membrane part
1.59 2.08e-07 GO:0005887 integral to plasma membrane
1.58 2.73e-07 GO:0031226 intrinsic to plasma membrane
1.42 4.18e-07 GO:0044459 plasma membrane part
1.16 6.84e-06 GO:0016020 membrane
2.50 5.45e-04 GO:0009897 external side of plasma membrane
1.31 2.04e-03 GO:0005576 extracellular region
1.51 6.18e-03 GO:0005615 extracellular space

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.84 2.41e-21 GO:0004872 receptor activity
1.71 1.25e-19 GO:0004871 signal transducer activity
1.71 1.25e-19 GO:0060089 molecular transducer activity
1.91 1.02e-17 GO:0004888 transmembrane receptor activity
2.63 8.64e-15 GO:0004984 olfactory receptor activity
2.01 1.40e-13 GO:0004930 G-protein coupled receptor activity
5.01 1.40e-06 GO:0003823 antigen binding
2.07 1.01e-02 GO:0005125 cytokine activity