Motif ID: RXR{A,B,G}.p2

Z-value: 2.392


Transcription factors associated with RXR{A,B,G}.p2:

Gene SymbolEntrez IDGene Name
RXRA 6256 retinoid X receptor, alpha
RXRB 6257 retinoid X receptor, beta
RXRG 6258 retinoid X receptor, gamma

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RXRBchr6_-_332761410.712.2e-03Click!
RXRAchr9_+_1363581340.581.9e-02Click!
RXRGchr1_-_1636809410.049.0e-01Click!


Activity profile for motif RXR{A,B,G}.p2.

activity profile for motif RXR{A,B,G}.p2


Sorted Z-values histogram for motif RXR{A,B,G}.p2

Sorted Z-values for motif RXR{A,B,G}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RXR{A,B,G}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_44429748 2.557 NM_001160423
NM_006546
 IGF2BP1

insulin-like growth factor 2 mRNA binding protein 1

chr19_-_1125257 2.421 SBNO2
strawberry notch homolog 2 (Drosophila)
chr7_+_2638108 2.403 NM_025250
 TTYH3
tweety homolog 3 (Drosophila)
chr22_+_18081968 2.160 NM_002688
 SEPT5
septin 5
chr7_+_100156358 2.106 NM_000799
 EPO
erythropoietin
chr17_+_76988134 2.070 NM_001080519
 BAHCC1
BAH domain and coiled-coil containing 1
chr12_+_50686990 2.070 NM_181711
 GRASP
GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein
chr19_+_55046229 1.980 PTOV1
prostate tumor overexpressed 1
chr19_+_55046088 1.977 NM_017432
 PTOV1
prostate tumor overexpressed 1
chr19_-_1125201 1.963


chr7_+_2638156 1.954 TTYH3
tweety homolog 3 (Drosophila)
chr17_+_78630793 1.949 NM_001004431
 METRNL
meteorin, glial cell differentiation regulator-like
chr16_-_69277355 1.844 NM_138383
 MTSS1L
metastasis suppressor 1-like
chr17_+_78286687 1.719 NM_022158
 FN3K
fructosamine 3 kinase
chr19_-_1125263 1.719 NM_014963
 SBNO2
strawberry notch homolog 2 (Drosophila)
chr19_+_18391211 1.715 NM_001009998
NM_032627
 SSBP4

single stranded DNA binding protein 4

chr17_+_56832255 1.651 TBX2
T-box 2
chr6_-_2916786 1.648 SERPINB6
serpin peptidase inhibitor, clade B (ovalbumin), member 6
chr17_+_56831951 1.595 NM_005994
 TBX2
T-box 2
chr17_-_74433048 1.510 NM_003255
 TIMP2
TIMP metallopeptidase inhibitor 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 73 entries
enrichment   p-value GO term description
2.53 4.31e-03 GO:0030326 embryonic limb morphogenesis
2.53 4.31e-03 GO:0035113 embryonic appendage morphogenesis
2.38 7.98e-03 GO:0035107 appendage morphogenesis
2.38 7.98e-03 GO:0035108 limb morphogenesis
2.36 6.55e-03 GO:0048736 appendage development
2.36 6.55e-03 GO:0060173 limb development
1.94 6.88e-03 GO:0048514 blood vessel morphogenesis
1.84 7.47e-03 GO:0001568 blood vessel development
1.76 4.07e-05 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.74 4.13e-02 GO:0001944 vasculature development
1.71 2.82e-02 GO:0060284 regulation of cell development
1.67 2.06e-04 GO:0051253 negative regulation of RNA metabolic process
1.67 2.54e-04 GO:0045892 negative regulation of transcription, DNA-dependent
1.64 1.50e-04 GO:0010629 negative regulation of gene expression
1.64 4.04e-03 GO:0072358 cardiovascular system development
1.64 4.04e-03 GO:0072359 circulatory system development
1.61 1.76e-04 GO:0010558 negative regulation of macromolecule biosynthetic process
1.61 2.74e-04 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.59 1.02e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.58 4.52e-04 GO:0010628 positive regulation of gene expression

Gene overrepresentation in compartment category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
2.44 2.35e-02 GO:0005604 basement membrane
1.75 6.28e-03 GO:0000323 lytic vacuole
1.75 6.28e-03 GO:0005764 lysosome
1.71 3.24e-03 GO:0005773 vacuole
1.57 1.51e-02 GO:0043005 neuron projection
1.09 1.07e-02 GO:0005737 cytoplasm
1.08 2.50e-04 GO:0044424 intracellular part
1.08 7.02e-03 GO:0043226 organelle
1.08 8.53e-03 GO:0043229 intracellular organelle
1.07 1.50e-04 GO:0005622 intracellular
1.03 1.85e-02 GO:0044464 cell part
1.03 1.92e-02 GO:0005623 cell

Gene overrepresentation in function category:

Showing 1 to 14 of 14 entries
enrichment   p-value GO term description
2.00 5.33e-04 GO:0000975 regulatory region DNA binding
2.00 5.33e-04 GO:0001067 regulatory region nucleic acid binding
2.00 5.33e-04 GO:0044212 transcription regulatory region DNA binding
1.96 2.00e-03 GO:0010843 promoter binding
1.75 1.47e-03 GO:0016563 transcription activator activity
1.66 5.20e-07 GO:0043565 sequence-specific DNA binding
1.62 4.10e-02 GO:0003779 actin binding
1.54 2.92e-02 GO:0019904 protein domain specific binding
1.52 1.27e-06 GO:0030528 transcription regulator activity
1.52 2.37e-06 GO:0001071 nucleic acid binding transcription factor activity
1.52 2.37e-06 GO:0003700 sequence-specific DNA binding transcription factor activity
1.28 7.59e-05 GO:0003677 DNA binding
1.17 1.50e-08 GO:0005515 protein binding
1.08 1.16e-05 GO:0005488 binding