Motif ID: SOX2.p2

Z-value: 1.190


Transcription factors associated with SOX2.p2:

Gene SymbolEntrez IDGene Name
SOX2 6657 SRY (sex determining region Y)-box 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SOX2chr3_+_1829124050.543.2e-02Click!


Activity profile for motif SOX2.p2.

activity profile for motif SOX2.p2


Sorted Z-values histogram for motif SOX2.p2

Sorted Z-values for motif SOX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_188021117 2.272 NM_005795
 CALCRL
calcitonin receptor-like
chrX_+_86659370 2.127 NM_019117
NM_057162
 KLHL4

kelch-like 4 (Drosophila)

chr3_-_150533948 2.066 NM_001184723
NM_138786
 TM4SF18

transmembrane 4 L six family member 18

chr9_+_18464090 2.040 NM_001040272
NM_052866
 ADAMTSL1

ADAMTS-like 1

chr1_-_197173159 1.899 LOC100131234
familial acute myelogenous leukemia related factor
chr6_+_12398514 1.853 NM_001168319
NM_001955
 EDN1

endothelin 1

chr7_-_27186400 1.844 NM_153715
 HOXA10
homeobox A10
chr10_-_13789628 1.817 FRMD4A
FERM domain containing 4A
chr9_+_18464138 1.767 ADAMTSL1
ADAMTS-like 1
chr12_-_6103945 1.674 NM_000552
 VWF
von Willebrand factor
chr8_+_32623792 1.620 NM_013959
 NRG1
neuregulin 1
chr8_-_124622434 1.541 NM_058229
 FBXO32
F-box protein 32
chr4_-_101658094 1.515 NM_001159694
NM_016242
 EMCN

endomucin

chr13_-_98428244 1.499 NM_001130048
NM_001130050
 DOCK9

dedicator of cytokinesis 9

chr10_+_11246934 1.453 NM_001025076
NM_001083591
 CELF2

CUGBP, Elav-like family member 2

chrX_+_77889861 1.449 NM_005296
 LPAR4
lysophosphatidic acid receptor 4
chr2_-_37752272 1.443 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr10_+_11087280 1.424 CELF2
CUGBP, Elav-like family member 2
chr1_+_66570363 1.303 NM_001037339
 PDE4B
phosphodiesterase 4B, cAMP-specific
chr5_+_15553288 1.303 NM_012304
 FBXL7
F-box and leucine-rich repeat protein 7

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
1.45 8.77e-03 GO:2000026 regulation of multicellular organismal development
1.34 1.12e-03 GO:0007399 nervous system development
1.24 7.75e-04 GO:0048731 system development
1.21 4.98e-04 GO:0007275 multicellular organismal development
1.18 3.97e-03 GO:0032502 developmental process
1.15 3.03e-03 GO:0032501 multicellular organismal process
1.13 2.43e-04 GO:0050794 regulation of cellular process
1.11 4.09e-03 GO:0065007 biological regulation
1.11 6.10e-03 GO:0050789 regulation of biological process

Gene overrepresentation in compartment category:

Showing 1 to 10 of 10 entries
enrichment   p-value GO term description
3.54 3.35e-03 GO:0001725 stress fiber
3.43 1.24e-03 GO:0042641 actomyosin
3.30 9.19e-03 GO:0032432 actin filament bundle
2.16 4.28e-03 GO:0030055 cell-substrate junction
2.07 1.22e-02 GO:0044420 extracellular matrix part
2.07 3.45e-02 GO:0005925 focal adhesion
1.85 3.63e-02 GO:0005912 adherens junction
1.74 3.47e-04 GO:0005578 proteinaceous extracellular matrix
1.63 1.68e-03 GO:0031012 extracellular matrix
1.58 4.93e-02 GO:0015629 actin cytoskeleton

Gene overrepresentation in function category:

Showing 1 to 5 of 5 entries
enrichment   p-value GO term description
2.42 1.04e-02 GO:0005089 Rho guanyl-nucleotide exchange factor activity
2.18 3.11e-02 GO:0005088 Ras guanyl-nucleotide exchange factor activity
2.12 1.18e-02 GO:0017124 SH3 domain binding
2.12 1.70e-02 GO:0019838 growth factor binding
1.61 1.81e-02 GO:0003779 actin binding