Motif ID: SOX5.p2

Z-value: 0.845


Transcription factors associated with SOX5.p2:

Gene SymbolEntrez IDGene Name
SOX5 6660 SRY (sex determining region Y)-box 5

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SOX5chr12_-_236287740.136.2e-01Click!


Activity profile for motif SOX5.p2.

activity profile for motif SOX5.p2


Sorted Z-values histogram for motif SOX5.p2

Sorted Z-values for motif SOX5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_16380967 1.342 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr1_+_196874759 1.314 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr1_+_196874839 1.146 PTPRC
protein tyrosine phosphatase, receptor type, C
chr13_-_83354474 1.069 NM_052910
SLITRK1
SLIT and NTRK-like family, member 1
chr8_-_102872354 1.056 NCALD
neurocalcin delta
chr4_-_105635499 1.043 CXXC4
CXXC finger protein 4
chr1_+_196874867 1.028 PTPRC
protein tyrosine phosphatase, receptor type, C
chr13_-_83354425 1.015 SLITRK1
SLIT and NTRK-like family, member 1
chr6_-_160599779 0.919 NM_003058
SLC22A2
solute carrier family 22 (organic cation transporter), member 2
chr11_-_123353607 0.856 NM_001004474
OR10S1
olfactory receptor, family 10, subfamily S, member 1
chr7_-_11838260 0.855 NM_015204
THSD7A
thrombospondin, type I, domain containing 7A
chr9_+_126460511 0.854


chr4_-_101658094 0.840 NM_001159694
NM_016242
EMCN

endomucin

chr4_+_42590038 0.838 NM_001080476
GRXCR1
glutaredoxin, cysteine rich 1
chr1_+_29113589 0.836 NM_001166006
EPB41
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
chr2_-_188021117 0.802 NM_005795
CALCRL
calcitonin receptor-like
chr3_+_89239363 0.802 NM_005233
NM_182644
EPHA3

EPH receptor A3

chr2_+_143603368 0.797 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr6_-_139654807 0.763 NM_153235
TXLNB
taxilin beta
chr6_-_32665409 0.763 NM_002124
HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr7_+_50314801 0.751 NM_006060
IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr16_+_64958025 0.749 NM_001795
CDH5
cadherin 5, type 2 (vascular endothelium)
chr3_+_174598937 0.733 NM_014932
NLGN1
neuroligin 1
chr18_-_13905534 0.731 NM_000529
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chr11_+_5925152 0.710 NM_001003443
OR56A3
olfactory receptor, family 56, subfamily A, member 3
chr16_-_20323533 0.710 NM_174924
PDILT
protein disulfide isomerase-like, testis expressed
chr13_+_112349358 0.699 NM_207440
C13orf35
chromosome 13 open reading frame 35
chr11_+_128067598 0.695 NM_001167681
FLI1
Friend leukemia virus integration 1
chr9_-_125070613 0.692 NM_018387
STRBP
spermatid perinuclear RNA binding protein
chr9_-_125070675 0.682 NM_001171137
STRBP
spermatid perinuclear RNA binding protein
chr4_-_64957595 0.674 NM_001010874
TECRL
trans-2,3-enoyl-CoA reductase-like
chr13_+_99431417 0.668


chr2_+_143351536 0.667 NM_001032998
NM_003937
KYNU

kynureninase

chr21_-_38792173 0.662 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr6_+_105511615 0.661 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr1_+_159943385 0.660 NM_001184866
NM_001184867
NM_001184870
NM_001184871
NM_001184872
NM_001184873
NM_032738
FCRLA






Fc receptor-like A






chr11_+_4799126 0.651 NM_001004753
OR51F2
olfactory receptor, family 51, subfamily F, member 2
chr5_-_141318810 0.646 NM_016580
PCDH12
protocadherin 12
chrX_+_77889861 0.637 NM_005296
LPAR4
lysophosphatidic acid receptor 4
chr9_-_40782062 0.622 NM_033160
ZNF658
zinc finger protein 658
chr6_-_29752909 0.618 NM_001109809
ZFP57
zinc finger protein 57 homolog (mouse)
chr9_-_129557373 0.607 NM_001142534
NM_001142533
SH2D3C

SH2 domain containing 3C

chr11_+_128068982 0.607 NM_002017
FLI1
Friend leukemia virus integration 1
chr3_+_190990142 0.605 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr2_-_60633908 0.602 NM_018014
NM_022893
NM_138559
BCL11A


B-cell CLL/lymphoma 11A (zinc finger protein)


chr1_+_246178701 0.602 NM_001001963
OR2L8
olfactory receptor, family 2, subfamily L, member 8
chr20_-_49612574 0.594 NM_001136021
NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr14_-_93493519 0.578 NM_016150
ASB2
ankyrin repeat and SOCS box containing 2
chr5_-_121842680 0.577


chr8_-_72437020 0.567 NM_000503
EYA1
eyes absent homolog 1 (Drosophila)
chr8_-_102872372 0.564 NCALD
neurocalcin delta
chr5_-_147266257 0.557 NM_206966
C5orf46
chromosome 5 open reading frame 46
chr1_-_195302973 0.547 NM_001994
F13B
coagulation factor XIII, B polypeptide
chr14_-_90953883 0.546 NM_001080414
CCDC88C
coiled-coil domain containing 88C
chr3_+_135996734 0.540 NM_004441
EPHB1
EPH receptor B1
chr5_-_39400319 0.539 NM_001737
C9
complement component 9
chr4_-_47831002 0.531 NM_003328
TXK
TXK tyrosine kinase
chr2_-_157890400 0.529 NM_020711
ERMN
ermin, ERM-like protein
chr16_+_65938753 0.529 NM_001161575
LRRC36
leucine rich repeat containing 36
chr20_-_49612745 0.527 NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr1_+_559129 0.527


chr1_-_204455269 0.526 NM_001007544
C1orf186
chromosome 1 open reading frame 186
chr7_-_86526880 0.525 NM_001142749
KIAA1324L
KIAA1324-like
chr1_+_173111306 0.521 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr9_+_263025 0.520 NM_001190458
NM_001193536
DOCK8

dedicator of cytokinesis 8

chr6_-_46155937 0.517 NM_001114086
CLIC5
chloride intracellular channel 5
chr7_+_113842284 0.514 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chr11_+_128069203 0.508 FLI1
Friend leukemia virus integration 1
chr3_+_88270951 0.507 NM_018293
ZNF654
zinc finger protein 654
chr3_+_190831909 0.507 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chr3_+_99350859 0.505 NM_001005514
OR5H14
olfactory receptor, family 5, subfamily H, member 14
chr13_-_93929719 0.504 NM_001129889
NM_001922
DCT

dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)

chr16_+_23673448 0.502 NM_022097
CHP2
calcineurin B homologous protein 2
chr3_-_113701073 0.501 NM_001085357
NM_181780
BTLA

B and T lymphocyte associated

chr7_-_27171673 0.496 NM_152739
HOXA9
homeobox A9
chr2_-_2313894 0.496 NM_015025
MYT1L
myelin transcription factor 1-like
chr5_-_158459276 0.494 NM_024007
EBF1
early B-cell factor 1
chr7_-_16811131 0.494 NM_006408
AGR2
anterior gradient homolog 2 (Xenopus laevis)
chr10_+_96433240 0.493 NM_000772
NM_001128925
CYP2C18

cytochrome P450, family 2, subfamily C, polypeptide 18

chr2_-_207291364 0.489 NM_001093730
DYTN
dystrotelin
chr10_+_49184658 0.484 MAPK8
mitogen-activated protein kinase 8
chr10_+_95507555 0.484 NM_005097
LGI1
leucine-rich, glioma inactivated 1
chrX_-_151370325 0.483 NM_000808
GABRA3
gamma-aminobutyric acid (GABA) A receptor, alpha 3
chr14_-_94855848 0.479 NM_024734
CLMN
calmin (calponin-like, transmembrane)
chrX_-_110541029 0.479 NM_000555
DCX
doublecortin
chr17_-_59817575 0.478 PECAM1
platelet/endothelial cell adhesion molecule
chr10_-_98109048 0.476 NM_001040102
NM_001040103
NM_033207
OPALIN


oligodendrocytic myelin paranodal and inner loop protein


chr14_-_87859284 0.476 NM_138317
KCNK10
potassium channel, subfamily K, member 10
chr3_-_150533948 0.475 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr8_-_30826074 0.475 NM_031271
TEX15
testis expressed 15
chr7_-_122126422 0.470 NM_139175
RNF133
ring finger protein 133
chr2_-_208697441 0.469 NM_006891
CRYGD
crystallin, gamma D
chr3_+_123095860 0.467 NM_001145998
NM_021082
SLC15A2

solute carrier family 15 (H+/peptide transporter), member 2

chr1_-_154665807 0.466 NM_006365
C1orf61
chromosome 1 open reading frame 61
chr2_+_208284610 0.466 CCNYL1
cyclin Y-like 1
chr6_-_41276901 0.464 NM_024807
TREML2
triggering receptor expressed on myeloid cells-like 2
chr14_+_19761708 0.461 NM_001004480
OR11H6
olfactory receptor, family 11, subfamily H, member 6
chr2_+_120233676 0.459 NM_002830
PTPN4
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
chr3_+_135996990 0.458 EPHB1
EPH receptor B1
chr6_+_27885692 0.455 NM_003536
HIST1H3H
histone cluster 1, H3h
chr14_+_36196523 0.454 NM_006194
PAX9
paired box 9
chr1_-_31003181 0.453 LAPTM5
lysosomal protein transmembrane 5
chr11_+_22652894 0.450 NM_005256
GAS2
growth arrest-specific 2
chr4_-_185376012 0.450 NM_153343
ENPP6
ectonucleotide pyrophosphatase/phosphodiesterase 6
chr4_+_175441619 0.449 NM_001145314
KIAA1712
KIAA1712
chr15_-_91078307 0.446 FAM174B
family with sequence similarity 174, member B
chr2_+_26924466 0.444 NM_020134
DPYSL5
dihydropyrimidinase-like 5
chr8_-_74821610 0.444 STAU2
LOC729696
staufen, RNA binding protein, homolog 2 (Drosophila)
hypothetical protein LOC729696
chr20_-_21326046 0.442 NM_033176
NKX2-4
NK2 homeobox 4
chr2_+_232281491 0.440 PTMA
prothymosin, alpha
chr17_+_63252668 0.438 BPTF
bromodomain PHD finger transcription factor
chr3_+_114733907 0.437 NM_017699
SIDT1
SID1 transmembrane family, member 1
chr5_+_94752803 0.437 NM_152548
FAM81B
family with sequence similarity 81, member B
chr12_-_85756766 0.435 NM_013244
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr1_-_7923464 0.434 NM_001561
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
chr5_+_137447479 0.433 NM_058244
WNT8A
wingless-type MMTV integration site family, member 8A
chr8_-_70907957 0.433 NM_001146009
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr6_+_21774624 0.433 FLJ22536
hypothetical locus LOC401237
chr1_+_2927905 0.429 NM_080431
ACTRT2
actin-related protein T2
chr2_+_143603439 0.427 ARHGAP15
Rho GTPase activating protein 15
chr17_-_59817456 0.426 PECAM1
platelet/endothelial cell adhesion molecule
chr6_+_50894397 0.423 NM_003221
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chr20_+_30019465 0.423 NM_001011718
XKR7
XK, Kell blood group complex subunit-related family, member 7
chr12_-_69289889 0.419 NM_002837
PTPRB
protein tyrosine phosphatase, receptor type, B
chr17_+_51585834 0.418 NM_153228
ANKFN1
ankyrin-repeat and fibronectin type III domain containing 1
chrX_+_15435351 0.418 NM_001721
BMX
BMX non-receptor tyrosine kinase
chr2_-_162717159 0.417 NM_002054
GCG
glucagon
chr10_+_18280773 0.417 NM_001145195
NM_152725
SLC39A12

solute carrier family 39 (zinc transporter), member 12

chr14_-_52088786 0.416 NM_001160047
NM_020784
TXNDC16

thioredoxin domain containing 16

chr8_+_65655367 0.416 NM_152414
BHLHE22
basic helix-loop-helix family, member e22
chrX_-_74062005 0.413 NM_001008537
KIAA2022
KIAA2022
chr17_-_16816113 0.413 NM_012452
TNFRSF13B
tumor necrosis factor receptor superfamily, member 13B
chr10_+_11247059 0.410 CELF2
CUGBP, Elav-like family member 2
chrX_-_50573759 0.409 NM_020717
SHROOM4
shroom family member 4
chr17_+_31415752 0.409 NM_002988
CCL18
chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
chr7_-_107230867 0.409 NM_000111
SLC26A3
solute carrier family 26, member 3
chr2_+_102401580 0.409 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr18_+_29412538 0.408 NM_030632
ASXL3
additional sex combs like 3 (Drosophila)
chr11_+_128069183 0.408 FLI1
Friend leukemia virus integration 1
chr5_+_56240843 0.407 NM_001171990
NM_153706
C5orf35

chromosome 5 open reading frame 35

chr1_-_117011824 0.406 NM_001007237
NM_001542
IGSF3

immunoglobulin superfamily, member 3

chr9_-_94206648 0.406 NM_014057
NM_033014
OGN

osteoglycin

chr18_-_72857665 0.405 MBP
myelin basic protein
chr5_-_131907071 0.405 NM_000879
IL5
interleukin 5 (colony-stimulating factor, eosinophil)
chr12_+_8557402 0.404 NM_080387
CLEC4D
C-type lectin domain family 4, member D
chr17_+_65009986 0.403 MAP2K6
mitogen-activated protein kinase kinase 6
chr12_-_10453409 0.402 NM_013431
KLRC4-KLRK1
KLRC4
KLRC4-KLRK1 read-through transcript
killer cell lectin-like receptor subfamily C, member 4
chr3_+_82117978 0.395


chr17_+_36599664 0.395 NM_001190460
KRTAP9-1
keratin associated protein 9-1
chr10_-_98263434 0.395 NM_012465
TLL2
tolloid-like 2
chr9_-_124981125 0.392 STRBP
spermatid perinuclear RNA binding protein
chr7_-_116854765 0.389 NM_130768
ASZ1
ankyrin repeat, SAM and basic leucine zipper domain containing 1
chr20_+_20296744 0.386 NM_002196
INSM1
insulinoma-associated 1
chr12_+_54172413 0.384 NM_001005519
OR6C68
olfactory receptor, family 6, subfamily C, member 68
chr4_-_187114407 0.382 SORBS2
sorbin and SH3 domain containing 2
chr8_-_59575249 0.382 NM_000780
CYP7A1
cytochrome P450, family 7, subfamily A, polypeptide 1
chr5_-_147142249 0.382 JAKMIP2
janus kinase and microtubule interacting protein 2
chr17_-_4216359 0.380 UBE2G1
ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)
chr10_+_97749837 0.376 NM_001001732
NM_001159747
CC2D2B

coiled-coil and C2 domain containing 2B

chr2_-_135498716 0.376 NM_001018046
NM_025052
YSK4

YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae)

chr6_+_122762384 0.376 NM_001135564
NM_004506
HSF2

heat shock transcription factor 2

chr20_+_10363949 0.375 NM_001009608
C20orf94
chromosome 20 open reading frame 94
chr12_-_84754289 0.374 NM_005447
RASSF9
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
chr3_+_173043832 0.373 NM_001164436
TMEM212
transmembrane protein 212
chr15_+_100175888 0.372 NM_001001674
OR4F15
olfactory receptor, family 4, subfamily F, member 15
chr12_-_69317441 0.372 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr2_-_158008763 0.372 NM_004288
CYTIP
cytohesin 1 interacting protein
chr1_-_115039614 0.371 NM_000036
NM_001172626
AMPD1

adenosine monophosphate deaminase 1

chr7_+_21434818 0.371


chr9_-_72673753 0.365 NM_001007470
NM_020952
NM_024971
NM_206944
NM_206945
NM_206946
NM_206947
NM_206948
TRPM3







transient receptor potential cation channel, subfamily M, member 3







chr4_+_35959638 0.365 NM_001136536
DTHD1
death domain containing 1
chr4_+_71492581 0.363 NM_016519
AMBN
ameloblastin (enamel matrix protein)
chr22_+_38213174 0.363 NM_001098270
MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr17_+_72376022 0.363 NM_144677
MGAT5B
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
chr6_+_126112417 0.361 NM_012259
HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr12_-_10173947 0.358 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr18_-_29412148 0.357


chr2_+_166137091 0.355 NM_024969
CSRNP3
cysteine-serine-rich nuclear protein 3
chr5_-_14706486 0.355


chr11_+_108798047 0.355 NM_207645
C11orf87
chromosome 11 open reading frame 87
chr6_-_76838944 0.353 NM_001563
IMPG1
interphotoreceptor matrix proteoglycan 1
chr2_-_160181206 0.353 NM_013450
BAZ2B
bromodomain adjacent to zinc finger domain, 2B
chr4_-_71751205 0.352 NM_144646
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr21_-_33107813 0.351 NM_001162495
NM_001162496
NM_019596
C21orf62


chromosome 21 open reading frame 62


chr21_-_14501114 0.350 NM_198996
LIPI
lipase, member I
chr1_-_246804680 0.349 NM_001001821
OR2T34
olfactory receptor, family 2, subfamily T, member 34
chr6_+_122762449 0.349 HSF2
heat shock transcription factor 2
chrX_+_15428820 0.348 NM_203281
BMX
BMX non-receptor tyrosine kinase
chr12_-_101398429 0.348 IGF1
insulin-like growth factor 1 (somatomedin C)
chr1_+_145841569 0.347 NM_005267
GJA8
gap junction protein, alpha 8, 50kDa
chr10_+_92970302 0.346 NM_032373
PCGF5
polycomb group ring finger 5
chr10_-_56230953 0.345 NM_001142763
NM_001142764
NM_001142765
NM_001142766
NM_001142767
NM_001142768
NM_001142769
NM_001142770
NM_001142771
NM_001142772
NM_001142773
NM_033056
PCDH15











protocadherin-related 15











chr8_-_102872614 0.344 NM_032041
NCALD
neurocalcin delta
chr18_-_22699650 0.343 NM_001650
AQP4
aquaporin 4
chrX_+_99726445 0.338 NM_022144
TNMD
tenomodulin
chr11_+_6998275 0.338 NM_176822
NLRP14
NLR family, pyrin domain containing 14
chr6_-_32271868 0.337 NOTCH4
notch 4
chr21_-_31049566 0.337 NM_181619
KRTAP21-1
keratin associated protein 21-1
chr18_-_55136673 0.337 NM_181654
CPLX4
complexin 4
chr12_+_368774 0.336 NM_001130147
NM_001130148
CCDC77

coiled-coil domain containing 77


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.92 9.14e-05 GO:0007608 sensory perception of smell
1.85 1.07e-04 GO:0007606 sensory perception of chemical stimulus
1.35 9.29e-03 GO:0003008 system process
1.50 1.89e-02 GO:0007600 sensory perception
1.16 2.98e-02 GO:0032501 multicellular organismal process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.93 3.37e-05 GO:0004984 olfactory receptor activity
1.35 1.64e-03 GO:0004872 receptor activity
1.36 1.68e-02 GO:0004888 transmembrane receptor activity
1.45 2.25e-02 GO:0004930 G-protein coupled receptor activity
3.33 4.19e-02 GO:0003823 antigen binding