Motif ID: SMAD1..7,9.p2

Z-value: 1.451


Transcription factors associated with SMAD1..7,9.p2:

Gene SymbolEntrez IDGene Name
SMAD1 4086 SMAD family member 1
SMAD2 4087 SMAD family member 2
SMAD3 4088 SMAD family member 3
SMAD4 4089 SMAD family member 4
SMAD5 4090 SMAD family member 5
SMAD6 4091 SMAD family member 6
SMAD7 4092 SMAD family member 7
SMAD9 4093 SMAD family member 9

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SMAD3chr15_+_651452150.802.1e-04Click!
SMAD4chr18_+_46810598-0.665.1e-03Click!
SMAD2chr18_-_43710917,
chr18_-_43711452
-0.552.7e-02Click!
SMAD7chr18_-_447310780.457.9e-02Click!
SMAD5chr5_+_135496437-0.449.2e-02Click!
SMAD1chr4_+_146623405-0.439.4e-02Click!
SMAD6chr15_+_647817230.194.8e-01Click!
SMAD9chr13_-_36392370-0.019.6e-01Click!


Activity profile for motif SMAD1..7,9.p2.

activity profile for motif SMAD1..7,9.p2


Sorted Z-values histogram for motif SMAD1..7,9.p2

Sorted Z-values for motif SMAD1..7,9.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SMAD1..7,9.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_65860450 4.226 NM_004292
RIN1
Ras and Rab interactor 1
chr11_-_18769703 2.774 NM_001039970
NM_006906
NM_032781
PTPN5


protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)


chrX_+_152682772 2.716 NM_001163257
NM_005393
PLXNB3

plexin B3

chr12_+_55896844 2.583 NM_007224
NXPH4
neurexophilin 4
chr8_+_32623792 2.571 NM_013959
NRG1
neuregulin 1
chr11_+_60626505 2.342 NM_014207
CD5
CD5 molecule
chr10_+_135333667 2.266 NM_033178
NM_012147
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr15_-_40236061 2.153 NM_213600
PLA2G4F
phospholipase A2, group IVF
chr11_+_66580884 2.119 RHOD
ras homolog gene family, member D
chr10_+_135343649 2.089 NM_012147
DUX2
double homeobox 2
chr4_+_191239247 2.004 NM_033178
NM_012147
NM_001177376
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L4
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr20_+_1194959 1.993 NM_014723
SNPH
syntaphilin
chr14_+_104462260 1.948 PLD4
phospholipase D family, member 4
chr20_+_30061905 1.938 NM_080625
C20orf160
chromosome 20 open reading frame 160
chr20_-_43370333 1.929 NM_003833
NM_030590
NM_030592
MATN4


matrilin 4


chr15_-_76890626 1.902 NM_014272
ADAMTS7
ADAM metallopeptidase with thrombospondin type 1 motif, 7
chr1_+_26220852 1.837 NM_004455
EXTL1
exostoses (multiple)-like 1
chr3_-_64186151 1.833 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr8_-_143864933 1.763 NM_003695
LY6D
lymphocyte antigen 6 complex, locus D
chr2_-_110231431 1.743 NM_005434
MALL
mal, T-cell differentiation protein-like
chr4_+_191226073 1.740 NM_012147
NM_001177376
NM_001127388
NM_001127389
NM_001164467
DUX2
DUX4L4
DUX4L6
DUX4L5
DUX4L3
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
chr12_+_56406296 1.726 LOC100130776
hypothetical LOC100130776
chr11_+_47564805 1.716 NM_001164379
FAM180B
family with sequence similarity 180, member B
chr19_-_59295882 1.714 NM_130771
NM_133168
NM_133169
NM_206818
OSCAR



osteoclast associated, immunoglobulin-like receptor



chr1_+_182622850 1.713 C1orf21
chromosome 1 open reading frame 21
chr19_-_46626474 1.704 NM_198540
B3GNT8
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
chr3_+_114414064 1.689 NM_033254
BOC
Boc homolog (mouse)
chr7_-_44195405 1.688 NM_000162
GCK
glucokinase (hexokinase 4)
chr15_-_81744469 1.669 NM_001717
BNC1
basonuclin 1
chr3_+_185762233 1.665 NM_004443
EPHB3
EPH receptor B3
chr10_-_100164877 1.630 NM_032709
PYROXD2
pyridine nucleotide-disulphide oxidoreductase domain 2
chr4_+_191242540 1.622 NM_033178
NM_012147
NM_001177376
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L4
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr4_+_191232653 1.615 NM_033178
NM_012147
NM_001177376
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L4
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr11_-_310775 1.596 NM_021034
IFITM3
interferon induced transmembrane protein 3 (1-8U)
chr17_-_1342700 1.590 NM_001080779
MYO1C
myosin IC
chr1_+_26220895 1.589 EXTL1
exostoses (multiple)-like 1
chr2_+_128009782 1.576 NM_001080527
MYO7B
myosin VIIB
chr4_+_191235959 1.551 NM_001177376
DUX4L4
double homeobox 4 like 4
chr9_+_123369219 1.549 NM_032552
DAB2IP
DAB2 interacting protein
chr1_+_182622751 1.547 NM_030806
C1orf21
chromosome 1 open reading frame 21
chr18_-_43821491 1.541 NM_001039360
ZBTB7C
zinc finger and BTB domain containing 7C
chr5_-_151046638 1.498 SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr7_-_41709191 1.492 NM_002192
INHBA
inhibin, beta A
chr9_-_109291130 1.489 KLF4
Kruppel-like factor 4 (gut)
chr1_+_177978920 1.466 NM_173509
FAM163A
family with sequence similarity 163, member A
chr19_+_12941431 1.463 NM_152654
DAND5
DAN domain family, member 5
chr16_-_29373785 1.445 NM_001031827
NM_001039182
BOLA2
BOLA2B
bolA homolog 2 (E. coli)
bolA homolog 2B (E. coli)
chr11_-_310925 1.436 IFITM3
interferon induced transmembrane protein 3 (1-8U)
chr9_+_139239464 1.417 NM_199001
C9orf169
chromosome 9 open reading frame 169
chr11_+_63864263 1.412 NM_032251
CCDC88B
coiled-coil domain containing 88B
chr10_+_102881050 1.409 NM_001195517
NM_005521
TLX1

T-cell leukemia homeobox 1

chrX_-_154341451 1.390 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated (intronic transcript) 2
coagulation factor VIII-associated (intronic transcript) 3
coagulation factor VIII-associated (intronic transcript) 1
chr12_-_45759691 1.354 NM_001143668
NM_181847
AMIGO2

adhesion molecule with Ig-like domain 2

chr22_-_28041650 1.353 NM_001007279
NM_006477
RASL10A

RAS-like, family 10, member A

chr9_-_139010805 1.340 NM_004669
CLIC3
chloride intracellular channel 3
chr5_-_74362479 1.330 NM_016591
GCNT4
glucosaminyl (N-acetyl) transferase 4, core 2
chr19_-_15436333 1.325 NM_022904
RASAL3
RAS protein activator like 3
chr15_+_75074483 1.325 NM_003978
PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr20_-_61669550 1.314 NM_033405
PRIC285
peroxisomal proliferator-activated receptor A interacting complex 285
chr14_+_23908141 1.313 NM_001198966
NFATC4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
chr17_+_67628749 1.309 NM_000346
SOX9
SRY (sex determining region Y)-box 9
chr19_+_60691671 1.300 NM_001144950
NM_001195267
SSC5D

scavenger receptor cysteine rich domain containing (5 domains)

chr7_+_75947762 1.278 NM_001102596
DTX2
deltex homolog 2 (Drosophila)
chr17_+_56884560 1.271 TBX4
T-box 4
chr10_-_102880892 1.265 NM_001085398
TLX1NB
TLX1 neighbor
chr2_+_17923404 1.263 NM_002252
KCNS3
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
chr17_+_3486753 1.251 CTNS
cystinosis, nephropathic
chr16_-_73830025 1.250 BCAR1
breast cancer anti-estrogen resistance 1
chr11_+_66580861 1.227 NM_014578
RHOD
ras homolog gene family, member D
chr3_-_46693902 1.214 NM_182775
ALS2CL
ALS2 C-terminal like
chr17_-_34607257 1.211 NM_000723
NM_199247
NM_199248
CACNB1


calcium channel, voltage-dependent, beta 1 subunit


chr1_-_10779291 1.209 NM_001079843
NM_017766
CASZ1

castor zinc finger 1

chr22_-_28041474 1.202 RASL10A
RAS-like, family 10, member A
chr1_+_31659246 1.200 NM_001199039
NM_018565
SERINC2

serine incorporator 2

chr16_+_55553262 1.191 NM_000078
CETP
cholesteryl ester transfer protein, plasma
chr5_-_151046680 1.190 NM_003118
SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr9_+_138497767 1.190 NM_152571
C9orf163
chromosome 9 open reading frame 163
chr5_+_149960820 1.189 NM_001166208
SYNPO
synaptopodin
chr4_+_191229360 1.187 NM_033178
NM_012147
NM_001177376
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L4
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr19_-_53808505 1.184 NM_017708
FAM83E
family with sequence similarity 83, member E
chr22_+_29848923 1.169 NM_001002837
INPP5J
inositol polyphosphate-5-phosphatase J
chr22_+_23221114 1.168 NM_016327
UPB1
ureidopropionase, beta
chr3_-_45162901 1.153 NM_022842
NM_178181
CDCP1

CUB domain containing protein 1

chr22_+_38720881 1.143 NM_138435
FAM83F
family with sequence similarity 83, member F
chr12_+_48641545 1.138 NM_001651
AQP5
aquaporin 5
chr17_-_35911340 1.138 NM_032865
TNS4
tensin 4
chr11_-_60475558 1.135 NM_016582
SLC15A3
solute carrier family 15, member 3
chr16_-_17472238 1.135 NM_022166
XYLT1
xylosyltransferase I
chr14_+_105012106 1.130 NM_001312
CRIP2
cysteine-rich protein 2
chr4_+_2783764 1.119 SH3BP2
SH3-domain binding protein 2
chr19_-_48976852 1.116 KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr14_+_66725862 1.104 NM_173526
FAM71D
family with sequence similarity 71, member D
chr15_-_68971665 1.102 NM_020147
THAP10
THAP domain containing 10
chr15_-_40089736 1.097 NM_001080490
PLA2G4E
phospholipase A2, group IVE
chrX_-_37916138 1.095 SRPX
sushi-repeat containing protein, X-linked
chrX_-_62891730 1.093 NM_001173480
NM_015185
ARHGEF9

Cdc42 guanine nucleotide exchange factor (GEF) 9

chr3_-_45162847 1.093 CDCP1
CUB domain containing protein 1
chr15_+_75074743 1.092 PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr8_-_8276598 1.090 NM_001080826
SGK223
homolog of rat pragma of Rnd2
chr19_-_56164628 1.084 NM_002774
KLK6
kallikrein-related peptidase 6
chr5_+_72452131 1.070 NM_001161342
NM_173490
TMEM171

transmembrane protein 171

chr19_+_40299058 1.068 FXYD3
FXYD domain containing ion transport regulator 3
chr3_+_89239363 1.065 NM_005233
NM_182644
EPHA3

EPH receptor A3

chr17_+_63713171 1.060


chr11_+_129823667 1.055 NM_139055
ADAMTS15
ADAM metallopeptidase with thrombospondin type 1 motif, 15
chr1_+_4614528 1.054 AJAP1
adherens junctions associated protein 1
chr13_-_39075304 1.053 LHFP
lipoma HMGIC fusion partner
chr20_-_57948653 1.048 NM_006242
PPP1R3D
protein phosphatase 1, regulatory (inhibitor) subunit 3D
chr21_-_41479035 1.048 NM_182832
PLAC4
placenta-specific 4
chr18_+_40513889 1.048 NM_001130110
SETBP1
SET binding protein 1
chr1_-_27212035 1.044 FAM46B
family with sequence similarity 46, member B
chr19_+_43572679 1.044 NM_001039616
NM_001042522
SPRED3

sprouty-related, EVH1 domain containing 3

chr1_+_8928508 1.038 NM_001215
CA6
carbonic anhydrase VI
chrX_+_133952633 1.029 NM_001163438
LOC644538
hypothetical protein LOC644538
chr19_-_17275083 1.028 NM_024527
ABHD8
abhydrolase domain containing 8
chr15_+_78774664 1.020 NM_021214
FAM108C1
family with sequence similarity 108, member C1
chr4_+_72271218 1.015 NM_001098484
NM_001134742
SLC4A4

solute carrier family 4, sodium bicarbonate cotransporter, member 4

chr4_+_191245840 1.013 NM_033178
NM_012147
NM_001177376
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L4
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr1_+_199426575 1.010 NM_001164586
IGFN1
immunoglobulin-like and fibronectin type III domain containing 1
chr5_+_170779664 1.009 FGF18
fibroblast growth factor 18
chr16_+_87232501 1.005 NM_013278
IL17C
interleukin 17C
chr1_+_181422016 1.004 LAMC2
laminin, gamma 2
chr8_+_22493928 1.001 NM_176871
NM_198042
PDLIM2

PDZ and LIM domain 2 (mystique)

chr3_-_197106828 0.995 NM_001010938
TNK2
tyrosine kinase, non-receptor, 2
chr19_+_60691733 0.989 SSC5D
scavenger receptor cysteine rich domain containing (5 domains)
chr1_-_158091760 0.988 NM_001134233
C1orf204
chromosome 1 open reading frame 204
chr19_-_48977247 0.987 NM_002250
KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr16_+_56219802 0.987 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr4_+_36923084 0.986 NM_001144990
KIAA1239
KIAA1239
chr1_+_182622987 0.985 C1orf21
chromosome 1 open reading frame 21
chr21_+_38550739 0.984 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr5_-_146813343 0.982 NM_001387
DPYSL3
dihydropyrimidinase-like 3
chr12_+_45759634 0.978 FAM113B
family with sequence similarity 113, member B
chr12_+_2032964 0.970 CACNA1C
calcium channel, voltage-dependent, L type, alpha 1C subunit
chr11_+_64114857 0.968 NM_144585
NM_153378
SLC22A12

solute carrier family 22 (organic anion/urate transporter), member 12

chr3_-_197103848 0.967 TNK2
tyrosine kinase, non-receptor, 2
chr19_-_48133089 0.966 NM_002783
PSG7
pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)
chr8_-_144726064 0.966 NM_001100878
C8orf73
chromosome 8 open reading frame 73
chr10_-_128067062 0.960 NM_003474
NM_021641
ADAM12

ADAM metallopeptidase domain 12

chr3_-_48576204 0.955 NM_033199
UCN2
urocortin 2
chr21_+_46370831 0.946 COL6A2
collagen, type VI, alpha 2
chr11_-_34491878 0.943 NM_001422
ELF5
E74-like factor 5 (ets domain transcription factor)
chr19_+_45807909 0.941


chr17_+_74531820 0.940 NM_030968
NM_198594
C1QTNF1

C1q and tumor necrosis factor related protein 1

chr19_-_52667056 0.933 NM_015063
SLC8A2
solute carrier family 8 (sodium/calcium exchanger), member 2
chr1_+_181421984 0.933 LAMC2
laminin, gamma 2
chr17_-_7238546 0.930 NM_020360
PLSCR3
phospholipid scramblase 3
chr19_-_41034734 0.924 NM_004646
NPHS1
nephrosis 1, congenital, Finnish type (nephrin)
chr6_+_26609427 0.924 NM_001732
BTN1A1
butyrophilin, subfamily 1, member A1
chr9_-_139455611 0.920 NM_001033113
NM_198585
ENTPD8

ectonucleoside triphosphate diphosphohydrolase 8

chrX_-_132376660 0.919 NM_001448
GPC4
glypican 4
chr1_-_41722883 0.918 NM_001956
EDN2
endothelin 2
chr14_+_64086366 0.917 NM_172365
C14orf50
chromosome 14 open reading frame 50
chr5_+_170779264 0.917 NM_003862
FGF18
fibroblast growth factor 18
chr11_+_124114985 0.916 NM_001126181
NM_006176
NRGN

neurogranin (protein kinase C substrate, RC3)

chr3_-_129024665 0.912 NM_001003794
MGLL
monoglyceride lipase
chr19_+_43446937 0.909 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr10_-_128067052 0.900 ADAM12
ADAM metallopeptidase domain 12
chr1_+_181421796 0.900 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr19_-_53912025 0.898 NM_182574
MAMSTR
MEF2 activating motif and SAP domain containing transcriptional regulator
chr5_-_149515502 0.898 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr21_+_44844924 0.894 NM_198689
KRTAP10-7
keratin associated protein 10-7
chr1_+_15964045 0.893 NM_001024216
FBLIM1
filamin binding LIM protein 1
chr1_-_27211913 0.893 NM_052943
FAM46B
family with sequence similarity 46, member B
chr1_-_112333192 0.892 NM_004980
NM_172198
KCND3

potassium voltage-gated channel, Shal-related subfamily, member 3

chr8_-_144770764 0.891 TSTA3
tissue specific transplantation antigen P35B
chr9_-_109291575 0.890 KLF4
Kruppel-like factor 4 (gut)
chr5_-_127447197 0.890 FLJ33630
hypothetical LOC644873
chr5_-_156468614 0.885 NM_032782
HAVCR2
hepatitis A virus cellular receptor 2
chrX_-_62891667 0.885 ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr11_+_122258600 0.884 NM_024806
NM_199124
C11orf63

chromosome 11 open reading frame 63

chr19_-_6230797 0.881


chr9_-_138387926 0.880 NM_052813
NM_052814
CARD9

caspase recruitment domain family, member 9

chrX_+_102749489 0.874 NM_001006933
NM_032926
TCEAL3

transcription elongation factor A (SII)-like 3

chr1_+_199884152 0.874 NAV1
neuron navigator 1
chr22_+_36286350 0.874 NM_152243
CDC42EP1
CDC42 effector protein (Rho GTPase binding) 1
chr3_-_45162783 0.873


chr17_+_74531873 0.867 C1QTNF1
C1q and tumor necrosis factor related protein 1
chr8_-_134378630 0.860 NM_001135242
NM_006096
NDRG1

N-myc downstream regulated 1

chr22_+_42137955 0.858 NM_001044370
MPPED1
metallophosphoesterase domain containing 1
chr19_+_50663089 0.857 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr1_-_145712107 0.854 NM_005266
GJA5
gap junction protein, alpha 5, 40kDa
chr22_+_29333069 0.852 NM_000355
NM_001184726
TCN2

transcobalamin II

chr21_+_44856423 0.850 NM_198695
KRTAP10-8
keratin associated protein 10-8
chr4_-_8211335 0.847 NM_001130083
NM_001130084
NM_001130085
NM_001130086
NM_001130087
NM_001130088
NM_032432
ABLIM2






actin binding LIM protein family, member 2






chr20_-_61676003 0.846 NM_001037335
PRIC285
peroxisomal proliferator-activated receptor A interacting complex 285
chr17_-_59403932 0.845 NM_000334
SCN4A
sodium channel, voltage-gated, type IV, alpha subunit
chrX_+_149280486 0.845 MAMLD1
mastermind-like domain containing 1
chr18_-_55091596 0.842 NM_013435
RAX
retina and anterior neural fold homeobox
chr9_-_21964825 0.841 NM_058197
CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr3_+_11171213 0.838 NM_001098212
HRH1
histamine receptor H1
chr1_+_155130146 0.837 NM_001080471
PEAR1
platelet endothelial aggregation receptor 1
chr11_-_110888273 0.836 NM_017589
BTG4
B-cell translocation gene 4
chr21_+_38550533 0.836 NM_002243
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr20_-_17459973 0.835 NM_001195
BFSP1
beaded filament structural protein 1, filensin
chr9_-_21965131 0.834 NM_000077
NM_001195132
CDKN2A

cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)

chrX_+_106956115 0.831 MID2
midline 2
chr3_-_140246423 0.829 NM_001134657
PRR23C
proline rich 23C
chr20_+_52525538 0.829 NM_018431
DOK5
docking protein 5
chr1_+_210864411 0.828 NM_153606
FAM71A
family with sequence similarity 71, member A

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.31 1.23e-11 GO:0023052 signaling
1.32 4.17e-11 GO:0007165 signal transduction
1.32 1.08e-08 GO:0048731 system development
1.28 5.69e-08 GO:0007275 multicellular organismal development
1.29 9.01e-08 GO:0048856 anatomical structure development
1.20 5.64e-07 GO:0032501 multicellular organismal process
1.45 2.09e-06 GO:0051239 regulation of multicellular organismal process
1.24 2.37e-06 GO:0032502 developmental process
1.37 2.42e-06 GO:0007166 cell surface receptor linked signaling pathway
1.42 2.76e-06 GO:0007399 nervous system development
1.40 8.72e-06 GO:0009653 anatomical structure morphogenesis
1.36 5.02e-05 GO:0023051 regulation of signaling
1.47 5.16e-05 GO:0007154 cell communication
1.20 6.90e-05 GO:0051716 cellular response to stimulus
1.31 1.22e-04 GO:0030154 cell differentiation
1.30 1.39e-04 GO:0048869 cellular developmental process
2.04 2.93e-04 GO:0072507 divalent inorganic cation homeostasis
2.04 4.86e-04 GO:0055074 calcium ion homeostasis
1.46 5.06e-04 GO:0048468 cell development
1.31 6.44e-04 GO:0048583 regulation of response to stimulus
1.36 1.03e-03 GO:0035556 intracellular signal transduction
2.00 1.22e-03 GO:0072503 cellular divalent inorganic cation homeostasis
1.45 1.53e-03 GO:0040011 locomotion
1.99 2.44e-03 GO:0006874 cellular calcium ion homeostasis
1.29 2.93e-03 GO:0048513 organ development
2.23 3.27e-03 GO:0030802 regulation of cyclic nucleotide biosynthetic process
2.23 3.27e-03 GO:0030808 regulation of nucleotide biosynthetic process
2.28 3.31e-03 GO:0030817 regulation of cAMP biosynthetic process
1.11 3.72e-03 GO:0065007 biological regulation
1.49 4.09e-03 GO:0030182 neuron differentiation
1.75 4.12e-03 GO:0007610 behavior
2.26 4.21e-03 GO:0030814 regulation of cAMP metabolic process
1.42 4.24e-03 GO:0022008 neurogenesis
1.79 4.31e-03 GO:0061061 muscle structure development
1.40 4.51e-03 GO:0009605 response to external stimulus
1.46 4.93e-03 GO:0007267 cell-cell signaling
1.12 5.59e-03 GO:0050794 regulation of cellular process
1.54 6.01e-03 GO:0007186 G-protein coupled receptor protein signaling pathway
2.17 6.46e-03 GO:0030799 regulation of cyclic nucleotide metabolic process
2.34 6.71e-03 GO:0045761 regulation of adenylate cyclase activity
1.43 6.84e-03 GO:0048699 generation of neurons
1.41 7.22e-03 GO:0050793 regulation of developmental process
1.13 7.98e-03 GO:0050896 response to stimulus
1.37 9.31e-03 GO:0010646 regulation of cell communication
2.30 1.11e-02 GO:0031279 regulation of cyclase activity
1.91 1.18e-02 GO:0007517 muscle organ development
1.41 1.36e-02 GO:0009888 tissue development
1.55 1.38e-02 GO:0000904 cell morphogenesis involved in differentiation
2.05 1.44e-02 GO:0034330 cell junction organization
1.47 1.51e-02 GO:0045595 regulation of cell differentiation
2.10 1.52e-02 GO:0034329 cell junction assembly
1.59 1.67e-02 GO:0048667 cell morphogenesis involved in neuron differentiation
1.31 1.72e-02 GO:0009966 regulation of signal transduction
1.11 1.75e-02 GO:0050789 regulation of biological process
2.25 1.81e-02 GO:0051339 regulation of lyase activity
1.50 1.96e-02 GO:0048666 neuron development
1.49 1.98e-02 GO:0009887 organ morphogenesis
1.53 2.00e-02 GO:0006935 chemotaxis
1.53 2.00e-02 GO:0042330 taxis
1.54 2.58e-02 GO:0031175 neuron projection development
1.43 2.61e-02 GO:0007155 cell adhesion
1.43 2.61e-02 GO:0022610 biological adhesion
1.41 3.45e-02 GO:0048584 positive regulation of response to stimulus
1.46 3.61e-02 GO:0001932 regulation of protein phosphorylation
1.42 3.80e-02 GO:2000026 regulation of multicellular organismal development
1.57 4.02e-02 GO:0007409 axonogenesis
1.44 4.64e-02 GO:0042325 regulation of phosphorylation
1.23 4.80e-02 GO:0065008 regulation of biological quality
1.68 4.88e-02 GO:0019932 second-messenger-mediated signaling

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.31 2.95e-15 GO:0071944 cell periphery
1.31 7.70e-15 GO:0005886 plasma membrane
1.39 6.14e-11 GO:0044459 plasma membrane part
1.15 3.23e-09 GO:0016020 membrane
1.66 6.28e-07 GO:0030054 cell junction
1.83 1.03e-06 GO:0031012 extracellular matrix
1.32 3.28e-06 GO:0005576 extracellular region
1.46 3.42e-06 GO:0044421 extracellular region part
1.87 5.07e-06 GO:0005578 proteinaceous extracellular matrix
1.41 9.64e-06 GO:0005887 integral to plasma membrane
1.40 1.31e-05 GO:0031226 intrinsic to plasma membrane
1.14 2.10e-05 GO:0044425 membrane part
2.08 5.38e-04 GO:0005912 adherens junction
1.14 1.00e-03 GO:0031224 intrinsic to membrane
1.96 1.79e-03 GO:0070161 anchoring junction
1.14 2.19e-03 GO:0016021 integral to membrane
1.86 2.98e-03 GO:0045111 intermediate filament cytoskeleton
1.58 3.62e-03 GO:0045202 synapse
2.37 4.23e-03 GO:0045095 keratin filament
1.85 1.35e-02 GO:0005882 intermediate filament
2.13 1.51e-02 GO:0005925 focal adhesion
1.35 3.47e-02 GO:0005615 extracellular space
2.03 4.18e-02 GO:0005924 cell-substrate adherens junction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.24 8.05e-03 GO:0004871 signal transducer activity
1.24 8.05e-03 GO:0060089 molecular transducer activity
1.52 1.30e-02 GO:0030695 GTPase regulator activity
1.48 3.90e-02 GO:0060589 nucleoside-triphosphatase regulator activity