Motif ID: SMAD1..7,9.p2

Z-value: 1.451


Transcription factors associated with SMAD1..7,9.p2:

Gene SymbolEntrez IDGene Name
SMAD1 4086 SMAD family member 1
SMAD2 4087 SMAD family member 2
SMAD3 4088 SMAD family member 3
SMAD4 4089 SMAD family member 4
SMAD5 4090 SMAD family member 5
SMAD6 4091 SMAD family member 6
SMAD7 4092 SMAD family member 7
SMAD9 4093 SMAD family member 9

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SMAD3chr15_+_651452150.802.1e-04Click!
SMAD4chr18_+_46810598-0.665.1e-03Click!
SMAD2chr18_-_43710917,
chr18_-_43711452		-0.552.7e-02Click!
SMAD7chr18_-_447310780.457.9e-02Click!
SMAD5chr5_+_135496437-0.449.2e-02Click!
SMAD1chr4_+_146623405-0.439.4e-02Click!
SMAD6chr15_+_647817230.194.8e-01Click!
SMAD9chr13_-_36392370-0.019.6e-01Click!


Activity profile for motif SMAD1..7,9.p2.

activity profile for motif SMAD1..7,9.p2


Sorted Z-values histogram for motif SMAD1..7,9.p2

Sorted Z-values for motif SMAD1..7,9.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SMAD1..7,9.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_65860450 4.226 NM_004292
 RIN1
Ras and Rab interactor 1
chr11_-_18769703 2.774 NM_001039970
NM_006906
NM_032781
 PTPN5


protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)


chrX_+_152682772 2.716 NM_001163257
NM_005393
 PLXNB3

plexin B3

chr12_+_55896844 2.583 NM_007224
 NXPH4
neurexophilin 4
chr8_+_32623792 2.571 NM_013959
 NRG1
neuregulin 1
chr11_+_60626505 2.342 NM_014207
 CD5
CD5 molecule
chr10_+_135333667 2.266 NM_033178
NM_012147
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
 DUX4
DUX2
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr15_-_40236061 2.153 NM_213600
 PLA2G4F
phospholipase A2, group IVF
chr11_+_66580884 2.119 RHOD
ras homolog gene family, member D
chr10_+_135343649 2.089 NM_012147
 DUX2
double homeobox 2
chr4_+_191239247 2.004 NM_033178
NM_012147
NM_001177376
NM_001127388
NM_001127389
NM_001164467
NM_001127386
 DUX4
DUX2
DUX4L4
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr20_+_1194959 1.993 NM_014723
 SNPH
syntaphilin
chr14_+_104462260 1.948 PLD4
phospholipase D family, member 4
chr20_+_30061905 1.938 NM_080625
 C20orf160
chromosome 20 open reading frame 160
chr20_-_43370333 1.929 NM_003833
NM_030590
NM_030592
 MATN4


matrilin 4


chr15_-_76890626 1.902 NM_014272
 ADAMTS7
ADAM metallopeptidase with thrombospondin type 1 motif, 7
chr1_+_26220852 1.837 NM_004455
 EXTL1
exostoses (multiple)-like 1
chr3_-_64186151 1.833 NM_198859
 PRICKLE2
prickle homolog 2 (Drosophila)
chr8_-_143864933 1.763 NM_003695
 LY6D
lymphocyte antigen 6 complex, locus D
chr2_-_110231431 1.743 NM_005434
 MALL
mal, T-cell differentiation protein-like

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 69 entries
enrichment   p-value GO term description
2.34 6.71e-03 GO:0045761 regulation of adenylate cyclase activity
2.30 1.11e-02 GO:0031279 regulation of cyclase activity
2.28 3.31e-03 GO:0030817 regulation of cAMP biosynthetic process
2.26 4.21e-03 GO:0030814 regulation of cAMP metabolic process
2.25 1.81e-02 GO:0051339 regulation of lyase activity
2.23 3.27e-03 GO:0030802 regulation of cyclic nucleotide biosynthetic process
2.23 3.27e-03 GO:0030808 regulation of nucleotide biosynthetic process
2.17 6.46e-03 GO:0030799 regulation of cyclic nucleotide metabolic process
2.10 1.52e-02 GO:0034329 cell junction assembly
2.05 1.44e-02 GO:0034330 cell junction organization
2.04 2.93e-04 GO:0072507 divalent inorganic cation homeostasis
2.04 4.86e-04 GO:0055074 calcium ion homeostasis
2.00 1.22e-03 GO:0072503 cellular divalent inorganic cation homeostasis
1.99 2.44e-03 GO:0006874 cellular calcium ion homeostasis
1.91 1.18e-02 GO:0007517 muscle organ development
1.79 4.31e-03 GO:0061061 muscle structure development
1.75 4.12e-03 GO:0007610 behavior
1.68 4.88e-02 GO:0019932 second-messenger-mediated signaling
1.59 1.67e-02 GO:0048667 cell morphogenesis involved in neuron differentiation
1.57 4.02e-02 GO:0007409 axonogenesis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 23 entries
enrichment   p-value GO term description
2.37 4.23e-03 GO:0045095 keratin filament
2.13 1.51e-02 GO:0005925 focal adhesion
2.08 5.38e-04 GO:0005912 adherens junction
2.03 4.18e-02 GO:0005924 cell-substrate adherens junction
1.96 1.79e-03 GO:0070161 anchoring junction
1.87 5.07e-06 GO:0005578 proteinaceous extracellular matrix
1.86 2.98e-03 GO:0045111 intermediate filament cytoskeleton
1.85 1.35e-02 GO:0005882 intermediate filament
1.83 1.03e-06 GO:0031012 extracellular matrix
1.66 6.28e-07 GO:0030054 cell junction
1.58 3.62e-03 GO:0045202 synapse
1.46 3.42e-06 GO:0044421 extracellular region part
1.41 9.64e-06 GO:0005887 integral to plasma membrane
1.40 1.31e-05 GO:0031226 intrinsic to plasma membrane
1.39 6.14e-11 GO:0044459 plasma membrane part
1.35 3.47e-02 GO:0005615 extracellular space
1.32 3.28e-06 GO:0005576 extracellular region
1.31 2.95e-15 GO:0071944 cell periphery
1.31 7.70e-15 GO:0005886 plasma membrane
1.15 3.23e-09 GO:0016020 membrane

Gene overrepresentation in function category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
1.52 1.30e-02 GO:0030695 GTPase regulator activity
1.48 3.90e-02 GO:0060589 nucleoside-triphosphatase regulator activity
1.24 8.05e-03 GO:0004871 signal transducer activity
1.24 8.05e-03 GO:0060089 molecular transducer activity