Motif ID: RXRA_VDR{dimer}.p2

Z-value: 1.130


Transcription factors associated with RXRA_VDR{dimer}.p2:

Gene SymbolEntrez IDGene Name
VDR 7421 vitamin D (1,25- dihydroxyvitamin D3) receptor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
VDRchr12_-_465850320.175.2e-01Click!


Activity profile for motif RXRA_VDR{dimer}.p2.

activity profile for motif RXRA_VDR{dimer}.p2


Sorted Z-values histogram for motif RXRA_VDR{dimer}.p2

Sorted Z-values for motif RXRA_VDR{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RXRA_VDR{dimer}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_132314004 1.916 NM_001901
CTGF
connective tissue growth factor
chr8_-_8276598 1.785 NM_001080826
SGK223
homolog of rat pragma of Rnd2
chr13_+_23742846 1.501 SPATA13
spermatogenesis associated 13
chr22_+_48966394 1.381 TRABD
TraB domain containing
chr22_+_48966480 1.120 NM_025204
TRABD
TraB domain containing
chr17_+_18320822 1.072 NM_001040078
LGALS9B
LGALS9C
lectin, galactoside-binding, soluble, 9B
lectin, galactoside-binding, soluble, 9C
chr19_+_60878238 0.986 NM_001130072
NM_013333
EPN1

epsin 1

chr17_-_31616071 0.936 NM_001001418
NM_032258
TBC1D3B
TBC1D3C
TBC1D3G
TBC1D3F
TBC1 domain family, member 3B
TBC1 domain family, member 3C
TBC1 domain family, member 3G
TBC1 domain family, member 3F
chr15_+_89229275 0.929 NM_001143783
NM_001143784
FES

feline sarcoma oncogene

chr11_+_1170045 0.926 MUC5AC
mucin 5AC, oligomeric mucus/gel-forming
chr19_+_60878381 0.850 EPN1
epsin 1
chr14_+_94117483 0.848 NM_000624
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr7_+_143331954 0.833 NM_001005281
OR6B1
olfactory receptor, family 6, subfamily B, member 1
chr19_+_60878392 0.821 EPN1
epsin 1
chr18_-_57711283 0.782 NM_173557
RNF152
ring finger protein 152
chr11_+_2378559 0.740 TSSC4
tumor suppressing subtransferable candidate 4
chr3_-_71196696 0.728 FOXP1
forkhead box P1
chr19_-_52679287 0.720 NM_007059
KPTN
kaptin (actin binding protein)
chr11_-_780103 0.695 NM_016564
CEND1
cell cycle exit and neuronal differentiation 1
chr16_+_30952350 0.685 STX4
syntaxin 4
chr1_+_93830106 0.659 LOC100129046
hypothetical LOC100129046
chr19_-_52679222 0.655 KPTN
kaptin (actin binding protein)
chr10_-_33663984 0.643 NRP1
neuropilin 1
chr19_-_1601246 0.625 NM_001136139
TCF3
transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
chr17_-_20311411 0.616 NM_001042685
LGALS9B
lectin, galactoside-binding, soluble, 9B
chr7_+_39956396 0.604


chr10_-_33663777 0.600 NM_001024628
NM_001024629
NM_003873
NRP1


neuropilin 1


chr3_+_32834513 0.592 NM_001039111
TRIM71
tripartite motif containing 71
chr2_-_27457088 0.592 NM_144631
ZNF513
zinc finger protein 513
chr2_+_220170804 0.587 NM_052902
STK11IP
serine/threonine kinase 11 interacting protein
chr17_-_36456949 0.580 NM_001123387
KRTAP2-1
keratin associated protein 2-1
chr1_+_224803123 0.561 NM_001003665
C1orf95
chromosome 1 open reading frame 95
chr17_-_33552166 0.557 NM_001123391
NM_032258
TBC1D3C
TBC1D3G
TBC1D3
TBC1D3F
TBC1 domain family, member 3C
TBC1 domain family, member 3G
TBC1 domain family, member 3
TBC1 domain family, member 3F
chr13_+_113369470 0.557 NM_002929
GRK1
G protein-coupled receptor kinase 1
chrX_-_21586337 0.555 NM_153270
KLHL34
kelch-like 34 (Drosophila)
chr20_-_33658823 0.549 FER1L4
fer-1-like 4 (C. elegans) pseudogene
chr19_+_1334877 0.541 NM_024407
NDUFS7
NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)
chr1_+_173303616 0.537 NM_022093
TNN
tenascin N
chr19_+_60878422 0.534 EPN1
epsin 1
chr13_-_50315832 0.533 NM_198989
DLEU7
deleted in lymphocytic leukemia, 7
chr1_-_203592538 0.533 NM_018203
KLHDC8A
kelch domain containing 8A
chr18_+_44319365 0.504 NM_001142397
NM_014772
CTIF

CBP80/20-dependent translation initiation factor

chr5_+_99899133 0.502 FAM174A
family with sequence similarity 174, member A
chr14_-_100420936 0.502 NM_001134888
RTL1
retrotransposon-like 1
chr20_+_3749164 0.491 NM_018347
C20orf29
chromosome 20 open reading frame 29
chr16_+_30952382 0.474 NM_004604
STX4
syntaxin 4
chr19_+_41322841 0.471 CAPNS1
calpain, small subunit 1
chr12_-_6450015 0.467 NM_014231
NM_016830
NM_199245
VAMP1


vesicle-associated membrane protein 1 (synaptobrevin 1)


chr8_-_93184629 0.453 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr20_+_42309319 0.449 NM_024034
GDAP1L1
ganglioside-induced differentiation-associated protein 1-like 1
chr17_-_31831093 0.441 NM_001123392
NM_032258
TBC1D3C
TBC1D3G
TBC1D3
TBC1D3H
TBC1D3F
TBC1 domain family, member 3C
TBC1 domain family, member 3G
TBC1 domain family, member 3
TBC1 domain family, member 3H
TBC1 domain family, member 3F
chr9_+_139245029 0.439 NM_001177316
NM_001177317
SLC34A3

solute carrier family 34 (sodium phosphate), member 3

chr16_+_18986459 0.437 COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr2_+_74594093 0.424 TLX2
T-cell leukemia homeobox 2
chr5_-_63293715 0.422 HTR1A
5-hydroxytryptamine (serotonin) receptor 1A
chr5_-_179166230 0.416 MGAT4B
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
chr12_+_56284867 0.410 NM_178502
DTX3
deltex homolog 3 (Drosophila)
chr17_-_39333490 0.402 MPP2
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
chr11_-_124311512 0.400 NM_152722
HEPACAM
hepatic and glial cell adhesion molecule
chr1_-_151852128 0.383 NM_080388
S100A16
S100 calcium binding protein A16
chr1_-_173979292 0.380 NM_003285
TNR
tenascin R (restrictin, janusin)
chr11_+_63883192 0.378 NM_001006944
NM_003942
RPS6KA4

ribosomal protein S6 kinase, 90kDa, polypeptide 4

chr11_+_64620287 0.374 C11orf2
chromosome 11 open reading frame 2
chr21_-_46399900 0.370 NM_006657
NM_206965
FTCD

formiminotransferase cyclodeaminase

chr1_+_99884018 0.369 NM_017734
PALMD
palmdelphin
chr11_-_66945190 0.368 PPP1CA
protein phosphatase 1, catalytic subunit, alpha isozyme
chr11_+_64620183 0.366 NM_013265
C11orf2
chromosome 11 open reading frame 2
chr13_+_23723831 0.366 SPATA13
spermatogenesis associated 13
chr17_-_33602374 0.364 NM_032258
TBC1D3C
TBC1D3G
TBC1D3
TBC1D3F
TBC1 domain family, member 3C
TBC1 domain family, member 3G
TBC1 domain family, member 3
TBC1 domain family, member 3F
chr1_+_93830169 0.362 LOC100129046
hypothetical LOC100129046
chr20_+_18516541 0.362 NM_080820
DTD1
D-tyrosyl-tRNA deacylase 1 homolog (S. cerevisiae)
chr1_+_156716290 0.357 NM_001004472
OR10R2
olfactory receptor, family 10, subfamily R, member 2
chr11_+_64620276 0.352 C11orf2
chromosome 11 open reading frame 2
chr2_+_20510312 0.350 NM_004040
RHOB
ras homolog gene family, member B
chr16_+_31027231 0.349 BCKDK
branched chain ketoacid dehydrogenase kinase
chr3_+_133518900 0.340 NM_001099
NM_001134194
ACPP

acid phosphatase, prostate

chr19_-_4510713 0.339 SEMA6B
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr14_+_54238581 0.337 SAMD4A
sterile alpha motif domain containing 4A
chr20_+_42309327 0.329 GDAP1L1
ganglioside-induced differentiation-associated protein 1-like 1
chr17_+_77528699 0.326 NM_024083
ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr11_-_63689780 0.322 MACROD1
MACRO domain containing 1
chr19_+_1334904 0.321 NDUFS7
NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)
chr12_+_55896844 0.315 NM_007224
NXPH4
neurexophilin 4
chr11_+_124115051 0.310 NRGN
neurogranin (protein kinase C substrate, RC3)
chr11_-_65841077 0.308 NM_020404
CD248
CD248 molecule, endosialin
chr9_+_130684601 0.302 NM_001127244
LRRC8A
leucine rich repeat containing 8 family, member A
chr12_-_6668085 0.302 NM_001039916
ZNF384
zinc finger protein 384
chr2_+_230495439 0.293 NM_174899
FBXO36
F-box protein 36
chr16_-_4232053 0.292 NM_001098814
SRL
sarcalumenin
chr4_-_2727548 0.289 NM_001161527
TNIP2
TNFAIP3 interacting protein 2
chr19_-_2259155 0.288 NM_001101391
LINGO3
leucine rich repeat and Ig domain containing 3
chr10_-_21825879 0.287 C10orf114
chromosome 10 open reading frame 114
chr18_+_46340400 0.285 NM_002747
MAPK4
mitogen-activated protein kinase 4
chr4_-_123092358 0.284 NM_001130698
TRPC3
transient receptor potential cation channel, subfamily C, member 3
chr2_-_217268492 0.279 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr17_-_31528027 0.279 NM_001001417
TBC1D3B
TBC1D3C
TBC1D3G
TBC1D3F
TBC1 domain family, member 3B
TBC1 domain family, member 3C
TBC1 domain family, member 3G
TBC1 domain family, member 3F
chr3_+_133518966 0.278 ACPP
acid phosphatase, prostate
chr19_-_2734225 0.277 SGTA
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
chr19_+_47509274 0.276 NM_173633
TMEM145
transmembrane protein 145
chr19_+_13111072 0.275 NACC1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr1_+_35031185 0.273 NM_002060
GJA4
gap junction protein, alpha 4, 37kDa
chr8_-_139995417 0.272 NM_152888
COL22A1
collagen, type XXII, alpha 1
chr11_+_60626505 0.271 NM_014207
CD5
CD5 molecule
chr12_+_52181643 0.268 NM_134324
TARBP2
TAR (HIV-1) RNA binding protein 2
chr16_+_28797309 0.266 NM_004320
NM_173201
ATP2A1

ATPase, Ca++ transporting, cardiac muscle, fast twitch 1

chr2_+_220071780 0.265 NM_013335
NM_205847
GMPPA

GDP-mannose pyrophosphorylase A

chr19_-_2734332 0.263 NM_003021
SGTA
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
chr19_+_1892157 0.263 NM_001319
CSNK1G2
casein kinase 1, gamma 2
chr2_+_238432925 0.263 NM_005855
RAMP1
receptor (G protein-coupled) activity modifying protein 1
chr19_-_2734313 0.259 SGTA
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
chr8_-_39814860 0.254 NM_001464
ADAM2
ADAM metallopeptidase domain 2
chr9_-_34554800 0.253 CNTFR
ciliary neurotrophic factor receptor
chr9_+_20648307 0.252 NM_017794
KIAA1797
KIAA1797
chr17_-_6557375 0.251 NM_001143838
NM_177550
SLC13A5

solute carrier family 13 (sodium-dependent citrate transporter), member 5

chr17_-_36469869 0.249 NM_001165252
LOC730755
keratin associated protein 2-4-like
chr7_+_142788579 0.248 ZYX
zyxin
chr17_-_36475652 0.248 NM_033184
KRTAP2-4
keratin associated protein 2-4
chrX_+_153339814 0.247 NM_017514
PLXNA3
plexin A3
chr11_+_76561471 0.246 MYO7A
myosin VIIA
chr22_+_29819343 0.245 SMTN
smoothelin
chr6_-_166960690 0.241 NM_021135
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr20_+_42309371 0.237 GDAP1L1
ganglioside-induced differentiation-associated protein 1-like 1
chr14_+_94117511 0.236 SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr7_+_142788480 0.231 NM_001010972
NM_003461
ZYX

zyxin

chr9_+_129605275 0.231 NM_001018078
FPGS
folylpolyglutamate synthase
chr3_-_54937001 0.230 NM_020678
LRTM1
leucine-rich repeats and transmembrane domains 1
chr3_+_52504410 0.228 STAB1
stabilin 1
chr3_-_49117169 0.227 NM_005051
QARS
glutaminyl-tRNA synthetase
chr22_+_48740432 0.226 PIM3
pim-3 oncogene
chr16_+_31027115 0.224 NM_001122957
NM_005881
BCKDK

branched chain ketoacid dehydrogenase kinase

chr7_-_122126422 0.221 NM_139175
RNF133
ring finger protein 133
chr17_+_77528782 0.220 ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr3_+_191588354 0.220 NM_006580
CLDN16
claudin 16
chrX_+_153423652 0.220 NM_001099856
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr1_-_27604656 0.217 WASF2
WAS protein family, member 2
chr19_-_47451119 0.216 NM_006494
ERF
Ets2 repressor factor
chr12_+_119900677 0.215 HNF1A
HNF1 homeobox A
chr19_+_58453356 0.215 NM_173856
VN1R2
vomeronasal 1 receptor 2
chr22_+_16973399 0.215 NM_001193414
NM_018943
TUBA8

tubulin, alpha 8

chr12_+_48784057 0.215 NM_005276
GPD1
glycerol-3-phosphate dehydrogenase 1 (soluble)
chr8_+_22493928 0.214 NM_176871
NM_198042
PDLIM2

PDZ and LIM domain 2 (mystique)

chr8_+_94998258 0.213 NM_018444
NM_001161780
NM_001161779
NM_001161781
PDP1



pyruvate dehyrogenase phosphatase catalytic subunit 1



chr4_-_2727816 0.212 NM_024309
TNIP2
TNFAIP3 interacting protein 2
chr3_+_49183983 0.211 NM_173546
KLHDC8B
kelch domain containing 8B
chr16_-_31135895 0.207 NM_152901
PYDC1
PYD (pyrin domain) containing 1
chr20_+_42309357 0.205 GDAP1L1
ganglioside-induced differentiation-associated protein 1-like 1
chr11_-_124311106 0.205 HEPACAM
hepatic and glial cell adhesion molecule
chr10_+_115929008 0.203 NM_198795
TDRD1
tudor domain containing 1
chr11_-_780065 0.203 CEND1
cell cycle exit and neuronal differentiation 1
chr12_+_112143670 0.202 TPCN1
two pore segment channel 1
chr19_-_56695458 0.202 NM_033329
SIGLEC12
sialic acid binding Ig-like lectin 12
chr11_+_76516957 0.201 NM_000260
NM_001127179
NM_001127180
MYO7A


myosin VIIA


chr22_+_16973556 0.200 TUBA8
tubulin, alpha 8
chr19_-_48700824 0.199 NM_198850
PHLDB3
pleckstrin homology-like domain, family B, member 3
chr19_-_51690989 0.199 NM_020709
PNMAL2
PNMA-like 2
chr4_+_2764609 0.197 SH3BP2
SH3-domain binding protein 2
chr1_-_153491575 0.194 FAM189B
family with sequence similarity 189, member B
chr2_+_100802923 0.194 NM_002518
NPAS2
neuronal PAS domain protein 2
chr3_-_48446405 0.193 NM_001130082
PLXNB1
plexin B1
chr19_+_44628080 0.190 SUPT5H
suppressor of Ty 5 homolog (S. cerevisiae)
chr7_+_44762311 0.188 NM_174929
ZMIZ2
zinc finger, MIZ-type containing 2
chr9_+_115678365 0.187 NM_133374
ZNF618
zinc finger protein 618
chr17_+_75808685 0.185 NM_001166347
NM_001166348
NM_001166349
NM_173626
SLC26A11



solute carrier family 26, member 11



chr16_+_1974182 0.185 GFER
growth factor, augmenter of liver regeneration
chr7_+_100792841 0.183 NM_133457
EMID2
EMI domain containing 2
chr19_+_1334898 0.180 NDUFS7
NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)
chr16_+_31027255 0.179 BCKDK
branched chain ketoacid dehydrogenase kinase
chr15_-_63185631 0.179 NM_001163692
LOC390595
ubiquitin-associated protein 1-like
chr10_+_102722275 0.178 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr17_-_40401138 0.176 NM_006688
C1QL1
complement component 1, q subcomponent-like 1
chr6_-_166960496 0.176 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr20_+_61963009 0.174 NM_080622
ABHD16B
abhydrolase domain containing 16B
chr17_-_77640237 0.173


chr11_-_110888273 0.171 NM_017589
BTG4
B-cell translocation gene 4
chr5_+_193372 0.169 NM_052909
PLEKHG4B
pleckstrin homology domain containing, family G (with RhoGef domain) member 4B
chr2_-_204108151 0.168 NM_203365
NM_213589
RAPH1

Ras association (RalGDS/AF-6) and pleckstrin homology domains 1

chr17_+_7063873 0.167 NM_000018
NM_001033859
ACADVL

acyl-CoA dehydrogenase, very long chain

chr7_+_97679501 0.167 NM_177455
BHLHA15
basic helix-loop-helix family, member a15
chr16_+_31027249 0.166 BCKDK
branched chain ketoacid dehydrogenase kinase
chr5_-_63293301 0.166 NM_000524
HTR1A
5-hydroxytryptamine (serotonin) receptor 1A
chr9_-_139437534 0.165 NM_017820
EXD3
exonuclease 3'-5' domain containing 3
chr13_-_32757835 0.165 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr19_+_7801110 0.164 NM_145245
EVI5L
ecotropic viral integration site 5-like
chr17_-_70367479 0.163 NM_000835
GRIN2C
glutamate receptor, ionotropic, N-methyl D-aspartate 2C
chr19_+_54961880 0.160 NM_014203
NM_130787
AP2A1

adaptor-related protein complex 2, alpha 1 subunit

chr1_+_26220895 0.160 EXTL1
exostoses (multiple)-like 1
chr5_-_180169720 0.160 NM_001114617
MGAT1
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr17_+_77603064 0.157 GPS1
G protein pathway suppressor 1
chr13_+_112999538 0.155 LAMP1
lysosomal-associated membrane protein 1
chr2_-_133895795 0.153 NCKAP5
NCK-associated protein 5
chr19_+_63670449 0.153 ZNF324
zinc finger protein 324
chr22_+_40800213 0.152 FAM109B
family with sequence similarity 109, member B
chr6_-_166960649 0.150 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr11_-_64283945 0.150 PYGM
phosphorylase, glycogen, muscle
chr3_+_185514937 0.149 NM_001194946
NM_001194947
NM_198241
NM_198242
NM_198244
EIF4G1




eukaryotic translation initiation factor 4 gamma, 1




chr19_-_47450991 0.149 ERF
Ets2 repressor factor
chr19_+_44628115 0.149 NM_003169
SUPT5H
suppressor of Ty 5 homolog (S. cerevisiae)
chr17_-_74990157 0.148 NM_001082575
RBFOX3
RNA binding protein, fox-1 homolog (C. elegans) 3
chr19_+_40223249 0.147 NM_002151
NM_182983
HPN

hepsin

chr10_+_80569464 0.147 ZMIZ1
zinc finger, MIZ-type containing 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
6.49 3.55e-02 GO:0032313 regulation of Rab GTPase activity
6.49 3.55e-02 GO:0032483 regulation of Rab protein signal transduction

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
8.11 1.61e-03 GO:0003823 antigen binding
6.36 1.05e-02 GO:0005097 Rab GTPase activator activity