Motif ID: RXRG_dimer.p3

Z-value: 0.996


Transcription factors associated with RXRG_dimer.p3:

Gene SymbolEntrez IDGene Name
NR1H2 7376 nuclear receptor subfamily 1, group H, member 2
PPARA 5465 peroxisome proliferator-activated receptor alpha
PPARG 5468 peroxisome proliferator-activated receptor gamma
RXRA 6256 retinoid X receptor, alpha
RXRB 6257 retinoid X receptor, beta
RXRG 6258 retinoid X receptor, gamma

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RXRAchr9_+_136358134-0.533.3e-02Click!
RXRBchr6_-_332761310.467.4e-02Click!
NR1H2chr19_+_55571493-0.411.1e-01Click!
RXRGchr1_-_163680941-0.194.8e-01Click!
PPARAchr22_+_449251620.145.9e-01Click!
PPARGchr3_+_12304332-0.097.5e-01Click!


Activity profile for motif RXRG_dimer.p3.

activity profile for motif RXRG_dimer.p3


Sorted Z-values histogram for motif RXRG_dimer.p3

Sorted Z-values for motif RXRG_dimer.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of RXRG_dimer.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_+_55569542 1.348 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr2_+_177965734 1.255 AGPS
alkylglycerone phosphate synthase
chr2_-_177965626 1.104 LOC100130691
hypothetical LOC100130691
chr2_+_218992053 1.076 NM_007127
VIL1
villin 1
chr2_-_219141199 1.074 NM_020935
USP37
ubiquitin specific peptidase 37
chr2_-_64099935 1.032 VPS54
vacuolar protein sorting 54 homolog (S. cerevisiae)
chr6_+_30702586 1.006 NM_024909
NM_001031722
NM_001190724
ATAT1


alpha tubulin acetyltransferase 1


chr2_+_161725172 1.002 TANK
TRAF family member-associated NFKB activator
chr10_+_102722275 0.962 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr10_-_52315390 0.936 A1CF
APOBEC1 complementation factor
chr16_-_86527608 0.925 NM_001739
CA5A
carbonic anhydrase VA, mitochondrial
chr6_+_144040751 0.909 NM_001100164
NM_001100165
PHACTR2

phosphatase and actin regulator 2

chr1_+_61320213 0.909 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chr11_+_116205830 0.906 NM_000040
APOC3
apolipoprotein C-III
chr2_+_206732859 0.904 EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr3_+_37259684 0.902 NM_001172713
NM_002078
GOLGA4

golgin A4

chr2_+_108432008 0.893 NM_181453
GCC2
GRIP and coiled-coil domain containing 2
chr2_+_108432097 0.865 GCC2
GRIP and coiled-coil domain containing 2
chr3_+_142587973 0.854


chr10_-_52315436 0.853 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr20_+_37024383 0.852 NM_001190809
NM_021931
DHX35

DEAH (Asp-Glu-Ala-His) box polypeptide 35

chr6_+_31731647 0.835 NM_019101
APOM
apolipoprotein M
chr2_-_206732348 0.832 NM_005006
NDUFS1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr5_-_42847716 0.816 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr12_+_94776836 0.805 NM_003095
SNRPF
small nuclear ribonucleoprotein polypeptide F
chr6_-_146326918 0.776 NM_001042683
NM_173082
SHPRH

SNF2 histone linker PHD RING helicase

chr2_-_175754366 0.772 NM_001002258
NM_001190329
NM_001689
ATP5G3


ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)


chr2_+_159021653 0.769 PKP4
plakophilin 4
chr7_-_100630912 0.749 NM_178176
MOGAT3
monoacylglycerol O-acyltransferase 3
chr16_-_45565068 0.747 NM_005880
DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr20_-_36095236 0.743 NM_014657
TTI1
Tel2 interacting protein 1 homolog (S. pombe)
chr6_+_142510108 0.741 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr20_+_36095263 0.740 NM_021215
RPRD1B
regulation of nuclear pre-mRNA domain containing 1B
chr6_+_142510094 0.737 NM_016485
VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr2_+_177965617 0.736 NM_003659
AGPS
alkylglycerone phosphate synthase
chr9_+_114182216 0.708 HSDL2
hydroxysteroid dehydrogenase like 2
chr6_+_31731667 0.707 APOM
apolipoprotein M
chr18_-_50004458 0.700 MBD2
methyl-CpG binding domain protein 2
chr12_+_65949631 0.697 CAND1
cullin-associated and neddylation-dissociated 1
chr6_+_142510075 0.691 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr3_-_114947330 0.679 NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr2_+_108604111 0.676 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr20_-_19981005 0.674 CRNKL1
crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
chr12_-_93991235 0.669 NM_001032287
NM_001127362
NM_003297
NR2C1


nuclear receptor subfamily 2, group C, member 1


chr12_+_65949414 0.665 CAND1
cullin-associated and neddylation-dissociated 1
chr20_+_30409649 0.659 NM_001164603
NM_015338
ASXL1

additional sex combs like 1 (Drosophila)

chr9_+_114182009 0.651 NM_001195822
NM_032303
HSDL2

hydroxysteroid dehydrogenase like 2

chr5_+_80292313 0.628 NM_006909
RASGRF2
Ras protein-specific guanine nucleotide-releasing factor 2
chr20_+_36095552 0.628 RPRD1B
regulation of nuclear pre-mRNA domain containing 1B
chr5_+_14717803 0.617 FAM105B
family with sequence similarity 105, member B
chr20_+_36095621 0.613


chr17_+_35532994 0.608 MSL1
male-specific lethal 1 homolog (Drosophila)
chr2_+_138438277 0.598 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr17_+_38403935 0.592 NM_000988
RPL27
ribosomal protein L27
chr20_+_43943254 0.587 NM_080603
ZSWIM1
zinc finger, SWIM-type containing 1
chrX_-_122694569 0.583 NM_001081550
THOC2
THO complex 2
chr1_-_224441024 0.582 NM_022735
ACBD3
acyl-CoA binding domain containing 3
chr1_-_224441023 0.580 ACBD3
acyl-CoA binding domain containing 3
chr6_+_142510034 0.549 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr12_+_94776901 0.547 SNRPF
small nuclear ribonucleoprotein polypeptide F
chr1_-_32632601 0.547 NM_001143888
NM_001143889
NM_001143890
NM_018045
BSDC1



BSD domain containing 1



chr2_+_206732562 0.546 NM_001037663
NM_001959
NM_021121
EEF1B2


eukaryotic translation elongation factor 1 beta 2


chr3_+_151747266 0.545 EIF2A
eukaryotic translation initiation factor 2A, 65kDa
chr1_+_144439069 0.543 NM_002614
PDZK1
PDZ domain containing 1
chr2_+_219354692 0.539 NM_000784
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr7_-_72574383 0.532 BAZ1B
bromodomain adjacent to zinc finger domain, 1B
chr17_-_33179118 0.530 NM_000458
NM_001165923
HNF1B

HNF1 homeobox B

chr2_+_27967102 0.526 BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr1_-_101263867 0.526 NM_001077394
NM_001077395
NM_015958
DPH5


DPH5 homolog (S. cerevisiae)


chr2_+_219141761 0.518 NM_005444
RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr14_-_94693359 0.515 DICER1
dicer 1, ribonuclease type III
chr2_+_206732575 0.514 EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr12_+_65949327 0.510 NM_018448
CAND1
cullin-associated and neddylation-dissociated 1
chr7_-_74127508 0.505 WBSCR16
Williams-Beuren syndrome chromosome region 16
chr7_-_72574528 0.505 NM_032408
BAZ1B
bromodomain adjacent to zinc finger domain, 1B
chr6_-_146326863 0.499 SHPRH
SNF2 histone linker PHD RING helicase
chr12_+_119900677 0.478 HNF1A
HNF1 homeobox A
chr6_-_146327238 0.477 SHPRH
SNF2 histone linker PHD RING helicase
chr2_-_27966715 0.472 NM_022128
RBKS
ribokinase
chr6_+_143813472 0.469 NM_003630
PEX3
peroxisomal biogenesis factor 3
chr7_-_72574474 0.467 BAZ1B
bromodomain adjacent to zinc finger domain, 1B
chr2_+_73294852 0.441 NM_006062
SMYD5
SMYD family member 5
chr11_+_86426518 0.438 NM_001168724
NM_022918
TMEM135

transmembrane protein 135

chrX_-_122694562 0.433 THOC2
THO complex 2
chr16_-_45564984 0.429 DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr20_+_41621079 0.428 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr12_-_49708279 0.428 NM_001174125
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr20_+_41621119 0.424 SGK2
serum/glucocorticoid regulated kinase 2
chr14_-_74713086 0.421 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr2_+_27967116 0.414 BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr2_+_119841611 0.393 NM_001079863
DBI
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr17_-_33178987 0.391 HNF1B
HNF1 homeobox B
chr20_+_43919662 0.384 NM_080752
ZSWIM3
zinc finger, SWIM-type containing 3
chr11_+_117948301 0.384 NM_001142281
NM_001655
ARCN1

archain 1

chr11_+_117948350 0.384 ARCN1
archain 1
chr7_-_65084641 0.379 GUSB
glucuronidase, beta
chr4_+_4594619 0.377 LOC100507266
hypothetical LOC100507266
chrX_-_18282698 0.374 NM_006089
SCML2
sex comb on midleg-like 2 (Drosophila)
chr9_+_73954174 0.368 GDA
guanine deaminase
chr1_-_172153087 0.362 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr6_-_146327155 0.361 SHPRH
SNF2 histone linker PHD RING helicase
chr20_-_43919360 0.361 NM_005469
ACOT8
acyl-CoA thioesterase 8
chr18_-_44730706 0.358 SMAD7
SMAD family member 7
chr4_-_84150885 0.358 LIN54
lin-54 homolog (C. elegans)
chr2_+_27967159 0.358 BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr5_+_14717764 0.357 NM_138348
FAM105B
family with sequence similarity 105, member B
chr18_-_44731078 0.347 NM_001190821
NM_005904
SMAD7

SMAD family member 7

chr7_-_74127572 0.346 WBSCR16
Williams-Beuren syndrome chromosome region 16
chr11_+_118374071 0.345 CCDC84
coiled-coil domain containing 84
chr7_+_120415958 0.343 NM_024913
C7orf58
chromosome 7 open reading frame 58
chr2_-_198072868 0.337 NM_002156
HSPD1
heat shock 60kDa protein 1 (chaperonin)
chrX_+_38305634 0.334 NM_004615
TSPAN7
tetraspanin 7
chr22_-_22389524 0.330 LOC91316
glucuronidase, beta/immunoglobulin lambda-like polypeptide 1 pseudogene
chr14_-_74713062 0.329 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr7_-_65084597 0.328 GUSB
glucuronidase, beta
chr1_+_43628136 0.327 NM_001012961
C1orf84
chromosome 1 open reading frame 84
chr1_+_78126787 0.324 NM_001172309
NM_144573
NEXN

nexilin (F actin binding protein)

chr3_-_114947681 0.318 NM_025146
NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr4_+_140806536 0.315 MGST2
microsomal glutathione S-transferase 2
chr7_-_106991941 0.312 NM_001161520
NM_006348
NM_181733
COG5


component of oligomeric golgi complex 5


chr11_+_117735530 0.312 UBE4A
ubiquitination factor E4A (UFD2 homolog, yeast)
chr1_-_15784048 0.305 NM_024758
AGMAT
agmatine ureohydrolase (agmatinase)
chr20_-_32363268 0.301 NM_001161766
AHCY
adenosylhomocysteinase
chr7_-_65084668 0.300 NM_000181
GUSB
glucuronidase, beta
chr11_+_117735558 0.299 UBE4A
ubiquitination factor E4A (UFD2 homolog, yeast)
chr16_+_30617962 0.298 NM_006662
SRCAP
Snf2-related CREBBP activator protein
chr4_+_109761170 0.294 NM_000995
NM_033625
RPL34

ribosomal protein L34

chr12_-_117294933 0.294 TAOK3
TAO kinase 3
chr11_-_116213511 0.294 NM_000039
APOA1
apolipoprotein A-I
chr2_+_26422495 0.287 EPT1
ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
chr1_-_149404954 0.282 NM_212551
NM_001136543
LYSMD1

LysM, putative peptidoglycan-binding, domain containing 1

chr14_-_74713039 0.281 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr9_+_73954237 0.280 GDA
guanine deaminase
chr5_+_1854493 0.271 NM_004553
NDUFS6
NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
chr1_-_154147787 0.267 NM_006912
RIT1
Ras-like without CAAX 1
chr7_-_65084622 0.266 GUSB
glucuronidase, beta
chr4_-_7120656 0.263 NM_025196
GRPEL1
GrpE-like 1, mitochondrial (E. coli)
chr14_-_74713088 0.262 NM_006827
TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr8_+_96106362 0.257 NM_152416
C8orf38
chromosome 8 open reading frame 38
chr20_+_54400979 0.250 NM_001324
CSTF1
cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
chr3_+_151747204 0.247 NM_032025
EIF2A
eukaryotic translation initiation factor 2A, 65kDa
chr16_+_79829794 0.246 NM_017429
BCMO1
beta-carotene 15,15'-monooxygenase 1
chr8_-_124355670 0.240 NM_001017926
NM_007222
ZHX1

zinc fingers and homeoboxes 1

chr17_+_71508581 0.235 NM_001258
CDK3
cyclin-dependent kinase 3
chr19_+_10223912 0.234 MRPL4
mitochondrial ribosomal protein L4
chr14_-_74713012 0.233 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr19_+_54708312 0.228 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr1_-_172153024 0.228 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr11_+_117735529 0.228 UBE4A
ubiquitination factor E4A (UFD2 homolog, yeast)
chr22_+_22445035 0.227 NM_005940
MMP11
matrix metallopeptidase 11 (stromelysin 3)
chr12_-_6949877 0.227 PHB2
prohibitin 2
chr11_+_117735502 0.224 NM_004788
UBE4A
ubiquitination factor E4A (UFD2 homolog, yeast)
chr15_-_50316996 0.223 MYO5C
myosin VC
chr2_+_219141546 0.221 RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr19_+_54708302 0.219 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr11_+_85690900 0.219 NM_016401
C11orf73
chromosome 11 open reading frame 73
chr6_+_33280396 0.218 NM_014234
HSD17B8
hydroxysteroid (17-beta) dehydrogenase 8
chr2_+_86521781 0.218 NM_018433
KDM3A
lysine (K)-specific demethylase 3A
chr10_+_103995297 0.217 NM_004193
GBF1
golgi brefeldin A resistant guanine nucleotide exchange factor 1
chr2_+_198072965 0.217 NM_002157
HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr12_+_119900931 0.215 NM_000545
HNF1A
HNF1 homeobox A
chr14_-_30927931 0.215 NM_015473
HEATR5A
HEAT repeat containing 5A
chr2_+_119841298 0.210 NM_001178017
DBI
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr17_+_7063970 0.209 ACADVL
acyl-CoA dehydrogenase, very long chain
chr4_-_84150997 0.209 NM_001115008
NM_194282
LIN54

lin-54 homolog (C. elegans)

chr5_+_92944680 0.208 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr19_+_6323805 0.207 ALKBH7
alkB, alkylation repair homolog 7 (E. coli)
chr4_-_4594591 0.207 STX18
syntaxin 18
chr17_+_38403991 0.204 RPL27
ribosomal protein L27
chr19_-_40317829 0.202 NM_139284
LGI4
leucine-rich repeat LGI family, member 4
chr2_+_201691664 0.196 CFLAR
CASP8 and FADD-like apoptosis regulator
chr3_-_151746970 0.195 NM_014445
SERP1
stress-associated endoplasmic reticulum protein 1
chr7_-_74127622 0.194 NM_030798
WBSCR16
Williams-Beuren syndrome chromosome region 16
chr9_+_103335983 0.192 RNF20
ring finger protein 20
chr12_-_117295095 0.192 NM_016281
TAOK3
TAO kinase 3
chr10_-_62431203 0.191 RHOBTB1
Rho-related BTB domain containing 1
chr19_+_6323720 0.190 ALKBH7
alkB, alkylation repair homolog 7 (E. coli)
chr9_-_138277467 0.187 NM_181701
QSOX2
quiescin Q6 sulfhydryl oxidase 2
chr12_-_49706364 0.187 NM_000617
NM_001174126
NM_001174127
NM_001174128
SLC11A2



solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2



chr19_-_60272708 0.186 NM_138412
RDH13
retinol dehydrogenase 13 (all-trans/9-cis)
chr10_+_103995248 0.186 GBF1
golgi brefeldin A resistant guanine nucleotide exchange factor 1
chr3_-_52287297 0.180 WDR82
WD repeat domain 82
chr16_+_31105579 0.179


chr2_+_27966985 0.179 NM_199193
NM_199194
NM_004899
NM_199191
NM_199192
BRE




brain and reproductive organ-expressed (TNFRSF1A modulator)




chr3_-_151746954 0.176 SERP1
stress-associated endoplasmic reticulum protein 1
chr9_+_103335964 0.174 RNF20
ring finger protein 20
chr6_-_2785682 0.173 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr5_+_172416959 0.173 C5orf41
chromosome 5 open reading frame 41
chr2_-_191107660 0.172 TMEM194B
transmembrane protein 194B
chr3_-_12856948 0.165 NM_001007074
RPL32
ribosomal protein L32
chr4_+_140806371 0.165 NM_002413
MGST2
microsomal glutathione S-transferase 2
chr12_+_67290881 0.164 NM_001010942
NM_015646
RAP1B

RAP1B, member of RAS oncogene family

chr14_-_94693418 0.163 NM_177438
DICER1
dicer 1, ribonuclease type III
chr19_-_62759536 0.163 NM_001039654
ZNF550
zinc finger protein 550
chr19_+_54708389 0.159 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr18_-_50004770 0.159 MBD2
methyl-CpG binding domain protein 2
chr1_-_209915443 0.157 NM_002497
NEK2
NIMA (never in mitosis gene a)-related kinase 2
chr12_+_67489063 0.153 MDM2
Mdm2 p53 binding protein homolog (mouse)
chr18_-_45594206 0.150 NM_006111
ACAA2
acetyl-CoA acyltransferase 2
chrX_-_130792297 0.150 LOC286467
hypothetical LOC286467

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.45 1.17e-04 GO:0008152 metabolic process
1.48 3.98e-04 GO:0044237 cellular metabolic process
9.08 2.63e-03 GO:0031647 regulation of protein stability
1.43 4.24e-03 GO:0044238 primary metabolic process
1.79 1.06e-02 GO:0009058 biosynthetic process
3.97 1.32e-02 GO:0010608 posttranscriptional regulation of gene expression
11.06 1.52e-02 GO:0050821 protein stabilization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.46 3.35e-04 GO:0044444 cytoplasmic part
1.20 6.26e-03 GO:0044424 intracellular part
2.05 8.43e-03 GO:0005739 mitochondrion
1.55 1.57e-02 GO:0032991 macromolecular complex
1.39 1.63e-02 GO:0044422 organelle part
1.28 1.70e-02 GO:0005737 cytoplasm
1.26 1.81e-02 GO:0043231 intracellular membrane-bounded organelle
1.26 1.94e-02 GO:0043227 membrane-bounded organelle
1.71 2.07e-02 GO:0031974 membrane-enclosed lumen
1.38 2.65e-02 GO:0044446 intracellular organelle part
27.64 2.66e-02 GO:0034366 spherical high-density lipoprotein particle
1.18 2.74e-02 GO:0005622 intracellular
2.40 4.16e-02 GO:0044429 mitochondrial part

Nothing significant found in function category.